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Gene: S100A4 |
Gene summary for S100A4 |
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Gene information | Species | Human | Gene symbol | S100A4 | Gene ID | 6275 |
Gene name | S100 calcium binding protein A4 | |
Gene Alias | 18A2 | |
Cytomap | 1q21.3 | |
Gene Type | protein-coding | GO ID | GO:0001837 | UniProtAcc | P26447 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
6275 | S100A4 | P84T-E | Human | Esophagus | ESCC | 3.71e-08 | 2.27e+00 | 0.0933 |
6275 | S100A4 | P91T-E | Human | Esophagus | ESCC | 2.11e-03 | 3.00e+00 | 0.1828 |
6275 | S100A4 | P107T-E | Human | Esophagus | ESCC | 3.33e-30 | 1.49e+00 | 0.171 |
6275 | S100A4 | P126T-E | Human | Esophagus | ESCC | 8.86e-07 | 1.89e+00 | 0.1125 |
6275 | S100A4 | P127T-E | Human | Esophagus | ESCC | 7.71e-19 | 6.62e-01 | 0.0826 |
6275 | S100A4 | P128T-E | Human | Esophagus | ESCC | 6.91e-62 | 3.64e+00 | 0.1241 |
6275 | S100A4 | P130T-E | Human | Esophagus | ESCC | 7.98e-154 | 6.55e+00 | 0.1676 |
6275 | S100A4 | S41 | Human | Liver | Cirrhotic | 9.42e-04 | -7.58e-01 | -0.0343 |
6275 | S100A4 | S43 | Human | Liver | Cirrhotic | 1.21e-23 | -7.36e-01 | -0.0187 |
6275 | S100A4 | HCC1_Meng | Human | Liver | HCC | 1.06e-20 | -4.79e-01 | 0.0246 |
6275 | S100A4 | HCC2_Meng | Human | Liver | HCC | 4.13e-28 | -8.00e-02 | 0.0107 |
6275 | S100A4 | cirrhotic1 | Human | Liver | Cirrhotic | 9.93e-12 | -3.96e-01 | 0.0202 |
6275 | S100A4 | cirrhotic2 | Human | Liver | Cirrhotic | 1.31e-20 | -1.39e-01 | 0.0201 |
6275 | S100A4 | cirrhotic3 | Human | Liver | Cirrhotic | 5.61e-03 | -2.22e-01 | 0.0215 |
6275 | S100A4 | p6 | Human | Liver | Cyst | 9.42e-04 | -7.58e-01 | -0.0218 |
6275 | S100A4 | HCC1 | Human | Liver | HCC | 7.68e-11 | -5.86e-01 | 0.5336 |
6275 | S100A4 | HCC2 | Human | Liver | HCC | 2.08e-02 | 1.51e+00 | 0.5341 |
6275 | S100A4 | Pt13.b | Human | Liver | HCC | 1.66e-06 | -5.13e-01 | 0.0251 |
6275 | S100A4 | S014 | Human | Liver | HCC | 3.50e-03 | 5.04e-02 | 0.2254 |
6275 | S100A4 | S015 | Human | Liver | HCC | 6.26e-03 | 3.00e-01 | 0.2375 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00431227 | Breast | IDC | regulation of I-kappaB kinase/NF-kappaB signaling | 34/1434 | 249/18723 | 7.18e-04 | 8.77e-03 | 34 |
GO:000724914 | Breast | IDC | I-kappaB kinase/NF-kappaB signaling | 37/1434 | 281/18723 | 8.58e-04 | 9.98e-03 | 37 |
GO:000183711 | Breast | IDC | epithelial to mesenchymal transition | 23/1434 | 157/18723 | 1.97e-03 | 1.88e-02 | 23 |
GO:00431236 | Breast | IDC | positive regulation of I-kappaB kinase/NF-kappaB signaling | 26/1434 | 186/18723 | 2.06e-03 | 1.95e-02 | 26 |
GO:004312214 | Breast | DCIS | regulation of I-kappaB kinase/NF-kappaB signaling | 32/1390 | 249/18723 | 1.67e-03 | 1.66e-02 | 32 |
GO:000724923 | Breast | DCIS | I-kappaB kinase/NF-kappaB signaling | 35/1390 | 281/18723 | 1.80e-03 | 1.74e-02 | 35 |
GO:000183721 | Breast | DCIS | epithelial to mesenchymal transition | 22/1390 | 157/18723 | 2.92e-03 | 2.50e-02 | 22 |
GO:004312313 | Breast | DCIS | positive regulation of I-kappaB kinase/NF-kappaB signaling | 24/1390 | 186/18723 | 5.66e-03 | 4.09e-02 | 24 |
GO:00431228 | Cervix | CC | regulation of I-kappaB kinase/NF-kappaB signaling | 53/2311 | 249/18723 | 4.50e-05 | 6.87e-04 | 53 |
GO:00072497 | Cervix | CC | I-kappaB kinase/NF-kappaB signaling | 56/2311 | 281/18723 | 1.81e-04 | 2.12e-03 | 56 |
GO:00431237 | Cervix | CC | positive regulation of I-kappaB kinase/NF-kappaB signaling | 37/2311 | 186/18723 | 2.15e-03 | 1.55e-02 | 37 |
