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Gene: IER2 |
Gene summary for IER2 |
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Gene information | Species | Human | Gene symbol | IER2 | Gene ID | 9592 |
Gene name | immediate early response 2 | |
Gene Alias | ETR101 | |
Cytomap | 19p13.13 | |
Gene Type | protein-coding | GO ID | GO:0006139 | UniProtAcc | A0A024R7H1 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
9592 | IER2 | P12T-E | Human | Esophagus | ESCC | 5.61e-56 | 2.59e+00 | 0.1122 |
9592 | IER2 | P15T-E | Human | Esophagus | ESCC | 3.67e-44 | 2.00e+00 | 0.1149 |
9592 | IER2 | P16T-E | Human | Esophagus | ESCC | 1.55e-43 | 1.58e+00 | 0.1153 |
9592 | IER2 | P17T-E | Human | Esophagus | ESCC | 4.03e-09 | 1.82e+00 | 0.1278 |
9592 | IER2 | P19T-E | Human | Esophagus | ESCC | 8.79e-07 | 1.16e+00 | 0.1662 |
9592 | IER2 | P20T-E | Human | Esophagus | ESCC | 7.79e-48 | 3.86e+00 | 0.1124 |
9592 | IER2 | P21T-E | Human | Esophagus | ESCC | 3.13e-29 | 1.59e+00 | 0.1617 |
9592 | IER2 | P22T-E | Human | Esophagus | ESCC | 1.38e-16 | 1.19e+00 | 0.1236 |
9592 | IER2 | P23T-E | Human | Esophagus | ESCC | 2.62e-55 | 3.84e+00 | 0.108 |
9592 | IER2 | P24T-E | Human | Esophagus | ESCC | 6.25e-16 | 1.62e+00 | 0.1287 |
9592 | IER2 | P26T-E | Human | Esophagus | ESCC | 1.27e-59 | 2.30e+00 | 0.1276 |
9592 | IER2 | P27T-E | Human | Esophagus | ESCC | 7.89e-59 | 3.14e+00 | 0.1055 |
9592 | IER2 | P28T-E | Human | Esophagus | ESCC | 8.84e-69 | 3.01e+00 | 0.1149 |
9592 | IER2 | P30T-E | Human | Esophagus | ESCC | 1.21e-26 | 2.60e+00 | 0.137 |
9592 | IER2 | P31T-E | Human | Esophagus | ESCC | 1.64e-31 | 1.42e+00 | 0.1251 |
9592 | IER2 | P32T-E | Human | Esophagus | ESCC | 1.31e-10 | 9.50e-01 | 0.1666 |
9592 | IER2 | P36T-E | Human | Esophagus | ESCC | 2.01e-36 | 3.00e+00 | 0.1187 |
9592 | IER2 | P37T-E | Human | Esophagus | ESCC | 8.02e-23 | 1.27e+00 | 0.1371 |
9592 | IER2 | P39T-E | Human | Esophagus | ESCC | 2.57e-45 | 2.34e+00 | 0.0894 |
9592 | IER2 | P40T-E | Human | Esophagus | ESCC | 8.53e-29 | 2.17e+00 | 0.109 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:0071774 | Breast | Precancer | response to fibroblast growth factor | 15/1080 | 120/18723 | 3.80e-03 | 3.05e-02 | 15 |
GO:001657015 | Esophagus | ESCC | histone modification | 323/8552 | 463/18723 | 2.61e-26 | 7.88e-24 | 323 |
GO:00356015 | Esophagus | ESCC | protein deacylation | 79/8552 | 112/18723 | 8.30e-08 | 1.42e-06 | 79 |
GO:00987325 | Esophagus | ESCC | macromolecule deacylation | 80/8552 | 116/18723 | 3.19e-07 | 4.50e-06 | 80 |
GO:00165754 | Esophagus | ESCC | histone deacetylation | 60/8552 | 82/18723 | 3.85e-07 | 5.32e-06 | 60 |
GO:00064765 | Esophagus | ESCC | protein deacetylation | 70/8552 | 101/18723 | 1.29e-06 | 1.58e-05 | 70 |
GO:00165707 | Oral cavity | OSCC | histone modification | 270/7305 | 463/18723 | 1.59e-17 | 1.50e-15 | 270 |
GO:00356014 | Oral cavity | OSCC | protein deacylation | 74/7305 | 112/18723 | 5.88e-09 | 1.26e-07 | 74 |
GO:00987324 | Oral cavity | OSCC | macromolecule deacylation | 74/7305 | 116/18723 | 5.52e-08 | 1.01e-06 | 74 |
GO:00064764 | Oral cavity | OSCC | protein deacetylation | 66/7305 | 101/18723 | 7.36e-08 | 1.30e-06 | 66 |
GO:00165753 | Oral cavity | OSCC | histone deacetylation | 54/7305 | 82/18723 | 7.68e-07 | 1.08e-05 | 54 |
