Schematic overview of the cellular and molecular mechanisms involved in the cancer progression, including the proposed cellular and molecular mechanisms in cancer cells trajectory. AT1: alveolar type 1 cells; AT2: alveolar type 2 cells; AAH: atypical adenomatous hyperplasia; AIS: adenocarcinoma in situ; MIA: minimally invasive adenocarcinoma; IA: invasive adenocarcinoma; EMT: epithelial-mesenchymal transition

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	Gene summary
	Malignant transformation analysis
	Malignant transformation related pathway analysis
	Cell-cell communication analysis
	Single-cell gene regulatory network inference analysis
	Somatic mutation of malignant transformation related genes
	Related drugs of malignant transformation related genes

Gene: POGZ

Gene summary for POGZ

Gene summary.

Gene information	Species	Human
	Gene symbol	POGZ
	Gene ID	23126
	Gene name	pogo transposable element derived with ZNF domain
	Gene Alias	MRD37
	Cytomap	1q21.3
	Gene Type	protein-coding
	GO ID	GO:0000070
	UniProtAcc	Q7Z3K3

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Malignant transformation analysis

Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells

Malignant transformation involving gene list.

Entrez ID	Symbol	Replicates	Species	Organ	Tissue	Adj P-value	Log2FC	Malignancy
23126	POGZ	HCC2_Meng	Human	Liver	HCC	8.62e-34	-3.31e-02	0.0107
23126	POGZ	cirrhotic1	Human	Liver	Cirrhotic	2.07e-02	-7.81e-02	0.0202
23126	POGZ	HCC1	Human	Liver	HCC	4.31e-03	3.53e+00	0.5336
23126	POGZ	HCC2	Human	Liver	HCC	1.17e-06	4.03e+00	0.5341
23126	POGZ	Pt13.a	Human	Liver	HCC	2.99e-02	-2.23e-01	0.021
23126	POGZ	Pt13.b	Human	Liver	HCC	1.89e-09	-3.98e-02	0.0251
23126	POGZ	Pt13.c	Human	Liver	HCC	6.94e-03	-3.19e-01	0.0076
23126	POGZ	Pt14.a	Human	Liver	HCC	2.37e-04	1.53e-01	0.0169
23126	POGZ	S014	Human	Liver	HCC	1.52e-03	4.86e-01	0.2254
23126	POGZ	S015	Human	Liver	HCC	3.55e-02	4.55e-01	0.2375
23126	POGZ	S016	Human	Liver	HCC	1.29e-02	4.44e-01	0.2243
23126	POGZ	S028	Human	Liver	HCC	1.40e-09	8.07e-01	0.2503
23126	POGZ	S029	Human	Liver	HCC	4.32e-04	5.84e-01	0.2581
23126	POGZ	TD9	Human	Lung	IAC	4.93e-03	6.01e-01	0.088
23126	POGZ	RNA-P17T-P17T-4	Human	Lung	IAC	1.27e-02	4.46e-01	0.343
23126	POGZ	RNA-P17T-P17T-6	Human	Lung	IAC	1.39e-02	4.54e-01	0.3385
23126	POGZ	RNA-P25T1-P25T1-1	Human	Lung	AIS	3.32e-06	4.89e-01	-0.2116
23126	POGZ	RNA-P25T1-P25T1-4	Human	Lung	AIS	5.27e-04	3.50e-01	-0.2119
23126	POGZ	RNA-P6T1-P6T1-3	Human	Lung	MIAC	7.42e-04	9.72e-01	-0.0296
23126	POGZ	RNA-P6T1-P6T1-4	Human	Lung	MIAC	1.20e-07	1.06e+00	-0.0263

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Transcriptomic changes along malignancy continuum.

