Schematic overview of the cellular and molecular mechanisms involved in the cancer progression, including the proposed cellular and molecular mechanisms in cancer cells trajectory. AT1: alveolar type 1 cells; AT2: alveolar type 2 cells; AAH: atypical adenomatous hyperplasia; AIS: adenocarcinoma in situ; MIA: minimally invasive adenocarcinoma; IA: invasive adenocarcinoma; EMT: epithelial-mesenchymal transition

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Center for Computational Systems Medicine
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Gene summary

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Malignant transformation analysis

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Malignant transformation related pathway analysis

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Cell-cell communication analysis

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Single-cell gene regulatory network inference analysis

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Somatic mutation of malignant transformation related genes

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Related drugs of malignant transformation related genes

Gene: MRPS36

Gene summary for MRPS36

check button Gene summary.

Gene informationSpeciesHuman
Gene symbol

MRPS36

Gene ID

92259

Gene namemitochondrial ribosomal protein S36
Gene AliasDC47
Cytomap5q13.2
Gene Typeprotein-coding
GO ID

GO:0006082

UniProtAcc

P82909


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Malignant transformation analysis

check button Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells
check button Malignant transformation involving gene list.
Entrez IDSymbolReplicatesSpeciesOrganTissueAdj P-valueLog2FCMalignancy
92259MRPS36C30HumanOral cavityOSCC1.01e-532.64e+000.3055
92259MRPS36C38HumanOral cavityOSCC1.46e-141.90e+000.172
92259MRPS36C43HumanOral cavityOSCC3.47e-398.52e-010.1704
92259MRPS36C46HumanOral cavityOSCC3.29e-401.11e+000.1673
92259MRPS36C51HumanOral cavityOSCC1.41e-088.84e-010.2674
92259MRPS36C57HumanOral cavityOSCC1.50e-361.10e+000.1679
92259MRPS36C06HumanOral cavityOSCC7.28e-111.80e+000.2699
92259MRPS36C07HumanOral cavityOSCC6.09e-061.52e+000.2491
92259MRPS36C08HumanOral cavityOSCC4.45e-258.11e-010.1919
92259MRPS36C09HumanOral cavityOSCC2.92e-147.14e-010.1431
92259MRPS36LN22HumanOral cavityOSCC3.82e-151.66e+000.1733
92259MRPS36LN38HumanOral cavityOSCC4.01e-071.51e+000.168
92259MRPS36LN46HumanOral cavityOSCC2.64e-211.09e+000.1666
92259MRPS36LP15HumanOral cavityLP1.83e-101.57e+000.2174
92259MRPS36LP17HumanOral cavityLP4.31e-049.64e-010.2349
92259MRPS36SYSMH1HumanOral cavityOSCC3.96e-061.52e-010.1127
92259MRPS36SYSMH2HumanOral cavityOSCC2.78e-261.14e+000.2326
92259MRPS36SYSMH3HumanOral cavityOSCC3.74e-241.08e+000.2442
92259MRPS36SYSMH4HumanOral cavityOSCC1.37e-122.50e-010.1226
92259MRPS36SYSMH6HumanOral cavityOSCC5.38e-167.23e-010.1275
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check button Transcriptomic changes along malignancy continuum.
TissueExpression DynamicsAbbreviation
EndometriumThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.AEH: Atypical endometrial hyperplasia
EEC: Endometrioid Cancer
EsophagusThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.ESCC: Esophageal squamous cell carcinoma
HGIN: High-grade intraepithelial neoplasias
LGIN: Low-grade intraepithelial neoplasias
LiverThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.HCC: Hepatocellular carcinoma
NAFLD: Non-alcoholic fatty liver disease
Oral CavityThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.EOLP: Erosive Oral lichen planus
LP: leukoplakia
NEOLP: Non-erosive oral lichen planus
OSCC: Oral squamous cell carcinoma
ProstateThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.BPH: Benign Prostatic Hyperplasia
SkinThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.AK: Actinic keratosis
cSCC: Cutaneous squamous cell carcinoma
SCCIS:squamous cell carcinoma in situ
ThyroidThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.ATC: Anaplastic thyroid cancer
HT: Hashimoto's thyroiditis
PTC: Papillary thyroid cancer
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.

