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Gene: NUDCD2 |
Gene summary for NUDCD2 |
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Gene information | Species | Human | Gene symbol | NUDCD2 | Gene ID | 134492 |
Gene name | NudC domain containing 2 | |
Gene Alias | NudCL2 | |
Cytomap | 5q34 | |
Gene Type | protein-coding | GO ID | GO:0006457 | UniProtAcc | Q8WVJ2 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
134492 | NUDCD2 | SYSMH4 | Human | Oral cavity | OSCC | 9.59e-04 | 1.26e-01 | 0.1226 |
134492 | NUDCD2 | SYSMH6 | Human | Oral cavity | OSCC | 7.31e-05 | 3.65e-01 | 0.1275 |
134492 | NUDCD2 | P4_S8_cSCC | Human | Skin | cSCC | 3.41e-08 | 1.42e-01 | -0.3095 |
134492 | NUDCD2 | P5_S10_cSCC | Human | Skin | cSCC | 2.76e-02 | 4.86e-02 | -0.299 |
134492 | NUDCD2 | P1_cSCC | Human | Skin | cSCC | 1.41e-29 | 1.03e+00 | 0.0292 |
134492 | NUDCD2 | P2_cSCC | Human | Skin | cSCC | 6.74e-26 | 7.53e-01 | -0.024 |
134492 | NUDCD2 | P4_cSCC | Human | Skin | cSCC | 2.95e-28 | 8.63e-01 | -0.00290000000000005 |
134492 | NUDCD2 | P10_cSCC | Human | Skin | cSCC | 9.31e-42 | 1.22e+00 | 0.1017 |
134492 | NUDCD2 | cSCC_p8 | Human | Skin | cSCC | 1.04e-05 | 9.73e-02 | -0.1971 |
134492 | NUDCD2 | cSCC_p9 | Human | Skin | cSCC | 3.15e-05 | 1.03e-01 | -0.1991 |
134492 | NUDCD2 | male-WTA | Human | Thyroid | PTC | 6.86e-18 | 7.97e-02 | 0.1037 |
134492 | NUDCD2 | PTC01 | Human | Thyroid | PTC | 9.74e-20 | 1.97e-01 | 0.1899 |
134492 | NUDCD2 | PTC04 | Human | Thyroid | PTC | 1.25e-04 | 1.72e-01 | 0.1927 |
134492 | NUDCD2 | PTC05 | Human | Thyroid | PTC | 1.41e-20 | 7.63e-01 | 0.2065 |
134492 | NUDCD2 | PTC06 | Human | Thyroid | PTC | 3.61e-29 | 7.06e-01 | 0.2057 |
134492 | NUDCD2 | PTC07 | Human | Thyroid | PTC | 2.97e-28 | 6.19e-01 | 0.2044 |
134492 | NUDCD2 | ATC11 | Human | Thyroid | ATC | 2.86e-05 | 4.85e-01 | 0.3386 |
134492 | NUDCD2 | ATC13 | Human | Thyroid | ATC | 1.90e-15 | 2.65e-01 | 0.34 |
134492 | NUDCD2 | ATC1 | Human | Thyroid | ATC | 2.12e-02 | 8.98e-02 | 0.2878 |
134492 | NUDCD2 | ATC2 | Human | Thyroid | ATC | 1.01e-09 | 8.54e-01 | 0.34 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:000645720 | Esophagus | HGIN | protein folding | 75/2587 | 212/18723 | 1.61e-15 | 3.86e-13 | 75 |
GO:0006457110 | Esophagus | ESCC | protein folding | 163/8552 | 212/18723 | 1.13e-20 | 1.74e-18 | 163 |
GO:00064577 | Liver | Cirrhotic | protein folding | 114/4634 | 212/18723 | 9.23e-20 | 2.31e-17 | 114 |
GO:000645712 | Liver | HCC | protein folding | 160/7958 | 212/18723 | 1.07e-22 | 1.88e-20 | 160 |
GO:000645718 | Oral cavity | OSCC | protein folding | 154/7305 | 212/18723 | 1.89e-23 | 4.60e-21 | 154 |
GO:000645719 | Oral cavity | LP | protein folding | 125/4623 | 212/18723 | 1.62e-26 | 8.45e-24 | 125 |
