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Gene: IFNGR1 |
Gene summary for IFNGR1 |
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Gene information | Species | Human | Gene symbol | IFNGR1 | Gene ID | 3459 |
Gene name | interferon gamma receptor 1 | |
Gene Alias | CD119 | |
Cytomap | 6q23.3 | |
Gene Type | protein-coding | GO ID | GO:0001774 | UniProtAcc | A0A0S2Z3Y2 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
3459 | IFNGR1 | Dong_P5 | Human | Prostate | Tumor | 3.06e-20 | -4.38e-01 | 0.053 |
3459 | IFNGR1 | Dong_P6 | Human | Prostate | Tumor | 3.57e-03 | -4.34e-01 | 0.0371 |
3459 | IFNGR1 | P9 | Human | Prostate | Tumor | 3.24e-02 | -3.76e-01 | -0.0285 |
3459 | IFNGR1 | GSM5353227_PA_PR5199-193K_Pool_1_2_3_S55_L002 | Human | Prostate | Tumor | 7.75e-05 | 1.40e-01 | 0.1602 |
3459 | IFNGR1 | GSM5353240_PA_PR5254_T1_S15_L001 | Human | Prostate | Tumor | 4.49e-02 | -6.04e-02 | 0.1575 |
3459 | IFNGR1 | GSM5353243_PA_PR5261_T1_S23_L002 | Human | Prostate | Tumor | 5.91e-10 | -7.80e-02 | 0.1545 |
3459 | IFNGR1 | GSM5353244_PA_PR5261_T2_S24_L002 | Human | Prostate | Tumor | 4.28e-06 | -1.32e-01 | 0.1569 |
3459 | IFNGR1 | P1_S1_AK | Human | Skin | AK | 6.26e-03 | 2.14e-01 | -0.3399 |
3459 | IFNGR1 | P4_S8_cSCC | Human | Skin | cSCC | 4.69e-05 | 1.25e-01 | -0.3095 |
3459 | IFNGR1 | P5_S10_cSCC | Human | Skin | cSCC | 3.07e-03 | -1.82e-01 | -0.299 |
3459 | IFNGR1 | P1_cSCC | Human | Skin | cSCC | 5.74e-35 | 1.41e+00 | 0.0292 |
3459 | IFNGR1 | P2_cSCC | Human | Skin | cSCC | 3.22e-25 | 7.77e-01 | -0.024 |
3459 | IFNGR1 | P4_cSCC | Human | Skin | cSCC | 6.15e-31 | 9.54e-01 | -0.00290000000000005 |
3459 | IFNGR1 | P10_cSCC | Human | Skin | cSCC | 1.43e-45 | 1.44e+00 | 0.1017 |
3459 | IFNGR1 | cSCC_p7 | Human | Skin | cSCC | 1.91e-04 | -2.82e-01 | -0.2332 |
3459 | IFNGR1 | cSCC_p8 | Human | Skin | cSCC | 2.59e-05 | -7.42e-02 | -0.1971 |
3459 | IFNGR1 | male-WTA | Human | Thyroid | PTC | 4.68e-42 | 3.14e-01 | 0.1037 |
3459 | IFNGR1 | PTC01 | Human | Thyroid | PTC | 1.55e-24 | 4.96e-01 | 0.1899 |
3459 | IFNGR1 | PTC04 | Human | Thyroid | PTC | 8.06e-28 | 6.39e-01 | 0.1927 |
3459 | IFNGR1 | PTC05 | Human | Thyroid | PTC | 9.95e-27 | 9.82e-01 | 0.2065 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:003425020 | Esophagus | HGIN | positive regulation of cellular amide metabolic process | 53/2587 | 162/18723 | 6.01e-10 | 5.15e-08 | 53 |
GO:000961517 | Esophagus | HGIN | response to virus | 69/2587 | 367/18723 | 4.39e-03 | 3.86e-02 | 69 |
GO:0034250111 | Esophagus | ESCC | positive regulation of cellular amide metabolic process | 123/8552 | 162/18723 | 3.32e-15 | 1.93e-13 | 123 |
GO:000961518 | Esophagus | ESCC | response to virus | 238/8552 | 367/18723 | 6.65e-14 | 3.32e-12 | 238 |
GO:00420636 | Esophagus | ESCC | gliogenesis | 172/8552 | 301/18723 | 3.75e-05 | 3.04e-04 | 172 |
