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Gene: SNHG16 |
Gene summary for SNHG16 |
 Gene summary. |
| Gene information | Species | Human | Gene symbol | SNHG16 | Gene ID | 100507246 |
| Gene name | small nucleolar RNA host gene 16 | |
| Gene Alias | Nbla10727 | |
| Cytomap | 17q25.1 | |
| Gene Type | ncRNA | GO ID | NA | UniProtAcc | NA |
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Malignant transformation analysis |
| Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
| Malignant transformation involving gene list. |
| Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
| 100507246 | SNHG16 | HCC2 | Human | Liver | HCC | 6.20e-28 | 4.73e+00 | 0.5341 |
| 100507246 | SNHG16 | GSM5252130_BPH340PrGF_Via | Human | Prostate | BPH | 2.94e-05 | 4.31e-01 | -0.1972 |
| 100507246 | SNHG16 | GSM5252131_BPH340PrSF_Via | Human | Prostate | BPH | 2.59e-06 | 4.98e-01 | -0.2126 |
| 100507246 | SNHG16 | GSM5252133_BPH389PrSF | Human | Prostate | BPH | 3.03e-04 | 7.72e-01 | -0.2027 |
| 100507246 | SNHG16 | 047563_1562-all-cells | Human | Prostate | BPH | 2.88e-24 | -3.83e-01 | 0.0791 |
| 100507246 | SNHG16 | 048752_1579-all-cells | Human | Prostate | BPH | 5.42e-15 | -4.12e-01 | 0.1008 |
| 100507246 | SNHG16 | 052095_1628-all-cells | Human | Prostate | BPH | 8.87e-05 | -3.25e-01 | 0.1032 |
| 100507246 | SNHG16 | 052099_1652-all-cells | Human | Prostate | BPH | 1.52e-04 | -3.56e-01 | 0.1038 |
| 100507246 | SNHG16 | Dong_P1 | Human | Prostate | Tumor | 3.72e-46 | -7.15e-01 | 0.035 |
| 100507246 | SNHG16 | Dong_P3 | Human | Prostate | Tumor | 1.29e-22 | -7.15e-01 | 0.0278 |
| 100507246 | SNHG16 | Dong_P4 | Human | Prostate | Tumor | 2.76e-07 | -7.15e-01 | 0.0292 |
| 100507246 | SNHG16 | Dong_P5 | Human | Prostate | Tumor | 3.72e-46 | -7.15e-01 | 0.053 |
| 100507246 | SNHG16 | Dong_P6 | Human | Prostate | Tumor | 5.54e-14 | -7.15e-01 | 0.0371 |
| 100507246 | SNHG16 | P7 | Human | Prostate | Tumor | 4.28e-08 | -7.15e-01 | -0.1025 |
| 100507246 | SNHG16 | P9 | Human | Prostate | Tumor | 4.23e-16 | -7.15e-01 | -0.0285 |
| 100507246 | SNHG16 | P10 | Human | Prostate | Tumor | 8.39e-18 | -7.15e-01 | -0.0902 |
| 100507246 | SNHG16 | GSM5353222_PA_PB2B_Pool_1_3_S52_L002 | Human | Prostate | Tumor | 6.53e-04 | -4.71e-01 | 0.1608 |
| 100507246 | SNHG16 | GSM5353236_PA_PR5251_T1_S7_L001 | Human | Prostate | Tumor | 9.88e-03 | -6.37e-01 | 0.1608 |
| 100507246 | SNHG16 | GSM5353240_PA_PR5254_T1_S15_L001 | Human | Prostate | Tumor | 1.99e-04 | -3.52e-01 | 0.1575 |
| 100507246 | SNHG16 | GSM5353243_PA_PR5261_T1_S23_L002 | Human | Prostate | Tumor | 1.87e-12 | -5.20e-01 | 0.1545 |
| Page: 1 2 3 4 5 6 7 |
| Transcriptomic changes along malignancy continuum. |
| Tissue | Expression Dynamics | Abbreviation |
| Cervix |  | CC: Cervix cancer |
| HSIL_HPV: HPV-infected high-grade squamous intraepithelial lesions | ||
| N_HPV: HPV-infected normal cervix | ||
| Colorectum (GSE201348) |  | FAP: Familial adenomatous polyposis |
| CRC: Colorectal cancer | ||
| Colorectum (HTA11) |  | AD: Adenomas |
| SER: Sessile serrated lesions | ||
| MSI-H: Microsatellite-high colorectal cancer | ||
| MSS: Microsatellite stable colorectal cancer | ||
| Esophagus |  | ESCC: Esophageal squamous cell carcinoma |
| HGIN: High-grade intraepithelial neoplasias | ||
| LGIN: Low-grade intraepithelial neoplasias | ||
| Liver |  | HCC: Hepatocellular carcinoma |
| NAFLD: Non-alcoholic fatty liver disease | ||
| Prostate |  | BPH: Benign Prostatic Hyperplasia |
| Skin |  | AK: Actinic keratosis |
| cSCC: Cutaneous squamous cell carcinoma | ||
| SCCIS:squamous cell carcinoma in situ |
| ∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
| Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
| Figure of enriched GO biological processes. |
| Tissue | Disease Stage | Enriched GO biological Processes |
| Colorectum | AD |  |
| Colorectum | SER |  |
| Colorectum | MSS |  |
| Colorectum | MSI-H |  |
| Colorectum | FAP |  |
| ∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
| Page: 1 2 3 4 5 6 7 8 9 |
| Enriched GO biological processes. |
| GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
| Page: 1 |
| Enriched KEGG pathways. |
| Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
| Page: 1 |
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Cell-cell communication analysis |
| Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
| Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
| Page: 1 |
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Single-cell gene regulatory network inference analysis |
| Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
| TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
| ∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
| Page: 1 |
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Somatic mutation of malignant transformation related genes |
| Annotation of somatic variants for genes involved in malignant transformation |
| Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
| Page: 1 |
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Related drugs of malignant transformation related genes |
| Identification of chemicals and drugs interact with genes involved in malignant transfromation |
| (DGIdb 4.0) |
| Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
| Page: 1 |
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