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Gene: TIMM50 |
Gene summary for TIMM50 |
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Gene information | Species | Human | Gene symbol | TIMM50 | Gene ID | 92609 |
Gene name | translocase of inner mitochondrial membrane 50 | |
Gene Alias | MGCA9 | |
Cytomap | 19q13.2 | |
Gene Type | protein-coding | GO ID | GO:0001836 | UniProtAcc | A0A024R0M6 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
92609 | TIMM50 | P4_cSCC | Human | Skin | cSCC | 1.12e-34 | 7.65e-01 | -0.00290000000000005 |
92609 | TIMM50 | P10_cSCC | Human | Skin | cSCC | 2.28e-38 | 9.77e-01 | 0.1017 |
92609 | TIMM50 | male-WTA | Human | Thyroid | PTC | 4.02e-24 | 1.74e-01 | 0.1037 |
92609 | TIMM50 | PTC01 | Human | Thyroid | PTC | 1.91e-16 | 1.43e-01 | 0.1899 |
92609 | TIMM50 | PTC04 | Human | Thyroid | PTC | 4.57e-08 | 1.23e-01 | 0.1927 |
92609 | TIMM50 | PTC05 | Human | Thyroid | PTC | 1.07e-14 | 4.42e-01 | 0.2065 |
92609 | TIMM50 | PTC06 | Human | Thyroid | PTC | 2.91e-21 | 4.50e-01 | 0.2057 |
92609 | TIMM50 | PTC07 | Human | Thyroid | PTC | 3.83e-22 | 3.87e-01 | 0.2044 |
92609 | TIMM50 | ATC09 | Human | Thyroid | ATC | 2.46e-02 | 2.57e-01 | 0.2871 |
92609 | TIMM50 | ATC11 | Human | Thyroid | ATC | 2.19e-03 | 2.93e-01 | 0.3386 |
92609 | TIMM50 | ATC12 | Human | Thyroid | ATC | 2.07e-13 | 2.95e-01 | 0.34 |
92609 | TIMM50 | ATC13 | Human | Thyroid | ATC | 6.85e-73 | 2.12e+00 | 0.34 |
92609 | TIMM50 | ATC1 | Human | Thyroid | ATC | 3.68e-02 | 2.72e-01 | 0.2878 |
92609 | TIMM50 | ATC2 | Human | Thyroid | ATC | 3.14e-14 | 1.36e+00 | 0.34 |
92609 | TIMM50 | ATC3 | Human | Thyroid | ATC | 2.11e-02 | 2.37e-01 | 0.338 |
92609 | TIMM50 | ATC4 | Human | Thyroid | ATC | 1.63e-16 | 4.58e-01 | 0.34 |
92609 | TIMM50 | ATC5 | Human | Thyroid | ATC | 1.62e-84 | 2.27e+00 | 0.34 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:0072594110 | Esophagus | ESCC | establishment of protein localization to organelle | 311/8552 | 422/18723 | 3.02e-32 | 2.13e-29 | 311 |
GO:0006605111 | Esophagus | ESCC | protein targeting | 229/8552 | 314/18723 | 4.93e-23 | 1.01e-20 | 229 |
GO:0006839110 | Esophagus | ESCC | mitochondrial transport | 187/8552 | 254/18723 | 8.35e-20 | 9.81e-18 | 187 |
GO:0072655110 | Esophagus | ESCC | establishment of protein localization to mitochondrion | 97/8552 | 120/18723 | 2.17e-15 | 1.33e-13 | 97 |
GO:0070585110 | Esophagus | ESCC | protein localization to mitochondrion | 100/8552 | 125/18723 | 2.96e-15 | 1.77e-13 | 100 |
GO:001703818 | Esophagus | ESCC | protein import | 149/8552 | 206/18723 | 5.90e-15 | 3.31e-13 | 149 |
GO:000700619 | Esophagus | ESCC | mitochondrial membrane organization | 93/8552 | 116/18723 | 2.16e-14 | 1.11e-12 | 93 |
GO:0006626110 | Esophagus | ESCC | protein targeting to mitochondrion | 81/8552 | 100/18723 | 3.60e-13 | 1.67e-11 | 81 |
GO:0008637110 | Esophagus | ESCC | apoptotic mitochondrial changes | 83/8552 | 107/18723 | 1.43e-11 | 5.08e-10 | 83 |
GO:001631110 | Esophagus | ESCC | dephosphorylation | 251/8552 | 417/18723 | 1.26e-09 | 2.99e-08 | 251 |
GO:000647018 | Esophagus | ESCC | protein dephosphorylation | 177/8552 | 281/18723 | 3.13e-09 | 6.72e-08 | 177 |
GO:000183619 | Esophagus | ESCC | release of cytochrome c from mitochondria | 47/8552 | 59/18723 | 9.02e-08 | 1.51e-06 | 47 |
