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Gene: SRSF5 |
Gene summary for SRSF5 |
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Gene information | Species | Human | Gene symbol | SRSF5 | Gene ID | 6430 |
Gene name | serine and arginine rich splicing factor 5 | |
Gene Alias | HRS | |
Cytomap | 14q24.1 | |
Gene Type | protein-coding | GO ID | GO:0000245 | UniProtAcc | A0A024R6D8 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
6430 | SRSF5 | P16T-E | Human | Esophagus | ESCC | 1.31e-37 | 9.19e-01 | 0.1153 |
6430 | SRSF5 | P17T-E | Human | Esophagus | ESCC | 2.43e-08 | 8.17e-01 | 0.1278 |
6430 | SRSF5 | P20T-E | Human | Esophagus | ESCC | 3.58e-37 | 1.02e+00 | 0.1124 |
6430 | SRSF5 | P21T-E | Human | Esophagus | ESCC | 8.08e-36 | 8.19e-01 | 0.1617 |
6430 | SRSF5 | P22T-E | Human | Esophagus | ESCC | 6.91e-32 | 8.16e-01 | 0.1236 |
6430 | SRSF5 | P23T-E | Human | Esophagus | ESCC | 1.60e-29 | 8.06e-01 | 0.108 |
6430 | SRSF5 | P24T-E | Human | Esophagus | ESCC | 6.82e-13 | 6.13e-01 | 0.1287 |
6430 | SRSF5 | P26T-E | Human | Esophagus | ESCC | 2.98e-24 | 4.80e-01 | 0.1276 |
6430 | SRSF5 | P27T-E | Human | Esophagus | ESCC | 1.18e-70 | 1.51e+00 | 0.1055 |
6430 | SRSF5 | P28T-E | Human | Esophagus | ESCC | 1.51e-34 | 8.78e-01 | 0.1149 |
6430 | SRSF5 | P30T-E | Human | Esophagus | ESCC | 1.56e-39 | 2.07e+00 | 0.137 |
6430 | SRSF5 | P31T-E | Human | Esophagus | ESCC | 2.88e-36 | 7.26e-01 | 0.1251 |
6430 | SRSF5 | P32T-E | Human | Esophagus | ESCC | 1.62e-16 | 3.45e-01 | 0.1666 |
6430 | SRSF5 | P36T-E | Human | Esophagus | ESCC | 4.00e-29 | 1.08e+00 | 0.1187 |
6430 | SRSF5 | P37T-E | Human | Esophagus | ESCC | 1.87e-29 | 7.66e-01 | 0.1371 |
6430 | SRSF5 | P39T-E | Human | Esophagus | ESCC | 1.03e-17 | 1.96e-01 | 0.0894 |
6430 | SRSF5 | P40T-E | Human | Esophagus | ESCC | 5.51e-12 | 3.24e-01 | 0.109 |
6430 | SRSF5 | P42T-E | Human | Esophagus | ESCC | 6.43e-35 | 1.11e+00 | 0.1175 |
6430 | SRSF5 | P44T-E | Human | Esophagus | ESCC | 1.14e-16 | 7.32e-01 | 0.1096 |
6430 | SRSF5 | P47T-E | Human | Esophagus | ESCC | 9.17e-36 | 8.66e-01 | 0.1067 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00226139 | Breast | Precancer | ribonucleoprotein complex biogenesis | 79/1080 | 463/18723 | 2.11e-18 | 1.03e-15 | 79 |
GO:00718269 | Breast | Precancer | ribonucleoprotein complex subunit organization | 48/1080 | 227/18723 | 2.68e-15 | 8.45e-13 | 48 |
GO:00226189 | Breast | Precancer | ribonucleoprotein complex assembly | 47/1080 | 220/18723 | 3.47e-15 | 1.03e-12 | 47 |
GO:00083809 | Breast | Precancer | RNA splicing | 65/1080 | 434/18723 | 1.27e-12 | 2.53e-10 | 65 |
GO:00434849 | Breast | Precancer | regulation of RNA splicing | 34/1080 | 148/18723 | 2.66e-12 | 4.75e-10 | 34 |
GO:00003759 | Breast | Precancer | RNA splicing, via transesterification reactions | 52/1080 | 324/18723 | 1.74e-11 | 2.22e-09 | 52 |
GO:00003779 | Breast | Precancer | RNA splicing, via transesterification reactions with bulged adenosine as nucleophile | 51/1080 | 320/18723 | 3.55e-11 | 4.04e-09 | 51 |
