![]() |
|||||
|
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() |
Gene: WDR13 |
Gene summary for WDR13 |
![]() |
Gene information | Species | Human | Gene symbol | WDR13 | Gene ID | 64743 |
Gene name | WD repeat domain 13 | |
Gene Alias | MG21 | |
Cytomap | Xp11.23 | |
Gene Type | protein-coding | GO ID | GO:0008150 | UniProtAcc | Q9H1Z4 |
Top |
Malignant transformation analysis |
![]() |
![]() |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
64743 | WDR13 | P1_cSCC | Human | Skin | cSCC | 2.67e-15 | 6.05e-01 | 0.0292 |
64743 | WDR13 | P2_cSCC | Human | Skin | cSCC | 2.70e-04 | 3.01e-01 | -0.024 |
64743 | WDR13 | P4_cSCC | Human | Skin | cSCC | 1.28e-09 | 3.22e-01 | -0.00290000000000005 |
64743 | WDR13 | P10_cSCC | Human | Skin | cSCC | 2.68e-06 | 3.92e-01 | 0.1017 |
64743 | WDR13 | cSCC_p9 | Human | Skin | cSCC | 1.58e-04 | 4.58e-02 | -0.1991 |
64743 | WDR13 | male-WTA | Human | Thyroid | PTC | 1.48e-28 | 2.81e-01 | 0.1037 |
64743 | WDR13 | PTC01 | Human | Thyroid | PTC | 6.59e-13 | 3.47e-01 | 0.1899 |
64743 | WDR13 | PTC03 | Human | Thyroid | PTC | 1.76e-05 | 1.98e-01 | 0.1784 |
64743 | WDR13 | PTC04 | Human | Thyroid | PTC | 3.83e-21 | 4.83e-01 | 0.1927 |
64743 | WDR13 | PTC05 | Human | Thyroid | PTC | 1.88e-22 | 7.24e-01 | 0.2065 |
64743 | WDR13 | PTC06 | Human | Thyroid | PTC | 5.85e-43 | 7.73e-01 | 0.2057 |
64743 | WDR13 | PTC07 | Human | Thyroid | PTC | 4.46e-44 | 6.86e-01 | 0.2044 |
64743 | WDR13 | ATC09 | Human | Thyroid | ATC | 1.03e-05 | 1.68e-01 | 0.2871 |
64743 | WDR13 | ATC11 | Human | Thyroid | ATC | 1.54e-07 | 7.40e-01 | 0.3386 |
64743 | WDR13 | ATC12 | Human | Thyroid | ATC | 1.04e-18 | 5.09e-01 | 0.34 |
64743 | WDR13 | ATC13 | Human | Thyroid | ATC | 9.44e-23 | 4.81e-01 | 0.34 |
64743 | WDR13 | ATC1 | Human | Thyroid | ATC | 1.67e-03 | 1.32e-01 | 0.2878 |
64743 | WDR13 | ATC2 | Human | Thyroid | ATC | 2.98e-26 | 1.53e+00 | 0.34 |
64743 | WDR13 | ATC3 | Human | Thyroid | ATC | 8.20e-09 | 5.41e-01 | 0.338 |
64743 | WDR13 | ATC4 | Human | Thyroid | ATC | 8.43e-32 | 6.76e-01 | 0.34 |
Page: 1 2 3 4 5 6 7 |
![]() |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
Top |
Malignant transformation related pathway analysis |
![]() |
![]() |
Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
![]() |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:005067318 | Esophagus | ESCC | epithelial cell proliferation | 238/8552 | 437/18723 | 1.19e-04 | 8.20e-04 | 238 |
GO:005067817 | Esophagus | ESCC | regulation of epithelial cell proliferation | 206/8552 | 381/18723 | 5.51e-04 | 3.02e-03 | 206 |
GO:00443423 | Esophagus | ESCC | type B pancreatic cell proliferation | 15/8552 | 21/18723 | 1.54e-02 | 4.96e-02 | 15 |
GO:005067310 | Oral cavity | OSCC | epithelial cell proliferation | 212/7305 | 437/18723 | 2.82e-05 | 2.61e-04 | 212 |
GO:005067810 | Oral cavity | OSCC | regulation of epithelial cell proliferation | 180/7305 | 381/18723 | 5.88e-04 | 3.35e-03 | 180 |
GO:005067324 | Skin | cSCC | epithelial cell proliferation | 144/4864 | 437/18723 | 6.07e-04 | 4.38e-03 | 144 |
GO:004434211 | Skin | cSCC | type B pancreatic cell proliferation | 11/4864 | 21/18723 | 8.71e-03 | 4.01e-02 | 11 |
