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Gene: YEATS4 |
Gene summary for YEATS4 |
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Gene information | Species | Human | Gene symbol | YEATS4 | Gene ID | 8089 |
Gene name | YEATS domain containing 4 | |
Gene Alias | 4930573H17Rik | |
Cytomap | 12q15 | |
Gene Type | protein-coding | GO ID | GO:0000278 | UniProtAcc | F8W0J4 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
8089 | YEATS4 | PTC07 | Human | Thyroid | PTC | 5.97e-18 | 3.27e-01 | 0.2044 |
8089 | YEATS4 | ATC12 | Human | Thyroid | ATC | 8.78e-03 | 6.86e-02 | 0.34 |
8089 | YEATS4 | ATC13 | Human | Thyroid | ATC | 4.91e-65 | 1.93e+00 | 0.34 |
8089 | YEATS4 | ATC2 | Human | Thyroid | ATC | 2.16e-05 | 4.24e-01 | 0.34 |
8089 | YEATS4 | ATC4 | Human | Thyroid | ATC | 2.87e-02 | 1.36e-01 | 0.34 |
8089 | YEATS4 | ATC5 | Human | Thyroid | ATC | 3.62e-82 | 2.19e+00 | 0.34 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:001657015 | Esophagus | ESCC | histone modification | 323/8552 | 463/18723 | 2.61e-26 | 7.88e-24 | 323 |
GO:001820514 | Esophagus | ESCC | peptidyl-lysine modification | 259/8552 | 376/18723 | 3.90e-20 | 5.26e-18 | 259 |
GO:001839413 | Esophagus | ESCC | peptidyl-lysine acetylation | 123/8552 | 169/18723 | 6.58e-13 | 2.94e-11 | 123 |
GO:004354313 | Esophagus | ESCC | protein acylation | 165/8552 | 243/18723 | 1.69e-12 | 7.14e-11 | 165 |
GO:000647313 | Esophagus | ESCC | protein acetylation | 140/8552 | 201/18723 | 4.37e-12 | 1.69e-10 | 140 |
GO:001839313 | Esophagus | ESCC | internal peptidyl-lysine acetylation | 114/8552 | 158/18723 | 1.16e-11 | 4.24e-10 | 114 |
GO:000647513 | Esophagus | ESCC | internal protein amino acid acetylation | 115/8552 | 160/18723 | 1.43e-11 | 5.08e-10 | 115 |
GO:00165735 | Esophagus | ESCC | histone acetylation | 110/8552 | 152/18723 | 1.95e-11 | 6.81e-10 | 110 |
GO:004396712 | Esophagus | ESCC | histone H4 acetylation | 53/8552 | 67/18723 | 2.11e-08 | 4.03e-07 | 53 |
GO:00439682 | Esophagus | ESCC | histone H2A acetylation | 15/8552 | 17/18723 | 3.48e-04 | 2.03e-03 | 15 |
GO:00064731 | Liver | Cirrhotic | protein acetylation | 84/4634 | 201/18723 | 7.50e-08 | 2.25e-06 | 84 |
GO:00183941 | Liver | Cirrhotic | peptidyl-lysine acetylation | 73/4634 | 169/18723 | 1.08e-07 | 3.07e-06 | 73 |
GO:00435431 | Liver | Cirrhotic | protein acylation | 95/4634 | 243/18723 | 4.73e-07 | 1.07e-05 | 95 |
GO:00182051 | Liver | Cirrhotic | peptidyl-lysine modification | 134/4634 | 376/18723 | 1.29e-06 | 2.59e-05 | 134 |
GO:00064751 | Liver | Cirrhotic | internal protein amino acid acetylation | 65/4634 | 160/18723 | 6.66e-06 | 1.04e-04 | 65 |
GO:00183931 | Liver | Cirrhotic | internal peptidyl-lysine acetylation | 64/4634 | 158/18723 | 8.75e-06 | 1.29e-04 | 64 |
GO:001657011 | Liver | Cirrhotic | histone modification | 154/4634 | 463/18723 | 1.92e-05 | 2.57e-04 | 154 |
GO:00165731 | Liver | Cirrhotic | histone acetylation | 61/4634 | 152/18723 | 1.97e-05 | 2.62e-04 | 61 |
GO:0043967 | Liver | Cirrhotic | histone H4 acetylation | 31/4634 | 67/18723 | 1.03e-04 | 1.06e-03 | 31 |
GO:0043968 | Liver | Cirrhotic | histone H2A acetylation | 11/4634 | 17/18723 | 5.66e-04 | 4.44e-03 | 11 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
YEATS4 | SNV | Missense_Mutation | c.489A>C | p.Leu163Phe | p.L163F | O95619 | protein_coding | tolerated(0.62) | benign(0.01) | TCGA-BH-A1EN-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
YEATS4 | insertion | Frame_Shift_Ins | novel | c.680_681insA | p.Ter228IlefsTer12 | p.*228Ifs*12 | O95619 | protein_coding | TCGA-A1-A0SP-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | SD | |||
YEATS4 | SNV | Missense_Mutation | novel | c.317A>G | p.Asp106Gly | p.D106G | O95619 | protein_coding | deleterious(0) | probably_damaging(0.998) | TCGA-C5-A901-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD |
YEATS4 | SNV | Missense_Mutation | c.148N>A | p.Tyr50Asn | p.Y50N | O95619 | protein_coding | deleterious(0) | probably_damaging(0.997) | TCGA-D5-6923-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD | |
YEATS4 | SNV | Missense_Mutation | c.557N>T | p.Ala186Val | p.A186V | O95619 | protein_coding | tolerated(0.06) | benign(0.221) | TCGA-WS-AB45-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
YEATS4 | SNV | Missense_Mutation | c.6N>G | p.Phe2Leu | p.F2L | O95619 | protein_coding | tolerated_low_confidence(0.4) | benign(0.01) | TCGA-AG-3731-01 | Colorectum | rectum adenocarcinoma | Male | >=65 | III/IV | Chemotherapy | folinic | PR | |
YEATS4 | SNV | Missense_Mutation | novel | c.289G>A | p.Glu97Lys | p.E97K | O95619 | protein_coding | deleterious(0) | probably_damaging(0.99) | TCGA-EI-6917-01 | Colorectum | rectum adenocarcinoma | Male | <65 | III/IV | Chemotherapy | 5fluorouracil+oxaciplatina+l-folinian | SD |
YEATS4 | SNV | Missense_Mutation | novel | c.494N>T | p.Ala165Val | p.A165V | O95619 | protein_coding | tolerated(0.33) | benign(0.007) | TCGA-AJ-A3EK-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Chemotherapy | carboplatin | CR |
YEATS4 | SNV | Missense_Mutation | novel | c.611N>A | p.Ser204Asn | p.S204N | O95619 | protein_coding | tolerated(0.14) | benign(0.006) | TCGA-AJ-A3EK-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Chemotherapy | carboplatin | CR |
YEATS4 | SNV | Missense_Mutation | novel | c.453N>A | p.Met151Ile | p.M151I | O95619 | protein_coding | deleterious(0.01) | possibly_damaging(0.656) | TCGA-AX-A1CE-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unspecific | Paclitaxel | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
8089 | YEATS4 | TRANSCRIPTION FACTOR, TUMOR SUPPRESSOR, CLINICALLY ACTIONABLE | hydrochlorothiazide | HYDROCHLOROTHIAZIDE |
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