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Gene: LMO7 |
Gene summary for LMO7 |
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Gene information | Species | Human | Gene symbol | LMO7 | Gene ID | 4008 |
Gene name | LIM domain 7 | |
Gene Alias | FBX20 | |
Cytomap | 13q22.2 | |
Gene Type | protein-coding | GO ID | GO:0006139 | UniProtAcc | F8J2B5 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
4008 | LMO7 | Pt14.d | Human | Liver | HCC | 9.10e-07 | -2.82e-01 | 0.0143 |
4008 | LMO7 | S028 | Human | Liver | HCC | 6.74e-04 | 3.91e-01 | 0.2503 |
4008 | LMO7 | S029 | Human | Liver | HCC | 1.66e-07 | 8.46e-01 | 0.2581 |
4008 | LMO7 | TD9 | Human | Lung | IAC | 3.07e-05 | 9.66e-01 | 0.088 |
4008 | LMO7 | RNA-P17T-P17T-2 | Human | Lung | IAC | 6.39e-08 | 8.19e-01 | 0.3371 |
4008 | LMO7 | RNA-P17T-P17T-4 | Human | Lung | IAC | 6.37e-06 | 5.90e-01 | 0.343 |
4008 | LMO7 | RNA-P17T-P17T-6 | Human | Lung | IAC | 1.93e-09 | 8.61e-01 | 0.3385 |
4008 | LMO7 | RNA-P17T-P17T-8 | Human | Lung | IAC | 6.11e-08 | 6.58e-01 | 0.3329 |
4008 | LMO7 | RNA-P25T1-P25T1-1 | Human | Lung | AIS | 2.42e-20 | 7.35e-01 | -0.2116 |
4008 | LMO7 | RNA-P25T1-P25T1-2 | Human | Lung | AIS | 2.77e-09 | 7.71e-01 | -0.1941 |
4008 | LMO7 | RNA-P25T1-P25T1-3 | Human | Lung | AIS | 1.18e-08 | 6.62e-01 | -0.2107 |
4008 | LMO7 | RNA-P25T1-P25T1-4 | Human | Lung | AIS | 9.05e-15 | 7.61e-01 | -0.2119 |
4008 | LMO7 | RNA-P3T-P3T-2 | Human | Lung | IAC | 4.11e-02 | 2.62e-01 | 0.1835 |
4008 | LMO7 | RNA-P3T-P3T-4 | Human | Lung | IAC | 8.20e-04 | 3.42e-01 | 0.1859 |
4008 | LMO7 | RNA-P6T1-P6T1-4 | Human | Lung | MIAC | 8.48e-03 | 7.16e-01 | -0.0263 |
4008 | LMO7 | RNA-P6T2-P6T2-1 | Human | Lung | IAC | 3.09e-18 | 2.05e-01 | -0.0166 |
4008 | LMO7 | RNA-P6T2-P6T2-2 | Human | Lung | IAC | 3.43e-25 | 1.80e-01 | -0.0132 |
4008 | LMO7 | RNA-P6T2-P6T2-3 | Human | Lung | IAC | 1.10e-23 | 1.52e-01 | -0.013 |
4008 | LMO7 | RNA-P6T2-P6T2-4 | Human | Lung | IAC | 1.32e-15 | 1.03e-01 | -0.0121 |
4008 | LMO7 | RNA-P7T1-P7T1-1 | Human | Lung | AIS | 3.70e-09 | 5.64e-01 | -0.0961 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa04520 | Colorectum | AD | Adherens junction | 50/2092 | 93/8465 | 1.52e-09 | 2.83e-08 | 1.81e-08 | 50 |
hsa045201 | Colorectum | AD | Adherens junction | 50/2092 | 93/8465 | 1.52e-09 | 2.83e-08 | 1.81e-08 | 50 |
hsa045202 | Colorectum | SER | Adherens junction | 37/1580 | 93/8465 | 1.54e-06 | 2.35e-05 | 1.71e-05 | 37 |
hsa045203 | Colorectum | SER | Adherens junction | 37/1580 | 93/8465 | 1.54e-06 | 2.35e-05 | 1.71e-05 | 37 |
hsa045204 | Colorectum | MSS | Adherens junction | 42/1875 | 93/8465 | 6.18e-07 | 9.01e-06 | 5.52e-06 | 42 |
hsa045205 | Colorectum | MSS | Adherens junction | 42/1875 | 93/8465 | 6.18e-07 | 9.01e-06 | 5.52e-06 | 42 |
hsa045208 | Colorectum | FAP | Adherens junction | 45/1404 | 93/8465 | 8.66e-13 | 2.89e-10 | 1.76e-10 | 45 |
hsa045209 | Colorectum | FAP | Adherens junction | 45/1404 | 93/8465 | 8.66e-13 | 2.89e-10 | 1.76e-10 | 45 |
hsa0452010 | Colorectum | CRC | Adherens junction | 37/1091 | 93/8465 | 5.72e-11 | 6.37e-09 | 4.32e-09 | 37 |
hsa0452011 | Colorectum | CRC | Adherens junction | 37/1091 | 93/8465 | 5.72e-11 | 6.37e-09 | 4.32e-09 | 37 |
hsa0452025 | Endometrium | AEH | Adherens junction | 36/1197 | 93/8465 | 3.49e-09 | 5.98e-08 | 4.37e-08 | 36 |
