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Gene: MINOS1 |
Gene summary for MINOS1 |
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Gene information | Species | Human | Gene symbol | MINOS1 | Gene ID | 440574 |
Gene name | mitochondrial contact site and cristae organizing system subunit 10 | |
Gene Alias | C1orf151 | |
Cytomap | 1p36.13 | |
Gene Type | protein-coding | GO ID | GO:0006996 | UniProtAcc | Q5TGZ0 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
440574 | MINOS1 | P62T-E | Human | Esophagus | ESCC | 1.06e-70 | 1.49e+00 | 0.1302 |
440574 | MINOS1 | P65T-E | Human | Esophagus | ESCC | 8.76e-41 | 9.81e-01 | 0.0978 |
440574 | MINOS1 | P74T-E | Human | Esophagus | ESCC | 6.99e-57 | 2.12e+00 | 0.1479 |
440574 | MINOS1 | P75T-E | Human | Esophagus | ESCC | 4.70e-95 | 2.18e+00 | 0.1125 |
440574 | MINOS1 | P76T-E | Human | Esophagus | ESCC | 9.52e-54 | 1.35e+00 | 0.1207 |
440574 | MINOS1 | P79T-E | Human | Esophagus | ESCC | 1.44e-37 | 9.92e-01 | 0.1154 |
440574 | MINOS1 | P80T-E | Human | Esophagus | ESCC | 3.90e-47 | 1.85e+00 | 0.155 |
440574 | MINOS1 | P82T-E | Human | Esophagus | ESCC | 1.81e-31 | 2.20e+00 | 0.1072 |
440574 | MINOS1 | P83T-E | Human | Esophagus | ESCC | 1.54e-56 | 1.94e+00 | 0.1738 |
440574 | MINOS1 | P84T-E | Human | Esophagus | ESCC | 4.10e-11 | 1.09e+00 | 0.0933 |
440574 | MINOS1 | P89T-E | Human | Esophagus | ESCC | 1.63e-30 | 2.41e+00 | 0.1752 |
440574 | MINOS1 | P91T-E | Human | Esophagus | ESCC | 6.38e-23 | 3.24e+00 | 0.1828 |
440574 | MINOS1 | P94T-E | Human | Esophagus | ESCC | 1.90e-05 | 2.11e+00 | 0.0879 |
440574 | MINOS1 | P104T-E | Human | Esophagus | ESCC | 6.68e-06 | 1.39e+00 | 0.0931 |
440574 | MINOS1 | P107T-E | Human | Esophagus | ESCC | 2.45e-90 | 2.77e+00 | 0.171 |
440574 | MINOS1 | P126T-E | Human | Esophagus | ESCC | 6.51e-18 | 2.31e+00 | 0.1125 |
440574 | MINOS1 | P127T-E | Human | Esophagus | ESCC | 5.86e-34 | 8.57e-01 | 0.0826 |
440574 | MINOS1 | P128T-E | Human | Esophagus | ESCC | 6.28e-69 | 2.80e+00 | 0.1241 |
440574 | MINOS1 | P130T-E | Human | Esophagus | ESCC | 4.33e-112 | 2.81e+00 | 0.1676 |
440574 | MINOS1 | S43 | Human | Liver | Cirrhotic | 6.97e-20 | -5.29e-01 | -0.0187 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
MINOS1 | SNV | Missense_Mutation | rs377291144 | c.31N>A | p.Asp11Asn | p.D11N | Q5TGZ0 | protein_coding | deleterious(0.02) | possibly_damaging(0.864) | TCGA-A5-A0G2-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
MINOS1 | SNV | Missense_Mutation | novel | c.116G>T | p.Arg39Ile | p.R39I | Q5TGZ0 | protein_coding | deleterious(0) | possibly_damaging(0.678) | TCGA-D1-A17Q-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
MINOS1 | SNV | Missense_Mutation | novel | c.101N>G | p.Thr34Ser | p.T34S | Q5TGZ0 | protein_coding | deleterious(0.01) | benign(0.097) | TCGA-22-1002-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
MINOS1 | insertion | Frame_Shift_Ins | novel | c.149dupG | p.Leu51IlefsTer11 | p.L51Ifs*11 | Q5TGZ0 | protein_coding | TCGA-55-8511-01 | Lung | lung adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | PD | ||
MINOS1 | SNV | Missense_Mutation | novel | c.202C>G | p.Leu68Val | p.L68V | Q5TGZ0 | protein_coding | tolerated(0.13) | benign(0.029) | TCGA-CV-5444-01 | Oral cavity | head & neck squamous cell carcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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