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Gene: USP7 |
Gene summary for USP7 |
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Gene information | Species | Human | Gene symbol | USP7 | Gene ID | 7874 |
Gene name | ubiquitin specific peptidase 7 | |
Gene Alias | HAFOUS | |
Cytomap | 16p13.2 | |
Gene Type | protein-coding | GO ID | GO:0000723 | UniProtAcc | B7ZAX6 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
7874 | USP7 | C43 | Human | Oral cavity | OSCC | 1.67e-05 | 1.78e-01 | 0.1704 |
7874 | USP7 | C51 | Human | Oral cavity | OSCC | 2.30e-10 | 5.81e-01 | 0.2674 |
7874 | USP7 | C57 | Human | Oral cavity | OSCC | 9.38e-05 | 2.75e-01 | 0.1679 |
7874 | USP7 | C08 | Human | Oral cavity | OSCC | 5.22e-08 | 1.97e-01 | 0.1919 |
7874 | USP7 | EOLP-1 | Human | Oral cavity | EOLP | 2.96e-04 | 1.72e-01 | -0.0202 |
7874 | USP7 | SYSMH1 | Human | Oral cavity | OSCC | 5.00e-12 | 3.51e-01 | 0.1127 |
7874 | USP7 | SYSMH2 | Human | Oral cavity | OSCC | 1.14e-17 | 5.88e-01 | 0.2326 |
7874 | USP7 | SYSMH3 | Human | Oral cavity | OSCC | 3.82e-29 | 8.23e-01 | 0.2442 |
7874 | USP7 | SYSMH4 | Human | Oral cavity | OSCC | 1.93e-02 | 9.82e-03 | 0.1226 |
7874 | USP7 | SYSMH5 | Human | Oral cavity | OSCC | 2.09e-10 | 4.96e-01 | 0.0647 |
7874 | USP7 | SYSMH6 | Human | Oral cavity | OSCC | 1.09e-02 | 2.31e-01 | 0.1275 |
7874 | USP7 | GSM5252132_BPH389PrGF | Human | Prostate | BPH | 1.11e-12 | 6.69e-01 | -0.2247 |
7874 | USP7 | GSM5252133_BPH389PrSF | Human | Prostate | BPH | 6.50e-06 | 7.18e-01 | -0.2027 |
7874 | USP7 | GSM5252134_BPH511PrG_Fcol_3GEX | Human | Prostate | BPH | 4.20e-04 | 2.11e-01 | -0.1433 |
7874 | USP7 | GSM5252135_BPH511PrPUr_Fcol_3GEX | Human | Prostate | BPH | 7.13e-14 | 4.59e-01 | -0.1833 |
7874 | USP7 | GSM5252136_BPH556PrGA1_Fcol | Human | Prostate | BPH | 1.10e-02 | 2.70e-01 | -0.23 |
7874 | USP7 | GSM5252137_BPH556PrGA2_Fcol | Human | Prostate | BPH | 2.68e-04 | 2.95e-01 | -0.23 |
7874 | USP7 | 048752_1579-all-cells | Human | Prostate | BPH | 2.22e-06 | 2.52e-01 | 0.1008 |
7874 | USP7 | 052095_1628-all-cells | Human | Prostate | BPH | 1.85e-05 | 1.88e-01 | 0.1032 |
7874 | USP7 | 052097_1595-all-cells | Human | Prostate | BPH | 1.88e-02 | 2.05e-01 | 0.0972 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:0042176 | Colorectum | AD | regulation of protein catabolic process | 160/3918 | 391/18723 | 1.06e-19 | 7.34e-17 | 160 |
GO:1903362 | Colorectum | AD | regulation of cellular protein catabolic process | 109/3918 | 255/18723 | 2.14e-15 | 6.08e-13 | 109 |
GO:0010498 | Colorectum | AD | proteasomal protein catabolic process | 174/3918 | 490/18723 | 3.18e-14 | 7.66e-12 | 174 |
GO:0009895 | Colorectum | AD | negative regulation of catabolic process | 124/3918 | 320/18723 | 1.66e-13 | 3.35e-11 | 124 |
GO:1903050 | Colorectum | AD | regulation of proteolysis involved in cellular protein catabolic process | 92/3918 | 221/18723 | 2.04e-12 | 3.19e-10 | 92 |
GO:0031330 | Colorectum | AD | negative regulation of cellular catabolic process | 104/3918 | 262/18723 | 2.66e-12 | 3.96e-10 | 104 |
GO:0043161 | Colorectum | AD | proteasome-mediated ubiquitin-dependent protein catabolic process | 141/3918 | 412/18723 | 1.77e-10 | 1.68e-08 | 141 |
GO:0016197 | Colorectum | AD | endosomal transport | 90/3918 | 230/18723 | 1.88e-10 | 1.73e-08 | 90 |
