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Gene: SAE1 |
Gene summary for SAE1 |
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Gene information | Species | Human | Gene symbol | SAE1 | Gene ID | 10055 |
Gene name | SUMO1 activating enzyme subunit 1 | |
Gene Alias | AOS1 | |
Cytomap | 19q13.32 | |
Gene Type | protein-coding | GO ID | GO:0006464 | UniProtAcc | Q9UBE0 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
10055 | SAE1 | C08 | Human | Oral cavity | OSCC | 1.99e-38 | 9.07e-01 | 0.1919 |
10055 | SAE1 | C09 | Human | Oral cavity | OSCC | 1.90e-04 | 2.47e-01 | 0.1431 |
10055 | SAE1 | LN22 | Human | Oral cavity | OSCC | 4.68e-22 | 2.01e+00 | 0.1733 |
10055 | SAE1 | LN38 | Human | Oral cavity | OSCC | 2.34e-05 | 7.55e-01 | 0.168 |
10055 | SAE1 | LN46 | Human | Oral cavity | OSCC | 2.60e-24 | 8.33e-01 | 0.1666 |
10055 | SAE1 | LP15 | Human | Oral cavity | LP | 6.61e-10 | 1.35e+00 | 0.2174 |
10055 | SAE1 | LP17 | Human | Oral cavity | LP | 2.08e-08 | 8.83e-01 | 0.2349 |
10055 | SAE1 | SYSMH1 | Human | Oral cavity | OSCC | 3.28e-08 | 2.57e-01 | 0.1127 |
10055 | SAE1 | SYSMH2 | Human | Oral cavity | OSCC | 1.92e-16 | 5.94e-01 | 0.2326 |
10055 | SAE1 | SYSMH3 | Human | Oral cavity | OSCC | 1.05e-16 | 5.88e-01 | 0.2442 |
10055 | SAE1 | SYSMH5 | Human | Oral cavity | OSCC | 3.35e-04 | 2.14e-01 | 0.0647 |
10055 | SAE1 | P4_S8_cSCC | Human | Skin | cSCC | 3.66e-04 | 1.50e-01 | -0.3095 |
10055 | SAE1 | P5_S10_cSCC | Human | Skin | cSCC | 2.45e-07 | 2.03e-01 | -0.299 |
10055 | SAE1 | P1_cSCC | Human | Skin | cSCC | 2.08e-22 | 8.63e-01 | 0.0292 |
10055 | SAE1 | P2_cSCC | Human | Skin | cSCC | 6.84e-20 | 6.23e-01 | -0.024 |
10055 | SAE1 | P4_cSCC | Human | Skin | cSCC | 6.62e-35 | 8.45e-01 | -0.00290000000000005 |
10055 | SAE1 | P10_cSCC | Human | Skin | cSCC | 1.61e-30 | 7.47e-01 | 0.1017 |
10055 | SAE1 | male-WTA | Human | Thyroid | PTC | 7.13e-42 | 1.10e-01 | 0.1037 |
10055 | SAE1 | PTC01 | Human | Thyroid | PTC | 8.36e-05 | 7.64e-02 | 0.1899 |
10055 | SAE1 | PTC04 | Human | Thyroid | PTC | 3.73e-10 | 4.63e-02 | 0.1927 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:190332016 | Endometrium | AEH | regulation of protein modification by small protein conjugation or removal | 67/2100 | 242/18723 | 1.10e-12 | 2.26e-10 | 67 |
GO:000683910 | Endometrium | AEH | mitochondrial transport | 66/2100 | 254/18723 | 3.55e-11 | 4.96e-09 | 66 |
GO:190495115 | Endometrium | AEH | positive regulation of establishment of protein localization | 74/2100 | 319/18723 | 7.05e-10 | 6.51e-08 | 74 |
GO:190382916 | Endometrium | AEH | positive regulation of cellular protein localization | 66/2100 | 276/18723 | 1.57e-09 | 1.36e-07 | 66 |
GO:007259410 | Endometrium | AEH | establishment of protein localization to organelle | 89/2100 | 422/18723 | 2.41e-09 | 1.90e-07 | 89 |
GO:000660516 | Endometrium | AEH | protein targeting | 68/2100 | 314/18723 | 6.30e-08 | 3.38e-06 | 68 |
GO:005122215 | Endometrium | AEH | positive regulation of protein transport | 66/2100 | 303/18723 | 7.79e-08 | 3.99e-06 | 66 |
GO:003315710 | Endometrium | AEH | regulation of intracellular protein transport | 51/2100 | 229/18723 | 1.13e-06 | 3.75e-05 | 51 |