GO:00018374 | Cervix | CC | epithelial to mesenchymal transition | 31/2311 | 157/18723 | 5.25e-03 | 3.08e-02 | 31 |
GO:00487624 | Cervix | CC | mesenchymal cell differentiation | 42/2311 | 236/18723 | 9.12e-03 | 4.60e-02 | 42 |
GO:004312215 | Cervix | HSIL_HPV | regulation of I-kappaB kinase/NF-kappaB signaling | 19/737 | 249/18723 | 4.66e-03 | 3.88e-02 | 19 |
GO:00431229 | Endometrium | AEH | regulation of I-kappaB kinase/NF-kappaB signaling | 52/2100 | 249/18723 | 6.58e-06 | 1.59e-04 | 52 |
GO:00431238 | Endometrium | AEH | positive regulation of I-kappaB kinase/NF-kappaB signaling | 41/2100 | 186/18723 | 1.59e-05 | 3.32e-04 | 41 |
GO:00072498 | Endometrium | AEH | I-kappaB kinase/NF-kappaB signaling | 55/2100 | 281/18723 | 2.60e-05 | 4.88e-04 | 55 |
GO:00487625 | Endometrium | AEH | mesenchymal cell differentiation | 46/2100 | 236/18723 | 1.27e-04 | 1.74e-03 | 46 |
GO:00604853 | Endometrium | AEH | mesenchyme development | 54/2100 | 291/18723 | 1.34e-04 | 1.83e-03 | 54 |
GO:00018375 | Endometrium | AEH | epithelial to mesenchymal transition | 33/2100 | 157/18723 | 2.64e-04 | 3.09e-03 | 33 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
S100A4 | SNV | Missense_Mutation | novel | c.277T>G | p.Phe93Val | p.F93V | P26447 | protein_coding | tolerated(0.5) | benign(0.003) | TCGA-AZ-4315-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
S100A4 | SNV | Missense_Mutation | novel | c.194N>G | p.Asn65Ser | p.N65S | P26447 | protein_coding | deleterious(0) | probably_damaging(0.92) | TCGA-CA-6717-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Chemotherapy | oxaliplatin | CR |
S100A4 | SNV | Missense_Mutation | novel | c.263N>C | p.Glu88Ala | p.E88A | P26447 | protein_coding | deleterious(0.01) | benign(0.127) | TCGA-A5-A2K5-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
S100A4 | SNV | Missense_Mutation | c.247N>A | p.Ala83Thr | p.A83T | P26447 | protein_coding | tolerated(1) | benign(0.162) | TCGA-AX-A06F-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | carboplatin | SD | |
S100A4 | SNV | Missense_Mutation | novel | c.235C>A | p.Leu79Met | p.L79M | P26447 | protein_coding | deleterious(0.01) | probably_damaging(0.993) | TCGA-B5-A1MX-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Hormone Therapy | megace | SD |
S100A4 | SNV | Missense_Mutation | novel | c.98N>G | p.Glu33Gly | p.E33G | P26447 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-B5-A3FA-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
S100A4 | SNV | Missense_Mutation | novel | c.300N>T | p.Lys100Asn | p.K100N | P26447 | protein_coding | deleterious(0) | benign(0.395) | TCGA-BK-A6W3-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
S100A4 | SNV | Missense_Mutation | rs368160023 | c.262N>A | p.Glu88Lys | p.E88K | P26447 | protein_coding | deleterious(0.01) | benign(0.098) | TCGA-E6-A1LX-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
S100A4 | SNV | Missense_Mutation | novel | c.205N>A | p.Glu69Lys | p.E69K | P26447 | protein_coding | deleterious(0.04) | possibly_damaging(0.488) | TCGA-EO-A22R-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
S100A4 | SNV | Missense_Mutation | c.247G>A | p.Ala83Thr | p.A83T | P26447 | protein_coding | tolerated(1) | benign(0.162) | TCGA-FI-A2D0-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
6275 | S100A4 | NA | SP-MET-1 | |||
6275 | S100A4 | NA | DOXORUBICIN HYDROCHLORIDE | DOXORUBICIN HYDROCHLORIDE | ||
6275 | S100A4 | NA | DAUNORUBICIN HYDROCHLORIDE | DAUNORUBICIN HYDROCHLORIDE | ||
6275 | S100A4 | NA | GNF-PF-4459 | CHEMBL585502 |
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