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Gene: TRADD |
Gene summary for TRADD |
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Gene information | Species | Human | Gene symbol | TRADD | Gene ID | 8717 |
Gene name | TNFRSF1A associated via death domain | |
Gene Alias | Hs.89862 | |
Cytomap | 16q22.1 | |
Gene Type | protein-coding | GO ID | GO:0001942 | UniProtAcc | Q15628 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
8717 | TRADD | P5_S10_cSCC | Human | Skin | cSCC | 4.20e-04 | 1.21e-01 | -0.299 |
8717 | TRADD | P1_cSCC | Human | Skin | cSCC | 6.17e-36 | 8.97e-01 | 0.0292 |
8717 | TRADD | P2_cSCC | Human | Skin | cSCC | 2.84e-14 | 3.74e-01 | -0.024 |
8717 | TRADD | P4_cSCC | Human | Skin | cSCC | 1.11e-23 | 5.69e-01 | -0.00290000000000005 |
8717 | TRADD | P10_cSCC | Human | Skin | cSCC | 9.37e-20 | 5.65e-01 | 0.1017 |
8717 | TRADD | cSCC_p8 | Human | Skin | cSCC | 1.82e-09 | 2.14e-01 | -0.1971 |
8717 | TRADD | cSCC_p9 | Human | Skin | cSCC | 1.94e-03 | 1.68e-01 | -0.1991 |
8717 | TRADD | male-WTA | Human | Thyroid | PTC | 1.47e-08 | 1.15e-01 | 0.1037 |
8717 | TRADD | PTC01 | Human | Thyroid | PTC | 1.06e-06 | 2.37e-01 | 0.1899 |
8717 | TRADD | PTC04 | Human | Thyroid | PTC | 2.89e-09 | 2.35e-01 | 0.1927 |
8717 | TRADD | PTC05 | Human | Thyroid | PTC | 1.87e-13 | 5.81e-01 | 0.2065 |
8717 | TRADD | PTC06 | Human | Thyroid | PTC | 2.62e-24 | 6.75e-01 | 0.2057 |
8717 | TRADD | PTC07 | Human | Thyroid | PTC | 1.35e-32 | 5.49e-01 | 0.2044 |
8717 | TRADD | ATC09 | Human | Thyroid | ATC | 1.12e-06 | 4.25e-01 | 0.2871 |
8717 | TRADD | ATC11 | Human | Thyroid | ATC | 2.59e-08 | 4.36e-01 | 0.3386 |
8717 | TRADD | ATC12 | Human | Thyroid | ATC | 3.27e-07 | 2.75e-01 | 0.34 |
8717 | TRADD | ATC13 | Human | Thyroid | ATC | 1.54e-23 | 5.29e-01 | 0.34 |
8717 | TRADD | ATC1 | Human | Thyroid | ATC | 4.63e-08 | 5.06e-01 | 0.2878 |
8717 | TRADD | ATC2 | Human | Thyroid | ATC | 5.28e-11 | 9.41e-01 | 0.34 |
8717 | TRADD | ATC3 | Human | Thyroid | ATC | 9.00e-11 | 5.27e-01 | 0.338 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:004312220 | Esophagus | HGIN | regulation of I-kappaB kinase/NF-kappaB signaling | 63/2587 | 249/18723 | 8.91e-07 | 3.61e-05 | 63 |
GO:009719126 | Esophagus | HGIN | extrinsic apoptotic signaling pathway | 56/2587 | 219/18723 | 2.48e-06 | 8.80e-05 | 56 |
GO:000724918 | Esophagus | HGIN | I-kappaB kinase/NF-kappaB signaling | 67/2587 | 281/18723 | 3.84e-06 | 1.29e-04 | 67 |
GO:004312317 | Esophagus | HGIN | positive regulation of I-kappaB kinase/NF-kappaB signaling | 49/2587 | 186/18723 | 4.22e-06 | 1.40e-04 | 49 |
GO:000862518 | Esophagus | HGIN | extrinsic apoptotic signaling pathway via death domain receptors | 23/2587 | 82/18723 | 5.47e-04 | 7.73e-03 | 23 |
GO:003320910 | Esophagus | HGIN | tumor necrosis factor-mediated signaling pathway | 26/2587 | 99/18723 | 7.45e-04 | 9.90e-03 | 26 |
GO:19012247 | Esophagus | HGIN | positive regulation of NIK/NF-kappaB signaling | 18/2587 | 69/18723 | 4.94e-03 | 4.18e-02 | 18 |
GO:0097191111 | Esophagus | ESCC | extrinsic apoptotic signaling pathway | 159/8552 | 219/18723 | 4.12e-16 | 2.94e-14 | 159 |
