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Gene: MPC1 |
Gene summary for MPC1 |
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Gene information | Species | Human | Gene symbol | MPC1 | Gene ID | 51660 |
Gene name | mitochondrial pyruvate carrier 1 | |
Gene Alias | BRP44L | |
Cytomap | 6q27 | |
Gene Type | protein-coding | GO ID | GO:0006810 | UniProtAcc | Q5TI65 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
51660 | MPC1 | HCC2 | Human | Liver | HCC | 4.76e-03 | 2.38e+00 | 0.5341 |
51660 | MPC1 | HCC5 | Human | Liver | HCC | 2.22e-10 | 5.46e-02 | 0.4932 |
51660 | MPC1 | Pt13.b | Human | Liver | HCC | 9.51e-19 | -1.64e-01 | 0.0251 |
51660 | MPC1 | Pt13.c | Human | Liver | HCC | 2.33e-02 | -4.09e-01 | 0.0076 |
51660 | MPC1 | Pt14.b | Human | Liver | HCC | 2.24e-05 | -1.86e-01 | 0.018 |
51660 | MPC1 | S028 | Human | Liver | HCC | 1.80e-03 | 6.18e-01 | 0.2503 |
51660 | MPC1 | S029 | Human | Liver | HCC | 3.00e-07 | 1.06e+00 | 0.2581 |
51660 | MPC1 | C04 | Human | Oral cavity | OSCC | 1.98e-07 | 4.97e-01 | 0.2633 |
51660 | MPC1 | C21 | Human | Oral cavity | OSCC | 4.59e-32 | 1.27e+00 | 0.2678 |
51660 | MPC1 | C30 | Human | Oral cavity | OSCC | 1.39e-11 | 7.97e-01 | 0.3055 |
51660 | MPC1 | C38 | Human | Oral cavity | OSCC | 6.24e-08 | 1.23e+00 | 0.172 |
51660 | MPC1 | C43 | Human | Oral cavity | OSCC | 4.42e-23 | 5.52e-01 | 0.1704 |
51660 | MPC1 | C46 | Human | Oral cavity | OSCC | 1.14e-24 | 7.03e-01 | 0.1673 |
51660 | MPC1 | C51 | Human | Oral cavity | OSCC | 1.07e-06 | 5.67e-01 | 0.2674 |
51660 | MPC1 | C57 | Human | Oral cavity | OSCC | 3.74e-23 | 8.79e-01 | 0.1679 |
51660 | MPC1 | C06 | Human | Oral cavity | OSCC | 8.27e-05 | 1.00e+00 | 0.2699 |
51660 | MPC1 | C08 | Human | Oral cavity | OSCC | 5.34e-25 | 5.23e-01 | 0.1919 |
51660 | MPC1 | C09 | Human | Oral cavity | OSCC | 1.02e-08 | 4.67e-01 | 0.1431 |
51660 | MPC1 | LN22 | Human | Oral cavity | OSCC | 2.69e-07 | 1.23e+00 | 0.1733 |
51660 | MPC1 | LN46 | Human | Oral cavity | OSCC | 5.32e-15 | 6.89e-01 | 0.1666 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:0006839 | Colorectum | AD | mitochondrial transport | 102/3918 | 254/18723 | 1.87e-12 | 3.08e-10 | 102 |
GO:1990542 | Colorectum | AD | mitochondrial transmembrane transport | 47/3918 | 102/18723 | 1.09e-08 | 6.52e-07 | 47 |
GO:00068391 | Colorectum | SER | mitochondrial transport | 87/2897 | 254/18723 | 7.91e-14 | 3.03e-11 | 87 |
GO:19905421 | Colorectum | SER | mitochondrial transmembrane transport | 42/2897 | 102/18723 | 3.65e-10 | 4.77e-08 | 42 |
GO:00068392 | Colorectum | MSS | mitochondrial transport | 93/3467 | 254/18723 | 6.14e-12 | 9.82e-10 | 93 |
GO:19905422 | Colorectum | MSS | mitochondrial transmembrane transport | 41/3467 | 102/18723 | 2.70e-07 | 1.11e-05 | 41 |
GO:19905423 | Colorectum | FAP | mitochondrial transmembrane transport | 29/2622 | 102/18723 | 1.09e-04 | 1.80e-03 | 29 |
GO:00068394 | Colorectum | FAP | mitochondrial transport | 55/2622 | 254/18723 | 5.58e-04 | 6.24e-03 | 55 |
GO:000683920 | Esophagus | HGIN | mitochondrial transport | 74/2587 | 254/18723 | 1.32e-10 | 1.32e-08 | 74 |
