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Gene: PWP1 |
Gene summary for PWP1 |
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Gene information | Species | Human | Gene symbol | PWP1 | Gene ID | 11137 |
Gene name | PWP1 homolog, endonuclein | |
Gene Alias | IEF-SSP-9502 | |
Cytomap | 12q23.3 | |
Gene Type | protein-coding | GO ID | GO:0001932 | UniProtAcc | B4DJV5 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
11137 | PWP1 | SYSMH5 | Human | Oral cavity | OSCC | 1.71e-06 | 4.17e-01 | 0.0647 |
11137 | PWP1 | SYSMH6 | Human | Oral cavity | OSCC | 2.28e-03 | 3.99e-01 | 0.1275 |
11137 | PWP1 | P4_S8_cSCC | Human | Skin | cSCC | 1.11e-14 | 2.31e-01 | -0.3095 |
11137 | PWP1 | P5_S10_cSCC | Human | Skin | cSCC | 2.84e-08 | 1.03e-01 | -0.299 |
11137 | PWP1 | P1_cSCC | Human | Skin | cSCC | 2.66e-44 | 1.20e+00 | 0.0292 |
11137 | PWP1 | P2_cSCC | Human | Skin | cSCC | 2.55e-29 | 8.23e-01 | -0.024 |
11137 | PWP1 | P4_cSCC | Human | Skin | cSCC | 3.06e-41 | 1.14e+00 | -0.00290000000000005 |
11137 | PWP1 | P10_cSCC | Human | Skin | cSCC | 3.90e-52 | 1.36e+00 | 0.1017 |
11137 | PWP1 | cSCC_p8 | Human | Skin | cSCC | 1.19e-07 | 1.22e-01 | -0.1971 |
11137 | PWP1 | cSCC_p9 | Human | Skin | cSCC | 6.12e-04 | 8.04e-02 | -0.1991 |
11137 | PWP1 | male-WTA | Human | Thyroid | PTC | 8.04e-26 | 1.63e-01 | 0.1037 |
11137 | PWP1 | PTC01 | Human | Thyroid | PTC | 7.96e-17 | 2.71e-01 | 0.1899 |
11137 | PWP1 | PTC03 | Human | Thyroid | PTC | 1.53e-02 | 1.82e-01 | 0.1784 |
11137 | PWP1 | PTC04 | Human | Thyroid | PTC | 1.27e-10 | 2.03e-01 | 0.1927 |
11137 | PWP1 | PTC05 | Human | Thyroid | PTC | 2.75e-16 | 5.42e-01 | 0.2065 |
11137 | PWP1 | PTC06 | Human | Thyroid | PTC | 4.69e-32 | 7.49e-01 | 0.2057 |
11137 | PWP1 | PTC07 | Human | Thyroid | PTC | 2.06e-36 | 6.51e-01 | 0.2044 |
11137 | PWP1 | ATC09 | Human | Thyroid | ATC | 1.67e-09 | 4.53e-01 | 0.2871 |
11137 | PWP1 | ATC11 | Human | Thyroid | ATC | 3.09e-04 | 4.84e-01 | 0.3386 |
11137 | PWP1 | ATC12 | Human | Thyroid | ATC | 8.01e-37 | 8.86e-01 | 0.34 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:0022613111 | Esophagus | ESCC | ribonucleoprotein complex biogenesis | 365/8552 | 463/18723 | 1.74e-49 | 1.11e-45 | 365 |
GO:0042254111 | Esophagus | ESCC | ribosome biogenesis | 252/8552 | 299/18723 | 3.27e-44 | 1.04e-40 | 252 |
GO:003447015 | Esophagus | ESCC | ncRNA processing | 300/8552 | 395/18723 | 3.09e-35 | 3.26e-32 | 300 |
GO:0016072110 | Esophagus | ESCC | rRNA metabolic process | 197/8552 | 236/18723 | 1.31e-33 | 1.18e-30 | 197 |
GO:0006364110 | Esophagus | ESCC | rRNA processing | 189/8552 | 225/18723 | 4.88e-33 | 3.87e-30 | 189 |
GO:003466012 | Esophagus | ESCC | ncRNA metabolic process | 346/8552 | 485/18723 | 4.35e-31 | 2.51e-28 | 346 |
GO:001657015 | Esophagus | ESCC | histone modification | 323/8552 | 463/18723 | 2.61e-26 | 7.88e-24 | 323 |
GO:001820514 | Esophagus | ESCC | peptidyl-lysine modification | 259/8552 | 376/18723 | 3.90e-20 | 5.26e-18 | 259 |
GO:0010563111 | Esophagus | ESCC | negative regulation of phosphorus metabolic process | 274/8552 | 442/18723 | 2.32e-12 | 9.41e-11 | 274 |
GO:0045936111 | Esophagus | ESCC | negative regulation of phosphate metabolic process | 273/8552 | 441/18723 | 3.18e-12 | 1.25e-10 | 273 |
GO:0042326111 | Esophagus | ESCC | negative regulation of phosphorylation | 237/8552 | 385/18723 | 1.86e-10 | 5.33e-09 | 237 |