GO:004312318 | Esophagus | ESCC | positive regulation of I-kappaB kinase/NF-kappaB signaling | 132/8552 | 186/18723 | 2.07e-12 | 8.58e-11 | 132 |
GO:0043122110 | Esophagus | ESCC | regulation of I-kappaB kinase/NF-kappaB signaling | 167/8552 | 249/18723 | 6.11e-12 | 2.32e-10 | 167 |
GO:000724919 | Esophagus | ESCC | I-kappaB kinase/NF-kappaB signaling | 183/8552 | 281/18723 | 3.02e-11 | 1.01e-09 | 183 |
GO:00435888 | Esophagus | ESCC | skin development | 163/8552 | 263/18723 | 6.48e-08 | 1.14e-06 | 163 |
GO:000854410 | Esophagus | ESCC | epidermis development | 193/8552 | 324/18723 | 2.87e-07 | 4.19e-06 | 193 |
GO:00510908 | Esophagus | ESCC | regulation of DNA-binding transcription factor activity | 252/8552 | 440/18723 | 5.22e-07 | 6.97e-06 | 252 |
GO:000862519 | Esophagus | ESCC | extrinsic apoptotic signaling pathway via death domain receptors | 59/8552 | 82/18723 | 1.23e-06 | 1.52e-05 | 59 |
GO:00510918 | Esophagus | ESCC | positive regulation of DNA-binding transcription factor activity | 155/8552 | 260/18723 | 3.83e-06 | 4.14e-05 | 155 |
GO:003320914 | Esophagus | ESCC | tumor necrosis factor-mediated signaling pathway | 67/8552 | 99/18723 | 7.87e-06 | 7.72e-05 | 67 |
GO:003461220 | Esophagus | ESCC | response to tumor necrosis factor | 149/8552 | 253/18723 | 1.47e-05 | 1.33e-04 | 149 |
GO:007135620 | Esophagus | ESCC | cellular response to tumor necrosis factor | 132/8552 | 229/18723 | 1.69e-04 | 1.11e-03 | 132 |
GO:00510926 | Esophagus | ESCC | positive regulation of NF-kappaB transcription factor activity | 91/8552 | 152/18723 | 2.91e-04 | 1.75e-03 | 91 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa0513139 | Esophagus | HGIN | Shigellosis | 71/1383 | 247/8465 | 4.89e-07 | 7.98e-06 | 6.34e-06 | 71 |
hsa0513239 | Esophagus | HGIN | Salmonella infection | 69/1383 | 249/8465 | 3.02e-06 | 4.47e-05 | 3.55e-05 | 69 |
hsa0513039 | Esophagus | HGIN | Pathogenic Escherichia coli infection | 54/1383 | 197/8465 | 4.91e-05 | 6.15e-04 | 4.89e-04 | 54 |
hsa0516730 | Esophagus | HGIN | Kaposi sarcoma-associated herpesvirus infection | 51/1383 | 194/8465 | 2.46e-04 | 2.69e-03 | 2.14e-03 | 51 |
hsa052039 | Esophagus | HGIN | Viral carcinogenesis | 53/1383 | 204/8465 | 2.58e-04 | 2.71e-03 | 2.15e-03 | 53 |
hsa0516420 | Esophagus | HGIN | Influenza A | 42/1383 | 171/8465 | 3.41e-03 | 2.54e-02 | 2.02e-02 | 42 |
hsa0516330 | Esophagus | HGIN | Human cytomegalovirus infection | 51/1383 | 225/8465 | 7.67e-03 | 4.63e-02 | 3.68e-02 | 51 |
hsa05131114 | Esophagus | HGIN | Shigellosis | 71/1383 | 247/8465 | 4.89e-07 | 7.98e-06 | 6.34e-06 | 71 |
hsa05132115 | Esophagus | HGIN | Salmonella infection | 69/1383 | 249/8465 | 3.02e-06 | 4.47e-05 | 3.55e-05 | 69 |
hsa05130115 | Esophagus | HGIN | Pathogenic Escherichia coli infection | 54/1383 | 197/8465 | 4.91e-05 | 6.15e-04 | 4.89e-04 | 54 |
hsa05167114 | Esophagus | HGIN | Kaposi sarcoma-associated herpesvirus infection | 51/1383 | 194/8465 | 2.46e-04 | 2.69e-03 | 2.14e-03 | 51 |
hsa0520315 | Esophagus | HGIN | Viral carcinogenesis | 53/1383 | 204/8465 | 2.58e-04 | 2.71e-03 | 2.15e-03 | 53 |
hsa05164110 | Esophagus | HGIN | Influenza A | 42/1383 | 171/8465 | 3.41e-03 | 2.54e-02 | 2.02e-02 | 42 |
