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Gene: ZSWIM6 |
Gene summary for ZSWIM6 |
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Gene information | Species | Human | Gene symbol | ZSWIM6 | Gene ID | 57688 |
Gene name | zinc finger SWIM-type containing 6 | |
Gene Alias | AFND | |
Cytomap | 5q12.1 | |
Gene Type | protein-coding | GO ID | GO:0007275 | UniProtAcc | Q9HCJ5 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
57688 | ZSWIM6 | RNA-P8T2-P8T2-3 | Human | Lung | AIS | 4.29e-02 | 9.25e-01 | -0.1284 |
57688 | ZSWIM6 | C21 | Human | Oral cavity | OSCC | 2.26e-02 | -1.79e-01 | 0.2678 |
57688 | ZSWIM6 | C30 | Human | Oral cavity | OSCC | 2.46e-03 | -4.59e-02 | 0.3055 |
57688 | ZSWIM6 | C43 | Human | Oral cavity | OSCC | 7.92e-09 | -2.05e-02 | 0.1704 |
57688 | ZSWIM6 | C46 | Human | Oral cavity | OSCC | 3.31e-04 | -1.69e-01 | 0.1673 |
57688 | ZSWIM6 | C57 | Human | Oral cavity | OSCC | 4.63e-04 | -1.91e-01 | 0.1679 |
57688 | ZSWIM6 | C08 | Human | Oral cavity | OSCC | 1.61e-07 | 3.75e-02 | 0.1919 |
57688 | ZSWIM6 | C09 | Human | Oral cavity | OSCC | 2.26e-03 | 3.08e-01 | 0.1431 |
57688 | ZSWIM6 | EOLP-1 | Human | Oral cavity | EOLP | 7.03e-15 | 5.70e-01 | -0.0202 |
57688 | ZSWIM6 | EOLP-2 | Human | Oral cavity | EOLP | 1.62e-02 | 3.88e-01 | -0.0203 |
57688 | ZSWIM6 | NEOLP-1 | Human | Oral cavity | NEOLP | 1.61e-14 | 7.29e-01 | -0.0194 |
57688 | ZSWIM6 | NEOLP-2 | Human | Oral cavity | NEOLP | 2.33e-04 | 4.32e-01 | -0.0196 |
57688 | ZSWIM6 | NEOLP-3 | Human | Oral cavity | NEOLP | 2.08e-05 | 4.95e-01 | -0.0191 |
57688 | ZSWIM6 | SYSMH1 | Human | Oral cavity | OSCC | 4.01e-06 | -2.12e-01 | 0.1127 |
57688 | ZSWIM6 | SYSMH2 | Human | Oral cavity | OSCC | 6.18e-06 | -2.17e-01 | 0.2326 |
57688 | ZSWIM6 | SYSMH3 | Human | Oral cavity | OSCC | 9.50e-09 | -2.18e-01 | 0.2442 |
57688 | ZSWIM6 | SYSMH4 | Human | Oral cavity | OSCC | 3.00e-06 | -3.17e-01 | 0.1226 |
57688 | ZSWIM6 | SYSMH5 | Human | Oral cavity | OSCC | 8.87e-08 | -3.57e-01 | 0.0647 |
57688 | ZSWIM6 | SYSMH6 | Human | Oral cavity | OSCC | 2.38e-06 | -2.25e-01 | 0.1275 |
57688 | ZSWIM6 | HTA12-15-2 | Human | Pancreas | PDAC | 1.73e-11 | 9.50e-01 | 0.2315 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00309003 | Cervix | CC | forebrain development | 64/2311 | 379/18723 | 5.53e-03 | 3.19e-02 | 64 |
GO:0030900 | Colorectum | FAP | forebrain development | 70/2622 | 379/18723 | 8.64e-03 | 4.98e-02 | 70 |
GO:00309001 | Colorectum | CRC | forebrain development | 66/2078 | 379/18723 | 1.36e-04 | 2.57e-03 | 66 |
GO:0021879 | Colorectum | CRC | forebrain neuron differentiation | 12/2078 | 42/18723 | 1.55e-03 | 1.63e-02 | 12 |
GO:0021537 | Colorectum | CRC | telencephalon development | 43/2078 | 248/18723 | 2.01e-03 | 2.01e-02 | 43 |
GO:0021872 | Colorectum | CRC | forebrain generation of neurons | 13/2078 | 51/18723 | 3.09e-03 | 2.73e-02 | 13 |
GO:0021953 | Colorectum | CRC | central nervous system neuron differentiation | 29/2078 | 162/18723 | 6.36e-03 | 4.62e-02 | 29 |
GO:00309002 | Lung | IAC | forebrain development | 61/2061 | 379/18723 | 1.52e-03 | 1.61e-02 | 61 |
GO:003090011 | Lung | AIS | forebrain development | 55/1849 | 379/18723 | 2.37e-03 | 2.48e-02 | 55 |
GO:00309005 | Oral cavity | EOLP | forebrain development | 68/2218 | 379/18723 | 2.97e-04 | 2.79e-03 | 68 |
GO:003090013 | Oral cavity | NEOLP | forebrain development | 67/2005 | 379/18723 | 2.54e-05 | 3.99e-04 | 67 |
