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Gene: LETMD1 |
Gene summary for LETMD1 |
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Gene information | Species | Human | Gene symbol | LETMD1 | Gene ID | 25875 |
Gene name | LETM1 domain containing 1 | |
Gene Alias | 1110019O13Rik | |
Cytomap | 12q13.12 | |
Gene Type | protein-coding | GO ID | GO:0005575 | UniProtAcc | Q6P1Q0 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
25875 | LETMD1 | C38 | Human | Oral cavity | OSCC | 1.12e-03 | 6.49e-01 | 0.172 |
25875 | LETMD1 | C43 | Human | Oral cavity | OSCC | 2.11e-32 | 6.74e-01 | 0.1704 |
25875 | LETMD1 | C46 | Human | Oral cavity | OSCC | 6.44e-29 | 7.68e-01 | 0.1673 |
25875 | LETMD1 | C51 | Human | Oral cavity | OSCC | 4.75e-05 | 3.66e-01 | 0.2674 |
25875 | LETMD1 | C57 | Human | Oral cavity | OSCC | 2.58e-06 | 3.81e-01 | 0.1679 |
25875 | LETMD1 | C08 | Human | Oral cavity | OSCC | 2.10e-28 | 6.25e-01 | 0.1919 |
25875 | LETMD1 | C09 | Human | Oral cavity | OSCC | 2.04e-07 | 3.61e-01 | 0.1431 |
25875 | LETMD1 | LN46 | Human | Oral cavity | OSCC | 1.42e-15 | 6.86e-01 | 0.1666 |
25875 | LETMD1 | LP15 | Human | Oral cavity | LP | 1.11e-02 | 7.48e-01 | 0.2174 |
25875 | LETMD1 | SYSMH1 | Human | Oral cavity | OSCC | 4.24e-13 | 3.65e-01 | 0.1127 |
25875 | LETMD1 | SYSMH2 | Human | Oral cavity | OSCC | 1.42e-13 | 4.51e-01 | 0.2326 |
25875 | LETMD1 | SYSMH3 | Human | Oral cavity | OSCC | 6.33e-14 | 3.46e-01 | 0.2442 |
25875 | LETMD1 | SYSMH4 | Human | Oral cavity | OSCC | 7.38e-04 | 1.91e-01 | 0.1226 |
25875 | LETMD1 | SYSMH5 | Human | Oral cavity | OSCC | 3.02e-02 | 1.34e-01 | 0.0647 |
25875 | LETMD1 | SYSMH6 | Human | Oral cavity | OSCC | 5.22e-09 | 4.04e-01 | 0.1275 |
25875 | LETMD1 | male-WTA | Human | Thyroid | PTC | 2.65e-27 | 1.20e-01 | 0.1037 |
25875 | LETMD1 | PTC01 | Human | Thyroid | PTC | 2.45e-18 | 3.78e-01 | 0.1899 |
25875 | LETMD1 | PTC04 | Human | Thyroid | PTC | 6.97e-22 | 1.24e-01 | 0.1927 |
25875 | LETMD1 | PTC05 | Human | Thyroid | PTC | 3.62e-13 | 4.83e-01 | 0.2065 |
25875 | LETMD1 | PTC06 | Human | Thyroid | PTC | 1.08e-28 | 6.32e-01 | 0.2057 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
LETMD1 | SNV | Missense_Mutation | c.176A>G | p.Tyr59Cys | p.Y59C | Q6P1Q0 | protein_coding | deleterious(0.03) | possibly_damaging(0.747) | TCGA-AO-A128-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | doxorubicin | SD | |
LETMD1 | SNV | Missense_Mutation | c.904N>A | p.Ala302Thr | p.A302T | Q6P1Q0 | protein_coding | deleterious(0) | probably_damaging(0.979) | TCGA-E2-A158-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | arimidex | SD | |
LETMD1 | SNV | Missense_Mutation | c.154G>A | p.Asp52Asn | p.D52N | Q6P1Q0 | protein_coding | tolerated(0.45) | benign(0.027) | TCGA-C5-A1M6-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | PD | |
LETMD1 | SNV | Missense_Mutation | c.28N>G | p.Arg10Gly | p.R10G | Q6P1Q0 | protein_coding | deleterious_low_confidence(0.01) | possibly_damaging(0.532) | TCGA-EA-A43B-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR | |
LETMD1 | SNV | Missense_Mutation | c.1001N>A | p.Arg334Lys | p.R334K | Q6P1Q0 | protein_coding | tolerated(0.16) | benign(0.005) | TCGA-A6-2686-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
LETMD1 | SNV | Missense_Mutation | c.721N>T | p.Ala241Ser | p.A241S | Q6P1Q0 | protein_coding | tolerated(0.64) | benign(0.001) | TCGA-AA-A010-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Chemotherapy | folinic | CR | |
LETMD1 | SNV | Missense_Mutation | c.125N>A | p.Ser42Tyr | p.S42Y | Q6P1Q0 | protein_coding | deleterious(0.03) | possibly_damaging(0.564) | TCGA-AG-A002-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD | |
LETMD1 | SNV | Missense_Mutation | c.442N>A | p.Val148Ile | p.V148I | Q6P1Q0 | protein_coding | tolerated(0.73) | benign(0.007) | TCGA-F5-6814-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD | |
LETMD1 | SNV | Missense_Mutation | novel | c.559N>C | p.Lys187Gln | p.K187Q | Q6P1Q0 | protein_coding | tolerated(0.48) | benign(0.159) | TCGA-A5-A0G1-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
LETMD1 | SNV | Missense_Mutation | novel | c.791C>T | p.Ala264Val | p.A264V | Q6P1Q0 | protein_coding | tolerated(0.61) | benign(0.003) | TCGA-A5-A0G2-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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