GO:00603336 | Esophagus | ESCC | interferon-gamma-mediated signaling pathway | 22/8552 | 27/18723 | 1.49e-04 | 9.92e-04 | 22 |
GO:00343418 | Esophagus | ESCC | response to interferon-gamma | 86/8552 | 141/18723 | 1.74e-04 | 1.14e-03 | 86 |
GO:00100016 | Esophagus | ESCC | glial cell differentiation | 129/8552 | 225/18723 | 2.73e-04 | 1.65e-03 | 129 |
GO:000181916 | Esophagus | ESCC | positive regulation of cytokine production | 244/8552 | 467/18723 | 2.29e-03 | 1.01e-02 | 244 |
GO:00713466 | Esophagus | ESCC | cellular response to interferon-gamma | 69/8552 | 118/18723 | 3.44e-03 | 1.41e-02 | 69 |
GO:003425012 | Liver | Cirrhotic | positive regulation of cellular amide metabolic process | 78/4634 | 162/18723 | 8.62e-11 | 4.66e-09 | 78 |
GO:00343413 | Liver | Cirrhotic | response to interferon-gamma | 60/4634 | 141/18723 | 2.57e-06 | 4.63e-05 | 60 |
GO:00096155 | Liver | Cirrhotic | response to virus | 126/4634 | 367/18723 | 2.10e-05 | 2.77e-04 | 126 |
GO:0071346 | Liver | Cirrhotic | cellular response to interferon-gamma | 49/4634 | 118/18723 | 4.43e-05 | 5.22e-04 | 49 |
GO:00603332 | Liver | Cirrhotic | interferon-gamma-mediated signaling pathway | 16/4634 | 27/18723 | 1.41e-04 | 1.36e-03 | 16 |
GO:0042063 | Liver | Cirrhotic | gliogenesis | 98/4634 | 301/18723 | 1.28e-03 | 8.60e-03 | 98 |
GO:0010001 | Liver | Cirrhotic | glial cell differentiation | 75/4634 | 225/18723 | 2.24e-03 | 1.36e-02 | 75 |
GO:00972421 | Liver | Cirrhotic | amyloid-beta clearance | 17/4634 | 38/18723 | 5.62e-03 | 2.84e-02 | 17 |
GO:003425022 | Liver | HCC | positive regulation of cellular amide metabolic process | 110/7958 | 162/18723 | 5.14e-11 | 1.92e-09 | 110 |
GO:000961511 | Liver | HCC | response to virus | 210/7958 | 367/18723 | 7.32e-09 | 1.86e-07 | 210 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa0516730 | Esophagus | HGIN | Kaposi sarcoma-associated herpesvirus infection | 51/1383 | 194/8465 | 2.46e-04 | 2.69e-03 | 2.14e-03 | 51 |
hsa0516420 | Esophagus | HGIN | Influenza A | 42/1383 | 171/8465 | 3.41e-03 | 2.54e-02 | 2.02e-02 | 42 |
hsa05167114 | Esophagus | HGIN | Kaposi sarcoma-associated herpesvirus infection | 51/1383 | 194/8465 | 2.46e-04 | 2.69e-03 | 2.14e-03 | 51 |
hsa05164110 | Esophagus | HGIN | Influenza A | 42/1383 | 171/8465 | 3.41e-03 | 2.54e-02 | 2.02e-02 | 42 |
hsa05167211 | Esophagus | ESCC | Kaposi sarcoma-associated herpesvirus infection | 136/4205 | 194/8465 | 4.28e-09 | 4.22e-08 | 2.16e-08 | 136 |
hsa0516425 | Esophagus | ESCC | Influenza A | 122/4205 | 171/8465 | 5.01e-09 | 4.79e-08 | 2.45e-08 | 122 |
hsa0406629 | Esophagus | ESCC | HIF-1 signaling pathway | 75/4205 | 109/8465 | 3.66e-05 | 1.68e-04 | 8.60e-05 | 75 |
hsa0514525 | Esophagus | ESCC | Toxoplasmosis | 76/4205 | 112/8465 | 6.83e-05 | 2.90e-04 | 1.48e-04 | 76 |
hsa051527 | Esophagus | ESCC | Tuberculosis | 111/4205 | 180/8465 | 7.14e-04 | 2.32e-03 | 1.19e-03 | 111 |