GO:00219532 | Oral cavity | NEOLP | central nervous system neuron differentiation | 30/2005 | 162/18723 | 1.96e-03 | 1.32e-02 | 30 |
GO:00215371 | Oral cavity | NEOLP | telencephalon development | 40/2005 | 248/18723 | 5.50e-03 | 2.93e-02 | 40 |
GO:00309004 | Prostate | BPH | forebrain development | 80/3107 | 379/18723 | 1.19e-02 | 4.82e-02 | 80 |
GO:003090012 | Prostate | Tumor | forebrain development | 86/3246 | 379/18723 | 4.22e-03 | 2.11e-02 | 86 |
GO:00309006 | Skin | AK | forebrain development | 66/1910 | 379/18723 | 1.02e-05 | 2.17e-04 | 66 |
GO:00215372 | Skin | AK | telencephalon development | 42/1910 | 248/18723 | 7.04e-04 | 6.01e-03 | 42 |
GO:003090014 | Skin | SCCIS | forebrain development | 34/919 | 379/18723 | 5.35e-04 | 8.26e-03 | 34 |
GO:002153711 | Skin | SCCIS | telencephalon development | 23/919 | 248/18723 | 2.63e-03 | 2.48e-02 | 23 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
ZSWIM6 | SNV | Missense_Mutation | novel | c.1558N>C | p.Glu520Gln | p.E520Q | Q9HCJ5 | protein_coding | tolerated(0.22) | possibly_damaging(0.852) | TCGA-3C-AALI-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unspecific | Poly E | Complete Response |
ZSWIM6 | SNV | Missense_Mutation | rs752185820 | c.3197N>C | p.His1066Pro | p.H1066P | Q9HCJ5 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-A2-A1G0-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | taxotere | SD |
ZSWIM6 | SNV | Missense_Mutation | novel | c.1030N>A | p.His344Asn | p.H344N | Q9HCJ5 | protein_coding | tolerated(0.16) | benign(0.03) | TCGA-AN-A046-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
ZSWIM6 | SNV | Missense_Mutation | rs754512309 | c.2040N>A | p.Phe680Leu | p.F680L | Q9HCJ5 | protein_coding | tolerated(0.75) | benign(0.003) | TCGA-AN-A046-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
ZSWIM6 | SNV | Missense_Mutation | c.741C>A | p.Asn247Lys | p.N247K | Q9HCJ5 | protein_coding | tolerated(1) | benign(0.015) | TCGA-AN-A0FW-01 | Breast | breast invasive carcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD | |
ZSWIM6 | SNV | Missense_Mutation | rs752185820 | c.3197A>C | p.His1066Pro | p.H1066P | Q9HCJ5 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-AR-A255-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Targeted Molecular therapy | trastuzumab | SD |
ZSWIM6 | SNV | Missense_Mutation | rs752185820 | c.3197N>C | p.His1066Pro | p.H1066P | Q9HCJ5 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-B6-A0I5-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
ZSWIM6 | SNV | Missense_Mutation | rs752185820 | c.3197N>C | p.His1066Pro | p.H1066P | Q9HCJ5 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-BH-A0HO-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | cyclophosphamide | SD |
ZSWIM6 | SNV | Missense_Mutation | c.1813N>C | p.Glu605Gln | p.E605Q | Q9HCJ5 | protein_coding | deleterious(0.02) | possibly_damaging(0.617) | TCGA-BH-A1F8-01 | Breast | breast invasive carcinoma | Female | >=65 | III/IV | Unknown | Unknown | PD | |
ZSWIM6 | SNV | Missense_Mutation | rs752185820 | c.3197A>C | p.His1066Pro | p.H1066P | Q9HCJ5 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-BH-A1FR-01 | Breast | breast invasive carcinoma | Female | >=65 | III/IV | Unknown | Unknown | PD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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