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Gene: PPP1R11 |
Gene summary for PPP1R11 |
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Gene information | Species | Human | Gene symbol | PPP1R11 | Gene ID | 6992 |
Gene name | protein phosphatase 1 regulatory inhibitor subunit 11 | |
Gene Alias | CFAP255 | |
Cytomap | 6p22.1 | |
Gene Type | protein-coding | GO ID | GO:0001816 | UniProtAcc | A2BEK1 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
6992 | PPP1R11 | SYSMH1 | Human | Oral cavity | OSCC | 4.05e-06 | 2.09e-01 | 0.1127 |
6992 | PPP1R11 | SYSMH2 | Human | Oral cavity | OSCC | 2.10e-21 | 6.96e-01 | 0.2326 |
6992 | PPP1R11 | SYSMH3 | Human | Oral cavity | OSCC | 8.39e-27 | 6.58e-01 | 0.2442 |
6992 | PPP1R11 | SYSMH4 | Human | Oral cavity | OSCC | 5.97e-04 | 1.27e-01 | 0.1226 |
6992 | PPP1R11 | SYSMH5 | Human | Oral cavity | OSCC | 1.53e-08 | 3.34e-01 | 0.0647 |
6992 | PPP1R11 | SYSMH6 | Human | Oral cavity | OSCC | 8.26e-09 | 3.45e-01 | 0.1275 |
6992 | PPP1R11 | P4_S8_cSCC | Human | Skin | cSCC | 2.38e-03 | 1.70e-02 | -0.3095 |
6992 | PPP1R11 | P1_cSCC | Human | Skin | cSCC | 3.37e-25 | 8.60e-01 | 0.0292 |
6992 | PPP1R11 | P2_cSCC | Human | Skin | cSCC | 3.97e-10 | 4.21e-01 | -0.024 |
6992 | PPP1R11 | P4_cSCC | Human | Skin | cSCC | 3.32e-19 | 6.53e-01 | -0.00290000000000005 |
6992 | PPP1R11 | P10_cSCC | Human | Skin | cSCC | 3.76e-29 | 8.69e-01 | 0.1017 |
6992 | PPP1R11 | cSCC_p8 | Human | Skin | cSCC | 1.60e-02 | 1.81e-01 | -0.1971 |
6992 | PPP1R11 | cSCC_p9 | Human | Skin | cSCC | 1.69e-02 | 1.11e-01 | -0.1991 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:004593626 | Esophagus | HGIN | negative regulation of phosphate metabolic process | 89/2587 | 441/18723 | 1.24e-04 | 2.54e-03 | 89 |
GO:001056326 | Esophagus | HGIN | negative regulation of phosphorus metabolic process | 89/2587 | 442/18723 | 1.34e-04 | 2.71e-03 | 89 |
GO:000647017 | Esophagus | HGIN | protein dephosphorylation | 61/2587 | 281/18723 | 1.86e-04 | 3.51e-03 | 61 |
GO:003530425 | Esophagus | HGIN | regulation of protein dephosphorylation | 24/2587 | 90/18723 | 9.27e-04 | 1.17e-02 | 24 |
GO:005134620 | Esophagus | HGIN | negative regulation of hydrolase activity | 72/2587 | 379/18723 | 2.81e-03 | 2.75e-02 | 72 |
GO:004366619 | Esophagus | HGIN | regulation of phosphoprotein phosphatase activity | 16/2587 | 58/18723 | 4.35e-03 | 3.84e-02 | 16 |
GO:003530320 | Esophagus | HGIN | regulation of dephosphorylation | 29/2587 | 128/18723 | 4.41e-03 | 3.87e-02 | 29 |
GO:0010563111 | Esophagus | ESCC | negative regulation of phosphorus metabolic process | 274/8552 | 442/18723 | 2.32e-12 | 9.41e-11 | 274 |
GO:0045936111 | Esophagus | ESCC | negative regulation of phosphate metabolic process | 273/8552 | 441/18723 | 3.18e-12 | 1.25e-10 | 273 |
GO:001631110 | Esophagus | ESCC | dephosphorylation | 251/8552 | 417/18723 | 1.26e-09 | 2.99e-08 | 251 |
GO:000647018 | Esophagus | ESCC | protein dephosphorylation | 177/8552 | 281/18723 | 3.13e-09 | 6.72e-08 | 177 |
GO:0035304111 | Esophagus | ESCC | regulation of protein dephosphorylation | 66/8552 | 90/18723 | 8.82e-08 | 1.48e-06 | 66 |
GO:0035303111 | Esophagus | ESCC | regulation of dephosphorylation | 88/8552 | 128/18723 | 1.04e-07 | 1.71e-06 | 88 |