GO:0050673111 | Thyroid | ATC | epithelial cell proliferation | 174/6293 | 437/18723 | 3.49e-03 | 1.55e-02 | 174 |
GO:0050678110 | Thyroid | ATC | regulation of epithelial cell proliferation | 151/6293 | 381/18723 | 7.47e-03 | 2.92e-02 | 151 |
Page: 1 |
![]() |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
Page: 1 |
Top |
Cell-cell communication analysis |
![]() |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
Page: 1 |
Top |
Single-cell gene regulatory network inference analysis |
![]() |
TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
Page: 1 |
Top |
Somatic mutation of malignant transformation related genes |
![]() |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
WDR13 | SNV | Missense_Mutation | c.541N>A | p.Ala181Thr | p.A181T | Q9H1Z4 | protein_coding | deleterious(0) | probably_damaging(0.988) | TCGA-A2-A3Y0-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | adriamycin | CR | |
WDR13 | SNV | Missense_Mutation | novel | c.455C>T | p.Thr152Met | p.T152M | Q9H1Z4 | protein_coding | tolerated(0.09) | possibly_damaging(0.812) | TCGA-AR-A2LK-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Hormone Therapy | anastrozole | PD |
WDR13 | SNV | Missense_Mutation | c.718N>G | p.Thr240Ala | p.T240A | Q9H1Z4 | protein_coding | deleterious(0.05) | benign(0.03) | TCGA-E2-A15M-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Hormone Therapy | arimidex | SD | |
WDR13 | SNV | Missense_Mutation | novel | c.1166N>G | p.Asn389Ser | p.N389S | Q9H1Z4 | protein_coding | tolerated(0.53) | benign(0.358) | TCGA-E2-A570-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Hormone Therapy | anastrozole | SD |
WDR13 | SNV | Missense_Mutation | c.962C>T | p.Ala321Val | p.A321V | Q9H1Z4 | protein_coding | tolerated(0.12) | possibly_damaging(0.532) | TCGA-E9-A1N9-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | doxorubicin | SD | |
WDR13 | deletion | Frame_Shift_Del | novel | c.319delN | p.His108ThrfsTer16 | p.H108Tfs*16 | Q9H1Z4 | protein_coding | TCGA-A7-A0D9-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | taxotere | SD | ||
WDR13 | SNV | Missense_Mutation | rs782786399 | c.631C>T | p.Arg211Cys | p.R211C | Q9H1Z4 | protein_coding | tolerated(0.33) | benign(0) | TCGA-MY-A5BE-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD |
WDR13 | SNV | Missense_Mutation | novel | c.97N>T | p.Arg33Trp | p.R33W | Q9H1Z4 | protein_coding | deleterious(0) | probably_damaging(0.994) | TCGA-AA-3549-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
WDR13 | SNV | Missense_Mutation | novel | c.247N>A | p.Val83Ile | p.V83I | Q9H1Z4 | protein_coding | tolerated(0.43) | benign(0.005) | TCGA-AA-3854-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
WDR13 | SNV | Missense_Mutation | rs782245413 | c.535N>T | p.Arg179Cys | p.R179C | Q9H1Z4 | protein_coding | deleterious(0) | possibly_damaging(0.498) | TCGA-AA-3949-01 | Colorectum | colon adenocarcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD |
Page: 1 2 3 4 5 6 7 8 |
Top |
Related drugs of malignant transformation related genes |
![]() |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
Page: 1 |