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Gene: PHPT1 |
Gene summary for PHPT1 |
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Gene information | Species | Human | Gene symbol | PHPT1 | Gene ID | 29085 |
Gene name | phosphohistidine phosphatase 1 | |
Gene Alias | CGI-202 | |
Cytomap | 9q34.3 | |
Gene Type | protein-coding | GO ID | GO:0001678 | UniProtAcc | Q9NRX4 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
29085 | PHPT1 | P38T-E | Human | Esophagus | ESCC | 2.37e-26 | 1.20e+00 | 0.127 |
29085 | PHPT1 | P39T-E | Human | Esophagus | ESCC | 5.82e-15 | 4.47e-01 | 0.0894 |
29085 | PHPT1 | P40T-E | Human | Esophagus | ESCC | 7.52e-25 | 9.79e-01 | 0.109 |
29085 | PHPT1 | P42T-E | Human | Esophagus | ESCC | 3.93e-43 | 1.23e+00 | 0.1175 |
29085 | PHPT1 | P44T-E | Human | Esophagus | ESCC | 1.19e-25 | 1.10e+00 | 0.1096 |
29085 | PHPT1 | P47T-E | Human | Esophagus | ESCC | 3.44e-18 | 6.15e-01 | 0.1067 |
29085 | PHPT1 | P48T-E | Human | Esophagus | ESCC | 9.65e-39 | 9.63e-01 | 0.0959 |
29085 | PHPT1 | P49T-E | Human | Esophagus | ESCC | 4.77e-16 | 2.15e+00 | 0.1768 |
29085 | PHPT1 | P52T-E | Human | Esophagus | ESCC | 1.77e-72 | 1.79e+00 | 0.1555 |
29085 | PHPT1 | P54T-E | Human | Esophagus | ESCC | 5.21e-34 | 8.92e-01 | 0.0975 |
29085 | PHPT1 | P56T-E | Human | Esophagus | ESCC | 6.66e-09 | 1.46e+00 | 0.1613 |
29085 | PHPT1 | P57T-E | Human | Esophagus | ESCC | 6.16e-46 | 9.02e-01 | 0.0926 |
29085 | PHPT1 | P61T-E | Human | Esophagus | ESCC | 1.77e-34 | 1.02e+00 | 0.099 |
29085 | PHPT1 | P62T-E | Human | Esophagus | ESCC | 1.56e-103 | 1.83e+00 | 0.1302 |
29085 | PHPT1 | P65T-E | Human | Esophagus | ESCC | 1.68e-41 | 9.07e-01 | 0.0978 |
29085 | PHPT1 | P74T-E | Human | Esophagus | ESCC | 7.85e-67 | 2.38e+00 | 0.1479 |
29085 | PHPT1 | P75T-E | Human | Esophagus | ESCC | 8.64e-79 | 1.98e+00 | 0.1125 |
29085 | PHPT1 | P76T-E | Human | Esophagus | ESCC | 4.60e-49 | 1.28e+00 | 0.1207 |
29085 | PHPT1 | P79T-E | Human | Esophagus | ESCC | 9.60e-32 | 8.67e-01 | 0.1154 |
29085 | PHPT1 | P80T-E | Human | Esophagus | ESCC | 2.70e-62 | 2.02e+00 | 0.155 |
Page: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00342849 | Breast | Precancer | response to monosaccharide | 29/1080 | 225/18723 | 4.19e-05 | 9.00e-04 | 29 |
GO:00097439 | Breast | Precancer | response to carbohydrate | 31/1080 | 253/18723 | 6.15e-05 | 1.25e-03 | 31 |
GO:00425938 | Breast | Precancer | glucose homeostasis | 31/1080 | 258/18723 | 8.89e-05 | 1.69e-03 | 31 |
GO:19049519 | Breast | Precancer | positive regulation of establishment of protein localization | 36/1080 | 319/18723 | 9.30e-05 | 1.75e-03 | 36 |
GO:00335008 | Breast | Precancer | carbohydrate homeostasis | 31/1080 | 259/18723 | 9.56e-05 | 1.79e-03 | 31 |
GO:00329709 | Breast | Precancer | regulation of actin filament-based process | 42/1080 | 397/18723 | 1.11e-04 | 2.01e-03 | 42 |
GO:00097469 | Breast | Precancer | response to hexose | 27/1080 | 219/18723 | 1.61e-04 | 2.69e-03 | 27 |
GO:00097498 | Breast | Precancer | response to glucose | 25/1080 | 212/18723 | 5.46e-04 | 7.00e-03 | 25 |
GO:00329569 | Breast | Precancer | regulation of actin cytoskeleton organization | 36/1080 | 358/18723 | 8.56e-04 | 9.88e-03 | 36 |
GO:00016787 | Breast | Precancer | cellular glucose homeostasis | 21/1080 | 172/18723 | 9.38e-04 | 1.06e-02 | 21 |
GO:00713337 | Breast | Precancer | cellular response to glucose stimulus | 19/1080 | 151/18723 | 1.12e-03 | 1.23e-02 | 19 |
