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Gene: PTGES3 |
Gene summary for PTGES3 |
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Gene information | Species | Human | Gene symbol | PTGES3 | Gene ID | 10728 |
Gene name | prostaglandin E synthase 3 | |
Gene Alias | P23 | |
Cytomap | 12q13.3 | |
Gene Type | protein-coding | GO ID | GO:0000271 | UniProtAcc | Q15185 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
10728 | PTGES3 | P17T-E | Human | Esophagus | ESCC | 4.45e-20 | 1.77e+00 | 0.1278 |
10728 | PTGES3 | P19T-E | Human | Esophagus | ESCC | 1.65e-21 | 2.77e+00 | 0.1662 |
10728 | PTGES3 | P20T-E | Human | Esophagus | ESCC | 8.81e-72 | 2.31e+00 | 0.1124 |
10728 | PTGES3 | P21T-E | Human | Esophagus | ESCC | 1.99e-80 | 2.48e+00 | 0.1617 |
10728 | PTGES3 | P22T-E | Human | Esophagus | ESCC | 1.57e-69 | 1.84e+00 | 0.1236 |
10728 | PTGES3 | P23T-E | Human | Esophagus | ESCC | 4.47e-64 | 2.81e+00 | 0.108 |
10728 | PTGES3 | P24T-E | Human | Esophagus | ESCC | 1.85e-62 | 1.96e+00 | 0.1287 |
10728 | PTGES3 | P26T-E | Human | Esophagus | ESCC | 6.17e-84 | 2.34e+00 | 0.1276 |
10728 | PTGES3 | P27T-E | Human | Esophagus | ESCC | 6.84e-73 | 2.46e+00 | 0.1055 |
10728 | PTGES3 | P28T-E | Human | Esophagus | ESCC | 2.41e-73 | 2.23e+00 | 0.1149 |
10728 | PTGES3 | P30T-E | Human | Esophagus | ESCC | 5.07e-46 | 2.65e+00 | 0.137 |
10728 | PTGES3 | P31T-E | Human | Esophagus | ESCC | 2.37e-82 | 2.31e+00 | 0.1251 |
10728 | PTGES3 | P32T-E | Human | Esophagus | ESCC | 4.41e-69 | 2.16e+00 | 0.1666 |
10728 | PTGES3 | P36T-E | Human | Esophagus | ESCC | 8.32e-53 | 2.68e+00 | 0.1187 |
10728 | PTGES3 | P37T-E | Human | Esophagus | ESCC | 1.96e-53 | 2.15e+00 | 0.1371 |
10728 | PTGES3 | P38T-E | Human | Esophagus | ESCC | 6.83e-20 | 1.81e+00 | 0.127 |
10728 | PTGES3 | P39T-E | Human | Esophagus | ESCC | 8.25e-59 | 1.79e+00 | 0.0894 |
10728 | PTGES3 | P40T-E | Human | Esophagus | ESCC | 7.30e-28 | 1.34e+00 | 0.109 |
10728 | PTGES3 | P42T-E | Human | Esophagus | ESCC | 3.32e-54 | 2.52e+00 | 0.1175 |
10728 | PTGES3 | P44T-E | Human | Esophagus | ESCC | 4.47e-32 | 1.35e+00 | 0.1096 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00060918 | Breast | Precancer | generation of precursor metabolites and energy | 94/1080 | 490/18723 | 1.54e-25 | 1.64e-22 | 94 |
GO:00159808 | Breast | Precancer | energy derivation by oxidation of organic compounds | 70/1080 | 318/18723 | 8.33e-23 | 6.37e-20 | 70 |
GO:00226139 | Breast | Precancer | ribonucleoprotein complex biogenesis | 79/1080 | 463/18723 | 2.11e-18 | 1.03e-15 | 79 |
GO:00718269 | Breast | Precancer | ribonucleoprotein complex subunit organization | 48/1080 | 227/18723 | 2.68e-15 | 8.45e-13 | 48 |
GO:00226189 | Breast | Precancer | ribonucleoprotein complex assembly | 47/1080 | 220/18723 | 3.47e-15 | 1.03e-12 | 47 |
GO:00064578 | Breast | Precancer | protein folding | 43/1080 | 212/18723 | 3.48e-13 | 7.45e-11 | 43 |
GO:00485459 | Breast | Precancer | response to steroid hormone | 53/1080 | 339/18723 | 3.07e-11 | 3.66e-09 | 53 |
GO:00064588 | Breast | Precancer | 'de novo' protein folding | 16/1080 | 43/18723 | 8.14e-10 | 6.92e-08 | 16 |
GO:00610778 | Breast | Precancer | chaperone-mediated protein folding | 19/1080 | 67/18723 | 4.22e-09 | 3.28e-07 | 19 |
GO:00510848 | Breast | Precancer | 'de novo' posttranslational protein folding | 14/1080 | 39/18723 | 1.61e-08 | 1.12e-06 | 14 |
GO:00510858 | Breast | Precancer | chaperone cofactor-dependent protein refolding | 13/1080 | 34/18723 | 2.17e-08 | 1.47e-06 | 13 |
GO:00508219 | Breast | Precancer | protein stabilization | 29/1080 | 191/18723 | 1.67e-06 | 6.08e-05 | 29 |
