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Gene: IRF1 |
Gene summary for IRF1 |
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Gene information | Species | Human | Gene symbol | IRF1 | Gene ID | 3659 |
Gene name | interferon regulatory factor 1 | |
Gene Alias | IRF-1 | |
Cytomap | 5q31.1 | |
Gene Type | protein-coding | GO ID | GO:0001775 | UniProtAcc | P10914 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
3659 | IRF1 | P65T-E | Human | Esophagus | ESCC | 1.52e-41 | 1.56e+00 | 0.0978 |
3659 | IRF1 | P74T-E | Human | Esophagus | ESCC | 2.52e-44 | 2.07e+00 | 0.1479 |
3659 | IRF1 | P75T-E | Human | Esophagus | ESCC | 1.83e-89 | 3.06e+00 | 0.1125 |
3659 | IRF1 | P76T-E | Human | Esophagus | ESCC | 2.65e-53 | 1.97e+00 | 0.1207 |
3659 | IRF1 | P79T-E | Human | Esophagus | ESCC | 1.79e-20 | 1.05e+00 | 0.1154 |
3659 | IRF1 | P80T-E | Human | Esophagus | ESCC | 1.24e-69 | 4.44e+00 | 0.155 |
3659 | IRF1 | P82T-E | Human | Esophagus | ESCC | 2.10e-24 | 1.77e+00 | 0.1072 |
3659 | IRF1 | P83T-E | Human | Esophagus | ESCC | 2.59e-52 | 2.87e+00 | 0.1738 |
3659 | IRF1 | P84T-E | Human | Esophagus | ESCC | 1.27e-14 | 1.66e+00 | 0.0933 |
3659 | IRF1 | P89T-E | Human | Esophagus | ESCC | 6.48e-12 | 1.67e+00 | 0.1752 |
3659 | IRF1 | P91T-E | Human | Esophagus | ESCC | 3.19e-15 | 2.98e+00 | 0.1828 |
3659 | IRF1 | P104T-E | Human | Esophagus | ESCC | 2.60e-04 | 1.13e+00 | 0.0931 |
3659 | IRF1 | P107T-E | Human | Esophagus | ESCC | 8.77e-46 | 1.63e+00 | 0.171 |
3659 | IRF1 | P126T-E | Human | Esophagus | ESCC | 1.28e-07 | 1.80e+00 | 0.1125 |
3659 | IRF1 | P127T-E | Human | Esophagus | ESCC | 1.17e-50 | 1.55e+00 | 0.0826 |
3659 | IRF1 | P128T-E | Human | Esophagus | ESCC | 1.77e-35 | 2.24e+00 | 0.1241 |
3659 | IRF1 | P130T-E | Human | Esophagus | ESCC | 1.51e-51 | 1.81e+00 | 0.1676 |
3659 | IRF1 | S43 | Human | Liver | Cirrhotic | 1.42e-15 | -4.19e-01 | -0.0187 |
3659 | IRF1 | HCC1_Meng | Human | Liver | HCC | 5.73e-37 | -2.99e-01 | 0.0246 |
3659 | IRF1 | HCC2_Meng | Human | Liver | HCC | 2.78e-18 | -1.59e-01 | 0.0107 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:007121413 | Breast | IDC | cellular response to abiotic stimulus | 48/1434 | 331/18723 | 1.37e-05 | 3.53e-04 | 48 |
GO:010400413 | Breast | IDC | cellular response to environmental stimulus | 48/1434 | 331/18723 | 1.37e-05 | 3.53e-04 | 48 |
GO:004211012 | Breast | IDC | T cell activation | 64/1434 | 487/18723 | 1.49e-05 | 3.77e-04 | 64 |
GO:005086311 | Breast | IDC | regulation of T cell activation | 47/1434 | 329/18723 | 2.49e-05 | 5.91e-04 | 47 |
GO:000181911 | Breast | IDC | positive regulation of cytokine production | 61/1434 | 467/18723 | 2.81e-05 | 6.58e-04 | 61 |
GO:000961211 | Breast | IDC | response to mechanical stimulus | 34/1434 | 216/18723 | 4.59e-05 | 1.03e-03 | 34 |
GO:007149614 | Breast | IDC | cellular response to external stimulus | 45/1434 | 320/18723 | 5.40e-05 | 1.15e-03 | 45 |
GO:190370612 | Breast | IDC | regulation of hemopoiesis | 49/1434 | 367/18723 | 9.74e-05 | 1.86e-03 | 49 |
GO:000715912 | Breast | IDC | leukocyte cell-cell adhesion | 49/1434 | 371/18723 | 1.27e-04 | 2.33e-03 | 49 |