GO:00713228 | Breast | Precancer | cellular response to carbohydrate stimulus | 20/1080 | 163/18723 | 1.15e-03 | 1.26e-02 | 20 |
GO:00713317 | Breast | Precancer | cellular response to hexose stimulus | 19/1080 | 153/18723 | 1.31e-03 | 1.39e-02 | 19 |
GO:00026836 | Breast | Precancer | negative regulation of immune system process | 41/1080 | 434/18723 | 1.33e-03 | 1.40e-02 | 41 |
GO:00713267 | Breast | Precancer | cellular response to monosaccharide stimulus | 19/1080 | 154/18723 | 1.42e-03 | 1.48e-02 | 19 |
GO:00512229 | Breast | Precancer | positive regulation of protein transport | 31/1080 | 303/18723 | 1.44e-03 | 1.50e-02 | 31 |
GO:00507086 | Breast | Precancer | regulation of protein secretion | 28/1080 | 268/18723 | 1.76e-03 | 1.74e-02 | 28 |
GO:00158336 | Breast | Precancer | peptide transport | 27/1080 | 264/18723 | 2.84e-03 | 2.49e-02 | 27 |
GO:00900875 | Breast | Precancer | regulation of peptide transport | 22/1080 | 202/18723 | 3.14e-03 | 2.65e-02 | 22 |
GO:00513489 | Breast | Precancer | negative regulation of transferase activity | 27/1080 | 268/18723 | 3.49e-03 | 2.90e-02 | 27 |
Page: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
PHPT1 | SNV | Missense_Mutation | novel | c.192N>A | p.Met64Ile | p.M64I | Q9NRX4 | protein_coding | tolerated(0.48) | benign(0) | TCGA-2W-A8YY-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
PHPT1 | SNV | Missense_Mutation | novel | c.203N>A | p.Gly68Asp | p.G68D | Q9NRX4 | protein_coding | deleterious(0.03) | probably_damaging(0.999) | TCGA-EA-A410-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD |
PHPT1 | SNV | Missense_Mutation | novel | c.98C>G | p.Ser33Cys | p.S33C | Q9NRX4 | protein_coding | deleterious(0.03) | possibly_damaging(0.45) | TCGA-VS-A9UH-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
PHPT1 | SNV | Missense_Mutation | c.308N>T | p.Ala103Val | p.A103V | Q9NRX4 | protein_coding | deleterious(0.02) | benign(0.222) | TCGA-B5-A11E-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
PHPT1 | SNV | Missense_Mutation | novel | c.317N>T | p.Thr106Ile | p.T106I | Q9NRX4 | protein_coding | tolerated(0.15) | probably_damaging(0.97) | TCGA-DF-A2KN-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | Unknown | I/II | Unknown | Unknown | SD |
PHPT1 | SNV | Missense_Mutation | rs764705291 | c.367G>A | p.Asp123Asn | p.D123N | Q9NRX4 | protein_coding | deleterious(0.01) | benign(0.104) | TCGA-EO-A22R-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
PHPT1 | SNV | Missense_Mutation | rs751950321 | c.203G>T | p.Gly68Val | p.G68V | Q9NRX4 | protein_coding | deleterious(0.02) | probably_damaging(0.968) | TCGA-DD-AADJ-01 | Liver | liver hepatocellular carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
PHPT1 | SNV | Missense_Mutation | novel | c.347N>T | p.Tyr116Phe | p.Y116F | Q9NRX4 | protein_coding | deleterious(0) | probably_damaging(0.995) | TCGA-05-4427-01 | Lung | lung adenocarcinoma | Female | >=65 | I/II | Chemotherapy | cisplatin | CR |
PHPT1 | SNV | Missense_Mutation | c.218N>T | p.Cys73Phe | p.C73F | Q9NRX4 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-L9-A7SV-01 | Lung | lung adenocarcinoma | Male | >=65 | I/II | Chemotherapy | cisplatin | CR | |
PHPT1 | SNV | Missense_Mutation | novel | c.147G>T | p.Trp49Cys | p.W49C | Q9NRX4 | protein_coding | tolerated(0.07) | probably_damaging(0.999) | TCGA-56-8308-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Chemotherapy | paclitaxel | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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