GO:199054220 | Esophagus | HGIN | mitochondrial transmembrane transport | 29/2587 | 102/18723 | 8.52e-05 | 1.87e-03 | 29 |
GO:0006839110 | Esophagus | ESCC | mitochondrial transport | 187/8552 | 254/18723 | 8.35e-20 | 9.81e-18 | 187 |
GO:1990542110 | Esophagus | ESCC | mitochondrial transmembrane transport | 72/8552 | 102/18723 | 2.94e-07 | 4.23e-06 | 72 |
GO:00068397 | Liver | Cirrhotic | mitochondrial transport | 112/4634 | 254/18723 | 1.03e-11 | 6.66e-10 | 112 |
GO:19905425 | Liver | Cirrhotic | mitochondrial transmembrane transport | 41/4634 | 102/18723 | 4.08e-04 | 3.37e-03 | 41 |
GO:000683912 | Liver | HCC | mitochondrial transport | 184/7958 | 254/18723 | 2.30e-22 | 3.83e-20 | 184 |
GO:199054212 | Liver | HCC | mitochondrial transmembrane transport | 78/7958 | 102/18723 | 2.73e-12 | 1.26e-10 | 78 |
GO:000683918 | Oral cavity | OSCC | mitochondrial transport | 162/7305 | 254/18723 | 8.96e-16 | 6.52e-14 | 162 |
GO:199054218 | Oral cavity | OSCC | mitochondrial transmembrane transport | 56/7305 | 102/18723 | 8.06e-04 | 4.32e-03 | 56 |
GO:000683919 | Oral cavity | LP | mitochondrial transport | 119/4623 | 254/18723 | 1.06e-14 | 1.33e-12 | 119 |
GO:199054219 | Oral cavity | LP | mitochondrial transmembrane transport | 37/4623 | 102/18723 | 5.93e-03 | 3.53e-02 | 37 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa05415 | Colorectum | AD | Diabetic cardiomyopathy | 114/2092 | 203/8465 | 3.65e-22 | 3.06e-20 | 1.95e-20 | 114 |
hsa054151 | Colorectum | AD | Diabetic cardiomyopathy | 114/2092 | 203/8465 | 3.65e-22 | 3.06e-20 | 1.95e-20 | 114 |
hsa054152 | Colorectum | SER | Diabetic cardiomyopathy | 103/1580 | 203/8465 | 1.45e-25 | 1.61e-23 | 1.17e-23 | 103 |
hsa054153 | Colorectum | SER | Diabetic cardiomyopathy | 103/1580 | 203/8465 | 1.45e-25 | 1.61e-23 | 1.17e-23 | 103 |
hsa054154 | Colorectum | MSS | Diabetic cardiomyopathy | 106/1875 | 203/8465 | 2.47e-21 | 1.62e-19 | 9.92e-20 | 106 |
hsa054155 | Colorectum | MSS | Diabetic cardiomyopathy | 106/1875 | 203/8465 | 2.47e-21 | 1.62e-19 | 9.92e-20 | 106 |
hsa054158 | Colorectum | FAP | Diabetic cardiomyopathy | 70/1404 | 203/8465 | 2.62e-10 | 2.18e-08 | 1.33e-08 | 70 |
hsa054159 | Colorectum | FAP | Diabetic cardiomyopathy | 70/1404 | 203/8465 | 2.62e-10 | 2.18e-08 | 1.33e-08 | 70 |
hsa0541530 | Esophagus | HGIN | Diabetic cardiomyopathy | 80/1383 | 203/8465 | 1.35e-15 | 3.38e-14 | 2.69e-14 | 80 |
hsa05415114 | Esophagus | HGIN | Diabetic cardiomyopathy | 80/1383 | 203/8465 | 1.35e-15 | 3.38e-14 | 2.69e-14 | 80 |
hsa05415211 | Esophagus | ESCC | Diabetic cardiomyopathy | 146/4205 | 203/8465 | 5.81e-11 | 7.78e-10 | 3.99e-10 | 146 |
hsa0541538 | Esophagus | ESCC | Diabetic cardiomyopathy | 146/4205 | 203/8465 | 5.81e-11 | 7.78e-10 | 3.99e-10 | 146 |
hsa0541514 | Liver | Cirrhotic | Diabetic cardiomyopathy | 108/2530 | 203/8465 | 1.99e-12 | 4.41e-11 | 2.72e-11 | 108 |
hsa0541515 | Liver | Cirrhotic | Diabetic cardiomyopathy | 108/2530 | 203/8465 | 1.99e-12 | 4.41e-11 | 2.72e-11 | 108 |