GO:000268311 | Breast | IDC | negative regulation of immune system process | 55/1434 | 434/18723 | 1.53e-04 | 2.67e-03 | 55 |
GO:190303711 | Breast | IDC | regulation of leukocyte cell-cell adhesion | 45/1434 | 336/18723 | 1.72e-04 | 2.92e-03 | 45 |
GO:002240712 | Breast | IDC | regulation of cell-cell adhesion | 55/1434 | 448/18723 | 3.43e-04 | 5.07e-03 | 55 |
GO:00096157 | Breast | IDC | response to virus | 47/1434 | 367/18723 | 3.53e-04 | 5.16e-03 | 47 |
GO:00354562 | Breast | IDC | response to interferon-beta | 9/1434 | 32/18723 | 4.92e-04 | 6.45e-03 | 9 |
GO:190313111 | Breast | IDC | mononuclear cell differentiation | 51/1434 | 426/18723 | 9.81e-04 | 1.11e-02 | 51 |
GO:004209812 | Breast | IDC | T cell proliferation | 28/1434 | 199/18723 | 1.29e-03 | 1.35e-02 | 28 |
GO:004212911 | Breast | IDC | regulation of T cell proliferation | 25/1434 | 171/18723 | 1.32e-03 | 1.38e-02 | 25 |
GO:190210511 | Breast | IDC | regulation of leukocyte differentiation | 36/1434 | 279/18723 | 1.44e-03 | 1.47e-02 | 36 |
GO:00343414 | Breast | IDC | response to interferon-gamma | 21/1434 | 141/18723 | 2.46e-03 | 2.22e-02 | 21 |
GO:00071625 | Breast | IDC | negative regulation of cell adhesion | 37/1434 | 303/18723 | 3.27e-03 | 2.75e-02 | 37 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa051336 | Breast | DCIS | Pertussis | 15/846 | 76/8465 | 7.42e-03 | 3.48e-02 | 2.56e-02 | 15 |
hsa0513311 | Breast | DCIS | Pertussis | 15/846 | 76/8465 | 7.42e-03 | 3.48e-02 | 2.56e-02 | 15 |
hsa051657 | Cervix | CC | Human papillomavirus infection | 74/1267 | 331/8465 | 1.70e-04 | 1.02e-03 | 6.03e-04 | 74 |
hsa051337 | Cervix | CC | Pertussis | 21/1267 | 76/8465 | 3.08e-03 | 1.19e-02 | 7.03e-03 | 21 |
hsa046686 | Cervix | CC | TNF signaling pathway | 28/1267 | 114/8465 | 4.60e-03 | 1.62e-02 | 9.59e-03 | 28 |
hsa046254 | Cervix | CC | C-type lectin receptor signaling pathway | 25/1267 | 104/8465 | 9.52e-03 | 2.94e-02 | 1.74e-02 | 25 |
hsa049172 | Cervix | CC | Prolactin signaling pathway | 18/1267 | 70/8465 | 1.29e-02 | 3.87e-02 | 2.29e-02 | 18 |
hsa0516512 | Cervix | CC | Human papillomavirus infection | 74/1267 | 331/8465 | 1.70e-04 | 1.02e-03 | 6.03e-04 | 74 |
hsa0513312 | Cervix | CC | Pertussis | 21/1267 | 76/8465 | 3.08e-03 | 1.19e-02 | 7.03e-03 | 21 |
hsa0466813 | Cervix | CC | TNF signaling pathway | 28/1267 | 114/8465 | 4.60e-03 | 1.62e-02 | 9.59e-03 | 28 |
hsa0462511 | Cervix | CC | C-type lectin receptor signaling pathway | 25/1267 | 104/8465 | 9.52e-03 | 2.94e-02 | 1.74e-02 | 25 |
hsa0491711 | Cervix | CC | Prolactin signaling pathway | 18/1267 | 70/8465 | 1.29e-02 | 3.87e-02 | 2.29e-02 | 18 |
hsa046687 | Endometrium | EEC | TNF signaling pathway | 27/1237 | 114/8465 | 6.47e-03 | 3.22e-02 | 2.40e-02 | 27 |
hsa0466814 | Endometrium | EEC | TNF signaling pathway | 27/1237 | 114/8465 | 6.47e-03 | 3.22e-02 | 2.40e-02 | 27 |
hsa0466810 | Esophagus | ESCC | TNF signaling pathway | 89/4205 | 114/8465 | 3.36e-10 | 4.01e-09 | 2.06e-09 | 89 |
hsa0516510 | Esophagus | ESCC | Human papillomavirus infection | 215/4205 | 331/8465 | 7.86e-09 | 7.12e-08 | 3.65e-08 | 215 |
