![]() |
|||||
|
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() |
Gene: OLA1 |
Gene summary for OLA1 |
![]() |
Gene information | Species | Human | Gene symbol | OLA1 | Gene ID | 29789 |
Gene name | Obg like ATPase 1 | |
Gene Alias | DOC45 | |
Cytomap | 2q31.1 | |
Gene Type | protein-coding | GO ID | GO:0008150 | UniProtAcc | Q9NTK5 |
Top |
Malignant transformation analysis |
![]() |
![]() |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
29789 | OLA1 | P104T-E | Human | Esophagus | ESCC | 1.01e-04 | 7.94e-01 | 0.0931 |
29789 | OLA1 | P107T-E | Human | Esophagus | ESCC | 1.22e-77 | 2.59e+00 | 0.171 |
29789 | OLA1 | P126T-E | Human | Esophagus | ESCC | 1.14e-14 | 1.58e+00 | 0.1125 |
29789 | OLA1 | P127T-E | Human | Esophagus | ESCC | 1.79e-35 | 8.23e-01 | 0.0826 |
29789 | OLA1 | P128T-E | Human | Esophagus | ESCC | 3.67e-61 | 2.25e+00 | 0.1241 |
29789 | OLA1 | P130T-E | Human | Esophagus | ESCC | 1.79e-89 | 2.53e+00 | 0.1676 |
29789 | OLA1 | S43 | Human | Liver | Cirrhotic | 4.21e-08 | -1.69e-01 | -0.0187 |
29789 | OLA1 | HCC1_Meng | Human | Liver | HCC | 7.20e-74 | 2.38e-01 | 0.0246 |
29789 | OLA1 | HCC2_Meng | Human | Liver | HCC | 5.42e-24 | 5.42e-02 | 0.0107 |
29789 | OLA1 | cirrhotic2 | Human | Liver | Cirrhotic | 2.03e-05 | 1.42e-01 | 0.0201 |
29789 | OLA1 | HCC1 | Human | Liver | HCC | 6.17e-08 | 4.07e+00 | 0.5336 |
29789 | OLA1 | HCC2 | Human | Liver | HCC | 8.31e-26 | 4.13e+00 | 0.5341 |
29789 | OLA1 | Pt13.b | Human | Liver | HCC | 2.46e-03 | 6.88e-04 | 0.0251 |
29789 | OLA1 | S014 | Human | Liver | HCC | 5.68e-28 | 1.16e+00 | 0.2254 |
29789 | OLA1 | S015 | Human | Liver | HCC | 9.88e-22 | 1.36e+00 | 0.2375 |
29789 | OLA1 | S016 | Human | Liver | HCC | 7.43e-26 | 1.22e+00 | 0.2243 |
29789 | OLA1 | S027 | Human | Liver | HCC | 1.52e-17 | 1.63e+00 | 0.2446 |
29789 | OLA1 | S028 | Human | Liver | HCC | 4.60e-24 | 1.59e+00 | 0.2503 |
29789 | OLA1 | S029 | Human | Liver | HCC | 3.84e-26 | 1.73e+00 | 0.2581 |
29789 | OLA1 | RNA-P17T-P17T-2 | Human | Lung | IAC | 7.22e-06 | 6.32e-01 | 0.3371 |
Page: 1 2 3 4 5 6 7 8 9 10 |
![]() |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
Top |
Malignant transformation related pathway analysis |
![]() |
![]() |
Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
![]() |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:004603410 | Cervix | CC | ATP metabolic process | 90/2311 | 277/18723 | 7.90e-19 | 2.36e-15 | 90 |
GO:00062602 | Cervix | CC | DNA replication | 48/2311 | 260/18723 | 2.70e-03 | 1.85e-02 | 48 |
GO:00324791 | Cervix | CC | regulation of type I interferon production | 21/2311 | 95/18723 | 5.32e-03 | 3.10e-02 | 21 |
GO:00326061 | Cervix | CC | type I interferon production | 21/2311 | 95/18723 | 5.32e-03 | 3.10e-02 | 21 |
GO:0046034 | Colorectum | AD | ATP metabolic process | 142/3918 | 277/18723 | 2.64e-29 | 8.26e-26 | 142 |
GO:00460341 | Colorectum | SER | ATP metabolic process | 117/2897 | 277/18723 | 5.54e-27 | 1.13e-23 | 117 |
GO:00460343 | Colorectum | MSI-H | ATP metabolic process | 71/1319 | 277/18723 | 3.18e-22 | 8.32e-19 | 71 |
GO:00460344 | Colorectum | FAP | ATP metabolic process | 87/2622 | 277/18723 | 6.50e-14 | 6.63e-11 | 87 |
GO:00460345 | Colorectum | CRC | ATP metabolic process | 51/2078 | 277/18723 | 1.92e-04 | 3.30e-03 | 51 |
GO:00718977 | Endometrium | AEH | DNA biosynthetic process | 37/2100 | 180/18723 | 1.87e-04 | 2.39e-03 | 37 |
GO:004603427 | Esophagus | HGIN | ATP metabolic process | 101/2587 | 277/18723 | 1.53e-21 | 1.02e-18 | 101 |
GO:0046034111 | Esophagus | ESCC | ATP metabolic process | 189/8552 | 277/18723 | 1.99e-14 | 1.04e-12 | 189 |
GO:004603412 | Liver | Cirrhotic | ATP metabolic process | 144/4634 | 277/18723 | 1.04e-22 | 5.02e-20 | 144 |