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Malignant transformation related pathway analysis

check buttonFind out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer
check button Figure of enriched GO biological processes.
TissueDisease StageEnriched GO biological Processes
ColorectumADGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumSERGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumMSSGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumMSI-HGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumFAPGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
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check button Enriched GO biological processes.
GO IDTissueDisease StageDescriptionGene RatioBg Ratiopvaluep.adjustCount
GO:00436485EsophagusESCCdicarboxylic acid metabolic process58/855296/187232.55e-031.09e-0258
GO:004364811LiverCirrhoticdicarboxylic acid metabolic process43/463496/187231.42e-051.97e-0443
GO:00436482LiverHCCdicarboxylic acid metabolic process68/795896/187231.73e-084.14e-0768
GO:00061031LiverHCC2-oxoglutarate metabolic process14/795818/187232.57e-031.23e-0214
GO:00436484Oral cavityOSCCdicarboxylic acid metabolic process50/730596/187236.24e-032.35e-0250
GO:00436486SkincSCCdicarboxylic acid metabolic process38/486496/187232.38e-031.38e-0238
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check button Enriched KEGG pathways.
Pathway IDTissueDisease StageDescriptionGene RatioBg Ratiopvaluep.adjustqvalueCount
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Cell-cell communication analysis

check buttonIdentification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states
LigandReceptorLRpairPathwayTissueDisease Stage
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Single-cell gene regulatory network inference analysis

check buttonFind out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states
TFCell TypeTissueDisease StageTarget GeneRSSRegulon Activity
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.
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Somatic mutation of malignant transformation related genes

check buttonAnnotation of somatic variants for genes involved in malignant transformation
Hugo SymbolVariant ClassVariant ClassificationdbSNP RSHGVScHGVSpHGVSp ShortSWISSPROTBIOTYPESIFTPolyPhenTumor Sample BarcodeTissueHistologySexAgeStageTherapy TypesDrugsOutcome
MRPS36insertionNonsense_Mutationnovelc.293_294insTTAAACAAGTGTAAAGATATTGAGAAAACTACCCTCp.Gln98delinsHisTerThrSerValLysIleLeuArgLysLeuProSerp.Q98delinsH*TSVKILRKLPSP82909protein_codingTCGA-A2-A0CQ-01Breastbreast invasive carcinomaFemale<65I/IIChemotherapyadriamycinSD
MRPS36SNVMissense_Mutationc.10N>Gp.Ser4Glyp.S4GP82909protein_codingdeleterious(0.04)probably_damaging(0.98)TCGA-AG-3882-01Colorectumrectum adenocarcinomaFemale>=65I/IIUnknownUnknownSD
MRPS36SNVMissense_Mutationc.232N>Cp.Lys78Glnp.K78QP82909protein_codingtolerated(0.23)possibly_damaging(0.876)TCGA-AX-A0J0-01Endometriumuterine corpus endometrioid carcinomaFemale<65I/IIUnknownUnknownSD
MRPS36SNVMissense_Mutationnovelc.271C>Gp.Gln91Glup.Q91EP82909protein_codingtolerated(0.72)benign(0.031)TCGA-MN-A4N4-01Lunglung adenocarcinomaMale<65I/IIUnknownUnknownSD
MRPS36SNVMissense_Mutationnovelc.67N>Gp.Ile23Valp.I23VP82909protein_codingdeleterious(0.01)probably_damaging(0.986)TCGA-NC-A5HL-01Lunglung squamous cell carcinomaMale>=65I/IIUnknownUnknownSD
MRPS36SNVMissense_Mutationc.16N>Gp.Met6Valp.M6VP82909protein_codingtolerated(0.16)benign(0.124)TCGA-BR-8687-01Stomachstomach adenocarcinomaFemale>=65III/IVUnknownUnknownPD
MRPS36SNVMissense_Mutationnovelc.206N>Cp.Gly69Alap.G69AP82909protein_codingdeleterious(0.02)possibly_damaging(0.874)TCGA-VQ-A8P3-01Stomachstomach adenocarcinomaMale>=65III/IVChemotherapyfluorouracilCR
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Related drugs of malignant transformation related genes

check buttonIdentification of chemicals and drugs interact with genes involved in malignant transfromation
(DGIdb 4.0)
Entrez IDSymbolCategoryInteraction TypesDrug Claim NameDrug NamePMIDs
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