hsa052356 | Esophagus | ESCC | PD-L1 expression and PD-1 checkpoint pathway in cancer | 58/4205 | 89/8465 | 2.19e-03 | 6.16e-03 | 3.16e-03 | 58 |
hsa051425 | Esophagus | ESCC | Chagas disease | 65/4205 | 102/8465 | 2.81e-03 | 7.59e-03 | 3.89e-03 | 65 |
hsa046599 | Esophagus | ESCC | Th17 cell differentiation | 68/4205 | 108/8465 | 3.53e-03 | 9.30e-03 | 4.76e-03 | 68 |
hsa046585 | Esophagus | ESCC | Th1 and Th2 cell differentiation | 58/4205 | 92/8465 | 6.49e-03 | 1.60e-02 | 8.19e-03 | 58 |
hsa0516738 | Esophagus | ESCC | Kaposi sarcoma-associated herpesvirus infection | 136/4205 | 194/8465 | 4.28e-09 | 4.22e-08 | 2.16e-08 | 136 |
hsa0516435 | Esophagus | ESCC | Influenza A | 122/4205 | 171/8465 | 5.01e-09 | 4.79e-08 | 2.45e-08 | 122 |
hsa04066113 | Esophagus | ESCC | HIF-1 signaling pathway | 75/4205 | 109/8465 | 3.66e-05 | 1.68e-04 | 8.60e-05 | 75 |
hsa05145111 | Esophagus | ESCC | Toxoplasmosis | 76/4205 | 112/8465 | 6.83e-05 | 2.90e-04 | 1.48e-04 | 76 |
hsa0515212 | Esophagus | ESCC | Tuberculosis | 111/4205 | 180/8465 | 7.14e-04 | 2.32e-03 | 1.19e-03 | 111 |
hsa0523511 | Esophagus | ESCC | PD-L1 expression and PD-1 checkpoint pathway in cancer | 58/4205 | 89/8465 | 2.19e-03 | 6.16e-03 | 3.16e-03 | 58 |
hsa0514213 | Esophagus | ESCC | Chagas disease | 65/4205 | 102/8465 | 2.81e-03 | 7.59e-03 | 3.89e-03 | 65 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
IFNG | IFNGR1_IFNGR2 | IFNG_IFNGR1_IFNGR2 | IFN-II | Breast | DCIS |
IFNG | IFNGR1_IFNGR2 | IFNG_IFNGR1_IFNGR2 | IFN-II | Breast | Healthy |
IFNG | IFNGR1_IFNGR2 | IFNG_IFNGR1_IFNGR2 | IFN-II | Breast | IDC |
IFNG | IFNGR1_IFNGR2 | IFNG_IFNGR1_IFNGR2 | IFN-II | Cervix | ADJ |
IFNG | IFNGR1_IFNGR2 | IFNG_IFNGR1_IFNGR2 | IFN-II | Cervix | CC |
IFNG | IFNGR1_IFNGR2 | IFNG_IFNGR1_IFNGR2 | IFN-II | Cervix | Healthy |
IFNG | IFNGR1_IFNGR2 | IFNG_IFNGR1_IFNGR2 | IFN-II | Cervix | Precancer |
IFNG | IFNGR1_IFNGR2 | IFNG_IFNGR1_IFNGR2 | IFN-II | Endometrium | ADJ |
IFNG | IFNGR1_IFNGR2 | IFNG_IFNGR1_IFNGR2 | IFN-II | Endometrium | AEH |
IFNG | IFNGR1_IFNGR2 | IFNG_IFNGR1_IFNGR2 | IFN-II | Endometrium | EEC |
IFNG | IFNGR1_IFNGR2 | IFNG_IFNGR1_IFNGR2 | IFN-II | Endometrium | Healthy |
IFNG | IFNGR1_IFNGR2 | IFNG_IFNGR1_IFNGR2 | IFN-II | GC | ADJ |
IFNG | IFNGR1_IFNGR2 | IFNG_IFNGR1_IFNGR2 | IFN-II | GC | GC |
IFNG | IFNGR1_IFNGR2 | IFNG_IFNGR1_IFNGR2 | IFN-II | HNSCC | ADJ |
IFNG | IFNGR1_IFNGR2 | IFNG_IFNGR1_IFNGR2 | IFN-II | HNSCC | Healthy |
IFNG | IFNGR1_IFNGR2 | IFNG_IFNGR1_IFNGR2 | IFN-II | HNSCC | OSCC |
IFNG | IFNGR1_IFNGR2 | IFNG_IFNGR1_IFNGR2 | IFN-II | HNSCC | Precancer |
IFNG | IFNGR1_IFNGR2 | IFNG_IFNGR1_IFNGR2 | IFN-II | Liver | Healthy |
IFNG | IFNGR1_IFNGR2 | IFNG_IFNGR1_IFNGR2 | IFN-II | Liver | Precancer |
IFNG | IFNGR1_IFNGR2 | IFNG_IFNGR1_IFNGR2 | IFN-II | Lung | AAH |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
