Tissue | Expression Dynamics | Abbreviation |
Esophagus | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Esophagus/KIF21A_pca_on_diff_genes.png) | ESCC: Esophageal squamous cell carcinoma |
HGIN: High-grade intraepithelial neoplasias |
LGIN: Low-grade intraepithelial neoplasias |
Liver | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Liver/KIF21A_pca_on_diff_genes.png) | HCC: Hepatocellular carcinoma |
NAFLD: Non-alcoholic fatty liver disease |
Oral Cavity | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/OralCavity/KIF21A_pca_on_diff_genes.png) | EOLP: Erosive Oral lichen planus |
LP: leukoplakia |
NEOLP: Non-erosive oral lichen planus |
OSCC: Oral squamous cell carcinoma |
Thyroid | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Thyroid/KIF21A_pca_on_diff_genes.png) | ATC: Anaplastic thyroid cancer |
HT: Hashimoto's thyroiditis |
PTC: Papillary thyroid cancer |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
KIF21A | SNV | Missense_Mutation | | c.3662T>C | p.Ile1221Thr | p.I1221T | Q7Z4S6 | protein_coding | tolerated(0.39) | benign(0) | TCGA-A1-A0SI-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
KIF21A | SNV | Missense_Mutation | | c.3893N>T | p.Ser1298Leu | p.S1298L | Q7Z4S6 | protein_coding | tolerated(0.27) | benign(0.06) | TCGA-AC-A23H-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | PD |
KIF21A | SNV | Missense_Mutation | rs139695269 | c.3836G>A | p.Arg1279Gln | p.R1279Q | Q7Z4S6 | protein_coding | tolerated(0.12) | possibly_damaging(0.765) | TCGA-B6-A1KI-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
KIF21A | SNV | Missense_Mutation | | c.1181N>T | p.Thr394Ile | p.T394I | Q7Z4S6 | protein_coding | deleterious(0.01) | benign(0.287) | TCGA-BH-A0HF-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Hormone Therapy | arimidex | SD |
KIF21A | SNV | Missense_Mutation | novel | c.1969N>G | p.Lys657Glu | p.K657E | Q7Z4S6 | protein_coding | deleterious(0.01) | probably_damaging(0.998) | TCGA-BH-A18G-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
KIF21A | SNV | Missense_Mutation | novel | c.2176C>A | p.Gln726Lys | p.Q726K | Q7Z4S6 | protein_coding | tolerated(0.95) | benign(0) | TCGA-BH-A1F5-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
KIF21A | SNV | Missense_Mutation | novel | c.2176C>A | p.Gln726Lys | p.Q726K | Q7Z4S6 | protein_coding | tolerated(0.95) | benign(0) | TCGA-D8-A1JA-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | adriamycin | PD |
KIF21A | SNV | Missense_Mutation | novel | c.3802N>C | p.Ala1268Pro | p.A1268P | Q7Z4S6 | protein_coding | tolerated(0.14) | benign(0.003) | TCGA-HN-A2NL-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | cyclophosphamide | SD |
KIF21A | insertion | Frame_Shift_Ins | novel | c.1804-1_1804insA | p.Glu602ArgfsTer8 | p.E602Rfs*8 | Q7Z4S6 | protein_coding | | | TCGA-AO-A128-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | doxorubicin | SD |
KIF21A | insertion | Frame_Shift_Ins | novel | c.387_388insA | p.His130ThrfsTer5 | p.H130Tfs*5 | Q7Z4S6 | protein_coding | | | TCGA-B6-A0RL-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |