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Gene: SAT1 |
Gene summary for SAT1 |
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Gene information | Species | Human | Gene symbol | SAT1 | Gene ID | 6303 |
Gene name | spermidine/spermine N1-acetyltransferase 1 | |
Gene Alias | DC21 | |
Cytomap | Xp22.11 | |
Gene Type | protein-coding | GO ID | GO:0001525 | UniProtAcc | P21673 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
6303 | SAT1 | LZE4T | Human | Esophagus | ESCC | 6.42e-33 | 2.69e+00 | 0.0811 |
6303 | SAT1 | LZE5T | Human | Esophagus | ESCC | 2.36e-13 | 2.98e+00 | 0.0514 |
6303 | SAT1 | LZE7T | Human | Esophagus | ESCC | 2.37e-21 | 2.98e+00 | 0.0667 |
6303 | SAT1 | LZE8T | Human | Esophagus | ESCC | 6.05e-44 | 3.63e+00 | 0.067 |
6303 | SAT1 | LZE20T | Human | Esophagus | ESCC | 3.19e-24 | 3.19e+00 | 0.0662 |
6303 | SAT1 | LZE21D1 | Human | Esophagus | HGIN | 3.61e-10 | 3.23e+00 | 0.0632 |
6303 | SAT1 | LZE22D1 | Human | Esophagus | HGIN | 3.46e-10 | 1.94e+00 | 0.0595 |
6303 | SAT1 | LZE22T | Human | Esophagus | ESCC | 1.40e-11 | 2.45e+00 | 0.068 |
6303 | SAT1 | LZE24D1 | Human | Esophagus | HGIN | 6.61e-11 | 2.44e+00 | 0.054 |
6303 | SAT1 | LZE24T | Human | Esophagus | ESCC | 2.92e-24 | 2.56e+00 | 0.0596 |
6303 | SAT1 | LZE22D3 | Human | Esophagus | HGIN | 4.15e-10 | 2.03e+00 | 0.0653 |
6303 | SAT1 | LZE21T | Human | Esophagus | ESCC | 6.53e-31 | 3.20e+00 | 0.0655 |
6303 | SAT1 | LZE6T | Human | Esophagus | ESCC | 2.07e-19 | 2.05e+00 | 0.0845 |
6303 | SAT1 | P1T-E | Human | Esophagus | ESCC | 5.57e-21 | 4.56e+00 | 0.0875 |
6303 | SAT1 | P2T-E | Human | Esophagus | ESCC | 1.85e-24 | 1.87e+00 | 0.1177 |
6303 | SAT1 | P4T-E | Human | Esophagus | ESCC | 1.06e-50 | 2.77e+00 | 0.1323 |
6303 | SAT1 | P5T-E | Human | Esophagus | ESCC | 2.97e-73 | 2.89e+00 | 0.1327 |
6303 | SAT1 | P8T-E | Human | Esophagus | ESCC | 2.80e-76 | 3.46e+00 | 0.0889 |
6303 | SAT1 | P9T-E | Human | Esophagus | ESCC | 1.06e-28 | 2.14e+00 | 0.1131 |
6303 | SAT1 | P10T-E | Human | Esophagus | ESCC | 3.61e-15 | 8.95e-01 | 0.116 |
Page: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:0042401 | Breast | Precancer | cellular biogenic amine biosynthetic process | 7/1080 | 37/18723 | 4.68e-03 | 3.60e-02 | 7 |
GO:0009309 | Breast | Precancer | amine biosynthetic process | 7/1080 | 38/18723 | 5.46e-03 | 4.01e-02 | 7 |
GO:00065963 | Breast | Precancer | polyamine biosynthetic process | 4/1080 | 14/18723 | 6.92e-03 | 4.67e-02 | 4 |
GO:00424011 | Breast | IDC | cellular biogenic amine biosynthetic process | 8/1434 | 37/18723 | 6.04e-03 | 4.33e-02 | 8 |
GO:00093091 | Breast | IDC | amine biosynthetic process | 8/1434 | 38/18723 | 7.15e-03 | 4.92e-02 | 8 |
GO:00424012 | Breast | DCIS | cellular biogenic amine biosynthetic process | 8/1390 | 37/18723 | 5.01e-03 | 3.72e-02 | 8 |
GO:00093092 | Breast | DCIS | amine biosynthetic process | 8/1390 | 38/18723 | 5.94e-03 | 4.25e-02 | 8 |
GO:0006596 | Colorectum | MSS | polyamine biosynthetic process | 7/3467 | 14/18723 | 7.51e-03 | 4.72e-02 | 7 |
GO:00065952 | Endometrium | EEC | polyamine metabolic process | 7/2168 | 18/18723 | 2.76e-03 | 1.97e-02 | 7 |
GO:00086525 | Esophagus | ESCC | cellular amino acid biosynthetic process | 51/8552 | 76/18723 | 1.30e-04 | 8.88e-04 | 51 |
GO:00067671 | Esophagus | ESCC | water-soluble vitamin metabolic process | 41/8552 | 59/18723 | 1.84e-04 | 1.17e-03 | 41 |
GO:00463948 | Esophagus | ESCC | carboxylic acid biosynthetic process | 175/8552 | 314/18723 | 1.98e-04 | 1.26e-03 | 175 |
GO:00067661 | Esophagus | ESCC | vitamin metabolic process | 67/8552 | 106/18723 | 2.03e-04 | 1.28e-03 | 67 |
GO:00160538 | Esophagus | ESCC | organic acid biosynthetic process | 175/8552 | 316/18723 | 3.04e-04 | 1.82e-03 | 175 |
GO:19016075 | Esophagus | ESCC | alpha-amino acid biosynthetic process | 45/8552 | 68/18723 | 5.13e-04 | 2.84e-03 | 45 |
GO:19016174 | Esophagus | ESCC | organic hydroxy compound biosynthetic process | 128/8552 | 237/18723 | 5.86e-03 | 2.16e-02 | 128 |
GO:0009110 | Esophagus | ESCC | vitamin biosynthetic process | 15/8552 | 20/18723 | 7.60e-03 | 2.71e-02 | 15 |
GO:0009310 | Liver | NAFLD | amine catabolic process | 9/1882 | 29/18723 | 1.59e-03 | 1.71e-02 | 9 |
GO:0042402 | Liver | NAFLD | cellular biogenic amine catabolic process | 8/1882 | 27/18723 | 3.97e-03 | 3.34e-02 | 8 |
GO:0006595 | Liver | Cirrhotic | polyamine metabolic process | 12/4634 | 18/18723 | 2.07e-04 | 1.90e-03 | 12 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa0421610 | Breast | Precancer | Ferroptosis | 11/684 | 41/8465 | 2.95e-04 | 2.45e-03 | 1.88e-03 | 11 |
hsa0421613 | Breast | Precancer | Ferroptosis | 11/684 | 41/8465 | 2.95e-04 | 2.45e-03 | 1.88e-03 | 11 |
hsa0421623 | Breast | IDC | Ferroptosis | 12/867 | 41/8465 | 5.87e-04 | 4.89e-03 | 3.66e-03 | 12 |
hsa0421633 | Breast | IDC | Ferroptosis | 12/867 | 41/8465 | 5.87e-04 | 4.89e-03 | 3.66e-03 | 12 |
hsa0421642 | Breast | DCIS | Ferroptosis | 12/846 | 41/8465 | 4.69e-04 | 3.69e-03 | 2.72e-03 | 12 |
hsa0421652 | Breast | DCIS | Ferroptosis | 12/846 | 41/8465 | 4.69e-04 | 3.69e-03 | 2.72e-03 | 12 |
hsa04216 | Colorectum | AD | Ferroptosis | 21/2092 | 41/8465 | 2.23e-04 | 1.78e-03 | 1.13e-03 | 21 |
hsa00330 | Colorectum | AD | Arginine and proline metabolism | 23/2092 | 50/8465 | 8.27e-04 | 5.90e-03 | 3.76e-03 | 23 |
hsa042161 | Colorectum | AD | Ferroptosis | 21/2092 | 41/8465 | 2.23e-04 | 1.78e-03 | 1.13e-03 | 21 |
hsa003301 | Colorectum | AD | Arginine and proline metabolism | 23/2092 | 50/8465 | 8.27e-04 | 5.90e-03 | 3.76e-03 | 23 |
hsa003302 | Colorectum | SER | Arginine and proline metabolism | 17/1580 | 50/8465 | 7.12e-03 | 3.77e-02 | 2.74e-02 | 17 |
hsa003303 | Colorectum | SER | Arginine and proline metabolism | 17/1580 | 50/8465 | 7.12e-03 | 3.77e-02 | 2.74e-02 | 17 |
hsa003304 | Colorectum | MSS | Arginine and proline metabolism | 23/1875 | 50/8465 | 1.52e-04 | 1.24e-03 | 7.61e-04 | 23 |
hsa042162 | Colorectum | MSS | Ferroptosis | 18/1875 | 41/8465 | 1.53e-03 | 8.53e-03 | 5.23e-03 | 18 |