GO:0051346110 | Esophagus | ESCC | negative regulation of hydrolase activity | 208/8552 | 379/18723 | 1.76e-04 | 1.14e-03 | 208 |
GO:003530816 | Esophagus | ESCC | negative regulation of protein dephosphorylation | 26/8552 | 34/18723 | 2.53e-04 | 1.55e-03 | 26 |
GO:0043666110 | Esophagus | ESCC | regulation of phosphoprotein phosphatase activity | 40/8552 | 58/18723 | 2.83e-04 | 1.71e-03 | 40 |
GO:00353056 | Esophagus | ESCC | negative regulation of dephosphorylation | 31/8552 | 45/18723 | 1.40e-03 | 6.62e-03 | 31 |
GO:001092115 | Esophagus | ESCC | regulation of phosphatase activity | 52/8552 | 84/18723 | 1.98e-03 | 8.90e-03 | 52 |
GO:00325155 | Esophagus | ESCC | negative regulation of phosphoprotein phosphatase activity | 19/8552 | 26/18723 | 4.31e-03 | 1.71e-02 | 19 |
GO:005134612 | Liver | Cirrhotic | negative regulation of hydrolase activity | 139/4634 | 379/18723 | 1.24e-07 | 3.42e-06 | 139 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
PPP1R11 | SNV | Missense_Mutation | c.70G>A | p.Glu24Lys | p.E24K | O60927 | protein_coding | tolerated(0.37) | probably_damaging(0.992) | TCGA-A6-2681-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | PD | |
PPP1R11 | SNV | Missense_Mutation | novel | c.97N>T | p.Arg33Trp | p.R33W | O60927 | protein_coding | deleterious(0) | probably_damaging(0.941) | TCGA-A5-A2K5-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
PPP1R11 | SNV | Missense_Mutation | rs770307762 | c.299G>A | p.Arg100His | p.R100H | O60927 | protein_coding | tolerated(0.19) | benign(0) | TCGA-AJ-A2QO-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
PPP1R11 | SNV | Missense_Mutation | novel | c.97N>T | p.Arg33Trp | p.R33W | O60927 | protein_coding | deleterious(0) | probably_damaging(0.941) | TCGA-AJ-A5DW-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
PPP1R11 | SNV | Missense_Mutation | novel | c.58N>G | p.Thr20Ala | p.T20A | O60927 | protein_coding | tolerated(0.76) | benign(0.157) | TCGA-EO-A22R-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
PPP1R11 | SNV | Missense_Mutation | novel | c.97N>T | p.Arg33Trp | p.R33W | O60927 | protein_coding | deleterious(0) | probably_damaging(0.941) | TCGA-EO-A3B0-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
PPP1R11 | SNV | Missense_Mutation | novel | c.97C>T | p.Arg33Trp | p.R33W | O60927 | protein_coding | deleterious(0) | probably_damaging(0.941) | TCGA-EY-A1GI-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
PPP1R11 | SNV | Missense_Mutation | novel | c.30N>T | p.Glu10Asp | p.E10D | O60927 | protein_coding | tolerated(0.07) | benign(0.084) | TCGA-DD-AACQ-01 | Liver | liver hepatocellular carcinoma | Male | <65 | I/II | Unknown | Unknown | PD |
PPP1R11 | SNV | Missense_Mutation | c.7G>A | p.Glu3Lys | p.E3K | O60927 | protein_coding | deleterious(0.01) | probably_damaging(0.959) | TCGA-55-A4DF-01 | Lung | lung adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD | |
PPP1R11 | SNV | Missense_Mutation | novel | c.19G>A | p.Gly7Arg | p.G7R | O60927 | protein_coding | tolerated(0.22) | benign(0.347) | TCGA-CN-5360-01 | Oral cavity | head & neck squamous cell carcinoma | Male | >=65 | I/II | Chemotherapy | cisplatin | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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