GO:0006457111 | Skin | cSCC | protein folding | 131/4864 | 212/18723 | 2.96e-28 | 1.32e-25 | 131 |
GO:0006457112 | Thyroid | PTC | protein folding | 137/5968 | 212/18723 | 8.29e-23 | 2.01e-20 | 137 |
GO:000645733 | Thyroid | ATC | protein folding | 140/6293 | 212/18723 | 3.46e-22 | 8.09e-20 | 140 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
NUDCD2 | SNV | Missense_Mutation | c.430N>T | p.Asn144Tyr | p.N144Y | Q8WVJ2 | protein_coding | deleterious(0) | probably_damaging(0.988) | TCGA-A8-A09Q-01 | Breast | breast invasive carcinoma | Female | >=65 | III/IV | Hormone Therapy | anastrozole | SD | |
NUDCD2 | SNV | Missense_Mutation | novel | c.191N>C | p.Gly64Ala | p.G64A | Q8WVJ2 | protein_coding | deleterious(0.01) | probably_damaging(0.999) | TCGA-E9-A2JS-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Chemotherapy | cyclophosphamide | PD |
NUDCD2 | SNV | Missense_Mutation | novel | c.331N>A | p.Asp111Asn | p.D111N | Q8WVJ2 | protein_coding | tolerated(0.08) | benign(0.062) | TCGA-A5-A0G2-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
NUDCD2 | SNV | Missense_Mutation | rs780024537 | c.122N>G | p.Gln41Arg | p.Q41R | Q8WVJ2 | protein_coding | tolerated(0.1) | benign(0) | TCGA-DF-A2KN-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | Unknown | I/II | Unknown | Unknown | SD |
NUDCD2 | SNV | Missense_Mutation | novel | c.56N>A | p.Gly19Asp | p.G19D | Q8WVJ2 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-4R-AA8I-01 | Liver | liver hepatocellular carcinoma | Male | >=65 | I/II | Unknown | Unknown | PD |
NUDCD2 | SNV | Missense_Mutation | c.134N>C | p.Cys45Ser | p.C45S | Q8WVJ2 | protein_coding | deleterious(0.01) | benign(0.125) | TCGA-44-7670-01 | Lung | lung adenocarcinoma | Female | <65 | I/II | Chemotherapy | docetaxel | SD | |
NUDCD2 | SNV | Missense_Mutation | c.373N>C | p.Glu125Gln | p.E125Q | Q8WVJ2 | protein_coding | tolerated(0.2) | possibly_damaging(0.606) | TCGA-78-7149-01 | Lung | lung adenocarcinoma | Male | >=65 | III/IV | Unknown | Unknown | SD | |
NUDCD2 | SNV | Missense_Mutation | novel | c.16G>C | p.Glu6Gln | p.E6Q | Q8WVJ2 | protein_coding | deleterious(0.02) | benign(0.2) | TCGA-21-1079-01 | Lung | lung squamous cell carcinoma | Male | >=65 | III/IV | Unknown | Unknown | PD |
NUDCD2 | deletion | Frame_Shift_Del | c.170delG | p.Gly57AlafsTer15 | p.G57Afs*15 | Q8WVJ2 | protein_coding | TCGA-60-2726-01 | Lung | lung squamous cell carcinoma | Male | <65 | I/II | Unknown | Unknown | SD | |||
NUDCD2 | SNV | Missense_Mutation | c.65A>G | p.Tyr22Cys | p.Y22C | Q8WVJ2 | protein_coding | tolerated(0.12) | benign(0.056) | TCGA-CG-5721-01 | Stomach | stomach adenocarcinoma | Male | <65 | III/IV | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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