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Gene: S100P |
Gene summary for S100P |
Gene summary. |
Gene information | Species | Human | Gene symbol | S100P | Gene ID | 6286 |
Gene name | S100 calcium binding protein P | |
Gene Alias | MIG9 | |
Cytomap | 4p16.1 | |
Gene Type | protein-coding | GO ID | GO:0001667 | UniProtAcc | P25815 |
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Malignant transformation analysis |
Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
Malignant transformation involving gene list. |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
6286 | S100P | HTA12-3-16 | Human | Pancreas | PDAC | 1.76e-06 | 1.13e+00 | 0.1553 |
6286 | S100P | HTA12-9-1 | Human | Pancreas | PDAC | 9.92e-13 | 8.16e-01 | 0.1532 |
6286 | S100P | 181429 | Human | Pancreas | PDAC | 3.35e-12 | 1.71e+00 | 0.1416 |
6286 | S100P | DS20191261Tumor | Human | Pancreas | PDAC | 2.75e-08 | 7.02e-01 | 0.1367 |
6286 | S100P | DS20191261TumorKeller | Human | Pancreas | PDAC | 3.88e-05 | 1.03e+00 | 0.1407 |
6286 | S100P | Pat01-B | Human | Stomach | GC | 7.89e-91 | -1.46e+00 | 0.5754 |
6286 | S100P | Pat02-B | Human | Stomach | GC | 2.64e-57 | -4.93e-01 | 0.0368 |
6286 | S100P | Pat03-B | Human | Stomach | GC | 3.95e-62 | -9.73e-01 | 0.3693 |
6286 | S100P | Pat04-B | Human | Stomach | GC | 2.66e-30 | -3.27e-01 | -0.1483 |
6286 | S100P | Pat05-B | Human | Stomach | GC | 1.80e-13 | -2.98e-01 | -0.0353 |
6286 | S100P | Pat06-B | Human | Stomach | GC | 2.89e-40 | -3.10e-01 | -0.1961 |
6286 | S100P | Pat07-B | Human | Stomach | GC | 2.12e-25 | -7.60e-01 | 0.0935 |
6286 | S100P | Pat08-B | Human | Stomach | GC | 2.26e-24 | -7.07e-01 | 0.0182 |
6286 | S100P | Pat09-B | Human | Stomach | GC | 6.19e-38 | -4.43e-01 | -0.0359 |
6286 | S100P | Pat10-B | Human | Stomach | GC | 4.07e-12 | -3.32e-01 | 0.084 |
6286 | S100P | Pat11-B | Human | Stomach | GC | 2.83e-16 | -2.31e-01 | -0.182 |
6286 | S100P | Pat12-B | Human | Stomach | GC | 4.15e-51 | -4.44e-01 | 0.0325 |
6286 | S100P | Pat13-B | Human | Stomach | GC | 6.67e-17 | -2.88e-01 | 0.0555 |
6286 | S100P | Pat15-B | Human | Stomach | GC | 4.40e-33 | -5.25e-01 | -0.0778 |
6286 | S100P | Pat16-B | Human | Stomach | GC | 7.07e-89 | -9.02e-01 | 0.1918 |
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Transcriptomic changes along malignancy continuum. |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
Figure of enriched GO biological processes. |
Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | |
Colorectum | SER | |
Colorectum | MSS | |
Colorectum | MSI-H | |
Colorectum | FAP |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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Enriched GO biological processes. |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:000166714 | Breast | IDC | ameboidal-type cell migration | 64/1434 | 475/18723 | 6.65e-06 | 2.05e-04 | 64 |
GO:001063112 | Breast | IDC | epithelial cell migration | 51/1434 | 357/18723 | 1.14e-05 | 3.08e-04 | 51 |
GO:009013212 | Breast | IDC | epithelium migration | 51/1434 | 360/18723 | 1.44e-05 | 3.70e-04 | 51 |
GO:009013012 | Breast | IDC | tissue migration | 51/1434 | 365/18723 | 2.11e-05 | 5.11e-04 | 51 |
GO:004354211 | Breast | IDC | endothelial cell migration | 40/1434 | 279/18723 | 8.97e-05 | 1.74e-03 | 40 |
GO:001063121 | Breast | DCIS | epithelial cell migration | 51/1390 | 357/18723 | 4.83e-06 | 1.43e-04 | 51 |
GO:009013221 | Breast | DCIS | epithelium migration | 51/1390 | 360/18723 | 6.14e-06 | 1.75e-04 | 51 |
GO:009013021 | Breast | DCIS | tissue migration | 51/1390 | 365/18723 | 9.09e-06 | 2.45e-04 | 51 |