GO:00003989 | Breast | Precancer | mRNA splicing, via spliceosome | 51/1080 | 320/18723 | 3.55e-11 | 4.04e-09 | 51 |
GO:00487329 | Breast | Precancer | gland development | 49/1080 | 436/18723 | 6.11e-06 | 1.73e-04 | 49 |
GO:00974216 | Breast | Precancer | liver regeneration | 10/1080 | 35/18723 | 1.91e-05 | 4.52e-04 | 10 |
GO:00311004 | Breast | Precancer | animal organ regeneration | 14/1080 | 76/18723 | 9.92e-05 | 1.83e-03 | 14 |
GO:00018898 | Breast | Precancer | liver development | 21/1080 | 147/18723 | 1.08e-04 | 1.96e-03 | 21 |
GO:00610088 | Breast | Precancer | hepaticobiliary system development | 21/1080 | 150/18723 | 1.45e-04 | 2.49e-03 | 21 |
GO:00310995 | Breast | Precancer | regeneration | 25/1080 | 198/18723 | 1.91e-04 | 3.06e-03 | 25 |
GO:00331207 | Breast | Precancer | positive regulation of RNA splicing | 9/1080 | 37/18723 | 1.96e-04 | 3.10e-03 | 9 |
GO:002261314 | Breast | IDC | ribonucleoprotein complex biogenesis | 83/1434 | 463/18723 | 2.01e-13 | 5.20e-11 | 83 |
GO:007182614 | Breast | IDC | ribonucleoprotein complex subunit organization | 52/1434 | 227/18723 | 5.18e-13 | 1.21e-10 | 52 |
GO:002261814 | Breast | IDC | ribonucleoprotein complex assembly | 51/1434 | 220/18723 | 5.32e-13 | 1.21e-10 | 51 |
GO:000838014 | Breast | IDC | RNA splicing | 73/1434 | 434/18723 | 1.27e-10 | 1.57e-08 | 73 |
GO:004348414 | Breast | IDC | regulation of RNA splicing | 36/1434 | 148/18723 | 3.32e-10 | 3.77e-08 | 36 |
Page: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa030408 | Breast | Precancer | Spliceosome | 39/684 | 217/8465 | 1.44e-06 | 2.27e-05 | 1.74e-05 | 39 |
hsa0304013 | Breast | Precancer | Spliceosome | 39/684 | 217/8465 | 1.44e-06 | 2.27e-05 | 1.74e-05 | 39 |
hsa0304023 | Breast | IDC | Spliceosome | 40/867 | 217/8465 | 1.53e-04 | 1.42e-03 | 1.06e-03 | 40 |
hsa0304033 | Breast | IDC | Spliceosome | 40/867 | 217/8465 | 1.53e-04 | 1.42e-03 | 1.06e-03 | 40 |
hsa0304043 | Breast | DCIS | Spliceosome | 40/846 | 217/8465 | 8.97e-05 | 8.52e-04 | 6.28e-04 | 40 |
hsa0304053 | Breast | DCIS | Spliceosome | 40/846 | 217/8465 | 8.97e-05 | 8.52e-04 | 6.28e-04 | 40 |
hsa03040 | Colorectum | AD | Spliceosome | 73/2092 | 217/8465 | 1.73e-03 | 9.68e-03 | 6.18e-03 | 73 |
hsa030401 | Colorectum | AD | Spliceosome | 73/2092 | 217/8465 | 1.73e-03 | 9.68e-03 | 6.18e-03 | 73 |
hsa030402 | Colorectum | MSS | Spliceosome | 66/1875 | 217/8465 | 2.58e-03 | 1.27e-02 | 7.81e-03 | 66 |
hsa030403 | Colorectum | MSS | Spliceosome | 66/1875 | 217/8465 | 2.58e-03 | 1.27e-02 | 7.81e-03 | 66 |
hsa030409 | Endometrium | AEH | Spliceosome | 54/1197 | 217/8465 | 1.47e-05 | 1.65e-04 | 1.21e-04 | 54 |
hsa0304014 | Endometrium | AEH | Spliceosome | 54/1197 | 217/8465 | 1.47e-05 | 1.65e-04 | 1.21e-04 | 54 |
hsa0304024 | Endometrium | EEC | Spliceosome | 54/1237 | 217/8465 | 3.78e-05 | 3.88e-04 | 2.89e-04 | 54 |
hsa0304034 | Endometrium | EEC | Spliceosome | 54/1237 | 217/8465 | 3.78e-05 | 3.88e-04 | 2.89e-04 | 54 |
hsa0304027 | Esophagus | ESCC | Spliceosome | 128/4205 | 217/8465 | 3.31e-03 | 8.79e-03 | 4.50e-03 | 128 |