GO:0031647 | Colorectum | AD | regulation of protein stability | 108/3918 | 298/18723 | 6.33e-10 | 5.08e-08 | 108 |
GO:0042177 | Colorectum | AD | negative regulation of protein catabolic process | 55/3918 | 121/18723 | 1.19e-09 | 8.85e-08 | 55 |
GO:0061136 | Colorectum | AD | regulation of proteasomal protein catabolic process | 75/3918 | 187/18723 | 1.65e-09 | 1.20e-07 | 75 |
GO:2000058 | Colorectum | AD | regulation of ubiquitin-dependent protein catabolic process | 68/3918 | 164/18723 | 1.82e-09 | 1.31e-07 | 68 |
GO:1903363 | Colorectum | AD | negative regulation of cellular protein catabolic process | 39/3918 | 75/18723 | 2.69e-09 | 1.87e-07 | 39 |
GO:0016482 | Colorectum | AD | cytosolic transport | 68/3918 | 168/18723 | 6.00e-09 | 3.72e-07 | 68 |
GO:0050821 | Colorectum | AD | protein stabilization | 73/3918 | 191/18723 | 3.02e-08 | 1.64e-06 | 73 |
GO:0051052 | Colorectum | AD | regulation of DNA metabolic process | 116/3918 | 359/18723 | 2.47e-07 | 1.00e-05 | 116 |
GO:0032434 | Colorectum | AD | regulation of proteasomal ubiquitin-dependent protein catabolic process | 54/3918 | 134/18723 | 2.51e-07 | 1.02e-05 | 54 |
GO:0051054 | Colorectum | AD | positive regulation of DNA metabolic process | 73/3918 | 201/18723 | 3.27e-07 | 1.29e-05 | 73 |
GO:0032386 | Colorectum | AD | regulation of intracellular transport | 109/3918 | 337/18723 | 5.33e-07 | 1.95e-05 | 109 |
GO:1903051 | Colorectum | AD | negative regulation of proteolysis involved in cellular protein catabolic process | 31/3918 | 64/18723 | 8.71e-07 | 2.98e-05 | 31 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa05169 | Colorectum | MSS | Epstein-Barr virus infection | 63/1875 | 202/8465 | 1.63e-03 | 8.98e-03 | 5.50e-03 | 63 |
hsa051691 | Colorectum | MSS | Epstein-Barr virus infection | 63/1875 | 202/8465 | 1.63e-03 | 8.98e-03 | 5.50e-03 | 63 |
hsa05169210 | Esophagus | ESCC | Epstein-Barr virus infection | 151/4205 | 202/8465 | 1.55e-13 | 3.45e-12 | 1.77e-12 | 151 |
hsa0520325 | Esophagus | ESCC | Viral carcinogenesis | 137/4205 | 204/8465 | 2.47e-07 | 1.88e-06 | 9.62e-07 | 137 |
hsa040689 | Esophagus | ESCC | FoxO signaling pathway | 89/4205 | 131/8465 | 1.56e-05 | 7.98e-05 | 4.09e-05 | 89 |
hsa0516937 | Esophagus | ESCC | Epstein-Barr virus infection | 151/4205 | 202/8465 | 1.55e-13 | 3.45e-12 | 1.77e-12 | 151 |
hsa0520335 | Esophagus | ESCC | Viral carcinogenesis | 137/4205 | 204/8465 | 2.47e-07 | 1.88e-06 | 9.62e-07 | 137 |
hsa0406814 | Esophagus | ESCC | FoxO signaling pathway | 89/4205 | 131/8465 | 1.56e-05 | 7.98e-05 | 4.09e-05 | 89 |
hsa0516921 | Liver | HCC | Epstein-Barr virus infection | 128/4020 | 202/8465 | 3.17e-06 | 2.79e-05 | 1.55e-05 | 128 |
hsa040684 | Liver | HCC | FoxO signaling pathway | 85/4020 | 131/8465 | 3.99e-05 | 2.16e-04 | 1.20e-04 | 85 |
hsa052032 | Liver | HCC | Viral carcinogenesis | 117/4020 | 204/8465 | 2.68e-03 | 8.98e-03 | 5.00e-03 | 117 |
hsa0516931 | Liver | HCC | Epstein-Barr virus infection | 128/4020 | 202/8465 | 3.17e-06 | 2.79e-05 | 1.55e-05 | 128 |
hsa040685 | Liver | HCC | FoxO signaling pathway | 85/4020 | 131/8465 | 3.99e-05 | 2.16e-04 | 1.20e-04 | 85 |
hsa052033 | Liver | HCC | Viral carcinogenesis | 117/4020 | 204/8465 | 2.68e-03 | 8.98e-03 | 5.00e-03 | 117 |
hsa0516928 | Oral cavity | OSCC | Epstein-Barr virus infection | 144/3704 | 202/8465 | 1.08e-15 | 3.60e-14 | 1.83e-14 | 144 |
