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Gene: PPCS |
Gene summary for PPCS |
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Gene information | Species | Human | Gene symbol | PPCS | Gene ID | 79717 |
Gene name | phosphopantothenoylcysteine synthetase | |
Gene Alias | CMD2C | |
Cytomap | 1p34.2 | |
Gene Type | protein-coding | GO ID | GO:0003008 | UniProtAcc | Q9HAB8 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
79717 | PPCS | P126T-E | Human | Esophagus | ESCC | 1.56e-15 | 1.63e+00 | 0.1125 |
79717 | PPCS | P127T-E | Human | Esophagus | ESCC | 8.62e-47 | 1.02e+00 | 0.0826 |
79717 | PPCS | P128T-E | Human | Esophagus | ESCC | 9.61e-56 | 2.15e+00 | 0.1241 |
79717 | PPCS | P130T-E | Human | Esophagus | ESCC | 8.84e-82 | 1.76e+00 | 0.1676 |
79717 | PPCS | S43 | Human | Liver | Cirrhotic | 2.60e-08 | -2.70e-01 | -0.0187 |
79717 | PPCS | HCC1_Meng | Human | Liver | HCC | 7.15e-90 | 8.97e-02 | 0.0246 |
79717 | PPCS | HCC2_Meng | Human | Liver | HCC | 1.03e-50 | 2.22e-01 | 0.0107 |
79717 | PPCS | cirrhotic1 | Human | Liver | Cirrhotic | 1.46e-22 | 3.19e-01 | 0.0202 |
79717 | PPCS | cirrhotic2 | Human | Liver | Cirrhotic | 2.04e-18 | 2.72e-01 | 0.0201 |
79717 | PPCS | cirrhotic3 | Human | Liver | Cirrhotic | 3.23e-11 | 1.89e-01 | 0.0215 |
79717 | PPCS | HCC1 | Human | Liver | HCC | 6.74e-03 | 3.35e+00 | 0.5336 |
79717 | PPCS | HCC2 | Human | Liver | HCC | 2.49e-19 | 5.05e+00 | 0.5341 |
79717 | PPCS | Pt13.b | Human | Liver | HCC | 7.92e-15 | 9.18e-02 | 0.0251 |
79717 | PPCS | Pt14.b | Human | Liver | HCC | 1.87e-04 | 1.70e-01 | 0.018 |
79717 | PPCS | S014 | Human | Liver | HCC | 2.05e-24 | 1.23e+00 | 0.2254 |
79717 | PPCS | S015 | Human | Liver | HCC | 6.62e-20 | 1.33e+00 | 0.2375 |
79717 | PPCS | S016 | Human | Liver | HCC | 1.77e-24 | 1.31e+00 | 0.2243 |
79717 | PPCS | S027 | Human | Liver | HCC | 2.69e-14 | 1.58e+00 | 0.2446 |
79717 | PPCS | S028 | Human | Liver | HCC | 7.07e-31 | 1.65e+00 | 0.2503 |
79717 | PPCS | S029 | Human | Liver | HCC | 5.38e-27 | 1.97e+00 | 0.2581 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00196938 | Breast | Precancer | ribose phosphate metabolic process | 49/1080 | 396/18723 | 3.81e-07 | 1.78e-05 | 49 |
GO:00091528 | Breast | Precancer | purine ribonucleotide biosynthetic process | 28/1080 | 169/18723 | 4.17e-07 | 1.89e-05 | 28 |
GO:00463907 | Breast | Precancer | ribose phosphate biosynthetic process | 30/1080 | 190/18723 | 4.75e-07 | 2.11e-05 | 30 |
GO:00092607 | Breast | Precancer | ribonucleotide biosynthetic process | 29/1080 | 182/18723 | 6.05e-07 | 2.55e-05 | 29 |
GO:00091509 | Breast | Precancer | purine ribonucleotide metabolic process | 46/1080 | 368/18723 | 6.47e-07 | 2.71e-05 | 46 |
GO:00091179 | Breast | Precancer | nucleotide metabolic process | 56/1080 | 489/18723 | 7.40e-07 | 3.00e-05 | 56 |