GO:003238810 | Endometrium | AEH | positive regulation of intracellular transport | 46/2100 | 202/18723 | 1.96e-06 | 5.93e-05 | 46 |
GO:00323869 | Endometrium | AEH | regulation of intracellular transport | 66/2100 | 337/18723 | 4.18e-06 | 1.10e-04 | 66 |
GO:00903168 | Endometrium | AEH | positive regulation of intracellular protein transport | 38/2100 | 160/18723 | 5.22e-06 | 1.33e-04 | 38 |
GO:007058510 | Endometrium | AEH | protein localization to mitochondrion | 32/2100 | 125/18723 | 5.38e-06 | 1.36e-04 | 32 |
GO:007265510 | Endometrium | AEH | establishment of protein localization to mitochondrion | 31/2100 | 120/18723 | 6.13e-06 | 1.50e-04 | 31 |
GO:000662610 | Endometrium | AEH | protein targeting to mitochondrion | 26/2100 | 100/18723 | 2.96e-05 | 5.47e-04 | 26 |
GO:19033225 | Endometrium | AEH | positive regulation of protein modification by small protein conjugation or removal | 31/2100 | 138/18723 | 1.14e-04 | 1.61e-03 | 31 |
GO:19032145 | Endometrium | AEH | regulation of protein targeting to mitochondrion | 13/2100 | 44/18723 | 7.79e-04 | 7.36e-03 | 13 |
GO:19037476 | Endometrium | AEH | regulation of establishment of protein localization to mitochondrion | 14/2100 | 50/18723 | 8.97e-04 | 8.24e-03 | 14 |
GO:19035335 | Endometrium | AEH | regulation of protein targeting | 18/2100 | 81/18723 | 3.28e-03 | 2.30e-02 | 18 |
GO:19037495 | Endometrium | AEH | positive regulation of establishment of protein localization to mitochondrion | 10/2100 | 36/18723 | 5.04e-03 | 3.16e-02 | 10 |
GO:19039554 | Endometrium | AEH | positive regulation of protein targeting to mitochondrion | 9/2100 | 32/18723 | 7.02e-03 | 4.07e-02 | 9 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa0412016 | Endometrium | AEH | Ubiquitin mediated proteolysis | 41/1197 | 142/8465 | 3.42e-06 | 4.27e-05 | 3.13e-05 | 41 |
hsa0412017 | Endometrium | AEH | Ubiquitin mediated proteolysis | 41/1197 | 142/8465 | 3.42e-06 | 4.27e-05 | 3.13e-05 | 41 |
hsa0412023 | Endometrium | EEC | Ubiquitin mediated proteolysis | 41/1237 | 142/8465 | 7.86e-06 | 9.58e-05 | 7.14e-05 | 41 |
hsa0412033 | Endometrium | EEC | Ubiquitin mediated proteolysis | 41/1237 | 142/8465 | 7.86e-06 | 9.58e-05 | 7.14e-05 | 41 |
hsa0412027 | Esophagus | ESCC | Ubiquitin mediated proteolysis | 122/4205 | 142/8465 | 6.53e-20 | 7.29e-18 | 3.74e-18 | 122 |
hsa0412036 | Esophagus | ESCC | Ubiquitin mediated proteolysis | 122/4205 | 142/8465 | 6.53e-20 | 7.29e-18 | 3.74e-18 | 122 |
hsa0412041 | Liver | HCC | Ubiquitin mediated proteolysis | 110/4020 | 142/8465 | 1.67e-13 | 3.74e-12 | 2.08e-12 | 110 |
hsa0412051 | Liver | HCC | Ubiquitin mediated proteolysis | 110/4020 | 142/8465 | 1.67e-13 | 3.74e-12 | 2.08e-12 | 110 |
hsa0412020 | Oral cavity | OSCC | Ubiquitin mediated proteolysis | 105/3704 | 142/8465 | 1.83e-13 | 4.37e-12 | 2.23e-12 | 105 |
hsa04120110 | Oral cavity | OSCC | Ubiquitin mediated proteolysis | 105/3704 | 142/8465 | 1.83e-13 | 4.37e-12 | 2.23e-12 | 105 |
hsa0412025 | Oral cavity | LP | Ubiquitin mediated proteolysis | 66/2418 | 142/8465 | 3.74e-06 | 3.46e-05 | 2.23e-05 | 66 |