IFNGR1 | SNV | Missense_Mutation | novel | c.534G>T | p.Met178Ile | p.M178I | P15260 | protein_coding | tolerated(1) | benign(0) | TCGA-AN-A046-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
IFNGR1 | insertion | Frame_Shift_Ins | novel | c.1217_1218insG | p.Asp406GlufsTer8 | p.D406Efs*8 | P15260 | protein_coding | TCGA-AO-A128-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | doxorubicin | SD | ||
IFNGR1 | insertion | Nonsense_Mutation | novel | c.1216_1217insTACACTA | p.Asp406ValfsTer3 | p.D406Vfs*3 | P15260 | protein_coding | TCGA-AO-A128-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | doxorubicin | SD | ||
IFNGR1 | SNV | Missense_Mutation | novel | c.122A>G | p.Asn41Ser | p.N41S | P15260 | protein_coding | deleterious(0.01) | probably_damaging(0.975) | TCGA-2W-A8YY-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
IFNGR1 | SNV | Missense_Mutation | novel | c.1439N>C | p.Arg480Thr | p.R480T | P15260 | protein_coding | deleterious(0) | probably_damaging(0.997) | TCGA-C5-A1MH-01 | Cervix | cervical & endocervical cancer | Female | >=65 | III/IV | Chemotherapy | cisplatin | PD |
IFNGR1 | SNV | Missense_Mutation | c.332N>G | p.Ser111Cys | p.S111C | P15260 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-JW-A5VJ-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | PD | |
IFNGR1 | SNV | Missense_Mutation | c.439N>T | p.His147Tyr | p.H147Y | P15260 | protein_coding | deleterious(0.03) | possibly_damaging(0.731) | TCGA-LP-A5U2-01 | Cervix | cervical & endocervical cancer | Female | <65 | III/IV | Unknown | Unknown | SD | |
IFNGR1 | SNV | Missense_Mutation | novel | c.1121N>G | p.Ile374Arg | p.I374R | P15260 | protein_coding | tolerated(0.07) | benign(0.04) | TCGA-AA-3877-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
IFNGR1 | SNV | Missense_Mutation | c.813G>T | p.Lys271Asn | p.K271N | P15260 | protein_coding | deleterious(0) | probably_damaging(0.989) | TCGA-AA-3977-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
IFNGR1 | SNV | Missense_Mutation | novel | c.1267N>G | p.Ser423Gly | p.S423G | P15260 | protein_coding | tolerated(0.19) | benign(0.012) | TCGA-CA-6717-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Chemotherapy | oxaliplatin | CR |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
3459 | IFNGR1 | DRUGGABLE GENOME, CLINICALLY ACTIONABLE | INDOLE-3-CARBINOL | INDOLE-3-CARBINOL | 14988219 | |
3459 | IFNGR1 | DRUGGABLE GENOME, CLINICALLY ACTIONABLE | INTERFERON GAMMA-1B | |||
3459 | IFNGR1 | DRUGGABLE GENOME, CLINICALLY ACTIONABLE | agonist | CHEMBL1201564 | INTERFERON GAMMA-1B | |
3459 | IFNGR1 | DRUGGABLE GENOME, CLINICALLY ACTIONABLE | IFN-GAMMA | INTERFERON GAMMA-1B | ||
3459 | IFNGR1 | DRUGGABLE GENOME, CLINICALLY ACTIONABLE | INTERFERON GAMMA-1B |
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