GO:00092598 | Breast | Precancer | ribonucleotide metabolic process | 47/1080 | 385/18723 | 9.69e-07 | 3.84e-05 | 47 |
GO:00067539 | Breast | Precancer | nucleoside phosphate metabolic process | 56/1080 | 497/18723 | 1.24e-06 | 4.70e-05 | 56 |
GO:00061639 | Breast | Precancer | purine nucleotide metabolic process | 47/1080 | 396/18723 | 2.14e-06 | 7.50e-05 | 47 |
GO:00061647 | Breast | Precancer | purine nucleotide biosynthetic process | 28/1080 | 191/18723 | 5.04e-06 | 1.52e-04 | 28 |
GO:00725219 | Breast | Precancer | purine-containing compound metabolic process | 47/1080 | 416/18723 | 8.19e-06 | 2.20e-04 | 47 |
GO:00725227 | Breast | Precancer | purine-containing compound biosynthetic process | 28/1080 | 200/18723 | 1.23e-05 | 3.17e-04 | 28 |
GO:00091655 | Breast | Precancer | nucleotide biosynthetic process | 32/1080 | 254/18723 | 2.72e-05 | 6.21e-04 | 32 |
GO:19012935 | Breast | Precancer | nucleoside phosphate biosynthetic process | 32/1080 | 256/18723 | 3.18e-05 | 6.97e-04 | 32 |
GO:000915214 | Breast | IDC | purine ribonucleotide biosynthetic process | 34/1434 | 169/18723 | 1.63e-07 | 8.92e-06 | 34 |
GO:004639013 | Breast | IDC | ribose phosphate biosynthetic process | 36/1434 | 190/18723 | 3.40e-07 | 1.73e-05 | 36 |
GO:000926013 | Breast | IDC | ribonucleotide biosynthetic process | 35/1434 | 182/18723 | 3.40e-07 | 1.73e-05 | 35 |
GO:000915014 | Breast | IDC | purine ribonucleotide metabolic process | 55/1434 | 368/18723 | 1.30e-06 | 5.72e-05 | 55 |
GO:001969314 | Breast | IDC | ribose phosphate metabolic process | 58/1434 | 396/18723 | 1.31e-06 | 5.73e-05 | 58 |
GO:000675313 | Breast | IDC | nucleoside phosphate metabolic process | 68/1434 | 497/18723 | 2.01e-06 | 8.23e-05 | 68 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa012405 | Esophagus | ESCC | Biosynthesis of cofactors | 97/4205 | 153/8465 | 3.88e-04 | 1.35e-03 | 6.94e-04 | 97 |
hsa0124012 | Esophagus | ESCC | Biosynthesis of cofactors | 97/4205 | 153/8465 | 3.88e-04 | 1.35e-03 | 6.94e-04 | 97 |
hsa01240 | Liver | Cirrhotic | Biosynthesis of cofactors | 66/2530 | 153/8465 | 3.11e-04 | 1.99e-03 | 1.23e-03 | 66 |
hsa00770 | Liver | Cirrhotic | Pantothenate and CoA biosynthesis | 13/2530 | 21/8465 | 2.32e-03 | 9.90e-03 | 6.10e-03 | 13 |
hsa012401 | Liver | Cirrhotic | Biosynthesis of cofactors | 66/2530 | 153/8465 | 3.11e-04 | 1.99e-03 | 1.23e-03 | 66 |
hsa007701 | Liver | Cirrhotic | Pantothenate and CoA biosynthesis | 13/2530 | 21/8465 | 2.32e-03 | 9.90e-03 | 6.10e-03 | 13 |
hsa012402 | Liver | HCC | Biosynthesis of cofactors | 103/4020 | 153/8465 | 4.67e-07 | 5.05e-06 | 2.81e-06 | 103 |
hsa007702 | Liver | HCC | Pantothenate and CoA biosynthesis | 16/4020 | 21/8465 | 7.16e-03 | 1.97e-02 | 1.09e-02 | 16 |
hsa012403 | Liver | HCC | Biosynthesis of cofactors | 103/4020 | 153/8465 | 4.67e-07 | 5.05e-06 | 2.81e-06 | 103 |
