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Gene: TNFRSF14 |
Gene summary for TNFRSF14 |
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Gene information | Species | Human | Gene symbol | TNFRSF14 | Gene ID | 8764 |
Gene name | TNF receptor superfamily member 14 | |
Gene Alias | ATAR | |
Cytomap | 1p36.32 | |
Gene Type | protein-coding | GO ID | GO:0001775 | UniProtAcc | A0A024R052 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
8764 | TNFRSF14 | ATC11 | Human | Thyroid | ATC | 1.77e-03 | 4.73e-01 | 0.3386 |
8764 | TNFRSF14 | ATC12 | Human | Thyroid | ATC | 9.23e-23 | 3.81e-01 | 0.34 |
8764 | TNFRSF14 | ATC1 | Human | Thyroid | ATC | 1.30e-04 | 2.79e-01 | 0.2878 |
8764 | TNFRSF14 | ATC2 | Human | Thyroid | ATC | 3.96e-08 | 5.99e-01 | 0.34 |
8764 | TNFRSF14 | ATC3 | Human | Thyroid | ATC | 5.09e-05 | 4.16e-01 | 0.338 |
8764 | TNFRSF14 | ATC4 | Human | Thyroid | ATC | 1.24e-20 | 4.84e-01 | 0.34 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:001603227 | Esophagus | HGIN | viral process | 118/2587 | 415/18723 | 3.01e-15 | 6.22e-13 | 118 |
GO:001905827 | Esophagus | HGIN | viral life cycle | 93/2587 | 317/18723 | 3.66e-13 | 5.63e-11 | 93 |
GO:004440326 | Esophagus | HGIN | biological process involved in symbiotic interaction | 71/2587 | 290/18723 | 7.09e-07 | 3.00e-05 | 71 |
GO:005170127 | Esophagus | HGIN | biological process involved in interaction with host | 51/2587 | 203/18723 | 1.16e-05 | 3.29e-04 | 51 |
GO:005212627 | Esophagus | HGIN | movement in host environment | 43/2587 | 175/18723 | 9.45e-05 | 2.03e-03 | 43 |
GO:003320910 | Esophagus | HGIN | tumor necrosis factor-mediated signaling pathway | 26/2587 | 99/18723 | 7.45e-04 | 9.90e-03 | 26 |
GO:004440927 | Esophagus | HGIN | entry into host | 34/2587 | 151/18723 | 2.43e-03 | 2.43e-02 | 34 |
GO:0016032111 | Esophagus | ESCC | viral process | 301/8552 | 415/18723 | 3.34e-29 | 1.32e-26 | 301 |
GO:0019058111 | Esophagus | ESCC | viral life cycle | 226/8552 | 317/18723 | 1.17e-20 | 1.76e-18 | 226 |
GO:0044403111 | Esophagus | ESCC | biological process involved in symbiotic interaction | 186/8552 | 290/18723 | 1.43e-10 | 4.16e-09 | 186 |
GO:0051701111 | Esophagus | ESCC | biological process involved in interaction with host | 135/8552 | 203/18723 | 1.49e-09 | 3.49e-08 | 135 |
GO:0052126111 | Esophagus | ESCC | movement in host environment | 117/8552 | 175/18723 | 1.14e-08 | 2.26e-07 | 117 |
GO:004578527 | Esophagus | ESCC | positive regulation of cell adhesion | 255/8552 | 437/18723 | 5.07e-08 | 9.11e-07 | 255 |
GO:0044409111 | Esophagus | ESCC | entry into host | 96/8552 | 151/18723 | 6.73e-06 | 6.84e-05 | 96 |
GO:003320914 | Esophagus | ESCC | tumor necrosis factor-mediated signaling pathway | 67/8552 | 99/18723 | 7.87e-06 | 7.72e-05 | 67 |
GO:003461220 | Esophagus | ESCC | response to tumor necrosis factor | 149/8552 | 253/18723 | 1.47e-05 | 1.33e-04 | 149 |
GO:004671827 | Esophagus | ESCC | viral entry into host cell | 89/8552 | 144/18723 | 6.84e-05 | 5.18e-04 | 89 |
GO:007135620 | Esophagus | ESCC | cellular response to tumor necrosis factor | 132/8552 | 229/18723 | 1.69e-04 | 1.11e-03 | 132 |
GO:00507775 | Esophagus | ESCC | negative regulation of immune response | 112/8552 | 194/18723 | 4.67e-04 | 2.62e-03 | 112 |
GO:002240720 | Esophagus | ESCC | regulation of cell-cell adhesion | 239/8552 | 448/18723 | 5.88e-04 | 3.19e-03 | 239 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
TNFSF14 | TNFRSF14 | TNFSF14_TNFRSF14 | LIGHT | Breast | DCIS |
LTA | TNFRSF14 | LTA_TNFRSF14 | LT | Cervix | ADJ |
BTLA | TNFRSF14 | BTLA_TNFRSF14 | BTLA | Cervix | ADJ |
TNFSF14 | TNFRSF14 | TNFSF14_TNFRSF14 | LIGHT | Cervix | CC |