GO:00434143 | Esophagus | ESCC | macromolecule methylation | 199/8552 | 316/18723 | 3.44e-10 | 9.57e-09 | 199 |
GO:0001933111 | Esophagus | ESCC | negative regulation of protein phosphorylation | 213/8552 | 342/18723 | 3.54e-10 | 9.76e-09 | 213 |
GO:00322592 | Esophagus | ESCC | methylation | 222/8552 | 364/18723 | 2.26e-09 | 5.09e-08 | 222 |
GO:00987812 | Esophagus | ESCC | ncRNA transcription | 45/8552 | 56/18723 | 1.05e-07 | 1.72e-06 | 45 |
GO:000647914 | Esophagus | ESCC | protein methylation | 115/8552 | 181/18723 | 9.07e-07 | 1.16e-05 | 115 |
GO:000821314 | Esophagus | ESCC | protein alkylation | 115/8552 | 181/18723 | 9.07e-07 | 1.16e-05 | 115 |
GO:00182099 | Esophagus | ESCC | peptidyl-serine modification | 196/8552 | 338/18723 | 3.07e-06 | 3.47e-05 | 196 |
GO:001810515 | Esophagus | ESCC | peptidyl-serine phosphorylation | 184/8552 | 315/18723 | 3.22e-06 | 3.61e-05 | 184 |
GO:00063602 | Esophagus | ESCC | transcription by RNA polymerase I | 42/8552 | 55/18723 | 3.41e-06 | 3.78e-05 | 42 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
PWP1 | SNV | Missense_Mutation | rs771006966 | c.1366N>T | p.Arg456Trp | p.R456W | Q13610 | protein_coding | deleterious(0) | probably_damaging(0.965) | TCGA-AC-A3EH-01 | Breast | breast invasive carcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD |
PWP1 | SNV | Missense_Mutation | novel | c.974C>A | p.Ala325Asp | p.A325D | Q13610 | protein_coding | tolerated(0.06) | benign(0.281) | TCGA-BH-A18V-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
PWP1 | SNV | Missense_Mutation | rs377490385 | c.560N>G | p.Tyr187Cys | p.Y187C | Q13610 | protein_coding | deleterious(0) | probably_damaging(0.94) | TCGA-BH-A1FU-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | PD |
PWP1 | SNV | Missense_Mutation | c.611C>T | p.Thr204Ile | p.T204I | Q13610 | protein_coding | tolerated(0.07) | benign(0.007) | TCGA-EW-A1IZ-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | taxotere | SD | |
PWP1 | SNV | Missense_Mutation | novel | c.542N>G | p.Asp181Gly | p.D181G | Q13610 | protein_coding | deleterious(0.01) | probably_damaging(0.994) | TCGA-2W-A8YY-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
PWP1 | SNV | Missense_Mutation | c.229G>A | p.Glu77Lys | p.E77K | Q13610 | protein_coding | tolerated(0.25) | benign(0.038) | TCGA-C5-A3HE-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | PD | |
PWP1 | SNV | Missense_Mutation | c.200G>A | p.Arg67His | p.R67H | Q13610 | protein_coding | tolerated(0.14) | benign(0) | TCGA-VS-A94Z-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR | |
PWP1 | SNV | Missense_Mutation | novel | c.704N>A | p.Gly235Glu | p.G235E | Q13610 | protein_coding | deleterious(0) | probably_damaging(0.997) | TCGA-A6-6780-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
PWP1 | SNV | Missense_Mutation | novel | c.1458N>G | p.Ile486Met | p.I486M | Q13610 | protein_coding | tolerated_low_confidence(0.19) | benign(0.043) | TCGA-AA-3930-01 | Colorectum | colon adenocarcinoma | Male | >=65 | III/IV | Chemotherapy | capecitabine | PD |
PWP1 | SNV | Missense_Mutation | novel | c.1217N>T | p.Ala406Val | p.A406V | Q13610 | protein_coding | tolerated(0.05) | possibly_damaging(0.735) | TCGA-AA-3950-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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