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Gene: MCFD2 |
Gene summary for MCFD2 |
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Gene information | Species | Human | Gene symbol | MCFD2 | Gene ID | 90411 |
Gene name | multiple coagulation factor deficiency 2, ER cargo receptor complex subunit | |
Gene Alias | F5F8D | |
Cytomap | 2p21 | |
Gene Type | protein-coding | GO ID | GO:0006810 | UniProtAcc | Q8NI22 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
90411 | MCFD2 | P10_cSCC | Human | Skin | cSCC | 2.08e-15 | 5.64e-01 | 0.1017 |
90411 | MCFD2 | Adj_PTCwithHT_6 | Human | Thyroid | HT | 1.29e-13 | -5.94e-01 | 0.02 |
90411 | MCFD2 | PTCwithHT_6 | Human | Thyroid | HT | 2.39e-10 | -5.49e-01 | 0.02 |
90411 | MCFD2 | PTCwithHT_8 | Human | Thyroid | HT | 6.81e-04 | -2.83e-01 | 0.0351 |
90411 | MCFD2 | PTCwithoutHT_2 | Human | Thyroid | PTC | 2.68e-08 | -4.90e-01 | 0.0419 |
90411 | MCFD2 | male-WTA | Human | Thyroid | PTC | 1.27e-48 | -1.97e-01 | 0.1037 |
90411 | MCFD2 | PTC01 | Human | Thyroid | PTC | 1.50e-11 | -5.40e-02 | 0.1899 |
90411 | MCFD2 | PTC04 | Human | Thyroid | PTC | 6.73e-06 | 2.34e-02 | 0.1927 |
90411 | MCFD2 | PTC05 | Human | Thyroid | PTC | 1.52e-09 | 6.29e-01 | 0.2065 |
90411 | MCFD2 | PTC06 | Human | Thyroid | PTC | 1.73e-27 | 7.65e-01 | 0.2057 |
90411 | MCFD2 | PTC07 | Human | Thyroid | PTC | 3.05e-26 | 5.43e-01 | 0.2044 |
90411 | MCFD2 | ATC08 | Human | Thyroid | ATC | 6.73e-08 | -4.81e-01 | 0.0541 |
90411 | MCFD2 | ATC09 | Human | Thyroid | ATC | 1.33e-05 | 2.90e-02 | 0.2871 |
90411 | MCFD2 | ATC11 | Human | Thyroid | ATC | 7.29e-03 | 8.11e-01 | 0.3386 |
90411 | MCFD2 | ATC12 | Human | Thyroid | ATC | 8.77e-08 | 5.80e-01 | 0.34 |
90411 | MCFD2 | ATC13 | Human | Thyroid | ATC | 9.89e-14 | 6.95e-01 | 0.34 |
90411 | MCFD2 | ATC1 | Human | Thyroid | ATC | 1.56e-05 | 1.02e-01 | 0.2878 |
90411 | MCFD2 | ATC2 | Human | Thyroid | ATC | 2.03e-06 | 1.21e+00 | 0.34 |
90411 | MCFD2 | ATC3 | Human | Thyroid | ATC | 8.73e-06 | 7.00e-01 | 0.338 |
90411 | MCFD2 | ATC4 | Human | Thyroid | ATC | 2.30e-22 | 8.78e-01 | 0.34 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
MCFD2 | SNV | Missense_Mutation | c.254A>G | p.Asn85Ser | p.N85S | Q8NI22 | protein_coding | deleterious(0) | probably_damaging(0.997) | TCGA-EA-A78R-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD | |
MCFD2 | SNV | Missense_Mutation | c.385G>T | p.Asp129Tyr | p.D129Y | Q8NI22 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-AD-6964-01 | Colorectum | colon adenocarcinoma | Male | <65 | III/IV | Chemotherapy | folfox | PD | |
MCFD2 | SNV | Missense_Mutation | c.242A>T | p.Asp81Val | p.D81V | Q8NI22 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-D5-6537-01 | Colorectum | colon adenocarcinoma | Male | <65 | III/IV | Unknown | Unknown | PD | |
MCFD2 | SNV | Missense_Mutation | c.364G>T | p.Asp122Tyr | p.D122Y | Q8NI22 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-AG-3892-01 | Colorectum | rectum adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
MCFD2 | SNV | Missense_Mutation | c.28N>G | p.Pro10Ala | p.P10A | Q8NI22 | protein_coding | tolerated_low_confidence(0.48) | benign(0.014) | TCGA-CI-6620-01 | Colorectum | rectum adenocarcinoma | Female | <65 | I/II | Ancillary | leucovorin | PD | |
MCFD2 | SNV | Missense_Mutation | rs754442571 | c.203C>T | p.Ser68Leu | p.S68L | Q8NI22 | protein_coding | deleterious(0.01) | probably_damaging(0.93) | TCGA-EI-6917-01 | Colorectum | rectum adenocarcinoma | Male | <65 | III/IV | Chemotherapy | 5fluorouracil+oxaciplatina+l-folinian | SD |
MCFD2 | SNV | Missense_Mutation | rs747338625 | c.70N>A | p.Ala24Thr | p.A24T | Q8NI22 | protein_coding | tolerated_low_confidence(0.26) | benign(0) | TCGA-AX-A06F-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | carboplatin | SD |
MCFD2 | SNV | Missense_Mutation | novel | c.92C>A | p.Ala31Asp | p.A31D | Q8NI22 | protein_coding | tolerated(0.21) | benign(0.005) | TCGA-AX-A2HA-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
MCFD2 | SNV | Missense_Mutation | rs746904307 | c.302N>G | p.His101Arg | p.H101R | Q8NI22 | protein_coding | deleterious(0) | probably_damaging(0.995) | TCGA-UB-A7MB-01 | Liver | liver hepatocellular carcinoma | Male | <65 | I/II | Targeted Molecular therapy | sorafenib | PD |
MCFD2 | SNV | Missense_Mutation | rs768254017 | c.65C>T | p.Pro22Leu | p.P22L | Q8NI22 | protein_coding | tolerated_low_confidence(0.75) | benign(0) | TCGA-64-5775-01 | Lung | lung adenocarcinoma | Male | >=65 | III/IV | Chemotherapy | carboplatin | PD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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