![]() |
|||||
|
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() |
Gene: SLC22A23 |
Gene summary for SLC22A23 |
![]() |
Gene information | Species | Human | Gene symbol | SLC22A23 | Gene ID | 63027 |
Gene name | solute carrier family 22 member 23 | |
Gene Alias | C6orf85 | |
Cytomap | 6p25.2 | |
Gene Type | protein-coding | GO ID | GO:0006810 | UniProtAcc | A1A5C7 |
Top |
Malignant transformation analysis |
![]() |
![]() |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
63027 | SLC22A23 | P128T-E | Human | Esophagus | ESCC | 3.98e-04 | 4.09e-01 | 0.1241 |
63027 | SLC22A23 | P130T-E | Human | Esophagus | ESCC | 2.16e-21 | 3.23e-01 | 0.1676 |
63027 | SLC22A23 | NAFLD1 | Human | Liver | NAFLD | 1.18e-07 | 7.35e-01 | -0.04 |
63027 | SLC22A23 | S43 | Human | Liver | Cirrhotic | 5.36e-05 | -1.05e-01 | -0.0187 |
63027 | SLC22A23 | HCC1_Meng | Human | Liver | HCC | 1.63e-46 | -8.82e-02 | 0.0246 |
63027 | SLC22A23 | HCC2_Meng | Human | Liver | HCC | 6.36e-09 | -1.17e-01 | 0.0107 |
63027 | SLC22A23 | cirrhotic1 | Human | Liver | Cirrhotic | 2.03e-03 | -1.86e-01 | 0.0202 |
63027 | SLC22A23 | cirrhotic2 | Human | Liver | Cirrhotic | 1.66e-03 | -1.88e-01 | 0.0201 |
63027 | SLC22A23 | HCC1 | Human | Liver | HCC | 1.56e-12 | 3.94e+00 | 0.5336 |
63027 | SLC22A23 | Pt13.a | Human | Liver | HCC | 1.20e-04 | -1.82e-01 | 0.021 |
63027 | SLC22A23 | Pt14.d | Human | Liver | HCC | 5.45e-05 | -2.00e-01 | 0.0143 |
63027 | SLC22A23 | RNA-P17T-P17T-4 | Human | Lung | IAC | 2.65e-03 | 5.95e-01 | 0.343 |
63027 | SLC22A23 | RNA-P17T-P17T-6 | Human | Lung | IAC | 4.71e-08 | 8.33e-01 | 0.3385 |
63027 | SLC22A23 | RNA-P17T-P17T-8 | Human | Lung | IAC | 4.86e-04 | 5.55e-01 | 0.3329 |
63027 | SLC22A23 | RNA-P25T1-P25T1-1 | Human | Lung | AIS | 2.74e-16 | 6.93e-01 | -0.2116 |
63027 | SLC22A23 | RNA-P25T1-P25T1-4 | Human | Lung | AIS | 4.66e-07 | 5.03e-01 | -0.2119 |
63027 | SLC22A23 | RNA-P6T2-P6T2-1 | Human | Lung | IAC | 8.69e-09 | 4.34e-01 | -0.0166 |
63027 | SLC22A23 | RNA-P6T2-P6T2-2 | Human | Lung | IAC | 7.68e-10 | 3.99e-01 | -0.0132 |
63027 | SLC22A23 | RNA-P6T2-P6T2-3 | Human | Lung | IAC | 2.92e-13 | 4.39e-01 | -0.013 |
63027 | SLC22A23 | RNA-P6T2-P6T2-4 | Human | Lung | IAC | 1.00e-07 | 3.72e-01 | -0.0121 |
Page: 1 2 3 4 5 6 7 |
![]() |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
Top |
Malignant transformation related pathway analysis |
![]() |
![]() |
Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
![]() |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
Page: 1 |
![]() |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
Page: 1 |
Top |
Cell-cell communication analysis |
![]() |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
Page: 1 |
Top |
Single-cell gene regulatory network inference analysis |
![]() |
TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
Page: 1 |
Top |
Somatic mutation of malignant transformation related genes |
![]() |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
SLC22A23 | SNV | Missense_Mutation | c.1091N>T | p.Pro364Leu | p.P364L | A1A5C7 | protein_coding | deleterious(0.04) | probably_damaging(0.984) | TCGA-A8-A09G-01 | Breast | breast invasive carcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD | |
SLC22A23 | SNV | Missense_Mutation | rs757839112 | c.1102C>T | p.Arg368Trp | p.R368W | A1A5C7 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-2W-A8YY-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
SLC22A23 | SNV | Missense_Mutation | novel | c.823G>A | p.Ala275Thr | p.A275T | A1A5C7 | protein_coding | tolerated(0.11) | probably_damaging(0.994) | TCGA-AA-A00N-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD |
SLC22A23 | SNV | Missense_Mutation | rs781457847 | c.1649N>T | p.Ala550Val | p.A550V | A1A5C7 | protein_coding | deleterious(0) | probably_damaging(0.976) | TCGA-AA-A010-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Chemotherapy | folinic | CR |
SLC22A23 | SNV | Missense_Mutation | c.1064N>C | p.Leu355Pro | p.L355P | A1A5C7 | protein_coding | deleterious(0) | possibly_damaging(0.802) | TCGA-AA-A010-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Chemotherapy | folinic | CR | |
SLC22A23 | SNV | Missense_Mutation | c.820N>A | p.Val274Met | p.V274M | A1A5C7 | protein_coding | deleterious(0) | probably_damaging(0.998) | TCGA-AD-5900-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
SLC22A23 | SNV | Missense_Mutation | rs778961106 | c.1327N>A | p.Gly443Arg | p.G443R | A1A5C7 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-CM-4746-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
SLC22A23 | SNV | Missense_Mutation | c.453N>G | p.Asn151Lys | p.N151K | A1A5C7 | protein_coding | tolerated(0.06) | benign(0.34) | TCGA-DM-A280-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
SLC22A23 | deletion | Frame_Shift_Del | novel | c.1942delN | p.Glu648SerfsTer36 | p.E648Sfs*36 | A1A5C7 | protein_coding | TCGA-AA-3947-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD | ||
SLC22A23 | SNV | Missense_Mutation | novel | c.1337N>T | p.His446Leu | p.H446L | A1A5C7 | protein_coding | deleterious(0) | possibly_damaging(0.904) | TCGA-A5-A0G2-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
Page: 1 2 3 4 5 6 |
Top |
Related drugs of malignant transformation related genes |
![]() |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
Page: 1 |