hsa052038 | Oral cavity | OSCC | Viral carcinogenesis | 124/3704 | 204/8465 | 5.57e-07 | 3.28e-06 | 1.67e-06 | 124 |
hsa040688 | Oral cavity | OSCC | FoxO signaling pathway | 85/3704 | 131/8465 | 7.50e-07 | 4.33e-06 | 2.21e-06 | 85 |
hsa05169113 | Oral cavity | OSCC | Epstein-Barr virus infection | 144/3704 | 202/8465 | 1.08e-15 | 3.60e-14 | 1.83e-14 | 144 |
hsa0520314 | Oral cavity | OSCC | Viral carcinogenesis | 124/3704 | 204/8465 | 5.57e-07 | 3.28e-06 | 1.67e-06 | 124 |
hsa0406813 | Oral cavity | OSCC | FoxO signaling pathway | 85/3704 | 131/8465 | 7.50e-07 | 4.33e-06 | 2.21e-06 | 85 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
USP7 | SNV | Missense_Mutation | novel | c.2788N>C | p.Glu930Gln | p.E930Q | Q93009 | protein_coding | tolerated(0.24) | benign(0.022) | TCGA-5L-AAT1-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Hormone Therapy | letrozol | SD |
USP7 | SNV | Missense_Mutation | novel | c.598N>G | p.Pro200Ala | p.P200A | Q93009 | protein_coding | deleterious(0) | probably_damaging(0.971) | TCGA-5L-AAT1-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Hormone Therapy | letrozol | SD |
USP7 | SNV | Missense_Mutation | c.2941N>C | p.Asp981His | p.D981H | Q93009 | protein_coding | tolerated(0.12) | benign(0.001) | TCGA-A8-A085-01 | Breast | breast invasive carcinoma | Male | <65 | I/II | Hormone Therapy | tamoxiphen | SD | |
USP7 | SNV | Missense_Mutation | c.1223N>A | p.Arg408Lys | p.R408K | Q93009 | protein_coding | deleterious(0.01) | probably_damaging(1) | TCGA-AC-A23H-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | PD | |
USP7 | SNV | Missense_Mutation | novel | c.913G>A | p.Asp305Asn | p.D305N | Q93009 | protein_coding | deleterious(0) | probably_damaging(0.916) | TCGA-AN-A046-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
USP7 | SNV | Missense_Mutation | c.2317N>T | p.Pro773Ser | p.P773S | Q93009 | protein_coding | tolerated(0.72) | benign(0.036) | TCGA-AN-A04A-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD | |
USP7 | SNV | Missense_Mutation | c.3011G>A | p.Gly1004Glu | p.G1004E | Q93009 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-D8-A1JN-01 | Breast | breast invasive carcinoma | Female | >=65 | III/IV | Hormone Therapy | anastrozolum | SD | |
USP7 | SNV | Missense_Mutation | novel | c.556N>A | p.Asp186Asn | p.D186N | Q93009 | protein_coding | tolerated(0.41) | benign(0.1) | TCGA-D8-A1XJ-01 | Breast | breast invasive carcinoma | Female | >=65 | III/IV | Hormone Therapy | tamoxiphen | SD |
USP7 | insertion | Nonsense_Mutation | novel | c.464_465insGTTTTCAATCTAAGT | p.Ser155delinsArgPheSerIleTerVal | p.S155delinsRFSI*V | Q93009 | protein_coding | TCGA-A8-A08H-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | ||
USP7 | deletion | Frame_Shift_Del | novel | c.1939delA | p.Thr647GlnfsTer2 | p.T647Qfs*2 | Q93009 | protein_coding | TCGA-D8-A27V-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Hormone Therapy | tamoxiphen | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
7874 | USP7 | DRUGGABLE GENOME, TRANSCRIPTION FACTOR, ENZYME, PROTEASE | PMID26077642-Compound-Vif1 | |||
7874 | USP7 | DRUGGABLE GENOME, TRANSCRIPTION FACTOR, ENZYME, PROTEASE | PMID26077642-Compound-Vif2 |
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