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Gene: AGFG1 |
Gene summary for AGFG1 |
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Gene information | Species | Human | Gene symbol | AGFG1 | Gene ID | 3267 |
Gene name | ArfGAP with FG repeats 1 | |
Gene Alias | HRB | |
Cytomap | 2q36.3 | |
Gene Type | protein-coding | GO ID | GO:0000003 | UniProtAcc | P52594 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
3267 | AGFG1 | SYSMH1 | Human | Oral cavity | OSCC | 2.72e-03 | 1.56e-01 | 0.1127 |
3267 | AGFG1 | SYSMH2 | Human | Oral cavity | OSCC | 6.56e-07 | 2.48e-01 | 0.2326 |
3267 | AGFG1 | SYSMH3 | Human | Oral cavity | OSCC | 7.30e-22 | 5.62e-01 | 0.2442 |
3267 | AGFG1 | SYSMH5 | Human | Oral cavity | OSCC | 1.73e-02 | 1.73e-01 | 0.0647 |
3267 | AGFG1 | HTA12-23-1 | Human | Pancreas | PDAC | 2.01e-03 | 6.27e-01 | 0.3405 |
3267 | AGFG1 | HTA12-25-1 | Human | Pancreas | PDAC | 8.73e-04 | 6.72e-01 | 0.313 |
3267 | AGFG1 | HTA12-26-1 | Human | Pancreas | PDAC | 5.33e-09 | 5.85e-01 | 0.3728 |
3267 | AGFG1 | HTA12-29-1 | Human | Pancreas | PDAC | 5.77e-22 | 5.96e-01 | 0.3722 |
3267 | AGFG1 | GSM5252132_BPH389PrGF | Human | Prostate | BPH | 2.66e-09 | 6.29e-01 | -0.2247 |
3267 | AGFG1 | GSM5252133_BPH389PrSF | Human | Prostate | BPH | 2.61e-02 | 5.58e-01 | -0.2027 |
3267 | AGFG1 | GSM5252135_BPH511PrPUr_Fcol_3GEX | Human | Prostate | BPH | 1.12e-09 | 4.79e-01 | -0.1833 |
3267 | AGFG1 | 047563_1562-all-cells | Human | Prostate | BPH | 4.57e-08 | 3.02e-01 | 0.0791 |
3267 | AGFG1 | 048752_1579-all-cells | Human | Prostate | BPH | 7.73e-21 | 5.56e-01 | 0.1008 |
3267 | AGFG1 | 052095_1628-all-cells | Human | Prostate | BPH | 1.11e-10 | 3.81e-01 | 0.1032 |
3267 | AGFG1 | 052097_1595-all-cells | Human | Prostate | BPH | 1.31e-29 | 6.26e-01 | 0.0972 |
3267 | AGFG1 | 052099_1652-all-cells | Human | Prostate | BPH | 1.38e-20 | 5.55e-01 | 0.1038 |
3267 | AGFG1 | Dong_P1 | Human | Prostate | Tumor | 1.38e-15 | 6.88e-02 | 0.035 |
3267 | AGFG1 | Dong_P3 | Human | Prostate | Tumor | 1.14e-03 | 5.26e-02 | 0.0278 |
3267 | AGFG1 | Dong_P5 | Human | Prostate | Tumor | 2.16e-07 | -7.74e-02 | 0.053 |
3267 | AGFG1 | P1_S1_AK | Human | Skin | AK | 1.55e-22 | 5.48e-01 | -0.3399 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00069139 | Cervix | CC | nucleocytoplasmic transport | 71/2311 | 301/18723 | 4.04e-08 | 2.54e-06 | 71 |
GO:00511699 | Cervix | CC | nuclear transport | 71/2311 | 301/18723 | 4.04e-08 | 2.54e-06 | 71 |
GO:00511689 | Cervix | CC | nuclear export | 38/2311 | 154/18723 | 1.86e-05 | 3.46e-04 | 38 |
GO:00512368 | Cervix | CC | establishment of RNA localization | 39/2311 | 166/18723 | 4.76e-05 | 7.25e-04 | 39 |
GO:00506578 | Cervix | CC | nucleic acid transport | 38/2311 | 163/18723 | 7.06e-05 | 9.85e-04 | 38 |
GO:00506588 | Cervix | CC | RNA transport | 38/2311 | 163/18723 | 7.06e-05 | 9.85e-04 | 38 |
GO:000640310 | Cervix | CC | RNA localization | 43/2311 | 201/18723 | 2.00e-04 | 2.29e-03 | 43 |
GO:00510284 | Cervix | CC | mRNA transport | 31/2311 | 130/18723 | 2.05e-04 | 2.33e-03 | 31 |
GO:00159318 | Cervix | CC | nucleobase-containing compound transport | 43/2311 | 222/18723 | 1.72e-03 | 1.30e-02 | 43 |
GO:00714262 | Cervix | CC | ribonucleoprotein complex export from nucleus | 18/2311 | 76/18723 | 4.45e-03 | 2.71e-02 | 18 |
