Schematic overview of the cellular and molecular mechanisms involved in the cancer progression, including the proposed cellular and molecular mechanisms in cancer cells trajectory. AT1: alveolar type 1 cells; AT2: alveolar type 2 cells; AAH: atypical adenomatous hyperplasia; AIS: adenocarcinoma in situ; MIA: minimally invasive adenocarcinoma; IA: invasive adenocarcinoma; EMT: epithelial-mesenchymal transition

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Center for Computational Systems Medicine
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Gene summary

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Malignant transformation analysis

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Malignant transformation related pathway analysis

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Cell-cell communication analysis

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Single-cell gene regulatory network inference analysis

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Somatic mutation of malignant transformation related genes

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Related drugs of malignant transformation related genes

Gene: MLF2

Gene summary for MLF2

check button Gene summary.

Gene informationSpeciesHuman
Gene symbol

MLF2

Gene ID

8079

Gene namemyeloid leukemia factor 2
Gene AliasNTN4
Cytomap12p13.31
Gene Typeprotein-coding
GO ID

GO:0006139

UniProtAcc

A8K1F4


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Malignant transformation analysis

check button Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells
check button Malignant transformation involving gene list.
Entrez IDSymbolReplicatesSpeciesOrganTissueAdj P-valueLog2FCMalignancy
8079MLF2P62T-EHumanEsophagusESCC6.43e-1232.53e+000.1302
8079MLF2P65T-EHumanEsophagusESCC2.82e-581.32e+000.0978
8079MLF2P74T-EHumanEsophagusESCC1.32e-692.64e+000.1479
8079MLF2P75T-EHumanEsophagusESCC8.46e-501.50e+000.1125
8079MLF2P76T-EHumanEsophagusESCC7.63e-982.22e+000.1207
8079MLF2P79T-EHumanEsophagusESCC8.11e-972.18e+000.1154
8079MLF2P80T-EHumanEsophagusESCC3.37e-682.91e+000.155
8079MLF2P82T-EHumanEsophagusESCC9.99e-332.19e+000.1072
8079MLF2P83T-EHumanEsophagusESCC1.46e-743.62e+000.1738
8079MLF2P84T-EHumanEsophagusESCC6.40e-262.01e+000.0933
8079MLF2P89T-EHumanEsophagusESCC4.82e-333.30e+000.1752
8079MLF2P91T-EHumanEsophagusESCC2.30e-243.22e+000.1828
8079MLF2P94T-EHumanEsophagusESCC1.25e-041.43e+000.0879
8079MLF2P104T-EHumanEsophagusESCC4.72e-031.14e+000.0931
8079MLF2P107T-EHumanEsophagusESCC7.57e-912.81e+000.171
8079MLF2P126T-EHumanEsophagusESCC1.80e-202.28e+000.1125
8079MLF2P127T-EHumanEsophagusESCC2.52e-671.33e+000.0826
8079MLF2P128T-EHumanEsophagusESCC8.02e-632.21e+000.1241
8079MLF2P130T-EHumanEsophagusESCC8.61e-1012.91e+000.1676
8079MLF2S43HumanLiverCirrhotic9.41e-09-3.22e-01-0.0187
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check button Transcriptomic changes along malignancy continuum.
TissueExpression DynamicsAbbreviation
Colorectum (GSE201348)The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.FAP: Familial adenomatous polyposis
CRC: Colorectal cancer
Colorectum (HTA11)The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.AD: Adenomas
SER: Sessile serrated lesions
MSI-H: Microsatellite-high colorectal cancer
MSS: Microsatellite stable colorectal cancer
EndometriumThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.AEH: Atypical endometrial hyperplasia
EEC: Endometrioid Cancer
EsophagusThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.ESCC: Esophageal squamous cell carcinoma
HGIN: High-grade intraepithelial neoplasias
LGIN: Low-grade intraepithelial neoplasias
LiverThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.HCC: Hepatocellular carcinoma
NAFLD: Non-alcoholic fatty liver disease
Oral CavityThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.EOLP: Erosive Oral lichen planus
LP: leukoplakia
NEOLP: Non-erosive oral lichen planus
OSCC: Oral squamous cell carcinoma
ProstateThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.BPH: Benign Prostatic Hyperplasia
SkinThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.AK: Actinic keratosis
cSCC: Cutaneous squamous cell carcinoma
SCCIS:squamous cell carcinoma in situ
ThyroidThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.ATC: Anaplastic thyroid cancer
HT: Hashimoto's thyroiditis
PTC: Papillary thyroid cancer
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.

