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Gene: TMEM134 |
Gene summary for TMEM134 |
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Gene information | Species | Human | Gene symbol | TMEM134 | Gene ID | 80194 |
Gene name | transmembrane protein 134 | |
Gene Alias | TMEM134 | |
Cytomap | 11q13.2 | |
Gene Type | protein-coding | GO ID | GO:0005575 | UniProtAcc | Q9H6X4 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
80194 | TMEM134 | C30 | Human | Oral cavity | OSCC | 2.04e-45 | 2.25e+00 | 0.3055 |
80194 | TMEM134 | C38 | Human | Oral cavity | OSCC | 1.22e-06 | 1.24e+00 | 0.172 |
80194 | TMEM134 | C43 | Human | Oral cavity | OSCC | 3.23e-70 | 1.46e+00 | 0.1704 |
80194 | TMEM134 | C46 | Human | Oral cavity | OSCC | 4.82e-75 | 1.77e+00 | 0.1673 |
80194 | TMEM134 | C51 | Human | Oral cavity | OSCC | 1.41e-41 | 3.08e+00 | 0.2674 |
80194 | TMEM134 | C57 | Human | Oral cavity | OSCC | 2.70e-29 | 1.16e+00 | 0.1679 |
80194 | TMEM134 | C06 | Human | Oral cavity | OSCC | 4.67e-06 | 1.35e+00 | 0.2699 |
80194 | TMEM134 | C07 | Human | Oral cavity | OSCC | 3.48e-05 | 1.60e+00 | 0.2491 |
80194 | TMEM134 | C08 | Human | Oral cavity | OSCC | 3.11e-66 | 1.78e+00 | 0.1919 |
80194 | TMEM134 | C86 | Human | Oral cavity | OSCC | 5.70e-04 | 7.50e-01 | 0.161 |
80194 | TMEM134 | C09 | Human | Oral cavity | OSCC | 8.57e-17 | 8.53e-01 | 0.1431 |
80194 | TMEM134 | LN22 | Human | Oral cavity | OSCC | 9.00e-19 | 1.89e+00 | 0.1733 |
80194 | TMEM134 | LN46 | Human | Oral cavity | OSCC | 5.53e-31 | 1.39e+00 | 0.1666 |
80194 | TMEM134 | LP15 | Human | Oral cavity | LP | 3.36e-15 | 1.92e+00 | 0.2174 |
80194 | TMEM134 | LP17 | Human | Oral cavity | LP | 2.35e-09 | 1.64e+00 | 0.2349 |
80194 | TMEM134 | SYSMH1 | Human | Oral cavity | OSCC | 3.05e-49 | 1.23e+00 | 0.1127 |
80194 | TMEM134 | SYSMH2 | Human | Oral cavity | OSCC | 1.66e-39 | 1.32e+00 | 0.2326 |
80194 | TMEM134 | SYSMH3 | Human | Oral cavity | OSCC | 9.73e-26 | 8.96e-01 | 0.2442 |
80194 | TMEM134 | SYSMH4 | Human | Oral cavity | OSCC | 1.20e-11 | 4.93e-01 | 0.1226 |
80194 | TMEM134 | GSM5252137_BPH556PrGA2_Fcol | Human | Prostate | BPH | 9.67e-05 | 4.57e-01 | -0.23 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
TMEM134 | SNV | Missense_Mutation | c.469N>A | p.Phe157Ile | p.F157I | Q9H6X4 | protein_coding | deleterious(0.01) | probably_damaging(0.994) | TCGA-G4-6588-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
TMEM134 | SNV | Missense_Mutation | rs754993164 | c.308G>A | p.Arg103His | p.R103H | Q9H6X4 | protein_coding | tolerated(0.13) | probably_damaging(0.996) | TCGA-EO-A3KX-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
TMEM134 | SNV | Missense_Mutation | c.503N>C | p.Gly168Ala | p.G168A | Q9H6X4 | protein_coding | tolerated(0.07) | probably_damaging(0.997) | TCGA-51-6867-01 | Lung | lung squamous cell carcinoma | Female | >=65 | I/II | Unknown | Unknown | PD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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