GO:004603422 | Liver | HCC | ATP metabolic process | 198/7958 | 277/18723 | 8.30e-23 | 1.55e-20 | 198 |
GO:00460348 | Lung | IAC | ATP metabolic process | 49/2061 | 277/18723 | 5.44e-04 | 7.59e-03 | 49 |
GO:004603413 | Lung | AIS | ATP metabolic process | 42/1849 | 277/18723 | 3.31e-03 | 3.16e-02 | 42 |
GO:004603420 | Oral cavity | OSCC | ATP metabolic process | 166/7305 | 277/18723 | 1.16e-12 | 5.12e-11 | 166 |
GO:0046034110 | Oral cavity | LP | ATP metabolic process | 128/4623 | 277/18723 | 3.95e-15 | 5.38e-13 | 128 |
GO:004603426 | Oral cavity | EOLP | ATP metabolic process | 68/2218 | 277/18723 | 2.72e-09 | 1.71e-07 | 68 |
GO:004603433 | Oral cavity | NEOLP | ATP metabolic process | 71/2005 | 277/18723 | 1.44e-12 | 3.17e-10 | 71 |
Page: 1 2 |
![]() |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
Page: 1 |
Top |
Cell-cell communication analysis |
![]() |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
Page: 1 |
Top |
Single-cell gene regulatory network inference analysis |
![]() |
TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
Page: 1 |
Top |
Somatic mutation of malignant transformation related genes |
![]() |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
OLA1 | SNV | Missense_Mutation | c.799N>A | p.Leu267Met | p.L267M | Q9NTK5 | protein_coding | tolerated(0.06) | benign(0.103) | TCGA-A8-A07P-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Chemotherapy | 5-fluorouracil | SD | |
OLA1 | SNV | Missense_Mutation | c.301N>G | p.His101Asp | p.H101D | Q9NTK5 | protein_coding | tolerated(0.05) | benign(0.232) | TCGA-AC-A23H-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | PD | |
OLA1 | SNV | Missense_Mutation | rs781608678 | c.1044N>A | p.Met348Ile | p.M348I | Q9NTK5 | protein_coding | tolerated(0.11) | benign(0.146) | TCGA-BH-A2L8-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | cytoxan | CR |
OLA1 | SNV | Missense_Mutation | rs375033952 | c.949N>T | p.Arg317Cys | p.R317C | Q9NTK5 | protein_coding | deleterious(0) | probably_damaging(0.975) | TCGA-D8-A1XK-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | doxorubicine+cyclophosphamide | SD |
OLA1 | SNV | Missense_Mutation | novel | c.205G>A | p.Glu69Lys | p.E69K | Q9NTK5 | protein_coding | tolerated(0.11) | benign(0.022) | TCGA-C5-A1MN-01 | Cervix | cervical & endocervical cancer | Female | <65 | III/IV | Chemotherapy | cisplatin | SD |
OLA1 | SNV | Missense_Mutation | c.107N>G | p.Ser36Cys | p.S36C | Q9NTK5 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-DR-A0ZM-01 | Cervix | cervical & endocervical cancer | Female | <65 | III/IV | Unspecific | Cisplatin | SD | |
OLA1 | SNV | Missense_Mutation | c.634G>A | p.Glu212Lys | p.E212K | Q9NTK5 | protein_coding | deleterious(0.01) | possibly_damaging(0.841) | TCGA-LP-A5U2-01 | Cervix | cervical & endocervical cancer | Female | <65 | III/IV | Unknown | Unknown | SD | |
OLA1 | SNV | Missense_Mutation | rs748811959 | c.211N>G | p.Phe71Val | p.F71V | Q9NTK5 | protein_coding | deleterious(0) | probably_damaging(0.957) | TCGA-A6-2686-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
OLA1 | SNV | Missense_Mutation | novel | c.1051G>A | p.Glu351Lys | p.E351K | Q9NTK5 | protein_coding | tolerated(0.15) | benign(0.025) | TCGA-AA-3877-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
OLA1 | SNV | Missense_Mutation | c.724N>G | p.Lys242Glu | p.K242E | Q9NTK5 | protein_coding | deleterious(0.02) | possibly_damaging(0.612) | TCGA-CK-4951-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | PD |
Page: 1 2 3 4 |
Top |
Related drugs of malignant transformation related genes |
![]() |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
Page: 1 |