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Gene: ZNF280D |
Gene summary for ZNF280D |
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Gene information | Species | Human | Gene symbol | ZNF280D | Gene ID | 54816 |
Gene name | zinc finger protein 280D | |
Gene Alias | SUHW4 | |
Cytomap | 15q21.3 | |
Gene Type | protein-coding | GO ID | GO:0006139 | UniProtAcc | Q6N043 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
54816 | ZNF280D | Dong_P5 | Human | Prostate | Tumor | 1.87e-03 | 2.57e-02 | 0.053 |
54816 | ZNF280D | GSM5353221_PA_PB2A_Pool_1_3_S25_L001 | Human | Prostate | Tumor | 1.55e-08 | 5.80e-01 | 0.1633 |
54816 | ZNF280D | GSM5353222_PA_PB2B_Pool_1_3_S52_L002 | Human | Prostate | Tumor | 1.43e-09 | 5.43e-01 | 0.1608 |
54816 | ZNF280D | GSM5353223_PA_PB2B_Pool_2_S26_L001 | Human | Prostate | Tumor | 3.88e-05 | 4.96e-01 | 0.1604 |
54816 | ZNF280D | GSM5353224_PA_PR5186_Pool_1_2_3_S27_L001 | Human | Prostate | Tumor | 3.68e-04 | 3.99e-01 | 0.1621 |
54816 | ZNF280D | male-WTA | Human | Thyroid | PTC | 6.61e-10 | 4.46e-02 | 0.1037 |
54816 | ZNF280D | PTC01 | Human | Thyroid | PTC | 9.31e-06 | 1.07e-01 | 0.1899 |
54816 | ZNF280D | PTC04 | Human | Thyroid | PTC | 6.19e-19 | 2.38e-01 | 0.1927 |
54816 | ZNF280D | PTC05 | Human | Thyroid | PTC | 8.40e-13 | 4.58e-01 | 0.2065 |
54816 | ZNF280D | PTC06 | Human | Thyroid | PTC | 2.17e-26 | 5.31e-01 | 0.2057 |
54816 | ZNF280D | PTC07 | Human | Thyroid | PTC | 8.15e-21 | 2.93e-01 | 0.2044 |
54816 | ZNF280D | ATC11 | Human | Thyroid | ATC | 4.85e-05 | 2.48e-01 | 0.3386 |
54816 | ZNF280D | ATC12 | Human | Thyroid | ATC | 2.94e-18 | 1.83e-01 | 0.34 |
54816 | ZNF280D | ATC13 | Human | Thyroid | ATC | 1.41e-24 | 2.63e-01 | 0.34 |
54816 | ZNF280D | ATC2 | Human | Thyroid | ATC | 6.15e-06 | 6.06e-01 | 0.34 |
54816 | ZNF280D | ATC3 | Human | Thyroid | ATC | 6.39e-16 | 4.11e-01 | 0.338 |
54816 | ZNF280D | ATC4 | Human | Thyroid | ATC | 7.09e-24 | 2.72e-01 | 0.34 |
54816 | ZNF280D | ATC5 | Human | Thyroid | ATC | 7.27e-20 | 2.91e-01 | 0.34 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
ZNF280D | SNV | Missense_Mutation | c.2923G>A | p.Glu975Lys | p.E975K | Q6N043 | protein_coding | tolerated_low_confidence(0.08) | benign(0.015) | TCGA-AC-A23H-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | PD | |
ZNF280D | SNV | Missense_Mutation | novel | c.647N>A | p.Ser216Tyr | p.S216Y | Q6N043 | protein_coding | tolerated(0.05) | possibly_damaging(0.646) | TCGA-AC-A3W6-01 | Breast | breast invasive carcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD |
ZNF280D | SNV | Missense_Mutation | rs866653627 | c.2773G>A | p.Glu925Lys | p.E925K | Q6N043 | protein_coding | deleterious(0) | probably_damaging(0.943) | TCGA-AN-A046-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
ZNF280D | SNV | Missense_Mutation | novel | c.1730N>T | p.Thr577Ile | p.T577I | Q6N043 | protein_coding | tolerated(0.05) | benign(0.046) | TCGA-B6-A3ZX-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | cyclophosphamide | PD |
ZNF280D | insertion | Frame_Shift_Ins | novel | c.1718_1719insAATTTTGAAAAAAGCACATA | p.Ser573ArgfsTer49 | p.S573Rfs*49 | Q6N043 | protein_coding | TCGA-AO-A128-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | doxorubicin | SD | ||
ZNF280D | SNV | Missense_Mutation | novel | c.158N>T | p.Ser53Leu | p.S53L | Q6N043 | protein_coding | deleterious(0.02) | benign(0.244) | TCGA-JW-A5VL-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD |
ZNF280D | SNV | Missense_Mutation | novel | c.2726N>G | p.Asp909Gly | p.D909G | Q6N043 | protein_coding | deleterious(0.05) | probably_damaging(0.946) | TCGA-ZJ-AAX4-01 | Cervix | cervical & endocervical cancer | Female | >=65 | I/II | Unknown | Unknown | SD |
ZNF280D | insertion | Frame_Shift_Ins | rs747375742 | c.2376_2377insCTTT | p.Gly793LeufsTer9 | p.G793Lfs*9 | Q6N043 | protein_coding | TCGA-DS-A1OC-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | gemcitabine | SD | ||
ZNF280D | SNV | Missense_Mutation | novel | c.2680G>T | p.Asp894Tyr | p.D894Y | Q6N043 | protein_coding | deleterious(0) | possibly_damaging(0.459) | TCGA-5M-AAT5-01 | Colorectum | colon adenocarcinoma | Unknown | Unknown | I/II | Unknown | Unknown | Unknown |
ZNF280D | SNV | Missense_Mutation | c.1924A>G | p.Thr642Ala | p.T642A | Q6N043 | protein_coding | tolerated(0.52) | benign(0.009) | TCGA-AA-3977-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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