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Gene: KLF13 |
Gene summary for KLF13 |
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Gene information | Species | Human | Gene symbol | KLF13 | Gene ID | 51621 |
Gene name | Kruppel like factor 13 | |
Gene Alias | BTEB3 | |
Cytomap | 15q13.3 | |
Gene Type | protein-coding | GO ID | GO:0002262 | UniProtAcc | Q9Y2Y9 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
51621 | KLF13 | P1_cSCC | Human | Skin | cSCC | 2.65e-25 | 9.11e-01 | 0.0292 |
51621 | KLF13 | P2_cSCC | Human | Skin | cSCC | 1.88e-18 | 6.53e-01 | -0.024 |
51621 | KLF13 | P4_cSCC | Human | Skin | cSCC | 1.14e-17 | 6.10e-01 | -0.00290000000000005 |
51621 | KLF13 | P10_cSCC | Human | Skin | cSCC | 9.36e-22 | 7.08e-01 | 0.1017 |
51621 | KLF13 | cSCC_p11 | Human | Skin | cSCC | 3.81e-02 | 2.57e-01 | -0.2102 |
51621 | KLF13 | cSCC_p8 | Human | Skin | cSCC | 2.32e-06 | 1.77e-01 | -0.1971 |
51621 | KLF13 | cSCC_p9 | Human | Skin | cSCC | 4.80e-04 | 1.91e-01 | -0.1991 |
51621 | KLF13 | PTCwithoutHT_2 | Human | Thyroid | PTC | 4.82e-02 | -1.89e-01 | 0.0419 |
51621 | KLF13 | male-WTA | Human | Thyroid | PTC | 5.16e-20 | -1.85e-02 | 0.1037 |
51621 | KLF13 | PTC01 | Human | Thyroid | PTC | 4.03e-11 | 1.72e-01 | 0.1899 |
51621 | KLF13 | PTC03 | Human | Thyroid | PTC | 1.21e-07 | 2.51e-01 | 0.1784 |
51621 | KLF13 | PTC04 | Human | Thyroid | PTC | 3.99e-29 | 7.20e-01 | 0.1927 |
51621 | KLF13 | PTC05 | Human | Thyroid | PTC | 8.39e-23 | 5.09e-01 | 0.2065 |
51621 | KLF13 | PTC06 | Human | Thyroid | PTC | 1.14e-29 | 5.89e-01 | 0.2057 |
51621 | KLF13 | PTC07 | Human | Thyroid | PTC | 1.01e-32 | 4.55e-01 | 0.2044 |
51621 | KLF13 | ATC09 | Human | Thyroid | ATC | 1.85e-09 | 1.42e-01 | 0.2871 |
51621 | KLF13 | ATC11 | Human | Thyroid | ATC | 1.20e-05 | 3.49e-01 | 0.3386 |
51621 | KLF13 | ATC12 | Human | Thyroid | ATC | 1.99e-16 | 1.65e-01 | 0.34 |
51621 | KLF13 | ATC13 | Human | Thyroid | ATC | 2.96e-26 | 3.21e-01 | 0.34 |
51621 | KLF13 | ATC1 | Human | Thyroid | ATC | 3.94e-08 | 1.51e-01 | 0.2878 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:0034101 | Colorectum | AD | erythrocyte homeostasis | 51/3918 | 129/18723 | 1.07e-06 | 3.59e-05 | 51 |
GO:0030099 | Colorectum | AD | myeloid cell differentiation | 119/3918 | 381/18723 | 1.24e-06 | 4.01e-05 | 119 |
GO:0002262 | Colorectum | AD | myeloid cell homeostasis | 57/3918 | 157/18723 | 6.17e-06 | 1.56e-04 | 57 |
GO:0048872 | Colorectum | AD | homeostasis of number of cells | 87/3918 | 272/18723 | 1.16e-05 | 2.61e-04 | 87 |
GO:0030218 | Colorectum | AD | erythrocyte differentiation | 45/3918 | 120/18723 | 2.22e-05 | 4.39e-04 | 45 |
GO:0045646 | Colorectum | AD | regulation of erythrocyte differentiation | 20/3918 | 47/18723 | 6.54e-04 | 6.75e-03 | 20 |
GO:1903706 | Colorectum | AD | regulation of hemopoiesis | 99/3918 | 367/18723 | 3.08e-03 | 2.28e-02 | 99 |
GO:0045637 | Colorectum | AD | regulation of myeloid cell differentiation | 61/3918 | 210/18723 | 3.17e-03 | 2.35e-02 | 61 |
GO:00341011 | Colorectum | SER | erythrocyte homeostasis | 39/2897 | 129/18723 | 1.70e-05 | 5.11e-04 | 39 |
GO:00022621 | Colorectum | SER | myeloid cell homeostasis | 44/2897 | 157/18723 | 4.09e-05 | 1.03e-03 | 44 |
GO:00488721 | Colorectum | SER | homeostasis of number of cells | 65/2897 | 272/18723 | 1.70e-04 | 3.19e-03 | 65 |
GO:00302181 | Colorectum | SER | erythrocyte differentiation | 33/2897 | 120/18723 | 5.15e-04 | 7.30e-03 | 33 |
