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Gene: SNRPA |
Gene summary for SNRPA |
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Gene information | Species | Human | Gene symbol | SNRPA | Gene ID | 6626 |
Gene name | small nuclear ribonucleoprotein polypeptide A | |
Gene Alias | Mud1 | |
Cytomap | 19q13.2 | |
Gene Type | protein-coding | GO ID | GO:0000375 | UniProtAcc | P09012 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
6626 | SNRPA | LN46 | Human | Oral cavity | OSCC | 1.25e-16 | 8.27e-01 | 0.1666 |
6626 | SNRPA | LP15 | Human | Oral cavity | LP | 1.80e-06 | 1.20e+00 | 0.2174 |
6626 | SNRPA | LP17 | Human | Oral cavity | LP | 2.30e-02 | 9.54e-01 | 0.2349 |
6626 | SNRPA | SYSMH2 | Human | Oral cavity | OSCC | 7.80e-18 | 7.34e-01 | 0.2326 |
6626 | SNRPA | SYSMH3 | Human | Oral cavity | OSCC | 8.18e-29 | 8.34e-01 | 0.2442 |
6626 | SNRPA | SYSMH5 | Human | Oral cavity | OSCC | 3.25e-11 | 3.75e-01 | 0.0647 |
6626 | SNRPA | SYSMH6 | Human | Oral cavity | OSCC | 5.84e-04 | 2.72e-01 | 0.1275 |
6626 | SNRPA | P4_S8_cSCC | Human | Skin | cSCC | 6.88e-05 | 1.56e-01 | -0.3095 |
6626 | SNRPA | P5_S10_cSCC | Human | Skin | cSCC | 3.30e-05 | 1.88e-01 | -0.299 |
6626 | SNRPA | P1_cSCC | Human | Skin | cSCC | 7.28e-19 | 7.97e-01 | 0.0292 |
6626 | SNRPA | P2_cSCC | Human | Skin | cSCC | 2.23e-20 | 7.29e-01 | -0.024 |
6626 | SNRPA | P4_cSCC | Human | Skin | cSCC | 1.82e-23 | 8.11e-01 | -0.00290000000000005 |
6626 | SNRPA | P10_cSCC | Human | Skin | cSCC | 2.42e-29 | 9.36e-01 | 0.1017 |
6626 | SNRPA | male-WTA | Human | Thyroid | PTC | 9.93e-25 | 2.72e-01 | 0.1037 |
6626 | SNRPA | PTC01 | Human | Thyroid | PTC | 4.45e-10 | 3.03e-01 | 0.1899 |
6626 | SNRPA | PTC04 | Human | Thyroid | PTC | 1.33e-08 | 1.27e-01 | 0.1927 |
6626 | SNRPA | PTC05 | Human | Thyroid | PTC | 3.02e-20 | 5.85e-01 | 0.2065 |
6626 | SNRPA | PTC06 | Human | Thyroid | PTC | 5.25e-27 | 4.93e-01 | 0.2057 |
6626 | SNRPA | PTC07 | Human | Thyroid | PTC | 8.73e-30 | 4.89e-01 | 0.2044 |
6626 | SNRPA | ATC11 | Human | Thyroid | ATC | 2.22e-02 | 1.82e-01 | 0.3386 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:0008380 | Colorectum | AD | RNA splicing | 169/3918 | 434/18723 | 3.59e-18 | 2.04e-15 | 169 |
GO:0000377 | Colorectum | AD | RNA splicing, via transesterification reactions with bulged adenosine as nucleophile | 130/3918 | 320/18723 | 5.88e-16 | 2.16e-13 | 130 |
GO:0000398 | Colorectum | AD | mRNA splicing, via spliceosome | 130/3918 | 320/18723 | 5.88e-16 | 2.16e-13 | 130 |
GO:0000375 | Colorectum | AD | RNA splicing, via transesterification reactions | 131/3918 | 324/18723 | 7.11e-16 | 2.22e-13 | 131 |
GO:00083801 | Colorectum | SER | RNA splicing | 123/2897 | 434/18723 | 3.84e-12 | 8.41e-10 | 123 |
GO:00003751 | Colorectum | SER | RNA splicing, via transesterification reactions | 90/2897 | 324/18723 | 8.68e-09 | 7.50e-07 | 90 |
GO:00003771 | Colorectum | SER | RNA splicing, via transesterification reactions with bulged adenosine as nucleophile | 89/2897 | 320/18723 | 9.82e-09 | 8.14e-07 | 89 |
GO:00003981 | Colorectum | SER | mRNA splicing, via spliceosome | 89/2897 | 320/18723 | 9.82e-09 | 8.14e-07 | 89 |
GO:00083802 | Colorectum | MSS | RNA splicing | 159/3467 | 434/18723 | 1.75e-19 | 1.22e-16 | 159 |
GO:00003772 | Colorectum | MSS | RNA splicing, via transesterification reactions with bulged adenosine as nucleophile | 121/3467 | 320/18723 | 2.52e-16 | 8.27e-14 | 121 |
GO:00003982 | Colorectum | MSS | mRNA splicing, via spliceosome | 121/3467 | 320/18723 | 2.52e-16 | 8.27e-14 | 121 |
GO:00003752 | Colorectum | MSS | RNA splicing, via transesterification reactions | 122/3467 | 324/18723 | 2.75e-16 | 8.58e-14 | 122 |
GO:000838026 | Esophagus | HGIN | RNA splicing | 160/2587 | 434/18723 | 3.74e-34 | 1.12e-30 | 160 |
GO:000037520 | Esophagus | HGIN | RNA splicing, via transesterification reactions | 115/2587 | 324/18723 | 3.16e-23 | 3.80e-20 | 115 |
GO:000037720 | Esophagus | HGIN | RNA splicing, via transesterification reactions with bulged adenosine as nucleophile | 113/2587 | 320/18723 | 1.24e-22 | 9.26e-20 | 113 |
GO:000039820 | Esophagus | HGIN | mRNA splicing, via spliceosome | 113/2587 | 320/18723 | 1.24e-22 | 9.26e-20 | 113 |