TNFSF14 | TNFRSF14 | TNFSF14_TNFRSF14 | LIGHT | Cervix | Healthy |
TNFSF14 | TNFRSF14 | TNFSF14_TNFRSF14 | LIGHT | Cervix | Precancer |
TNFSF14 | TNFRSF14 | TNFSF14_TNFRSF14 | LIGHT | Endometrium | ADJ |
TNFSF14 | TNFRSF14 | TNFSF14_TNFRSF14 | LIGHT | Endometrium | AEH |
TNFSF14 | TNFRSF14 | TNFSF14_TNFRSF14 | LIGHT | Endometrium | Healthy |
LTA | TNFRSF14 | LTA_TNFRSF14 | LT | Esophagus | ADJ |
LTA | TNFRSF14 | LTA_TNFRSF14 | LT | Esophagus | ESCC |
TNFSF14 | TNFRSF14 | TNFSF14_TNFRSF14 | LIGHT | Esophagus | ESCC |
TNFSF14 | TNFRSF14 | TNFSF14_TNFRSF14 | LIGHT | HNSCC | ADJ |
TNFSF14 | TNFRSF14 | TNFSF14_TNFRSF14 | LIGHT | HNSCC | OSCC |
TNFSF14 | TNFRSF14 | TNFSF14_TNFRSF14 | LIGHT | Liver | Healthy |
TNFSF14 | TNFRSF14 | TNFSF14_TNFRSF14 | LIGHT | Liver | Precancer |
TNFSF14 | TNFRSF14 | TNFSF14_TNFRSF14 | LIGHT | Lung | AAH |
TNFSF14 | TNFRSF14 | TNFSF14_TNFRSF14 | LIGHT | Prostate | BPH |
TNFSF14 | TNFRSF14 | TNFSF14_TNFRSF14 | LIGHT | Prostate | Tumor |
TNFSF14 | TNFRSF14 | TNFSF14_TNFRSF14 | LIGHT | Skin | cSCC |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
TNFRSF14 | SNV | Missense_Mutation | c.583G>T | p.Gly195Trp | p.G195W | Q92956 | protein_coding | deleterious(0) | probably_damaging(0.992) | TCGA-OL-A66P-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Chemotherapy | cytoxan | CR | |
TNFRSF14 | SNV | Missense_Mutation | novel | c.531G>T | p.Glu177Asp | p.E177D | Q92956 | protein_coding | tolerated(0.23) | benign(0.007) | TCGA-2W-A8YY-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
TNFRSF14 | SNV | Missense_Mutation | c.160N>C | p.Cys54Arg | p.C54R | Q92956 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-A6-A565-01 | Colorectum | colon adenocarcinoma | Female | <65 | III/IV | Unspecific | 5FU | PD | |
TNFRSF14 | SNV | Missense_Mutation | rs371087831 | c.785C>T | p.Pro262Leu | p.P262L | Q92956 | protein_coding | deleterious(0.01) | possibly_damaging(0.818) | TCGA-AM-5821-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
TNFRSF14 | SNV | Missense_Mutation | c.558N>A | p.Ser186Arg | p.S186R | Q92956 | protein_coding | deleterious(0.03) | benign(0.3) | TCGA-CM-6678-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Chemotherapy | fluorouracil | SD | |
TNFRSF14 | SNV | Missense_Mutation | c.823T>A | p.Ser275Thr | p.S275T | Q92956 | protein_coding | tolerated(0.76) | benign(0) | TCGA-QL-A97D-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
TNFRSF14 | SNV | Missense_Mutation | c.779C>T | p.Ala260Val | p.A260V | Q92956 | protein_coding | tolerated(0.39) | benign(0.003) | TCGA-AF-A56N-01 | Colorectum | rectum adenocarcinoma | Female | <65 | I/II | Chemotherapy | xeloda | CR | |
TNFRSF14 | SNV | Missense_Mutation | novel | c.631N>A | p.Val211Ile | p.V211I | Q92956 | protein_coding | tolerated(0.52) | benign(0.003) | TCGA-A5-A2K5-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
TNFRSF14 | SNV | Missense_Mutation | novel | c.454N>G | p.Lys152Glu | p.K152E | Q92956 | protein_coding | tolerated(1) | benign(0) | TCGA-AJ-A3EL-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
TNFRSF14 | SNV | Missense_Mutation | novel | c.644T>C | p.Val215Ala | p.V215A | Q92956 | protein_coding | tolerated(0.41) | benign(0.006) | TCGA-AP-A1DM-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
8764 | TNFRSF14 | CLINICALLY ACTIONABLE, EXTERNAL SIDE OF PLASMA MEMBRANE, DRUGGABLE GENOME | 178101757 | |||
8764 | TNFRSF14 | CLINICALLY ACTIONABLE, EXTERNAL SIDE OF PLASMA MEMBRANE, DRUGGABLE GENOME | 178101763 | |||
8764 | TNFRSF14 | CLINICALLY ACTIONABLE, EXTERNAL SIDE OF PLASMA MEMBRANE, DRUGGABLE GENOME | 178101591 |
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