GO:00456461 | Colorectum | SER | regulation of erythrocyte differentiation | 16/2897 | 47/18723 | 1.29e-03 | 1.44e-02 | 16 |
GO:00300991 | Colorectum | SER | myeloid cell differentiation | 80/2897 | 381/18723 | 2.28e-03 | 2.18e-02 | 80 |
GO:00341012 | Colorectum | MSS | erythrocyte homeostasis | 49/3467 | 129/18723 | 1.58e-07 | 7.19e-06 | 49 |
GO:00300992 | Colorectum | MSS | myeloid cell differentiation | 110/3467 | 381/18723 | 4.48e-07 | 1.75e-05 | 110 |
GO:00022622 | Colorectum | MSS | myeloid cell homeostasis | 55/3467 | 157/18723 | 6.35e-07 | 2.34e-05 | 55 |
GO:00488722 | Colorectum | MSS | homeostasis of number of cells | 82/3467 | 272/18723 | 2.02e-06 | 6.28e-05 | 82 |
GO:00302182 | Colorectum | MSS | erythrocyte differentiation | 44/3467 | 120/18723 | 2.03e-06 | 6.28e-05 | 44 |
GO:00456462 | Colorectum | MSS | regulation of erythrocyte differentiation | 19/3467 | 47/18723 | 3.88e-04 | 4.86e-03 | 19 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
KLF13 | deletion | Frame_Shift_Del | novel | c.512_516delACGCG | p.Tyr171TrpfsTer22 | p.Y171Wfs*22 | Q9Y2Y9 | protein_coding | TCGA-E2-A9RU-01 | Breast | breast invasive carcinoma | Female | >=65 | III/IV | Hormone Therapy | arimidex | SD | ||
KLF13 | SNV | Missense_Mutation | novel | c.592G>A | p.Ala198Thr | p.A198T | Q9Y2Y9 | protein_coding | deleterious(0.01) | possibly_damaging(0.72) | TCGA-AA-3549-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
KLF13 | SNV | Missense_Mutation | c.712C>T | p.Arg238Cys | p.R238C | Q9Y2Y9 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-AA-3713-01 | Colorectum | colon adenocarcinoma | Male | >=65 | III/IV | Chemotherapy | 5-fluorouracil | PR | |
KLF13 | SNV | Missense_Mutation | novel | c.614A>G | p.Asn205Ser | p.N205S | Q9Y2Y9 | protein_coding | tolerated(0.93) | benign(0.03) | TCGA-AA-A010-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Chemotherapy | folinic | CR |
KLF13 | SNV | Missense_Mutation | c.704N>A | p.Arg235His | p.R235H | Q9Y2Y9 | protein_coding | deleterious(0) | probably_damaging(0.993) | TCGA-G4-6588-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
KLF13 | SNV | Missense_Mutation | rs778732073 | c.794N>A | p.Arg265Gln | p.R265Q | Q9Y2Y9 | protein_coding | deleterious_low_confidence(0.01) | probably_damaging(0.92) | TCGA-WS-AB45-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
KLF13 | SNV | Missense_Mutation | novel | c.592N>A | p.Ala198Thr | p.A198T | Q9Y2Y9 | protein_coding | deleterious(0.01) | possibly_damaging(0.72) | TCGA-AX-A2HD-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD |
KLF13 | SNV | Missense_Mutation | rs147413291 | c.703N>T | p.Arg235Cys | p.R235C | Q9Y2Y9 | protein_coding | deleterious(0.03) | possibly_damaging(0.658) | TCGA-AX-A2HD-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD |
KLF13 | SNV | Missense_Mutation | novel | c.595N>C | p.Cys199Arg | p.C199R | Q9Y2Y9 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-B5-A5OC-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | III/IV | Chemotherapy | cisplatin | SD |
KLF13 | SNV | Missense_Mutation | c.712N>T | p.Arg238Cys | p.R238C | Q9Y2Y9 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-FI-A2D5-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | carboplatinum | PD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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