GO:00711662 | Cervix | CC | ribonucleoprotein complex localization | 18/2311 | 77/18723 | 5.15e-03 | 3.03e-02 | 18 |
GO:00064054 | Cervix | CC | RNA export from nucleus | 19/2311 | 84/18723 | 6.02e-03 | 3.43e-02 | 19 |
GO:0006913 | Colorectum | AD | nucleocytoplasmic transport | 102/3918 | 301/18723 | 1.00e-07 | 4.85e-06 | 102 |
GO:0051169 | Colorectum | AD | nuclear transport | 102/3918 | 301/18723 | 1.00e-07 | 4.85e-06 | 102 |
GO:0006403 | Colorectum | AD | RNA localization | 71/3918 | 201/18723 | 1.54e-06 | 4.76e-05 | 71 |
GO:0051236 | Colorectum | AD | establishment of RNA localization | 58/3918 | 166/18723 | 1.95e-05 | 4.01e-04 | 58 |
GO:0015931 | Colorectum | AD | nucleobase-containing compound transport | 73/3918 | 222/18723 | 2.02e-05 | 4.10e-04 | 73 |
GO:0050657 | Colorectum | AD | nucleic acid transport | 57/3918 | 163/18723 | 2.22e-05 | 4.39e-04 | 57 |
GO:0050658 | Colorectum | AD | RNA transport | 57/3918 | 163/18723 | 2.22e-05 | 4.39e-04 | 57 |
GO:0051168 | Colorectum | AD | nuclear export | 53/3918 | 154/18723 | 6.89e-05 | 1.11e-03 | 53 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
AGFG1 | SNV | Missense_Mutation | c.1400N>T | p.Ser467Phe | p.S467F | P52594 | protein_coding | deleterious(0) | benign(0.259) | TCGA-BH-A2L8-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | cytoxan | CR | |
AGFG1 | SNV | Missense_Mutation | novel | c.953N>G | p.Ala318Gly | p.A318G | P52594 | protein_coding | tolerated(0.16) | probably_damaging(0.985) | TCGA-D8-A73U-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Hormone Therapy | tamoxiphen | SD |
AGFG1 | SNV | Missense_Mutation | novel | c.896N>A | p.Ala299Asp | p.A299D | P52594 | protein_coding | tolerated(0.06) | benign(0.03) | TCGA-EA-A3HU-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD |
AGFG1 | SNV | Missense_Mutation | rs755915101 | c.631N>T | p.Pro211Ser | p.P211S | P52594 | protein_coding | deleterious(0.04) | benign(0.011) | TCGA-IR-A3LH-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
AGFG1 | SNV | Missense_Mutation | c.1310C>G | p.Ser437Cys | p.S437C | P52594 | protein_coding | deleterious(0.02) | benign(0.219) | TCGA-Q1-A5R2-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | PR | |
AGFG1 | SNV | Missense_Mutation | c.893G>T | p.Ser298Ile | p.S298I | P52594 | protein_coding | deleterious(0.02) | benign(0.441) | TCGA-AA-A00N-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD | |
AGFG1 | SNV | Missense_Mutation | rs142029380 | c.557N>A | p.Arg186His | p.R186H | P52594 | protein_coding | tolerated(0.08) | benign(0.047) | TCGA-AA-A010-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Chemotherapy | folinic | CR |
AGFG1 | SNV | Missense_Mutation | c.1700G>A | p.Gly567Asp | p.G567D | P52594 | protein_coding | deleterious(0) | benign(0.076) | TCGA-AD-6895-01 | Colorectum | colon adenocarcinoma | Male | >=65 | III/IV | Unknown | Unknown | SD | |
AGFG1 | SNV | Missense_Mutation | novel | c.56A>C | p.Asp19Ala | p.D19A | P52594 | protein_coding | deleterious(0) | benign(0.043) | TCGA-AM-5821-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
AGFG1 | SNV | Missense_Mutation | novel | c.1482N>T | p.Met494Ile | p.M494I | P52594 | protein_coding | deleterious(0) | benign(0.021) | TCGA-AZ-4315-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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