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Gene: SPATS2 |
Gene summary for SPATS2 |
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Gene information | Species | Human | Gene symbol | SPATS2 | Gene ID | 65244 |
Gene name | spermatogenesis associated serine rich 2 | |
Gene Alias | Nbla00526 | |
Cytomap | 12q13.12 | |
Gene Type | protein-coding | GO ID | GO:0005575 | UniProtAcc | A0A024R101 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
65244 | SPATS2 | P83T-E | Human | Esophagus | ESCC | 1.75e-28 | 8.12e-01 | 0.1738 |
65244 | SPATS2 | P84T-E | Human | Esophagus | ESCC | 2.22e-03 | 2.98e-01 | 0.0933 |
65244 | SPATS2 | P89T-E | Human | Esophagus | ESCC | 1.41e-17 | 1.23e+00 | 0.1752 |
65244 | SPATS2 | P91T-E | Human | Esophagus | ESCC | 8.69e-11 | 1.05e+00 | 0.1828 |
65244 | SPATS2 | P104T-E | Human | Esophagus | ESCC | 3.85e-02 | 3.24e-01 | 0.0931 |
65244 | SPATS2 | P107T-E | Human | Esophagus | ESCC | 4.02e-41 | 9.87e-01 | 0.171 |
65244 | SPATS2 | P126T-E | Human | Esophagus | ESCC | 1.66e-07 | 3.28e-01 | 0.1125 |
65244 | SPATS2 | P127T-E | Human | Esophagus | ESCC | 8.88e-13 | 1.27e-01 | 0.0826 |
65244 | SPATS2 | P128T-E | Human | Esophagus | ESCC | 2.52e-40 | 1.33e+00 | 0.1241 |
65244 | SPATS2 | P130T-E | Human | Esophagus | ESCC | 3.09e-63 | 1.37e+00 | 0.1676 |
65244 | SPATS2 | HCC1_Meng | Human | Liver | HCC | 1.02e-67 | 7.75e-02 | 0.0246 |
65244 | SPATS2 | HCC2_Meng | Human | Liver | HCC | 6.64e-16 | -1.71e-02 | 0.0107 |
65244 | SPATS2 | cirrhotic1 | Human | Liver | Cirrhotic | 1.70e-02 | 1.42e-01 | 0.0202 |
65244 | SPATS2 | cirrhotic2 | Human | Liver | Cirrhotic | 7.88e-04 | 8.47e-02 | 0.0201 |
65244 | SPATS2 | HCC1 | Human | Liver | HCC | 6.24e-16 | 3.99e+00 | 0.5336 |
65244 | SPATS2 | HCC2 | Human | Liver | HCC | 3.73e-31 | 4.77e+00 | 0.5341 |
65244 | SPATS2 | HCC5 | Human | Liver | HCC | 2.89e-16 | 2.52e+00 | 0.4932 |
65244 | SPATS2 | Pt13.b | Human | Liver | HCC | 2.69e-05 | 6.21e-02 | 0.0251 |
65244 | SPATS2 | S014 | Human | Liver | HCC | 1.28e-21 | 9.02e-01 | 0.2254 |
65244 | SPATS2 | S015 | Human | Liver | HCC | 4.79e-16 | 9.39e-01 | 0.2375 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
SPATS2 | SNV | Missense_Mutation | rs781041192 | c.1265N>T | p.Pro422Leu | p.P422L | Q86XZ4 | protein_coding | deleterious(0.03) | benign(0.166) | TCGA-D8-A1Y3-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | doxorubicine+cyclophosphamide | SD |
SPATS2 | SNV | Missense_Mutation | c.229G>T | p.Val77Leu | p.V77L | Q86XZ4 | protein_coding | deleterious(0.01) | probably_damaging(0.978) | TCGA-EW-A1PC-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Hormone Therapy | tamoxiphen | SD | |
SPATS2 | deletion | Frame_Shift_Del | novel | c.565delN | p.Lys189SerfsTer3 | p.K189Sfs*3 | Q86XZ4 | protein_coding | TCGA-D8-A27V-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Hormone Therapy | tamoxiphen | SD | ||
SPATS2 | deletion | Frame_Shift_Del | novel | c.663delN | p.Met223TrpfsTer12 | p.M223Wfs*12 | Q86XZ4 | protein_coding | TCGA-D8-A27V-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Hormone Therapy | tamoxiphen | SD | ||
SPATS2 | SNV | Missense_Mutation | c.371N>T | p.Ser124Leu | p.S124L | Q86XZ4 | protein_coding | tolerated(0.17) | benign(0.01) | TCGA-IR-A3LI-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR | |
SPATS2 | SNV | Missense_Mutation | c.1480N>G | p.Gln494Glu | p.Q494E | Q86XZ4 | protein_coding | tolerated(0.09) | benign(0.107) | TCGA-IR-A3LI-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR | |
SPATS2 | SNV | Missense_Mutation | rs769173005 | c.767N>A | p.Arg256Gln | p.R256Q | Q86XZ4 | protein_coding | deleterious(0.02) | benign(0.046) | TCGA-VS-A9V4-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | PD |
SPATS2 | SNV | Missense_Mutation | c.1423N>T | p.Arg475Cys | p.R475C | Q86XZ4 | protein_coding | deleterious(0.01) | possibly_damaging(0.609) | TCGA-A6-5661-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
SPATS2 | SNV | Missense_Mutation | novel | c.263N>C | p.Lys88Thr | p.K88T | Q86XZ4 | protein_coding | deleterious(0.02) | probably_damaging(0.998) | TCGA-AA-3855-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
SPATS2 | SNV | Missense_Mutation | c.314N>A | p.Gly105Asp | p.G105D | Q86XZ4 | protein_coding | tolerated(0.33) | benign(0.061) | TCGA-AA-3864-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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