GO:00718069 | Esophagus | ESCC | protein transmembrane transport | 47/8552 | 59/18723 | 9.02e-08 | 1.51e-06 | 47 |
GO:1990542110 | Esophagus | ESCC | mitochondrial transmembrane transport | 72/8552 | 102/18723 | 2.94e-07 | 4.23e-06 | 72 |
GO:00650026 | Esophagus | ESCC | intracellular protein transmembrane transport | 40/8552 | 51/18723 | 1.76e-06 | 2.08e-05 | 40 |
GO:00447433 | Esophagus | ESCC | protein transmembrane import into intracellular organelle | 29/8552 | 36/18723 | 1.91e-05 | 1.67e-04 | 29 |
GO:00301503 | Esophagus | ESCC | protein import into mitochondrial matrix | 16/8552 | 20/18723 | 1.85e-03 | 8.40e-03 | 16 |
GO:007259412 | Liver | Cirrhotic | establishment of protein localization to organelle | 189/4634 | 422/18723 | 1.01e-19 | 2.45e-17 | 189 |
GO:00066057 | Liver | Cirrhotic | protein targeting | 148/4634 | 314/18723 | 3.86e-18 | 6.20e-16 | 148 |
GO:00068397 | Liver | Cirrhotic | mitochondrial transport | 112/4634 | 254/18723 | 1.03e-11 | 6.66e-10 | 112 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
TIMM50 | SNV | Missense_Mutation | c.184N>C | p.Asp62His | p.D62H | Q3ZCQ8 | protein_coding | deleterious_low_confidence(0) | benign(0.154) | TCGA-BH-A0DZ-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | docetaxel | SD | |
TIMM50 | SNV | Missense_Mutation | rs755137391 | c.1336N>C | p.Thr446Pro | p.T446P | Q3ZCQ8 | protein_coding | deleterious(0) | possibly_damaging(0.698) | TCGA-D8-A1JM-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | ChemotherapyHormone Therapy | doxorubicine | SD |
TIMM50 | SNV | Missense_Mutation | rs755137391 | c.1336N>C | p.Thr446Pro | p.T446P | Q3ZCQ8 | protein_coding | deleterious(0) | possibly_damaging(0.698) | TCGA-E2-A1LA-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Hormone Therapy | arimidex | SD |
TIMM50 | SNV | Missense_Mutation | rs202166024 | c.1355N>A | p.Arg452His | p.R452H | Q3ZCQ8 | protein_coding | deleterious_low_confidence(0) | probably_damaging(0.917) | TCGA-2W-A8YY-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
TIMM50 | SNV | Missense_Mutation | c.584N>G | p.Asp195Gly | p.D195G | Q3ZCQ8 | protein_coding | deleterious(0.01) | benign(0.203) | TCGA-A6-6653-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
TIMM50 | SNV | Missense_Mutation | rs371263769 | c.1283N>A | p.Arg428His | p.R428H | Q3ZCQ8 | protein_coding | deleterious(0.02) | probably_damaging(0.917) | TCGA-AA-3492-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
TIMM50 | SNV | Missense_Mutation | c.1096N>A | p.Ala366Thr | p.A366T | Q3ZCQ8 | protein_coding | tolerated(0.13) | possibly_damaging(0.675) | TCGA-AA-3966-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
TIMM50 | SNV | Missense_Mutation | rs746734633 | c.1282N>T | p.Arg428Cys | p.R428C | Q3ZCQ8 | protein_coding | deleterious(0) | probably_damaging(0.917) | TCGA-CM-6162-01 | Colorectum | colon adenocarcinoma | Female | <65 | III/IV | Chemotherapy | oxaliplatin | SD |
TIMM50 | SNV | Missense_Mutation | rs780195132 | c.691N>A | p.Glu231Lys | p.E231K | Q3ZCQ8 | protein_coding | deleterious(0.05) | benign(0.41) | TCGA-AG-A002-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
TIMM50 | SNV | Missense_Mutation | c.901N>A | p.Gly301Ser | p.G301S | Q3ZCQ8 | protein_coding | tolerated(0.17) | possibly_damaging(0.834) | TCGA-AG-A002-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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