Schematic overview of the cellular and molecular mechanisms involved in the cancer progression, including the proposed cellular and molecular mechanisms in cancer cells trajectory. AT1: alveolar type 1 cells; AT2: alveolar type 2 cells; AAH: atypical adenomatous hyperplasia; AIS: adenocarcinoma in situ; MIA: minimally invasive adenocarcinoma; IA: invasive adenocarcinoma; EMT: epithelial-mesenchymal transition

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Center for Computational Systems Medicine
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Gene summary

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Malignant transformation analysis

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Malignant transformation related pathway analysis

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Cell-cell communication analysis

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Single-cell gene regulatory network inference analysis

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Somatic mutation of malignant transformation related genes

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Related drugs of malignant transformation related genes

Gene: SBF2

Gene summary for SBF2

check button Gene summary.

Gene informationSpeciesHuman
Gene symbol

SBF2

Gene ID

81846

Gene nameSET binding factor 2
Gene AliasCMT4B2
Cytomap11p15.4
Gene Typeprotein-coding
GO ID

GO:0006914

UniProtAcc

Q86WG5


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Malignant transformation analysis

check button Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells
check button Malignant transformation involving gene list.
Entrez IDSymbolReplicatesSpeciesOrganTissueAdj P-valueLog2FCMalignancy
81846SBF2P39T-EHumanEsophagusESCC1.79e-121.45e-010.0894
81846SBF2P40T-EHumanEsophagusESCC8.68e-073.65e-010.109
81846SBF2P42T-EHumanEsophagusESCC1.97e-072.68e-010.1175
81846SBF2P47T-EHumanEsophagusESCC2.58e-142.18e-010.1067
81846SBF2P48T-EHumanEsophagusESCC1.05e-153.19e-010.0959
81846SBF2P49T-EHumanEsophagusESCC1.59e-085.81e-010.1768
81846SBF2P52T-EHumanEsophagusESCC7.45e-193.53e-010.1555
81846SBF2P54T-EHumanEsophagusESCC6.71e-093.21e-010.0975
81846SBF2P56T-EHumanEsophagusESCC6.20e-055.70e-010.1613
81846SBF2P57T-EHumanEsophagusESCC1.21e-152.86e-010.0926
81846SBF2P61T-EHumanEsophagusESCC9.13e-152.99e-010.099
81846SBF2P62T-EHumanEsophagusESCC2.16e-255.50e-010.1302
81846SBF2P65T-EHumanEsophagusESCC5.36e-122.54e-010.0978
81846SBF2P74T-EHumanEsophagusESCC5.40e-133.33e-010.1479
81846SBF2P75T-EHumanEsophagusESCC4.73e-142.71e-010.1125
81846SBF2P79T-EHumanEsophagusESCC1.78e-102.26e-010.1154
81846SBF2P80T-EHumanEsophagusESCC7.23e-173.32e-010.155
81846SBF2P82T-EHumanEsophagusESCC2.39e-064.34e-010.1072
81846SBF2P83T-EHumanEsophagusESCC4.46e-093.42e-010.1738
81846SBF2P91T-EHumanEsophagusESCC2.00e-065.85e-010.1828
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check button Transcriptomic changes along malignancy continuum.
TissueExpression DynamicsAbbreviation
CervixThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.CC: Cervix cancer
HSIL_HPV: HPV-infected high-grade squamous intraepithelial lesions
N_HPV: HPV-infected normal cervix
Colorectum (GSE201348)The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.FAP: Familial adenomatous polyposis
CRC: Colorectal cancer
Colorectum (HTA11)The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.AD: Adenomas
SER: Sessile serrated lesions
MSI-H: Microsatellite-high colorectal cancer
MSS: Microsatellite stable colorectal cancer
EndometriumThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.AEH: Atypical endometrial hyperplasia
EEC: Endometrioid Cancer
EsophagusThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.ESCC: Esophageal squamous cell carcinoma
HGIN: High-grade intraepithelial neoplasias
LGIN: Low-grade intraepithelial neoplasias
LiverThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.HCC: Hepatocellular carcinoma
NAFLD: Non-alcoholic fatty liver disease
LungThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.AAH: Atypical adenomatous hyperplasia
AIS: Adenocarcinoma in situ
IAC: Invasive lung adenocarcinoma
MIA: Minimally invasive adenocarcinoma
Oral CavityThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.EOLP: Erosive Oral lichen planus
LP: leukoplakia
NEOLP: Non-erosive oral lichen planus
OSCC: Oral squamous cell carcinoma
ProstateThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.BPH: Benign Prostatic Hyperplasia
SkinThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.AK: Actinic keratosis
cSCC: Cutaneous squamous cell carcinoma
SCCIS:squamous cell carcinoma in situ
ThyroidThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.ATC: Anaplastic thyroid cancer
HT: Hashimoto's thyroiditis
PTC: Papillary thyroid cancer
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.