hsa0412035 | Oral cavity | LP | Ubiquitin mediated proteolysis | 66/2418 | 142/8465 | 3.74e-06 | 3.46e-05 | 2.23e-05 | 66 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
SAE1 | SNV | Missense_Mutation | c.37N>C | p.Glu13Gln | p.E13Q | Q9UBE0 | protein_coding | deleterious(0) | benign(0.251) | TCGA-AC-A23H-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | PD | |
SAE1 | SNV | Missense_Mutation | c.911N>T | p.Ala304Val | p.A304V | Q9UBE0 | protein_coding | deleterious(0) | possibly_damaging(0.533) | TCGA-BH-A18G-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
SAE1 | SNV | Missense_Mutation | novel | c.836N>T | p.Ser279Leu | p.S279L | Q9UBE0 | protein_coding | tolerated(0.14) | benign(0.01) | TCGA-C8-A8HP-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | 5-fluorouracil | CR |
SAE1 | SNV | Missense_Mutation | c.376N>C | p.Phe126Leu | p.F126L | Q9UBE0 | protein_coding | deleterious(0.01) | probably_damaging(0.97) | TCGA-D8-A1XK-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | doxorubicine+cyclophosphamide | SD | |
SAE1 | SNV | Missense_Mutation | rs747367118 | c.656C>T | p.Ala219Val | p.A219V | Q9UBE0 | protein_coding | tolerated(0.38) | benign(0.263) | TCGA-E9-A1NC-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | doxorubicin | CR |
SAE1 | SNV | Missense_Mutation | rs778336657 | c.112N>T | p.Arg38Trp | p.R38W | Q9UBE0 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-MY-A5BE-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD |
SAE1 | SNV | Missense_Mutation | novel | c.58N>A | p.Asp20Asn | p.D20N | Q9UBE0 | protein_coding | deleterious(0.03) | probably_damaging(0.996) | TCGA-VS-A94Z-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
SAE1 | SNV | Missense_Mutation | rs199801330 | c.127G>A | p.Gly43Ser | p.G43S | Q9UBE0 | protein_coding | deleterious(0.05) | probably_damaging(0.992) | TCGA-5M-AAT6-01 | Colorectum | colon adenocarcinoma | Female | <65 | III/IV | Unknown | Unknown | PD |
SAE1 | SNV | Missense_Mutation | c.689N>T | p.Lys230Met | p.K230M | Q9UBE0 | protein_coding | deleterious(0.01) | benign(0.007) | TCGA-A6-5661-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
SAE1 | SNV | Missense_Mutation | c.358N>A | p.Glu120Lys | p.E120K | Q9UBE0 | protein_coding | deleterious(0.05) | benign(0.102) | TCGA-AA-3869-01 | Colorectum | colon adenocarcinoma | Male | >=65 | III/IV | Chemotherapy | capecitabine | PD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
10055 | SAE1 | ENZYME, DRUGGABLE GENOME | 4-PHENYLAMINO-[1,2]NAPHTHOQUINONE | CHEMBL299853 | ||
10055 | SAE1 | ENZYME, DRUGGABLE GENOME | BENSERAZIDE HYDROCHLORIDE | BENSERAZIDE HYDROCHLORIDE | ||
10055 | SAE1 | ENZYME, DRUGGABLE GENOME | GINGKOLIC ACID | GINGKOLIC ACID | 23920437 | |
10055 | SAE1 | ENZYME, DRUGGABLE GENOME | PEVONEDISTAT | PEVONEDISTAT | ||
10055 | SAE1 | ENZYME, DRUGGABLE GENOME | BETULINIC ACID | BETULINIC ACID | ||
10055 | SAE1 | ENZYME, DRUGGABLE GENOME | LIPOIC ACID, ALPHA | LIPOIC ACID, ALPHA | ||
10055 | SAE1 | ENZYME, DRUGGABLE GENOME | LOBARIC ACID | LOBARIC ACID | ||
10055 | SAE1 | ENZYME, DRUGGABLE GENOME | ASTERRIC ACID | ASTERRIC ACID |
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