hsa046259 | Esophagus | ESCC | C-type lectin receptor signaling pathway | 73/4205 | 104/8465 | 1.57e-05 | 7.98e-05 | 4.09e-05 | 73 |
hsa051339 | Esophagus | ESCC | Pertussis | 48/4205 | 76/8465 | 1.21e-02 | 2.77e-02 | 1.42e-02 | 48 |
hsa0466817 | Esophagus | ESCC | TNF signaling pathway | 89/4205 | 114/8465 | 3.36e-10 | 4.01e-09 | 2.06e-09 | 89 |
hsa0516515 | Esophagus | ESCC | Human papillomavirus infection | 215/4205 | 331/8465 | 7.86e-09 | 7.12e-08 | 3.65e-08 | 215 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
IRF1 | IMENT | Colorectum | ADJ | AHDC1,AC246817.1,APOL2, etc. | 2.96e-01 | ![]() |
IRF1 | MDSC | Lung | Healthy | GBP5,CXCL10,RNF114, etc. | 8.74e-01 | ![]() |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
IRF1 | SNV | Missense_Mutation | c.158N>A | p.Cys53Tyr | p.C53Y | P10914 | protein_coding | deleterious(0) | probably_damaging(0.998) | TCGA-A8-A097-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Hormone Therapy | tamoxiphen | SD | |
IRF1 | SNV | Missense_Mutation | c.454N>T | p.Leu152Phe | p.L152F | P10914 | protein_coding | tolerated(0.1) | probably_damaging(0.994) | TCGA-BH-A1FN-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | PD | |
IRF1 | SNV | Missense_Mutation | c.778N>C | p.Glu260Gln | p.E260Q | P10914 | protein_coding | deleterious(0.03) | probably_damaging(0.986) | TCGA-C5-A1BQ-01 | Cervix | cervical & endocervical cancer | Female | >=65 | III/IV | Chemotherapy | cisplatin | CR | |
IRF1 | SNV | Missense_Mutation | rs777589347 | c.13C>T | p.Arg5Trp | p.R5W | P10914 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-DS-A1OB-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | carboplatin | PD |
IRF1 | SNV | Missense_Mutation | c.39N>C | p.Glu13Asp | p.E13D | P10914 | protein_coding | deleterious(0) | probably_damaging(0.983) | TCGA-FU-A3HY-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR | |
IRF1 | SNV | Missense_Mutation | novel | c.78N>C | p.Trp26Cys | p.W26C | P10914 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-HM-A4S6-01 | Cervix | cervical & endocervical cancer | Female | <65 | III/IV | Chemotherapy | cisplatin | CR |
IRF1 | SNV | Missense_Mutation | c.96N>C | p.Met32Ile | p.M32I | P10914 | protein_coding | deleterious(0.04) | probably_damaging(0.925) | TCGA-IR-A3LH-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR | |
IRF1 | SNV | Missense_Mutation | novel | c.173N>T | p.Trp58Leu | p.W58L | P10914 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-UC-A7PG-06 | Cervix | cervical & endocervical cancer | Female | <65 | III/IV | Chemotherapy | cisplatin | PD |
IRF1 | SNV | Missense_Mutation | c.757N>C | p.Gly253Arg | p.G253R | P10914 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-AA-3831-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
IRF1 | SNV | Missense_Mutation | c.793C>T | p.Pro265Ser | p.P265S | P10914 | protein_coding | tolerated(0.75) | benign(0.073) | TCGA-CK-4951-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | PD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
3659 | IRF1 | CLINICALLY ACTIONABLE, TUMOR SUPPRESSOR | CYTOKINES | 17947510 |
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