Schematic overview of the cellular and molecular mechanisms involved in the cancer progression, including the proposed cellular and molecular mechanisms in cancer cells trajectory. AT1: alveolar type 1 cells; AT2: alveolar type 2 cells; AAH: atypical adenomatous hyperplasia; AIS: adenocarcinoma in situ; MIA: minimally invasive adenocarcinoma; IA: invasive adenocarcinoma; EMT: epithelial-mesenchymal transition

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Center for Computational Systems Medicine
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Gene summary

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Malignant transformation analysis

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Malignant transformation related pathway analysis

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Cell-cell communication analysis

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Single-cell gene regulatory network inference analysis

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Somatic mutation of malignant transformation related genes

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Related drugs of malignant transformation related genes

Gene: JMJD8

Gene summary for JMJD8

check button Gene summary.

Gene informationSpeciesHuman
Gene symbol

JMJD8

Gene ID

339123

Gene namejumonji domain containing 8
Gene AliasC16orf20
Cytomap16p13.3
Gene Typeprotein-coding
GO ID

GO:0001525

UniProtAcc

Q96S16


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Malignant transformation analysis

check button Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells
check button Malignant transformation involving gene list.
Entrez IDSymbolReplicatesSpeciesOrganTissueAdj P-valueLog2FCMalignancy
339123JMJD8PTC05HumanThyroidPTC4.66e-175.37e-010.2065
339123JMJD8PTC06HumanThyroidPTC1.26e-214.70e-010.2057
339123JMJD8PTC07HumanThyroidPTC4.99e-305.30e-010.2044
339123JMJD8ATC09HumanThyroidATC4.66e-081.78e-010.2871
339123JMJD8ATC12HumanThyroidATC2.16e-182.24e-010.34
339123JMJD8ATC13HumanThyroidATC3.10e-171.71e-010.34
339123JMJD8ATC1HumanThyroidATC2.40e-061.76e-010.2878
339123JMJD8ATC2HumanThyroidATC3.59e-022.41e-010.34
339123JMJD8ATC4HumanThyroidATC1.96e-212.98e-010.34
339123JMJD8ATC5HumanThyroidATC6.30e-191.93e-010.34
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check button Transcriptomic changes along malignancy continuum.
TissueExpression DynamicsAbbreviation
EsophagusThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.ESCC: Esophageal squamous cell carcinoma
HGIN: High-grade intraepithelial neoplasias
LGIN: Low-grade intraepithelial neoplasias
LiverThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.HCC: Hepatocellular carcinoma
NAFLD: Non-alcoholic fatty liver disease
Oral CavityThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.EOLP: Erosive Oral lichen planus
LP: leukoplakia
NEOLP: Non-erosive oral lichen planus
OSCC: Oral squamous cell carcinoma
SkinThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.AK: Actinic keratosis
cSCC: Cutaneous squamous cell carcinoma
SCCIS:squamous cell carcinoma in situ
ThyroidThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.ATC: Anaplastic thyroid cancer
HT: Hashimoto's thyroiditis
PTC: Papillary thyroid cancer
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.

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Malignant transformation related pathway analysis

check buttonFind out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer
check button Figure of enriched GO biological processes.
TissueDisease StageEnriched GO biological Processes
ColorectumADGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumSERGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumMSSGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumMSI-HGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumFAPGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
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check button Enriched GO biological processes.
GO IDTissueDisease StageDescriptionGene RatioBg Ratiopvaluep.adjustCount
GO:0006091110EsophagusESCCgeneration of precursor metabolites and energy331/8552490/187233.86e-238.45e-21331
GO:0046034111EsophagusESCCATP metabolic process189/8552277/187231.99e-141.04e-12189
GO:004312318EsophagusESCCpositive regulation of I-kappaB kinase/NF-kappaB signaling132/8552186/187232.07e-128.58e-11132
GO:0043122110EsophagusESCCregulation of I-kappaB kinase/NF-kappaB signaling167/8552249/187236.11e-122.32e-10167
GO:000724919EsophagusESCCI-kappaB kinase/NF-kappaB signaling183/8552281/187233.02e-111.01e-09183
GO:0006753110EsophagusESCCnucleoside phosphate metabolic process288/8552497/187231.80e-083.50e-07288
GO:0019693111EsophagusESCCribose phosphate metabolic process234/8552396/187234.24e-087.76e-07234
GO:0009117111EsophagusESCCnucleotide metabolic process282/8552489/187234.70e-088.50e-07282
GO:0009259111EsophagusESCCribonucleotide metabolic process224/8552385/187234.41e-076.00e-06224
GO:0072521111EsophagusESCCpurine-containing compound metabolic process238/8552416/187231.20e-061.49e-05238
GO:0009150111EsophagusESCCpurine ribonucleotide metabolic process213/8552368/187231.40e-061.69e-05213
GO:0006163111EsophagusESCCpurine nucleotide metabolic process226/8552396/187232.81e-063.21e-05226
GO:004346719EsophagusESCCregulation of generation of precursor metabolites and energy81/8552130/187239.58e-056.81e-0481
GO:000913219EsophagusESCCnucleoside diphosphate metabolic process77/8552124/187231.65e-041.09e-0377
GO:00620129EsophagusESCCregulation of small molecule metabolic process184/8552334/187233.11e-041.85e-03184
GO:000918520EsophagusESCCribonucleoside diphosphate metabolic process66/8552106/187234.21e-042.39e-0366
GO:001605216EsophagusESCCcarbohydrate catabolic process91/8552154/187235.39e-042.97e-0391
GO:000913520EsophagusESCCpurine nucleoside diphosphate metabolic process63/8552103/187231.10e-035.52e-0363
GO:000917920EsophagusESCCpurine ribonucleoside diphosphate metabolic process63/8552103/187231.10e-035.52e-0363
GO:00061096EsophagusESCCregulation of carbohydrate metabolic process101/8552178/187231.89e-038.52e-03101
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check button Enriched KEGG pathways.
Pathway IDTissueDisease StageDescriptionGene RatioBg Ratiopvaluep.adjustqvalueCount
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Cell-cell communication analysis