hsa04520111 | Endometrium | AEH | Adherens junction | 36/1197 | 93/8465 | 3.49e-09 | 5.98e-08 | 4.37e-08 | 36 |
hsa0452030 | Esophagus | ESCC | Adherens junction | 69/4205 | 93/8465 | 1.08e-06 | 6.83e-06 | 3.50e-06 | 69 |
hsa04520114 | Esophagus | ESCC | Adherens junction | 69/4205 | 93/8465 | 1.08e-06 | 6.83e-06 | 3.50e-06 | 69 |
hsa0452014 | Liver | NAFLD | Adherens junction | 37/1043 | 93/8465 | 1.50e-11 | 1.64e-09 | 1.32e-09 | 37 |
hsa0452015 | Liver | NAFLD | Adherens junction | 37/1043 | 93/8465 | 1.50e-11 | 1.64e-09 | 1.32e-09 | 37 |
hsa0452022 | Liver | Cirrhotic | Adherens junction | 52/2530 | 93/8465 | 1.36e-07 | 1.97e-06 | 1.21e-06 | 52 |
hsa0452032 | Liver | Cirrhotic | Adherens junction | 52/2530 | 93/8465 | 1.36e-07 | 1.97e-06 | 1.21e-06 | 52 |
hsa0452042 | Liver | HCC | Adherens junction | 68/4020 | 93/8465 | 3.99e-07 | 4.46e-06 | 2.48e-06 | 68 |
hsa0452052 | Liver | HCC | Adherens junction | 68/4020 | 93/8465 | 3.99e-07 | 4.46e-06 | 2.48e-06 | 68 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
LMO7 | SNV | Missense_Mutation | rs190179934 | c.1771N>T | p.Arg591Cys | p.R591C | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-A8-A09E-01 | Breast | breast invasive carcinoma | Female | >=65 | III/IV | Hormone Therapy | anastrozole | SD | |
LMO7 | SNV | Missense_Mutation | novel | c.255N>C | p.Leu85Phe | p.L85F | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-AC-A2QI-01 | Breast | breast invasive carcinoma | Female | >=65 | III/IV | Chemotherapy | cytoxan | CR | |
LMO7 | SNV | Missense_Mutation | c.3701G>A | p.Ser1234Asn | p.S1234N | protein_coding | tolerated(0.16) | benign(0.023) | TCGA-AN-A0AK-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | ||
LMO7 | SNV | Missense_Mutation | novel | c.4529N>A | p.Pro1510His | p.P1510H | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-BH-A0B4-01 | Breast | breast invasive carcinoma | Male | >=65 | III/IV | Hormone Therapy | tamoxiphen | SD | |
LMO7 | SNV | Missense_Mutation | novel | c.2328N>A | p.Ser776Arg | p.S776R | protein_coding | tolerated(0.07) | benign(0.171) | TCGA-BH-A1FM-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD | |
LMO7 | SNV | Missense_Mutation | rs775633721 | c.3550A>G | p.Arg1184Gly | p.R1184G | protein_coding | deleterious(0) | benign(0.082) | TCGA-D8-A1XG-01 | Breast | breast invasive carcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD | |
LMO7 | SNV | Missense_Mutation | novel | c.1481N>C | p.Val494Ala | p.V494A | protein_coding | tolerated(0.09) | benign(0.445) | TCGA-D8-A1XQ-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
LMO7 | insertion | Frame_Shift_Ins | novel | c.2809_2810insGAATTGGATGGTGTTGGCTGTGTCTGATGCAGGAAATACACTG | p.Pro937ArgfsTer31 | p.P937Rfs*31 | protein_coding | TCGA-A2-A0EX-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Hormone Therapy | tamoxiphen | SD | |||
LMO7 | insertion | In_Frame_Ins | novel | c.1275_1276insAAA | p.Pro425_Thr426insLys | p.P425_T426insK | protein_coding | TCGA-BH-A0AY-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | SD | ||||
LMO7 | insertion | Frame_Shift_Ins | novel | c.1277_1278insCCAACTTAAATTAGGCAAACAAGCAAGTAATAACCGA | p.Ser427GlnfsTer31 | p.S427Qfs*31 | protein_coding | TCGA-BH-A0AY-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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