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Malignant transformation related pathway analysis

check buttonFind out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer
check button Figure of enriched GO biological processes.
TissueDisease StageEnriched GO biological Processes
ColorectumADGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumSERGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumMSSGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumMSI-HGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumFAPGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
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check button Enriched GO biological processes.
GO IDTissueDisease StageDescriptionGene RatioBg Ratiopvaluep.adjustCount
GO:00430877CervixCCregulation of GTPase activity79/2311348/187234.21e-082.60e-0679
GO:0043087ColorectumADregulation of GTPase activity110/3918348/187231.64e-065.03e-05110
GO:00430871ColorectumSERregulation of GTPase activity77/2897348/187235.90e-048.07e-0377
GO:00430872ColorectumMSSregulation of GTPase activity101/3467348/187231.00e-063.46e-05101
GO:00430873ColorectumFAPregulation of GTPase activity85/2622348/187231.20e-077.68e-0685
GO:00430874ColorectumCRCregulation of GTPase activity69/2078348/187231.11e-066.69e-0569
GO:00430878EndometriumAEHregulation of GTPase activity66/2100348/187231.26e-052.77e-0466
GO:004308712EndometriumEECregulation of GTPase activity67/2168348/187231.84e-053.43e-0467
GO:00425524EsophagusESCCmyelination85/8552134/187232.51e-052.13e-0485
GO:00072724EsophagusESCCensheathment of neurons86/8552136/187232.68e-052.24e-0486
GO:00083664EsophagusESCCaxon ensheathment86/8552136/187232.68e-052.24e-0486
GO:004308715EsophagusESCCregulation of GTPase activity183/8552348/187235.34e-032.00e-02183
GO:00430875LiverNAFLDregulation of GTPase activity62/1882348/187235.65e-062.03e-0462
GO:0042552LiverCirrhoticmyelination46/4634134/187238.04e-033.77e-0246
GO:0007272LiverCirrhoticensheathment of neurons46/4634136/187231.08e-024.75e-0246
GO:0008366LiverCirrhoticaxon ensheathment46/4634136/187231.08e-024.75e-0246
GO:00072721LiverHCCensheathment of neurons72/7958136/187238.87e-033.44e-0272
GO:00083661LiverHCCaxon ensheathment72/7958136/187238.87e-033.44e-0272
GO:00425521LiverHCCmyelination71/7958134/187239.08e-033.49e-0271
GO:00430876LungIACregulation of GTPase activity67/2061348/187233.43e-061.44e-0467
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check button Enriched KEGG pathways.
Pathway IDTissueDisease StageDescriptionGene RatioBg Ratiopvaluep.adjustqvalueCount
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Cell-cell communication analysis

check buttonIdentification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states
LigandReceptorLRpairPathwayTissueDisease Stage
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Single-cell gene regulatory network inference analysis

check buttonFind out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states
TFCell TypeTissueDisease StageTarget GeneRSSRegulon Activity
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.
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Somatic mutation of malignant transformation related genes

check buttonAnnotation of somatic variants for genes involved in malignant transformation
Hugo SymbolVariant ClassVariant ClassificationdbSNP RSHGVScHGVSpHGVSp ShortSWISSPROTBIOTYPESIFTPolyPhenTumor Sample BarcodeTissueHistologySexAgeStageTherapy TypesDrugsOutcome
SBF2SNVMissense_Mutationc.2084N>Ap.Pro695Glnp.P695QQ86WG5protein_codingtolerated(0.47)benign(0.027)TCGA-A7-A0DB-01Breastbreast invasive carcinomaFemale<65I/IIHormone TherapyarimidexSD
SBF2SNVMissense_Mutationc.1201N>Cp.Asn401Hisp.N401HQ86WG5protein_codingdeleterious(0.04)probably_damaging(0.942)TCGA-A8-A075-01Breastbreast invasive carcinomaFemale<65I/IIChemotherapyepirubicinCR
SBF2SNVMissense_Mutationnovelc.1350G>Cp.Lys450Asnp.K450NQ86WG5protein_codingtolerated(0.08)benign(0.056)TCGA-AC-A2FO-01Breastbreast invasive carcinomaFemale>=65I/IIChemotherapychemoCR
SBF2SNVMissense_Mutationc.1536N>Gp.Asn512Lysp.N512KQ86WG5protein_codingtolerated(0.29)benign(0.017)TCGA-AC-A8OP-01Breastbreast invasive carcinomaFemale>=65I/IIUnknownUnknownSD
SBF2SNVMissense_Mutationnovelc.4946N>Cp.Leu1649Serp.L1649SQ86WG5protein_codingdeleterious(0)probably_damaging(0.986)TCGA-AN-A046-01Breastbreast invasive carcinomaFemale>=65I/IIUnknownUnknownSD
SBF2SNVMissense_Mutationrs750021823c.3223N>Tp.Arg1075Cysp.R1075CQ86WG5protein_codingtolerated(0.05)possibly_damaging(0.856)TCGA-AN-A046-01Breastbreast invasive carcinomaFemale>=65I/IIUnknownUnknownSD
SBF2SNVMissense_Mutationc.4024G>Cp.Glu1342Glnp.E1342QQ86WG5protein_codingdeleterious(0.01)possibly_damaging(0.772)TCGA-AN-A0AT-01Breastbreast invasive carcinomaFemale<65I/IIUnknownUnknownSD
SBF2SNVMissense_Mutationc.1025N>Ap.Arg342Glnp.R342QQ86WG5protein_codingtolerated(0.51)benign(0.049)TCGA-AO-A0J3-01Breastbreast invasive carcinomaFemale>=65I/IIChemotherapycyclophosphamideSD
SBF2SNVMissense_Mutationc.683N>Tp.Ser228Phep.S228FQ86WG5protein_codingdeleterious(0)probably_damaging(1)TCGA-BH-A0AW-01Breastbreast invasive carcinomaFemale<65I/IIChemotherapycarboplatinSD
SBF2SNVMissense_Mutationnovelc.2413N>Cp.Asp805Hisp.D805HQ86WG5protein_codingdeleterious(0.03)probably_damaging(0.993)TCGA-BH-A0HP-01Breastbreast invasive carcinomaFemale>=65III/IVChemotherapydoxorubicinSD
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Related drugs of malignant transformation related genes

check buttonIdentification of chemicals and drugs interact with genes involved in malignant transfromation
(DGIdb 4.0)
Entrez IDSymbolCategoryInteraction TypesDrug Claim NameDrug NamePMIDs
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