Tissue	Expression Dynamics	Abbreviation
Cervix		CC: Cervix cancer
		HSIL_HPV: HPV-infected high-grade squamous intraepithelial lesions
		N_HPV: HPV-infected normal cervix
Colorectum (GSE201348)		FAP: Familial adenomatous polyposis
		CRC: Colorectal cancer
Colorectum (HTA11)		AD: Adenomas
		SER: Sessile serrated lesions
		MSI-H: Microsatellite-high colorectal cancer
		MSS: Microsatellite stable colorectal cancer
Esophagus		ESCC: Esophageal squamous cell carcinoma
		HGIN: High-grade intraepithelial neoplasias
		LGIN: Low-grade intraepithelial neoplasias
Liver		HCC: Hepatocellular carcinoma
		NAFLD: Non-alcoholic fatty liver disease
Lung		AAH: Atypical adenomatous hyperplasia
		AIS: Adenocarcinoma in situ
		IAC: Invasive lung adenocarcinoma
		MIA: Minimally invasive adenocarcinoma
Oral Cavity		EOLP: Erosive Oral lichen planus
		LP: leukoplakia
		NEOLP: Non-erosive oral lichen planus
		OSCC: Oral squamous cell carcinoma
Thyroid		ATC: Anaplastic thyroid cancer
		HT: Hashimoto's thyroiditis
		PTC: Papillary thyroid cancer

∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.

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Malignant transformation related pathway analysis

Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer

Figure of enriched GO biological processes.

Tissue	Disease Stage	Enriched GO biological Processes
Colorectum	AD
Colorectum	SER
Colorectum	MSS
Colorectum	MSI-H
Colorectum	FAP

∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).

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Enriched GO biological processes.

GO ID	Tissue	Disease Stage	Description	Gene Ratio	Bg Ratio	pvalue	p.adjust	Count
GO:00070646	Cervix	CC	mitotic sister chromatid cohesion	12/2311	28/18723	5.47e-05	8.06e-04	12
GO:01400143	Cervix	CC	mitotic nuclear division	50/2311	287/18723	7.27e-03	3.91e-02	50
GO:00070625	Cervix	CC	sister chromatid cohesion	15/2311	62/18723	7.30e-03	3.92e-02	15
GO:00482851	Cervix	CC	organelle fission	78/2311	488/18723	9.70e-03	4.79e-02	78
GO:0007064	Colorectum	AD	mitotic sister chromatid cohesion	13/3918	28/18723	2.22e-03	1.75e-02	13
GO:0007062	Colorectum	AD	sister chromatid cohesion	23/3918	62/18723	2.51e-03	1.92e-02	23
GO:0140014	Colorectum	AD	mitotic nuclear division	78/3918	287/18723	6.48e-03	4.05e-02	78
GO:00070621	Colorectum	MSS	sister chromatid cohesion	20/3467	62/18723	6.63e-03	4.38e-02	20
GO:01400141	Colorectum	MSS	mitotic nuclear division	70/3467	287/18723	7.48e-03	4.72e-02	70
GO:00070641	Colorectum	MSS	mitotic sister chromatid cohesion	11/3467	28/18723	8.30e-03	5.00e-02	11
GO:00070642	Colorectum	FAP	mitotic sister chromatid cohesion	11/2622	28/18723	8.55e-04	8.79e-03	11
GO:00070622	Colorectum	FAP	sister chromatid cohesion	18/2622	62/18723	1.60e-03	1.42e-02	18
GO:00070623	Colorectum	CRC	sister chromatid cohesion	16/2078	62/18723	9.40e-04	1.15e-02	16
GO:00070643	Colorectum	CRC	mitotic sister chromatid cohesion	9/2078	28/18723	2.43e-03	2.30e-02	9
GO:01400146	Esophagus	HGIN	mitotic nuclear division	61/2587	287/18723	3.38e-04	5.55e-03	61
GO:00070593	Esophagus	HGIN	chromosome segregation	71/2587	346/18723	3.47e-04	5.62e-03	71
GO:00000703	Esophagus	HGIN	mitotic sister chromatid segregation	36/2587	168/18723	4.42e-03	3.87e-02	36
GO:014001414	Esophagus	ESCC	mitotic nuclear division	218/8552	287/18723	6.17e-26	1.78e-23	218
GO:000007011	Esophagus	ESCC	mitotic sister chromatid segregation	138/8552	168/18723	1.37e-22	2.63e-20	138
GO:00008194	Esophagus	ESCC	sister chromatid segregation	157/8552	202/18723	8.41e-21	1.33e-18	157

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Enriched KEGG pathways.