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Malignant transformation related pathway analysis

check buttonFind out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer
check button Figure of enriched GO biological processes.
TissueDisease StageEnriched GO biological Processes
ColorectumADGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumSERGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumMSSGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumMSI-HGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumFAPGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
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check button Enriched GO biological processes.
GO IDTissueDisease StageDescriptionGene RatioBg Ratiopvaluep.adjustCount
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check button Enriched KEGG pathways.
Pathway IDTissueDisease StageDescriptionGene RatioBg Ratiopvaluep.adjustqvalueCount
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Cell-cell communication analysis

check buttonIdentification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states
LigandReceptorLRpairPathwayTissueDisease Stage
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Single-cell gene regulatory network inference analysis

check buttonFind out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states
TFCell TypeTissueDisease StageTarget GeneRSSRegulon Activity
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.
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Somatic mutation of malignant transformation related genes

check buttonAnnotation of somatic variants for genes involved in malignant transformation
Hugo SymbolVariant ClassVariant ClassificationdbSNP RSHGVScHGVSpHGVSp ShortSWISSPROTBIOTYPESIFTPolyPhenTumor Sample BarcodeTissueHistologySexAgeStageTherapy TypesDrugsOutcome
MLF2deletionFrame_Shift_Delnovelc.685delNp.Arg229AlafsTer56p.R229Afs*56Q15773protein_codingTCGA-D8-A27V-01Breastbreast invasive carcinomaFemale<65I/IIHormone TherapytamoxiphenSD
MLF2SNVMissense_Mutationnovelc.682N>Tp.Pro228Serp.P228SQ15773protein_codingtolerated(0.3)benign(0.018)TCGA-EK-A2RJ-01Cervixcervical & endocervical cancerFemale<65I/IIUnknownUnknownSD
MLF2SNVMissense_Mutationnovelc.134N>Gp.Asp45Glyp.D45GQ15773protein_codingdeleterious(0.03)benign(0.099)TCGA-AZ-4315-01Colorectumcolon adenocarcinomaMale<65I/IIUnknownUnknownSD
MLF2SNVMissense_Mutationc.520G>Cp.Asp174Hisp.D174HQ15773protein_codingdeleterious(0)probably_damaging(0.983)TCGA-CK-5912-01Colorectumcolon adenocarcinomaMale>=65I/IIUnknownUnknownSD
MLF2SNVMissense_Mutationc.249N>Ap.Met83Ilep.M83IQ15773protein_codingtolerated(0.07)probably_damaging(0.95)TCGA-CM-6172-01Colorectumcolon adenocarcinomaFemale>=65III/IVAncillaryleucovorinSD
MLF2SNVMissense_Mutationc.512G>Ap.Arg171Hisp.R171HQ15773protein_codingdeleterious(0.05)benign(0.042)TCGA-CM-6674-01Colorectumcolon adenocarcinomaMale<65I/IIUnknownUnknownSD
MLF2SNVMissense_Mutationrs745833590c.412N>Tp.Arg138Trpp.R138WQ15773protein_codingdeleterious(0)probably_damaging(0.995)TCGA-F4-6570-01Colorectumcolon adenocarcinomaFemale>=65I/IIUnknownUnknownSD
MLF2insertionFrame_Shift_Insnovelc.475dupGp.Asp159GlyfsTer28p.D159Gfs*28Q15773protein_codingTCGA-G4-6309-01Colorectumcolon adenocarcinomaFemale<65III/IVChemotherapyxelodaPD
MLF2SNVMissense_Mutationnovelc.254A>Cp.Asp85Alap.D85AQ15773protein_codingtolerated(0.12)benign(0.258)TCGA-A5-A0G2-01Endometriumuterine corpus endometrioid carcinomaFemale<65III/IVUnknownUnknownSD
MLF2SNVMissense_Mutationrs749240926c.566N>Tp.Ala189Valp.A189VQ15773protein_codingdeleterious(0.04)possibly_damaging(0.87)TCGA-AJ-A3EK-01Endometriumuterine corpus endometrioid carcinomaFemale<65I/IIChemotherapycarboplatinCR
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Related drugs of malignant transformation related genes

check buttonIdentification of chemicals and drugs interact with genes involved in malignant transfromation
(DGIdb 4.0)
Entrez IDSymbolCategoryInteraction TypesDrug Claim NameDrug NamePMIDs
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