hsa0541522 | Liver | HCC | Diabetic cardiomyopathy | 151/4020 | 203/8465 | 2.72e-15 | 1.01e-13 | 5.63e-14 | 151 |
hsa0541532 | Liver | HCC | Diabetic cardiomyopathy | 151/4020 | 203/8465 | 2.72e-15 | 1.01e-13 | 5.63e-14 | 151 |
hsa0541529 | Oral cavity | OSCC | Diabetic cardiomyopathy | 131/3704 | 203/8465 | 1.33e-09 | 1.49e-08 | 7.57e-09 | 131 |
hsa05415113 | Oral cavity | OSCC | Diabetic cardiomyopathy | 131/3704 | 203/8465 | 1.33e-09 | 1.49e-08 | 7.57e-09 | 131 |
hsa05415210 | Oral cavity | LP | Diabetic cardiomyopathy | 106/2418 | 203/8465 | 6.51e-13 | 1.36e-11 | 8.74e-12 | 106 |
hsa0541537 | Oral cavity | LP | Diabetic cardiomyopathy | 106/2418 | 203/8465 | 6.51e-13 | 1.36e-11 | 8.74e-12 | 106 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
MPC1 | SNV | Missense_Mutation | c.110N>T | p.Pro37Leu | p.P37L | Q9Y5U8 | protein_coding | deleterious(0) | probably_damaging(0.99) | TCGA-BH-A0HF-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Hormone Therapy | arimidex | SD | |
MPC1 | SNV | Missense_Mutation | rs139776186 | c.253N>A | p.Ala85Thr | p.A85T | Q9Y5U8 | protein_coding | tolerated(0.36) | benign(0.027) | TCGA-E2-A15D-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Hormone Therapy | tamoxiphen | SD |
MPC1 | SNV | Missense_Mutation | c.253N>T | p.Ala85Ser | p.A85S | Q9Y5U8 | protein_coding | tolerated(0.46) | benign(0.047) | TCGA-05-4244-01 | Lung | lung adenocarcinoma | Male | >=65 | III/IV | Unknown | Unknown | SD | |
MPC1 | SNV | Missense_Mutation | rs767692880 | c.41N>A | p.Arg14Gln | p.R14Q | Q9Y5U8 | protein_coding | tolerated(0.09) | benign(0.009) | TCGA-CN-5374-01 | Oral cavity | head & neck squamous cell carcinoma | Female | <65 | I/II | Chemotherapy | cisplatin | PD |
MPC1 | SNV | Missense_Mutation | novel | c.84G>T | p.Trp28Cys | p.W28C | Q9Y5U8 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-KU-A66S-01 | Oral cavity | head & neck squamous cell carcinoma | Female | >=65 | III/IV | Unknown | Unknown | PD |
MPC1 | insertion | Frame_Shift_Ins | novel | c.104_105insG | p.Leu36SerfsTer8 | p.L36Sfs*8 | Q9Y5U8 | protein_coding | TCGA-UF-A71D-01 | Oral cavity | head & neck squamous cell carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | ||
MPC1 | SNV | Missense_Mutation | rs753601697 | c.160N>T | p.Arg54Trp | p.R54W | Q9Y5U8 | protein_coding | deleterious(0) | benign(0.112) | TCGA-XK-AAIW-01 | Prostate | prostate adenocarcinoma | Male | >=65 | 9 | Unknown | Unknown | PD |
MPC1 | SNV | Missense_Mutation | rs387907237 | c.289N>T | p.Arg97Trp | p.R97W | Q9Y5U8 | protein_coding | deleterious(0.01) | possibly_damaging(0.741) | TCGA-VQ-AA6D-01 | Stomach | stomach adenocarcinoma | Female | <65 | III/IV | Chemotherapy | fluorouracil | CR |
MPC1 | SNV | Missense_Mutation | rs753601697 | c.160N>T | p.Arg54Trp | p.R54W | Q9Y5U8 | protein_coding | deleterious(0) | benign(0.112) | TCGA-VQ-AA6D-01 | Stomach | stomach adenocarcinoma | Female | <65 | III/IV | Chemotherapy | fluorouracil | CR |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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