hsa007703 | Liver | HCC | Pantothenate and CoA biosynthesis | 16/4020 | 21/8465 | 7.16e-03 | 1.97e-02 | 1.09e-02 | 16 |
hsa012404 | Oral cavity | OSCC | Biosynthesis of cofactors | 88/3704 | 153/8465 | 3.84e-04 | 1.20e-03 | 6.12e-04 | 88 |
hsa0124011 | Oral cavity | OSCC | Biosynthesis of cofactors | 88/3704 | 153/8465 | 3.84e-04 | 1.20e-03 | 6.12e-04 | 88 |
hsa0124021 | Oral cavity | LP | Biosynthesis of cofactors | 57/2418 | 153/8465 | 1.17e-02 | 3.91e-02 | 2.52e-02 | 57 |
hsa0124031 | Oral cavity | LP | Biosynthesis of cofactors | 57/2418 | 153/8465 | 1.17e-02 | 3.91e-02 | 2.52e-02 | 57 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
PPCS | SNV | Missense_Mutation | c.211N>C | p.Glu71Gln | p.E71Q | Q9HAB8 | protein_coding | deleterious(0) | possibly_damaging(0.905) | TCGA-A8-A09E-01 | Breast | breast invasive carcinoma | Female | >=65 | III/IV | Hormone Therapy | anastrozole | SD | |
PPCS | insertion | Frame_Shift_Ins | novel | c.491_492insCAGTACGGCGCGGCGCGTACACCAGGTAGGCGAGAAGG | p.Gln164HisfsTer19 | p.Q164Hfs*19 | Q9HAB8 | protein_coding | TCGA-AN-A03X-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | ||
PPCS | SNV | Missense_Mutation | c.709N>A | p.Ala237Thr | p.A237T | Q9HAB8 | protein_coding | tolerated(0.2) | benign(0) | TCGA-AA-3821-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
PPCS | SNV | Missense_Mutation | c.709N>A | p.Ala237Thr | p.A237T | Q9HAB8 | protein_coding | tolerated(0.2) | benign(0) | TCGA-AA-3947-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
PPCS | SNV | Missense_Mutation | novel | c.536C>T | p.Ala179Val | p.A179V | Q9HAB8 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-AA-3949-01 | Colorectum | colon adenocarcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD |
PPCS | SNV | Missense_Mutation | novel | c.929N>T | p.Arg310Ile | p.R310I | Q9HAB8 | protein_coding | deleterious(0.01) | benign(0.043) | TCGA-CA-6717-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Chemotherapy | oxaliplatin | CR |
PPCS | SNV | Missense_Mutation | c.430N>A | p.Phe144Ile | p.F144I | Q9HAB8 | protein_coding | tolerated(0.14) | benign(0.007) | TCGA-F4-6570-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
PPCS | SNV | Missense_Mutation | rs748847721 | c.730C>T | p.Arg244Trp | p.R244W | Q9HAB8 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-AG-A002-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
PPCS | insertion | Frame_Shift_Ins | novel | c.336_337dupTT | p.Ser113PhefsTer5 | p.S113Ffs*5 | Q9HAB8 | protein_coding | TCGA-DC-6681-01 | Colorectum | rectum adenocarcinoma | Female | >=65 | I/II | Chemotherapy | 5-fluorouracil | SD | ||
PPCS | SNV | Missense_Mutation | c.772N>G | p.Asn258Asp | p.N258D | Q9HAB8 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-A5-A0VP-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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