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Gene: KRT6A |
Gene summary for KRT6A |
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Gene information | Species | Human | Gene symbol | KRT6A | Gene ID | 3853 |
Gene name | keratin 6A | |
Gene Alias | CK-6C | |
Cytomap | 12q13.13 | |
Gene Type | protein-coding | GO ID | GO:0001897 | UniProtAcc | A0A0S2Z428 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
3853 | KRT6A | NEOLP-3 | Human | Oral cavity | NEOLP | 3.29e-06 | -5.03e-01 | -0.0191 |
3853 | KRT6A | SYSMH1 | Human | Oral cavity | OSCC | 3.82e-90 | 4.13e+00 | 0.1127 |
3853 | KRT6A | SYSMH2 | Human | Oral cavity | OSCC | 1.16e-57 | 5.03e+00 | 0.2326 |
3853 | KRT6A | SYSMH3 | Human | Oral cavity | OSCC | 4.73e-100 | 5.01e+00 | 0.2442 |
3853 | KRT6A | SYSMH4 | Human | Oral cavity | OSCC | 2.72e-89 | 2.40e+00 | 0.1226 |
3853 | KRT6A | SYSMH5 | Human | Oral cavity | OSCC | 3.12e-88 | 3.53e+00 | 0.0647 |
3853 | KRT6A | P1_S1_AK | Human | Skin | AK | 1.59e-21 | 7.19e-01 | -0.3399 |
3853 | KRT6A | P2_S3_AK | Human | Skin | AK | 2.14e-30 | 7.67e-01 | -0.3287 |
3853 | KRT6A | P2_S4_SCCIS | Human | Skin | SCCIS | 5.23e-27 | 7.96e-01 | -0.3043 |
3853 | KRT6A | P3_S6_AK | Human | Skin | AK | 1.58e-37 | 9.92e-01 | -0.3256 |
3853 | KRT6A | P4_S8_cSCC | Human | Skin | cSCC | 8.06e-07 | 4.12e-01 | -0.3095 |
3853 | KRT6A | P5_S10_cSCC | Human | Skin | cSCC | 3.51e-152 | 1.85e+00 | -0.299 |
3853 | KRT6A | P1_cSCC | Human | Skin | cSCC | 6.61e-103 | 6.23e+00 | 0.0292 |
3853 | KRT6A | P2_cSCC | Human | Skin | cSCC | 4.04e-113 | 4.75e+00 | -0.024 |
3853 | KRT6A | P4_cSCC | Human | Skin | cSCC | 9.29e-141 | 5.90e+00 | -0.00290000000000005 |
3853 | KRT6A | P10_cSCC | Human | Skin | cSCC | 1.11e-98 | 5.83e+00 | 0.1017 |
3853 | KRT6A | cSCC_p10 | Human | Skin | cSCC | 3.20e-27 | 7.99e-01 | -0.2095 |
3853 | KRT6A | cSCC_p3 | Human | Skin | cSCC | 2.52e-62 | 1.38e+00 | -0.2085 |
3853 | KRT6A | cSCC_p6 | Human | Skin | cSCC | 3.56e-37 | 9.89e-01 | -0.1989 |
3853 | KRT6A | cSCC_p8 | Human | Skin | cSCC | 3.81e-09 | 3.90e-01 | -0.1971 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:004206010 | Cervix | CC | wound healing | 109/2311 | 422/18723 | 1.84e-14 | 1.57e-11 | 109 |
GO:005212610 | Cervix | CC | movement in host environment | 52/2311 | 175/18723 | 7.03e-10 | 8.76e-08 | 52 |
GO:004440910 | Cervix | CC | entry into host | 47/2311 | 151/18723 | 8.45e-10 | 1.03e-07 | 47 |
GO:005170110 | Cervix | CC | biological process involved in interaction with host | 57/2311 | 203/18723 | 1.18e-09 | 1.41e-07 | 57 |
GO:004440310 | Cervix | CC | biological process involved in symbiotic interaction | 71/2311 | 290/18723 | 7.94e-09 | 6.98e-07 | 71 |
GO:00523728 | Cervix | CC | modulation by symbiont of entry into host | 15/2311 | 49/18723 | 5.81e-04 | 5.52e-03 | 15 |
GO:004390310 | Cervix | CC | regulation of biological process involved in symbiotic interaction | 19/2311 | 72/18723 | 9.11e-04 | 7.81e-03 | 19 |
GO:00313423 | Cervix | CC | negative regulation of cell killing | 10/2311 | 28/18723 | 1.28e-03 | 1.02e-02 | 10 |
GO:00197308 | Cervix | CC | antimicrobial humoral response | 27/2311 | 122/18723 | 1.70e-03 | 1.29e-02 | 27 |
GO:00019067 | Cervix | CC | cell killing | 37/2311 | 188/18723 | 2.61e-03 | 1.80e-02 | 37 |
GO:00618447 | Cervix | CC | antimicrobial humoral immune response mediated by antimicrobial peptide | 18/2311 | 79/18723 | 6.82e-03 | 3.74e-02 | 18 |