GO:000166723 | Breast | DCIS | ameboidal-type cell migration | 62/1390 | 475/18723 | 9.60e-06 | 2.56e-04 | 62 |
GO:004354221 | Breast | DCIS | endothelial cell migration | 40/1390 | 279/18723 | 4.54e-05 | 9.49e-04 | 40 |
GO:009013210 | Cervix | CC | epithelium migration | 90/2311 | 360/18723 | 2.45e-11 | 6.11e-09 | 90 |
GO:00016679 | Cervix | CC | ameboidal-type cell migration | 110/2311 | 475/18723 | 2.66e-11 | 6.36e-09 | 110 |
GO:001063110 | Cervix | CC | epithelial cell migration | 89/2311 | 357/18723 | 3.72e-11 | 8.54e-09 | 89 |
GO:009013010 | Cervix | CC | tissue migration | 90/2311 | 365/18723 | 5.42e-11 | 1.05e-08 | 90 |
GO:00435427 | Cervix | CC | endothelial cell migration | 60/2311 | 279/18723 | 1.05e-05 | 2.33e-04 | 60 |
GO:001063113 | Cervix | HSIL_HPV | epithelial cell migration | 33/737 | 357/18723 | 5.28e-06 | 2.04e-04 | 33 |
GO:000166715 | Cervix | HSIL_HPV | ameboidal-type cell migration | 40/737 | 475/18723 | 5.48e-06 | 2.07e-04 | 40 |
GO:009013213 | Cervix | HSIL_HPV | epithelium migration | 33/737 | 360/18723 | 6.31e-06 | 2.29e-04 | 33 |
GO:009013013 | Cervix | HSIL_HPV | tissue migration | 33/737 | 365/18723 | 8.43e-06 | 2.97e-04 | 33 |
GO:004354212 | Cervix | HSIL_HPV | endothelial cell migration | 24/737 | 279/18723 | 2.95e-04 | 4.83e-03 | 24 |
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Enriched KEGG pathways. |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
Annotation of somatic variants for genes involved in malignant transformation |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
S100P | deletion | In_Frame_Del | c.115_117delAAG | p.Lys39del | p.K39del | P25815 | protein_coding | TCGA-A2-A1G4-01 | Breast | breast invasive carcinoma | Female | >=65 | III/IV | Chemotherapy | adriamycin | SD | |||
S100P | deletion | Frame_Shift_Del | c.265delN | p.Phe89LeufsTer43 | p.F89Lfs*43 | P25815 | protein_coding | TCGA-BH-A0DO-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |||
S100P | SNV | Missense_Mutation | rs770673207 | c.245C>T | p.Thr82Met | p.T82M | P25815 | protein_coding | deleterious(0.01) | benign(0.165) | TCGA-AA-3510-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
S100P | SNV | Missense_Mutation | rs770673207 | c.245C>T | p.Thr82Met | p.T82M | P25815 | protein_coding | deleterious(0.01) | benign(0.165) | TCGA-A5-A0G2-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
S100P | SNV | Missense_Mutation | c.20N>T | p.Ala7Val | p.A7V | P25815 | protein_coding | deleterious(0.01) | probably_damaging(0.966) | TCGA-AP-A059-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
S100P | SNV | Missense_Mutation | novel | c.251N>T | p.Ala84Val | p.A84V | P25815 | protein_coding | tolerated(0.06) | benign(0) | TCGA-AP-A059-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
S100P | SNV | Missense_Mutation | c.194N>A | p.Gly65Glu | p.G65E | P25815 | protein_coding | tolerated(0.09) | probably_damaging(0.953) | TCGA-49-AARN-01 | Lung | lung adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
S100P | deletion | In_Frame_Del | c.113_115delNNN | p.Lys39del | p.K39del | P25815 | protein_coding | TCGA-HU-A4H8-01 | Stomach | stomach adenocarcinoma | Male | >=65 | I/II | Chemotherapy | didox | PD |
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Related drugs of malignant transformation related genes |
Identification of chemicals and drugs interact with genes involved in malignant transfromation |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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