GO:00316479 | Breast | Precancer | regulation of protein stability | 38/1080 | 298/18723 | 3.73e-06 | 1.19e-04 | 38 |
GO:00713838 | Breast | Precancer | cellular response to steroid hormone stimulus | 28/1080 | 204/18723 | 1.78e-05 | 4.26e-04 | 28 |
GO:00108338 | Breast | Precancer | telomere maintenance via telomere lengthening | 15/1080 | 81/18723 | 5.31e-05 | 1.11e-03 | 15 |
GO:00007238 | Breast | Precancer | telomere maintenance | 20/1080 | 131/18723 | 6.10e-05 | 1.25e-03 | 20 |
GO:20005738 | Breast | Precancer | positive regulation of DNA biosynthetic process | 13/1080 | 66/18723 | 8.54e-05 | 1.63e-03 | 13 |
GO:00070047 | Breast | Precancer | telomere maintenance via telomerase | 13/1080 | 69/18723 | 1.37e-04 | 2.38e-03 | 13 |
GO:00062786 | Breast | Precancer | RNA-dependent DNA biosynthetic process | 13/1080 | 75/18723 | 3.27e-04 | 4.64e-03 | 13 |
GO:20002788 | Breast | Precancer | regulation of DNA biosynthetic process | 16/1080 | 106/18723 | 3.68e-04 | 5.03e-03 | 16 |
Page: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa05207 | Colorectum | CRC | Chemical carcinogenesis - receptor activation | 42/1091 | 212/8465 | 2.62e-03 | 1.75e-02 | 1.19e-02 | 42 |
hsa052071 | Colorectum | CRC | Chemical carcinogenesis - receptor activation | 42/1091 | 212/8465 | 2.62e-03 | 1.75e-02 | 1.19e-02 | 42 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
PTGES3 | SNV | Missense_Mutation | novel | c.44N>A | p.Arg15Gln | p.R15Q | protein_coding | tolerated(0.06) | possibly_damaging(0.479) | TCGA-AN-A046-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
PTGES3 | SNV | Missense_Mutation | c.215G>C | p.Arg72Thr | p.R72T | protein_coding | deleterious(0.02) | probably_damaging(0.958) | TCGA-D8-A27N-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | taxol+adriamycin+cyclophosphamide+herceptin | SD | ||
PTGES3 | SNV | Missense_Mutation | c.127A>G | p.Ser43Gly | p.S43G | protein_coding | deleterious(0.03) | benign(0.007) | TCGA-AA-3710-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | ||
PTGES3 | SNV | Missense_Mutation | novel | c.112N>C | p.Ser38Pro | p.S38P | protein_coding | tolerated(0.08) | possibly_damaging(0.631) | TCGA-CA-6717-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Chemotherapy | oxaliplatin | CR | |
PTGES3 | SNV | Missense_Mutation | c.365N>G | p.Ser122Cys | p.S122C | protein_coding | deleterious(0) | probably_damaging(0.94) | TCGA-DM-A1D7-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD | ||
PTGES3 | SNV | Missense_Mutation | novel | c.398A>G | p.Asn133Ser | p.N133S | protein_coding | tolerated(0.25) | benign(0.02) | TCGA-A5-A0G2-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD | |
PTGES3 | SNV | Missense_Mutation | c.28G>A | p.Ala10Thr | p.A10T | protein_coding | tolerated(0.53) | benign(0.343) | TCGA-AX-A063-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | ||
PTGES3 | SNV | Missense_Mutation | novel | c.232T>G | p.Leu78Val | p.L78V | protein_coding | tolerated(0.38) | benign(0.143) | TCGA-EO-A3B0-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD | |
PTGES3 | SNV | Missense_Mutation | novel | c.403N>T | p.Gly135Cys | p.G135C | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-EO-A3KX-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
PTGES3 | SNV | Missense_Mutation | novel | c.20N>A | p.Pro7His | p.P7H | protein_coding | tolerated(0.24) | benign(0.108) | TCGA-EO-A3KX-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
10728 | PTGES3 | ENZYME | GENISTEIN | GENISTEIN | 15229138 | |
10728 | PTGES3 | ENZYME | DIETHYLSTILBESTROL | DIETHYLSTILBESTROL | 15229138 | |
10728 | PTGES3 | ENZYME | GEDUNIN | GEDUNIN | 25756299 |
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