GO:0008380111 | Esophagus | ESCC | RNA splicing | 336/8552 | 434/18723 | 1.74e-42 | 3.67e-39 | 336 |
GO:0000375111 | Esophagus | ESCC | RNA splicing, via transesterification reactions | 248/8552 | 324/18723 | 3.05e-30 | 1.49e-27 | 248 |
GO:0000377111 | Esophagus | ESCC | RNA splicing, via transesterification reactions with bulged adenosine as nucleophile | 244/8552 | 320/18723 | 2.52e-29 | 1.07e-26 | 244 |
GO:0000398111 | Esophagus | ESCC | mRNA splicing, via spliceosome | 244/8552 | 320/18723 | 2.52e-29 | 1.07e-26 | 244 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa03040 | Colorectum | AD | Spliceosome | 73/2092 | 217/8465 | 1.73e-03 | 9.68e-03 | 6.18e-03 | 73 |
hsa030401 | Colorectum | AD | Spliceosome | 73/2092 | 217/8465 | 1.73e-03 | 9.68e-03 | 6.18e-03 | 73 |
hsa030402 | Colorectum | MSS | Spliceosome | 66/1875 | 217/8465 | 2.58e-03 | 1.27e-02 | 7.81e-03 | 66 |
hsa030403 | Colorectum | MSS | Spliceosome | 66/1875 | 217/8465 | 2.58e-03 | 1.27e-02 | 7.81e-03 | 66 |
hsa0304027 | Esophagus | ESCC | Spliceosome | 128/4205 | 217/8465 | 3.31e-03 | 8.79e-03 | 4.50e-03 | 128 |
hsa0304037 | Esophagus | ESCC | Spliceosome | 128/4205 | 217/8465 | 3.31e-03 | 8.79e-03 | 4.50e-03 | 128 |
hsa0304022 | Liver | HCC | Spliceosome | 122/4020 | 217/8465 | 5.55e-03 | 1.60e-02 | 8.91e-03 | 122 |
hsa0304032 | Liver | HCC | Spliceosome | 122/4020 | 217/8465 | 5.55e-03 | 1.60e-02 | 8.91e-03 | 122 |
hsa0304016 | Oral cavity | OSCC | Spliceosome | 123/3704 | 217/8465 | 7.21e-05 | 2.74e-04 | 1.40e-04 | 123 |
hsa0304017 | Oral cavity | OSCC | Spliceosome | 123/3704 | 217/8465 | 7.21e-05 | 2.74e-04 | 1.40e-04 | 123 |
hsa0304026 | Oral cavity | LP | Spliceosome | 106/2418 | 217/8465 | 1.30e-10 | 2.40e-09 | 1.55e-09 | 106 |
hsa0304036 | Oral cavity | LP | Spliceosome | 106/2418 | 217/8465 | 1.30e-10 | 2.40e-09 | 1.55e-09 | 106 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
SNRPA | SNV | Missense_Mutation | c.146N>C | p.Leu49Pro | p.L49P | P09012 | protein_coding | tolerated(0.24) | benign(0.015) | TCGA-A8-A09Z-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
SNRPA | SNV | Missense_Mutation | novel | c.60N>C | p.Lys20Asn | p.K20N | P09012 | protein_coding | deleterious(0) | probably_damaging(0.996) | TCGA-AN-A0AR-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
SNRPA | SNV | Missense_Mutation | rs775040575 | c.455N>A | p.Arg152His | p.R152H | P09012 | protein_coding | tolerated(0.06) | benign(0.382) | TCGA-2W-A8YY-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
SNRPA | SNV | Missense_Mutation | c.358N>A | p.Ala120Thr | p.A120T | P09012 | protein_coding | tolerated(0.41) | benign(0.007) | TCGA-A6-2686-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
SNRPA | SNV | Missense_Mutation | c.769N>A | p.Ala257Thr | p.A257T | P09012 | protein_coding | deleterious(0) | probably_damaging(0.994) | TCGA-AA-3488-01 | Colorectum | colon adenocarcinoma | Male | <65 | III/IV | Unknown | Unknown | PD | |
SNRPA | SNV | Missense_Mutation | rs775580802 | c.425N>T | p.Pro142Leu | p.P142L | P09012 | protein_coding | tolerated(0.16) | benign(0.073) | TCGA-CM-4743-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Chemotherapy | capecitabine | SD |
SNRPA | SNV | Missense_Mutation | rs368973112 | c.139N>T | p.Arg47Trp | p.R47W | P09012 | protein_coding | deleterious(0) | possibly_damaging(0.884) | TCGA-D5-6928-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
SNRPA | SNV | Missense_Mutation | rs750727750 | c.193N>A | p.Ala65Thr | p.A65T | P09012 | protein_coding | deleterious(0.02) | benign(0.116) | TCGA-AG-A02N-01 | Colorectum | rectum adenocarcinoma | Male | >=65 | I/II | Chemotherapy | folinic | CR |
SNRPA | SNV | Missense_Mutation | rs773157493 | c.248N>A | p.Arg83His | p.R83H | P09012 | protein_coding | deleterious(0.03) | benign(0.014) | TCGA-AX-A2HC-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | paclitaxel | PD |
SNRPA | SNV | Missense_Mutation | c.551C>T | p.Ala184Val | p.A184V | P09012 | protein_coding | tolerated(0.22) | benign(0.077) | TCGA-B5-A11E-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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