hsa003305 | Colorectum | MSS | Arginine and proline metabolism | 23/1875 | 50/8465 | 1.52e-04 | 1.24e-03 | 7.61e-04 | 23 |
hsa042163 | Colorectum | MSS | Ferroptosis | 18/1875 | 41/8465 | 1.53e-03 | 8.53e-03 | 5.23e-03 | 18 |
hsa042164 | Colorectum | FAP | Ferroptosis | 18/1404 | 41/8465 | 3.49e-05 | 3.65e-04 | 2.22e-04 | 18 |
hsa003306 | Colorectum | FAP | Arginine and proline metabolism | 16/1404 | 50/8465 | 5.33e-03 | 2.10e-02 | 1.27e-02 | 16 |
hsa042165 | Colorectum | FAP | Ferroptosis | 18/1404 | 41/8465 | 3.49e-05 | 3.65e-04 | 2.22e-04 | 18 |
hsa003307 | Colorectum | FAP | Arginine and proline metabolism | 16/1404 | 50/8465 | 5.33e-03 | 2.10e-02 | 1.27e-02 | 16 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
SAT1 | SNV | Missense_Mutation | c.167T>C | p.Val56Ala | p.V56A | P21673 | protein_coding | deleterious(0) | possibly_damaging(0.667) | TCGA-AN-A0FS-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
SAT1 | SNV | Missense_Mutation | c.442C>A | p.Leu148Met | p.L148M | P21673 | protein_coding | deleterious(0.01) | probably_damaging(0.997) | TCGA-AR-A1AP-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Hormone Therapy | anastrozole | SD | |
SAT1 | SNV | Missense_Mutation | c.184N>C | p.Glu62Gln | p.E62Q | P21673 | protein_coding | tolerated(0.29) | benign(0.003) | TCGA-BH-A0C7-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | adriamycin | CR | |
SAT1 | insertion | Frame_Shift_Ins | novel | c.420_421insA | p.Arg142LysfsTer6 | p.R142Kfs*6 | P21673 | protein_coding | TCGA-EA-A44S-01 | Cervix | cervical & endocervical cancer | Female | <65 | III/IV | Chemotherapy | carboplatin | SD | ||
SAT1 | SNV | Missense_Mutation | novel | c.449N>T | p.Ser150Ile | p.S150I | P21673 | protein_coding | deleterious(0.04) | benign(0.2) | TCGA-AA-3947-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
SAT1 | SNV | Missense_Mutation | c.13N>A | p.Val5Met | p.V5M | P21673 | protein_coding | tolerated(0.22) | benign(0.087) | TCGA-QG-A5Z2-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD | |
SAT1 | SNV | Missense_Mutation | c.362G>A | p.Arg121His | p.R121H | P21673 | protein_coding | tolerated(0.34) | benign(0.006) | TCGA-AG-A00Y-01 | Colorectum | rectum adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD | |
SAT1 | SNV | Missense_Mutation | c.362N>A | p.Arg121His | p.R121H | P21673 | protein_coding | tolerated(0.34) | benign(0.006) | TCGA-CI-6620-01 | Colorectum | rectum adenocarcinoma | Female | <65 | I/II | Ancillary | leucovorin | PD | |
SAT1 | deletion | Frame_Shift_Del | c.117delA | p.Asp40IlefsTer3 | p.D40Ifs*3 | P21673 | protein_coding | TCGA-WS-AB45-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |||
SAT1 | SNV | Missense_Mutation | novel | c.29N>T | p.Thr10Ile | p.T10I | P21673 | protein_coding | deleterious(0.04) | benign(0.012) | TCGA-AJ-A3EK-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Chemotherapy | carboplatin | CR |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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