GO:003560113 | Oral cavity | LP | protein deacylation | 48/4623 | 112/18723 | 1.85e-05 | 3.14e-04 | 48 |
GO:001657014 | Oral cavity | LP | histone modification | 152/4623 | 463/18723 | 4.04e-05 | 5.90e-04 | 152 |
GO:001657511 | Oral cavity | LP | histone deacetylation | 37/4623 | 82/18723 | 4.28e-05 | 6.15e-04 | 37 |
GO:009873212 | Oral cavity | LP | macromolecule deacylation | 48/4623 | 116/18723 | 5.51e-05 | 7.58e-04 | 48 |
GO:000647613 | Oral cavity | LP | protein deacetylation | 41/4623 | 101/18723 | 3.03e-04 | 3.12e-03 | 41 |
GO:00717742 | Prostate | BPH | response to fibroblast growth factor | 31/3107 | 120/18723 | 6.55e-03 | 2.94e-02 | 31 |
GO:00717741 | Prostate | Tumor | response to fibroblast growth factor | 31/3246 | 120/18723 | 1.22e-02 | 4.97e-02 | 31 |
GO:00717743 | Skin | AK | response to fibroblast growth factor | 28/1910 | 120/18723 | 2.23e-05 | 4.08e-04 | 28 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
IER2 | SNV | Missense_Mutation | c.146C>T | p.Ser49Leu | p.S49L | Q9BTL4 | protein_coding | deleterious(0) | probably_damaging(0.986) | TCGA-C8-A12Z-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | 5-fluorouracil | CR | |
IER2 | SNV | Missense_Mutation | c.244G>C | p.Glu82Gln | p.E82Q | Q9BTL4 | protein_coding | tolerated(0.34) | benign(0.057) | TCGA-EK-A3GJ-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD | |
IER2 | SNV | Missense_Mutation | novel | c.246N>T | p.Glu82Asp | p.E82D | Q9BTL4 | protein_coding | tolerated(0.58) | benign(0.012) | TCGA-AZ-4315-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
IER2 | SNV | Missense_Mutation | novel | c.371N>T | p.Ser124Ile | p.S124I | Q9BTL4 | protein_coding | deleterious(0) | possibly_damaging(0.787) | TCGA-AP-A1E0-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | paclitaxel | SD |
IER2 | SNV | Missense_Mutation | novel | c.504G>T | p.Glu168Asp | p.E168D | Q9BTL4 | protein_coding | tolerated(0.13) | probably_damaging(0.931) | TCGA-B5-A3FC-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
IER2 | SNV | Missense_Mutation | novel | c.125N>T | p.Ser42Ile | p.S42I | Q9BTL4 | protein_coding | deleterious(0) | probably_damaging(0.99) | TCGA-EO-A22R-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
IER2 | SNV | Missense_Mutation | novel | c.91N>T | p.His31Tyr | p.H31Y | Q9BTL4 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-EO-A22X-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unspecific | Carboplatin | Complete Response |
IER2 | SNV | Missense_Mutation | c.628N>T | p.Asp210Tyr | p.D210Y | Q9BTL4 | protein_coding | deleterious(0) | probably_damaging(0.929) | TCGA-CC-A7IG-01 | Liver | liver hepatocellular carcinoma | Male | <65 | I/II | Unknown | Unknown | PD | |
IER2 | SNV | Missense_Mutation | rs771644993 | c.541N>T | p.Arg181Cys | p.R181C | Q9BTL4 | protein_coding | deleterious(0.01) | possibly_damaging(0.871) | TCGA-44-A47A-01 | Lung | lung adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | PD |
IER2 | SNV | Missense_Mutation | c.469G>T | p.Ala157Ser | p.A157S | Q9BTL4 | protein_coding | tolerated(0.73) | benign(0.006) | TCGA-69-7979-01 | Lung | lung adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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