Pathway ID

Tissue

Disease Stage

Description

Gene Ratio

Bg Ratio

pvalue

p.adjust

qvalue

Count

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Cell-cell communication analysis

Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states

Ligand

Receptor

LRpair

Pathway

Tissue

Disease Stage

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Single-cell gene regulatory network inference analysis

Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states

Cell Type

Tissue

Disease Stage

Target Gene

RSS

Regulon Activity

∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.

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Somatic mutation of malignant transformation related genes

Annotation of somatic variants for genes involved in malignant transformation

Hugo Symbol

Variant Class

Variant Classification

dbSNP RS

HGVSc

HGVSp

HGVSp Short

SWISSPROT

BIOTYPE

SIFT

PolyPhen

Tumor Sample Barcode

Tissue

Histology

Sex

Age

Stage

Therapy Types

Drugs

Outcome

POGZ

SNV

Missense_Mutation

novel

c.1545C>A

p.His515Gln

p.H515Q

Q7Z3K3

protein_coding

deleterious(0.01)

possibly_damaging(0.624)

TCGA-A7-A5ZX-01

Breast

breast invasive carcinoma

Female

<65

III/IV

Chemotherapy

doxorubicin

POGZ

SNV

Missense_Mutation

c.3695G>A

p.Arg1232His

p.R1232H

Q7Z3K3

protein_coding

tolerated(0.4)

possibly_damaging(0.543)

TCGA-AN-A046-01

Breast

breast invasive carcinoma

Female

>=65

I/II

Unknown

POGZ

SNV

Missense_Mutation

c.3377A>G

p.Asp1126Gly

p.D1126G

Q7Z3K3

protein_coding

deleterious(0)

probably_damaging(0.999)

TCGA-AN-A0FD-01

Breast

breast invasive carcinoma

Female

>=65

I/II

Unknown

POGZ

SNV

Missense_Mutation

c.2235N>C

p.Met745Ile

p.M745I

Q7Z3K3

protein_coding

tolerated(0.12)

benign(0.117)

TCGA-AO-A0JC-01

Breast

breast invasive carcinoma

Female

<65

I/II

Chemotherapy

fluorouracil

POGZ

SNV

Missense_Mutation

c.367C>G

p.Gln123Glu

p.Q123E

Q7Z3K3

protein_coding

tolerated(0.17)

benign(0.024)

TCGA-BH-A0AV-01

Breast

breast invasive carcinoma

Female

<65

I/II

Chemotherapy

taxotere

POGZ

SNV

Missense_Mutation

c.3926N>C

p.Leu1309Pro

p.L1309P

Q7Z3K3

protein_coding

deleterious(0)

probably_damaging(0.942)

TCGA-BH-A0BA-01

Breast

breast invasive carcinoma

Female

<65

III/IV

Chemotherapy

cytoxan

POGZ

SNV

Missense_Mutation

novel

c.2116G>A

p.Asp706Asn

p.D706N

Q7Z3K3

protein_coding

tolerated(0.14)

possibly_damaging(0.823)

TCGA-C8-A3M7-01

Breast

breast invasive carcinoma

Female

<65

III/IV

Unknown

POGZ

SNV

Missense_Mutation

c.3225N>G

p.Phe1075Leu

p.F1075L

Q7Z3K3

protein_coding

deleterious(0)

probably_damaging(0.989)

TCGA-D8-A1JA-01

Breast

breast invasive carcinoma

Female

<65

III/IV

Chemotherapy

adriamycin

POGZ

SNV

Missense_Mutation

c.2423N>G

p.Asn808Ser

p.N808S

Q7Z3K3

protein_coding

tolerated(0.59)

benign(0.046)

TCGA-D8-A27I-01

Breast

breast invasive carcinoma

Female

<65

III/IV

Chemotherapy

adrimycin+cyclophosphamide

POGZ

SNV

Missense_Mutation

novel

c.3881N>T

p.Ser1294Phe

p.S1294F

Q7Z3K3

protein_coding

deleterious(0.03)

probably_damaging(0.972)

TCGA-E2-A572-01

Breast

breast invasive carcinoma

Female

>=65

III/IV

Chemotherapy

doxorubicin

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Related drugs of malignant transformation related genes

Identification of chemicals and drugs interact with genes involved in malignant transfromation

(DGIdb 4.0)

Entrez ID

Symbol

Category

Interaction Types

Drug Claim Name

Drug Name

PMIDs

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