GO:00069597 | Cervix | CC | humoral immune response | 54/2311 | 317/18723 | 8.57e-03 | 4.42e-02 | 54 |
GO:000695912 | Cervix | HSIL_HPV | humoral immune response | 39/737 | 317/18723 | 2.88e-10 | 7.02e-08 | 39 |
GO:004440915 | Cervix | HSIL_HPV | entry into host | 24/737 | 151/18723 | 5.42e-09 | 7.61e-07 | 24 |
GO:005212615 | Cervix | HSIL_HPV | movement in host environment | 25/737 | 175/18723 | 2.41e-08 | 2.18e-06 | 25 |
GO:004440315 | Cervix | HSIL_HPV | biological process involved in symbiotic interaction | 33/737 | 290/18723 | 4.67e-08 | 3.59e-06 | 33 |
GO:004206015 | Cervix | HSIL_HPV | wound healing | 40/737 | 422/18723 | 2.80e-07 | 1.61e-05 | 40 |
GO:005170115 | Cervix | HSIL_HPV | biological process involved in interaction with host | 25/737 | 203/18723 | 4.50e-07 | 2.36e-05 | 25 |
GO:001973012 | Cervix | HSIL_HPV | antimicrobial humoral response | 18/737 | 122/18723 | 1.35e-06 | 6.21e-05 | 18 |
GO:000190611 | Cervix | HSIL_HPV | cell killing | 23/737 | 188/18723 | 1.45e-06 | 6.47e-05 | 23 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
KRT6A | SNV | Missense_Mutation | rs369911781 | c.1081G>A | p.Glu361Lys | p.E361K | P02538 | protein_coding | deleterious(0.01) | benign(0.394) | TCGA-AN-A0XW-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
KRT6A | SNV | Missense_Mutation | c.1610N>A | p.Gly537Asp | p.G537D | P02538 | protein_coding | tolerated(0.05) | benign(0.071) | TCGA-D8-A1J8-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Hormone Therapy | nolvadex | SD | |
KRT6A | SNV | Missense_Mutation | rs533157590 | c.44G>A | p.Arg15His | p.R15H | P02538 | protein_coding | tolerated(0.28) | benign(0) | TCGA-LD-A66U-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | adriamycin | SD |
KRT6A | SNV | Missense_Mutation | novel | c.314N>A | p.Gly105Glu | p.G105E | P02538 | protein_coding | deleterious(0.02) | benign(0.154) | TCGA-DS-A1OB-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | carboplatin | PD |
KRT6A | SNV | Missense_Mutation | c.1502N>A | p.Ser501Asn | p.S501N | P02538 | protein_coding | tolerated(0.39) | benign(0.035) | TCGA-FU-A3TQ-01 | Cervix | cervical & endocervical cancer | Female | <65 | III/IV | Unknown | Unknown | SD | |
KRT6A | SNV | Missense_Mutation | c.1117G>T | p.Asp373Tyr | p.D373Y | P02538 | protein_coding | deleterious(0) | possibly_damaging(0.787) | TCGA-FU-A3WB-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR | |
KRT6A | SNV | Missense_Mutation | novel | c.1278G>T | p.Lys426Asn | p.K426N | P02538 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-A6-3809-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
KRT6A | SNV | Missense_Mutation | c.799N>G | p.Phe267Val | p.F267V | P02538 | protein_coding | deleterious(0) | probably_damaging(0.998) | TCGA-AA-3977-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
KRT6A | SNV | Missense_Mutation | novel | c.457N>A | p.Asp153Asn | p.D153N | P02538 | protein_coding | deleterious(0) | probably_damaging(0.989) | TCGA-AA-3984-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
KRT6A | SNV | Missense_Mutation | rs758984854 | c.244N>A | p.Gly82Ser | p.G82S | P02538 | protein_coding | tolerated(0.15) | benign(0.005) | TCGA-AA-A010-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Chemotherapy | folinic | CR |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
3853 | KRT6A | NA | TD101 |
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