hsa0304037 | Esophagus | ESCC | Spliceosome | 128/4205 | 217/8465 | 3.31e-03 | 8.79e-03 | 4.50e-03 | 128 |
hsa030407 | Liver | Cirrhotic | Spliceosome | 102/2530 | 217/8465 | 5.69e-08 | 9.47e-07 | 5.84e-07 | 102 |
hsa0304012 | Liver | Cirrhotic | Spliceosome | 102/2530 | 217/8465 | 5.69e-08 | 9.47e-07 | 5.84e-07 | 102 |
hsa0304022 | Liver | HCC | Spliceosome | 122/4020 | 217/8465 | 5.55e-03 | 1.60e-02 | 8.91e-03 | 122 |
hsa0304032 | Liver | HCC | Spliceosome | 122/4020 | 217/8465 | 5.55e-03 | 1.60e-02 | 8.91e-03 | 122 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
SRSF5 | SNV | Missense_Mutation | c.325N>T | p.Arg109Cys | p.R109C | Q13243 | protein_coding | deleterious(0) | probably_damaging(0.996) | TCGA-AO-A0JM-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | doxorubicin | SD | |
SRSF5 | SNV | Missense_Mutation | c.38N>G | p.Pro13Arg | p.P13R | Q13243 | protein_coding | tolerated(0.2) | possibly_damaging(0.739) | TCGA-C5-A1BM-01 | Cervix | cervical & endocervical cancer | Female | >=65 | I/II | Unknown | Unknown | SD | |
SRSF5 | SNV | Missense_Mutation | rs141668513 | c.614N>A | p.Arg205His | p.R205H | Q13243 | protein_coding | deleterious(0.04) | benign(0.001) | TCGA-EK-A2PG-01 | Cervix | cervical & endocervical cancer | Female | >=65 | I/II | Unknown | Unknown | SD |
SRSF5 | SNV | Missense_Mutation | rs746899808 | c.304N>T | p.Pro102Ser | p.P102S | Q13243 | protein_coding | deleterious(0.01) | probably_damaging(0.996) | TCGA-EX-A69M-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | PD |
SRSF5 | SNV | Missense_Mutation | novel | c.127N>A | p.Glu43Lys | p.E43K | Q13243 | protein_coding | deleterious(0) | probably_damaging(0.996) | TCGA-HM-A4S6-01 | Cervix | cervical & endocervical cancer | Female | <65 | III/IV | Chemotherapy | cisplatin | CR |
SRSF5 | SNV | Missense_Mutation | rs759069069 | c.410N>T | p.Ala137Val | p.A137V | Q13243 | protein_coding | tolerated(0.07) | benign(0.153) | TCGA-AA-3666-01 | Colorectum | colon adenocarcinoma | Male | >=65 | III/IV | Unknown | Unknown | PD |
SRSF5 | SNV | Missense_Mutation | novel | c.66N>C | p.Arg22Ser | p.R22S | Q13243 | protein_coding | deleterious(0) | possibly_damaging(0.828) | TCGA-AA-A00N-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD |
SRSF5 | SNV | Missense_Mutation | c.474N>T | p.Lys158Asn | p.K158N | Q13243 | protein_coding | deleterious(0) | probably_damaging(0.966) | TCGA-AA-A010-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Chemotherapy | folinic | CR | |
SRSF5 | SNV | Missense_Mutation | novel | c.378T>G | p.Asp126Glu | p.D126E | Q13243 | protein_coding | deleterious(0) | possibly_damaging(0.893) | TCGA-CA-6717-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Chemotherapy | oxaliplatin | CR |
SRSF5 | SNV | Missense_Mutation | c.509N>G | p.Asn170Ser | p.N170S | Q13243 | protein_coding | tolerated(0.05) | benign(0.191) | TCGA-CK-4951-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | PD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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