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Gene: MRPL57 |
Gene summary for MRPL57 |
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Gene information | Species | Human | Gene symbol | MRPL57 | Gene ID | 78988 |
Gene name | mitochondrial ribosomal protein L57 | |
Gene Alias | MRP63 | |
Cytomap | 13q12.11 | |
Gene Type | protein-coding | GO ID | GO:0006412 | UniProtAcc | A0A024RDM4 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
78988 | MRPL57 | P30T-E | Human | Esophagus | ESCC | 8.07e-42 | 1.89e+00 | 0.137 |
78988 | MRPL57 | P31T-E | Human | Esophagus | ESCC | 5.84e-50 | 1.04e+00 | 0.1251 |
78988 | MRPL57 | P32T-E | Human | Esophagus | ESCC | 3.38e-43 | 1.04e+00 | 0.1666 |
78988 | MRPL57 | P36T-E | Human | Esophagus | ESCC | 8.23e-32 | 1.35e+00 | 0.1187 |
78988 | MRPL57 | P37T-E | Human | Esophagus | ESCC | 3.61e-34 | 7.99e-01 | 0.1371 |
78988 | MRPL57 | P38T-E | Human | Esophagus | ESCC | 1.85e-08 | 7.60e-01 | 0.127 |
78988 | MRPL57 | P39T-E | Human | Esophagus | ESCC | 2.07e-22 | 4.86e-01 | 0.0894 |
78988 | MRPL57 | P40T-E | Human | Esophagus | ESCC | 3.89e-17 | 6.72e-01 | 0.109 |
78988 | MRPL57 | P42T-E | Human | Esophagus | ESCC | 6.52e-23 | 8.09e-01 | 0.1175 |
78988 | MRPL57 | P44T-E | Human | Esophagus | ESCC | 1.89e-11 | 5.09e-01 | 0.1096 |
78988 | MRPL57 | P47T-E | Human | Esophagus | ESCC | 4.79e-39 | 9.40e-01 | 0.1067 |
78988 | MRPL57 | P48T-E | Human | Esophagus | ESCC | 5.12e-19 | 5.26e-01 | 0.0959 |
78988 | MRPL57 | P49T-E | Human | Esophagus | ESCC | 3.82e-19 | 2.80e+00 | 0.1768 |
78988 | MRPL57 | P52T-E | Human | Esophagus | ESCC | 2.91e-42 | 1.08e+00 | 0.1555 |
78988 | MRPL57 | P54T-E | Human | Esophagus | ESCC | 2.01e-22 | 4.58e-01 | 0.0975 |
78988 | MRPL57 | P56T-E | Human | Esophagus | ESCC | 4.64e-07 | 1.37e+00 | 0.1613 |
78988 | MRPL57 | P57T-E | Human | Esophagus | ESCC | 5.19e-35 | 8.10e-01 | 0.0926 |
78988 | MRPL57 | P61T-E | Human | Esophagus | ESCC | 3.73e-17 | 5.80e-01 | 0.099 |
78988 | MRPL57 | P62T-E | Human | Esophagus | ESCC | 1.71e-72 | 1.52e+00 | 0.1302 |
78988 | MRPL57 | P65T-E | Human | Esophagus | ESCC | 1.13e-47 | 1.19e+00 | 0.0978 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00325432 | Breast | IDC | mitochondrial translation | 13/1434 | 76/18723 | 4.81e-03 | 3.67e-02 | 13 |
GO:003254311 | Breast | DCIS | mitochondrial translation | 13/1390 | 76/18723 | 3.70e-03 | 2.99e-02 | 13 |
GO:00325435 | Esophagus | HGIN | mitochondrial translation | 23/2587 | 76/18723 | 1.61e-04 | 3.16e-03 | 23 |
GO:01400534 | Esophagus | HGIN | mitochondrial gene expression | 27/2587 | 108/18723 | 1.34e-03 | 1.57e-02 | 27 |
GO:014005313 | Esophagus | ESCC | mitochondrial gene expression | 93/8552 | 108/18723 | 1.96e-18 | 2.03e-16 | 93 |
GO:003254314 | Esophagus | ESCC | mitochondrial translation | 68/8552 | 76/18723 | 1.02e-15 | 6.86e-14 | 68 |
GO:0032543 | Liver | Cirrhotic | mitochondrial translation | 40/4634 | 76/18723 | 1.61e-07 | 4.29e-06 | 40 |
GO:0140053 | Liver | Cirrhotic | mitochondrial gene expression | 49/4634 | 108/18723 | 2.35e-06 | 4.31e-05 | 49 |
GO:01400531 | Liver | HCC | mitochondrial gene expression | 82/7958 | 108/18723 | 1.49e-12 | 7.20e-11 | 82 |
