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Gene: TOP1MT |
Gene summary for TOP1MT |
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Gene information | Species | Human | Gene symbol | TOP1MT | Gene ID | 116447 |
Gene name | DNA topoisomerase I mitochondrial | |
Gene Alias | TOP1MT | |
Cytomap | 8q24.3 | |
Gene Type | protein-coding | GO ID | GO:0006139 | UniProtAcc | Q969P6 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
116447 | TOP1MT | LP15 | Human | Oral cavity | LP | 2.60e-03 | 7.60e-01 | 0.2174 |
116447 | TOP1MT | LP17 | Human | Oral cavity | LP | 1.56e-03 | 5.59e-01 | 0.2349 |
116447 | TOP1MT | SYSMH1 | Human | Oral cavity | OSCC | 4.16e-07 | 2.76e-01 | 0.1127 |
116447 | TOP1MT | SYSMH2 | Human | Oral cavity | OSCC | 2.10e-18 | 5.80e-01 | 0.2326 |
116447 | TOP1MT | SYSMH3 | Human | Oral cavity | OSCC | 3.27e-24 | 6.00e-01 | 0.2442 |
116447 | TOP1MT | SYSMH5 | Human | Oral cavity | OSCC | 2.16e-07 | 2.29e-01 | 0.0647 |
116447 | TOP1MT | P1_cSCC | Human | Skin | cSCC | 1.18e-09 | 4.17e-01 | 0.0292 |
116447 | TOP1MT | P2_cSCC | Human | Skin | cSCC | 2.33e-12 | 3.43e-01 | -0.024 |
116447 | TOP1MT | P10_cSCC | Human | Skin | cSCC | 2.80e-05 | 2.75e-01 | 0.1017 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00062604 | Esophagus | ESCC | DNA replication | 181/8552 | 260/18723 | 3.55e-15 | 2.05e-13 | 181 |
GO:00062601 | Liver | HCC | DNA replication | 146/7958 | 260/18723 | 5.68e-06 | 7.02e-05 | 146 |
GO:00062603 | Oral cavity | OSCC | DNA replication | 159/7305 | 260/18723 | 3.25e-13 | 1.59e-11 | 159 |
GO:000626011 | Oral cavity | LP | DNA replication | 97/4623 | 260/18723 | 3.67e-06 | 7.75e-05 | 97 |
GO:000626012 | Skin | cSCC | DNA replication | 106/4864 | 260/18723 | 1.18e-07 | 2.77e-06 | 106 |
GO:00711031 | Skin | cSCC | DNA conformation change | 96/4864 | 290/18723 | 3.87e-03 | 2.07e-02 | 96 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
TOP1MT | SNV | Missense_Mutation | novel | c.1127N>C | p.Arg376Thr | p.R376T | Q969P6 | protein_coding | tolerated(0.54) | benign(0.216) | TCGA-C8-A8HP-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | 5-fluorouracil | CR |
TOP1MT | SNV | Missense_Mutation | c.1213A>C | p.Thr405Pro | p.T405P | Q969P6 | protein_coding | deleterious(0) | possibly_damaging(0.53) | TCGA-D8-A1XW-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | adriamycin+cyclophosphamide | SD | |
TOP1MT | insertion | In_Frame_Ins | novel | c.1353_1354insGGCAAAACTCTCATGCTTTTATCATGGAATATGATGTTA | p.Lys451_Ile452insGlyLysThrLeuMetLeuLeuSerTrpAsnMetMetLeu | p.K451_I452insGKTLMLLSWNMML | Q969P6 | protein_coding | TCGA-B6-A0I5-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | ||
TOP1MT | SNV | Missense_Mutation | rs764616681 | c.416N>T | p.Thr139Met | p.T139M | Q969P6 | protein_coding | deleterious(0.03) | possibly_damaging(0.893) | TCGA-ZJ-AB0H-01 | Cervix | cervical & endocervical cancer | Female | <65 | III/IV | Unknown | Unknown | SD |
TOP1MT | SNV | Missense_Mutation | c.1390N>G | p.Ile464Val | p.I464V | Q969P6 | protein_coding | tolerated(0.18) | benign(0.009) | TCGA-AA-3710-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
TOP1MT | SNV | Missense_Mutation | c.524G>T | p.Gly175Val | p.G175V | Q969P6 | protein_coding | deleterious(0.04) | probably_damaging(1) | TCGA-AA-A010-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Chemotherapy | folinic | CR | |
TOP1MT | SNV | Missense_Mutation | c.538G>C | p.Asp180His | p.D180H | Q969P6 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-AD-6895-01 | Colorectum | colon adenocarcinoma | Male | >=65 | III/IV | Unknown | Unknown | SD | |
TOP1MT | SNV | Missense_Mutation | c.1003N>A | p.Ala335Thr | p.A335T | Q969P6 | protein_coding | deleterious(0) | probably_damaging(0.998) | TCGA-AD-A5EJ-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
TOP1MT | SNV | Missense_Mutation | c.122N>A | p.Arg41Lys | p.R41K | Q969P6 | protein_coding | tolerated(0.4) | benign(0.051) | TCGA-CA-6718-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | PD | |
TOP1MT | SNV | Missense_Mutation | c.692C>T | p.Pro231Leu | p.P231L | Q969P6 | protein_coding | deleterious(0.01) | probably_damaging(0.993) | TCGA-CK-6746-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
116447 | TOP1MT | DRUGGABLE GENOME, ENZYME | TOPOTECAN | TOPOTECAN | ||
116447 | TOP1MT | DRUGGABLE GENOME, ENZYME | LE-SN38 | |||
116447 | TOP1MT | DRUGGABLE GENOME, ENZYME | PEG-SN38 | |||
116447 | TOP1MT | DRUGGABLE GENOME, ENZYME | inhibitor | CHEMBL1607 | TOPOTECAN HYDROCHLORIDE | |
116447 | TOP1MT | DRUGGABLE GENOME, ENZYME | IRINOTECAN | IRINOTECAN | ||
116447 | TOP1MT | DRUGGABLE GENOME, ENZYME | PEG-IRINOTECAN |
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