hsa05163113 | Esophagus | HGIN | Human cytomegalovirus infection | 51/1383 | 225/8465 | 7.67e-03 | 4.63e-02 | 3.68e-02 | 51 |
hsa05132211 | Esophagus | ESCC | Salmonella infection | 191/4205 | 249/8465 | 6.51e-19 | 5.45e-17 | 2.79e-17 | 191 |
hsa05169210 | Esophagus | ESCC | Epstein-Barr virus infection | 151/4205 | 202/8465 | 1.55e-13 | 3.45e-12 | 1.77e-12 | 151 |
hsa05131211 | Esophagus | ESCC | Shigellosis | 176/4205 | 247/8465 | 2.27e-12 | 4.01e-11 | 2.05e-11 | 176 |
hsa05130211 | Esophagus | ESCC | Pathogenic Escherichia coli infection | 142/4205 | 197/8465 | 8.21e-11 | 1.06e-09 | 5.42e-10 | 142 |
hsa0466810 | Esophagus | ESCC | TNF signaling pathway | 89/4205 | 114/8465 | 3.36e-10 | 4.01e-09 | 2.06e-09 | 89 |
hsa0421027 | Esophagus | ESCC | Apoptosis | 102/4205 | 136/8465 | 1.05e-09 | 1.21e-08 | 6.21e-09 | 102 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
TRADD | SNV | Missense_Mutation | c.98N>T | p.Ala33Val | p.A33V | Q15628 | protein_coding | tolerated(0.2) | benign(0) | TCGA-BH-A0C1-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | adriamycin | PD | |
TRADD | SNV | Missense_Mutation | novel | c.530N>T | p.Ser177Leu | p.S177L | Q15628 | protein_coding | tolerated(0.37) | benign(0) | TCGA-MU-A51Y-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD |
TRADD | SNV | Missense_Mutation | c.667G>A | p.Ala223Thr | p.A223T | Q15628 | protein_coding | deleterious(0) | probably_damaging(0.967) | TCGA-AZ-6601-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD | |
TRADD | SNV | Missense_Mutation | c.934G>A | p.Ala312Thr | p.A312T | Q15628 | protein_coding | deleterious_low_confidence(0.01) | benign(0.06) | TCGA-G4-6628-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
TRADD | SNV | Missense_Mutation | novel | c.900N>A | p.Asp300Glu | p.D300E | Q15628 | protein_coding | tolerated(0.7) | benign(0.018) | TCGA-AJ-A23O-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
TRADD | SNV | Missense_Mutation | novel | c.811C>T | p.Arg271Cys | p.R271C | Q15628 | protein_coding | deleterious(0) | probably_damaging(0.963) | TCGA-AJ-A3BG-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Chemotherapy | carboplatin | PD |
TRADD | SNV | Missense_Mutation | novel | c.468N>T | p.Glu156Asp | p.E156D | Q15628 | protein_coding | tolerated(0.09) | benign(0.017) | TCGA-AX-A2HC-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | paclitaxel | PD |
TRADD | SNV | Missense_Mutation | c.877G>A | p.Glu293Lys | p.E293K | Q15628 | protein_coding | tolerated(0.54) | benign(0.097) | TCGA-EO-A22X-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unspecific | Carboplatin | Complete Response | |
TRADD | SNV | Missense_Mutation | novel | c.5C>T | p.Ala2Val | p.A2V | Q15628 | protein_coding | deleterious_low_confidence(0) | probably_damaging(0.946) | TCGA-EO-A3AU-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | PD |
TRADD | SNV | Missense_Mutation | novel | c.479N>A | p.Arg160Gln | p.R160Q | Q15628 | protein_coding | tolerated(0.6) | benign(0.006) | TCGA-FI-A2D0-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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