GO:00325431 | Liver | HCC | mitochondrial translation | 62/7958 | 76/18723 | 2.95e-12 | 1.34e-10 | 62 |
GO:01400533 | Oral cavity | OSCC | mitochondrial gene expression | 78/7305 | 108/18723 | 2.37e-12 | 9.86e-11 | 78 |
GO:00325434 | Oral cavity | OSCC | mitochondrial translation | 59/7305 | 76/18723 | 7.21e-12 | 2.70e-10 | 59 |
GO:003254313 | Oral cavity | LP | mitochondrial translation | 43/4623 | 76/18723 | 2.85e-09 | 1.26e-07 | 43 |
GO:014005312 | Oral cavity | LP | mitochondrial gene expression | 53/4623 | 108/18723 | 3.54e-08 | 1.27e-06 | 53 |
GO:00325433 | Prostate | BPH | mitochondrial translation | 23/3107 | 76/18723 | 2.21e-03 | 1.22e-02 | 23 |
GO:01400532 | Prostate | BPH | mitochondrial gene expression | 29/3107 | 108/18723 | 4.68e-03 | 2.25e-02 | 29 |
GO:003254312 | Prostate | Tumor | mitochondrial translation | 24/3246 | 76/18723 | 1.73e-03 | 1.03e-02 | 24 |
GO:014005311 | Prostate | Tumor | mitochondrial gene expression | 31/3246 | 108/18723 | 2.31e-03 | 1.30e-02 | 31 |
GO:00325436 | Skin | cSCC | mitochondrial translation | 47/4864 | 76/18723 | 4.70e-11 | 2.22e-09 | 47 |
GO:01400535 | Skin | cSCC | mitochondrial gene expression | 56/4864 | 108/18723 | 8.06e-09 | 2.56e-07 | 56 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
MRPL57 | SNV | Missense_Mutation | c.297G>T | p.Lys99Asn | p.K99N | Q9BQC6 | protein_coding | tolerated(0.09) | possibly_damaging(0.893) | TCGA-AA-3984-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
MRPL57 | SNV | Missense_Mutation | c.151N>G | p.Met51Val | p.M51V | Q9BQC6 | protein_coding | tolerated(0.13) | benign(0.037) | TCGA-CM-6171-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
MRPL57 | SNV | Missense_Mutation | c.297G>T | p.Lys99Asn | p.K99N | Q9BQC6 | protein_coding | tolerated(0.09) | possibly_damaging(0.893) | TCGA-AP-A056-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
MRPL57 | SNV | Missense_Mutation | c.297G>T | p.Lys99Asn | p.K99N | Q9BQC6 | protein_coding | tolerated(0.09) | possibly_damaging(0.893) | TCGA-AP-A1E0-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | paclitaxel | SD | |
MRPL57 | SNV | Missense_Mutation | novel | c.290T>C | p.Val97Ala | p.V97A | Q9BQC6 | protein_coding | deleterious(0.01) | possibly_damaging(0.83) | TCGA-AX-A2HD-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD |
MRPL57 | SNV | Missense_Mutation | novel | c.179N>C | p.Arg60Pro | p.R60P | Q9BQC6 | protein_coding | tolerated(0.12) | benign(0.127) | TCGA-55-8506-01 | Lung | lung adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
MRPL57 | SNV | Missense_Mutation | rs756534195 | c.11C>T | p.Thr4Ile | p.T4I | Q9BQC6 | protein_coding | tolerated(0.06) | possibly_damaging(0.742) | TCGA-MN-A4N4-01 | Lung | lung adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
MRPL57 | SNV | Missense_Mutation | c.118N>A | p.Glu40Lys | p.E40K | Q9BQC6 | protein_coding | deleterious(0.01) | probably_damaging(0.999) | TCGA-18-3409-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | PD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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