check buttonIdentification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states
LigandReceptorLRpairPathwayTissueDisease Stage
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Single-cell gene regulatory network inference analysis

check buttonFind out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states
TFCell TypeTissueDisease StageTarget GeneRSSRegulon Activity
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.
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Somatic mutation of malignant transformation related genes

check buttonAnnotation of somatic variants for genes involved in malignant transformation
Hugo SymbolVariant ClassVariant ClassificationdbSNP RSHGVScHGVSpHGVSp ShortSWISSPROTBIOTYPESIFTPolyPhenTumor Sample BarcodeTissueHistologySexAgeStageTherapy TypesDrugsOutcome
JMJD8SNVMissense_Mutationc.490N>Ap.Glu164Lysp.E164KQ96S16protein_codingtolerated(0.15)probably_damaging(0.909)TCGA-AC-A23H-01Breastbreast invasive carcinomaFemale>=65I/IIUnknownUnknownPD
JMJD8SNVMissense_Mutationnovelc.584N>Tp.Ser195Leup.S195LQ96S16protein_codingdeleterious(0.03)possibly_damaging(0.63)TCGA-EA-A6QX-01Cervixcervical & endocervical cancerFemale<65III/IVUnknownUnknownSD
JMJD8SNVMissense_Mutationc.284A>Tp.Asn95Ilep.N95IQ96S16protein_codingdeleterious(0)probably_damaging(0.992)TCGA-AD-5900-01Colorectumcolon adenocarcinomaMale>=65I/IIUnknownUnknownSD
JMJD8SNVMissense_Mutationrs571730014c.737C>Tp.Pro246Leup.P246LQ96S16protein_codingtolerated(0.27)benign(0.007)TCGA-G4-6588-01Colorectumcolon adenocarcinomaFemale<65I/IIUnknownUnknownSD
JMJD8SNVMissense_Mutationnovelc.520N>Ap.Pro174Thrp.P174TQ96S16protein_codingtolerated(0.2)benign(0.306)TCGA-AX-A2HG-01Endometriumuterine corpus endometrioid carcinomaFemale<65I/IIUnknownUnknownSD
JMJD8SNVMissense_Mutationnovelc.290G>Tp.Arg97Metp.R97MQ96S16protein_codingtolerated(0.08)possibly_damaging(0.58)TCGA-AX-A3FT-01Endometriumuterine corpus endometrioid carcinomaFemale<65I/IIUnknownUnknownSD
JMJD8SNVMissense_Mutationrs750654939c.547G>Ap.Ala183Thrp.A183TQ96S16protein_codingtolerated(0.97)benign(0.005)TCGA-SL-A6JA-01Endometriumuterine corpus endometrioid carcinomaFemale>=65I/IIUnknownUnknownSD
JMJD8SNVMissense_Mutationc.532N>Ap.Gly178Serp.G178SQ96S16protein_codingtolerated(0.74)benign(0.033)TCGA-DD-A3A5-01Liverliver hepatocellular carcinomaFemale>=65III/IVUnknownUnknownPD
JMJD8SNVMissense_Mutationrs778481377c.664N>Ap.Glu222Lysp.E222KQ96S16protein_codingtolerated(0.22)benign(0.137)TCGA-CV-7252-01Oral cavityhead & neck squamous cell carcinomaFemale<65I/IIUnknownUnknownPD
JMJD8SNVMissense_Mutationc.658N>Tp.Pro220Serp.P220SQ96S16protein_codingdeleterious(0.03)possibly_damaging(0.869)TCGA-BR-4257-01Stomachstomach adenocarcinomaFemale>=65I/IIUnknownUnknownSD
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Related drugs of malignant transformation related genes

check buttonIdentification of chemicals and drugs interact with genes involved in malignant transfromation
(DGIdb 4.0)
Entrez IDSymbolCategoryInteraction TypesDrug Claim NameDrug NamePMIDs
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