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Gene: HADH |
Gene summary for HADH |
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Gene information | Species | Human | Gene symbol | HADH | Gene ID | 3033 |
Gene name | hydroxyacyl-CoA dehydrogenase | |
Gene Alias | HAD | |
Cytomap | 4q25 | |
Gene Type | protein-coding | GO ID | GO:0001659 | UniProtAcc | Q16836 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
3033 | HADH | S015 | Human | Liver | HCC | 1.40e-05 | 5.17e-01 | 0.2375 |
3033 | HADH | S016 | Human | Liver | HCC | 1.14e-07 | 3.95e-01 | 0.2243 |
3033 | HADH | S027 | Human | Liver | HCC | 5.62e-07 | 7.54e-01 | 0.2446 |
3033 | HADH | S028 | Human | Liver | HCC | 1.03e-21 | 1.02e+00 | 0.2503 |
3033 | HADH | S029 | Human | Liver | HCC | 1.06e-20 | 1.17e+00 | 0.2581 |
3033 | HADH | C04 | Human | Oral cavity | OSCC | 4.90e-02 | 4.90e-01 | 0.2633 |
3033 | HADH | C21 | Human | Oral cavity | OSCC | 5.00e-23 | 1.07e+00 | 0.2678 |
3033 | HADH | C30 | Human | Oral cavity | OSCC | 3.14e-05 | 6.12e-01 | 0.3055 |
3033 | HADH | C43 | Human | Oral cavity | OSCC | 4.36e-51 | 9.41e-01 | 0.1704 |
3033 | HADH | C46 | Human | Oral cavity | OSCC | 2.50e-20 | 7.64e-01 | 0.1673 |
3033 | HADH | C51 | Human | Oral cavity | OSCC | 1.24e-04 | 6.00e-01 | 0.2674 |
3033 | HADH | C57 | Human | Oral cavity | OSCC | 6.61e-07 | 7.41e-01 | 0.1679 |
3033 | HADH | C08 | Human | Oral cavity | OSCC | 3.80e-27 | 6.81e-01 | 0.1919 |
3033 | HADH | LN46 | Human | Oral cavity | OSCC | 7.82e-09 | 6.26e-01 | 0.1666 |
3033 | HADH | LP15 | Human | Oral cavity | LP | 2.09e-07 | 1.30e+00 | 0.2174 |
3033 | HADH | SYSMH2 | Human | Oral cavity | OSCC | 1.95e-10 | 3.15e-01 | 0.2326 |
3033 | HADH | SYSMH3 | Human | Oral cavity | OSCC | 1.33e-12 | 3.68e-01 | 0.2442 |
3033 | HADH | SYSMH4 | Human | Oral cavity | OSCC | 8.61e-07 | 1.13e-01 | 0.1226 |
3033 | HADH | SYSMH6 | Human | Oral cavity | OSCC | 3.18e-08 | 2.81e-01 | 0.1275 |
3033 | HADH | HTA12-15-2 | Human | Pancreas | PDAC | 3.57e-10 | 8.29e-01 | 0.2315 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:0032868 | Colorectum | AD | response to insulin | 91/3918 | 264/18723 | 2.02e-07 | 8.48e-06 | 91 |
GO:0044282 | Colorectum | AD | small molecule catabolic process | 118/3918 | 376/18723 | 1.05e-06 | 3.55e-05 | 118 |
GO:0043434 | Colorectum | AD | response to peptide hormone | 126/3918 | 414/18723 | 2.70e-06 | 7.86e-05 | 126 |
GO:0006635 | Colorectum | AD | fatty acid beta-oxidation | 33/3918 | 74/18723 | 3.98e-06 | 1.09e-04 | 33 |
GO:0009062 | Colorectum | AD | fatty acid catabolic process | 41/3918 | 100/18723 | 4.02e-06 | 1.09e-04 | 41 |
GO:0019395 | Colorectum | AD | fatty acid oxidation | 40/3918 | 103/18723 | 2.43e-05 | 4.69e-04 | 40 |
GO:0016042 | Colorectum | AD | lipid catabolic process | 97/3918 | 320/18723 | 4.31e-05 | 7.56e-04 | 97 |
GO:0006631 | Colorectum | AD | fatty acid metabolic process | 114/3918 | 390/18723 | 5.58e-05 | 9.44e-04 | 114 |
GO:0050708 | Colorectum | AD | regulation of protein secretion | 83/3918 | 268/18723 | 6.59e-05 | 1.07e-03 | 83 |
GO:0072329 | Colorectum | AD | monocarboxylic acid catabolic process | 44/3918 | 122/18723 | 8.05e-05 | 1.28e-03 | 44 |
GO:0034440 | Colorectum | AD | lipid oxidation | 40/3918 | 108/18723 | 8.52e-05 | 1.32e-03 | 40 |
GO:0009306 | Colorectum | AD | protein secretion | 105/3918 | 359/18723 | 1.05e-04 | 1.57e-03 | 105 |
GO:0035592 | Colorectum | AD | establishment of protein localization to extracellular region | 105/3918 | 360/18723 | 1.18e-04 | 1.73e-03 | 105 |
GO:0030258 | Colorectum | AD | lipid modification | 67/3918 | 212/18723 | 1.66e-04 | 2.27e-03 | 67 |
GO:0071692 | Colorectum | AD | protein localization to extracellular region | 106/3918 | 368/18723 | 1.86e-04 | 2.49e-03 | 106 |
GO:0050796 | Colorectum | AD | regulation of insulin secretion | 54/3918 | 165/18723 | 2.60e-04 | 3.25e-03 | 54 |
GO:0009410 | Colorectum | AD | response to xenobiotic stimulus | 128/3918 | 462/18723 | 2.69e-04 | 3.31e-03 | 128 |
GO:0016054 | Colorectum | AD | organic acid catabolic process | 73/3918 | 240/18723 | 3.20e-04 | 3.81e-03 | 73 |
GO:0044242 | Colorectum | AD | cellular lipid catabolic process | 66/3918 | 214/18723 | 3.96e-04 | 4.50e-03 | 66 |
GO:0030073 | Colorectum | AD | insulin secretion | 61/3918 | 195/18723 | 4.28e-04 | 4.81e-03 | 61 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa00280 | Colorectum | AD | Valine, leucine and isoleucine degradation | 25/2092 | 48/8465 | 3.97e-05 | 3.41e-04 | 2.18e-04 | 25 |
hsa00310 | Colorectum | AD | Lysine degradation | 27/2092 | 63/8465 | 1.17e-03 | 7.75e-03 | 4.94e-03 | 27 |
hsa00071 | Colorectum | AD | Fatty acid degradation | 20/2092 | 43/8465 | 1.50e-03 | 8.69e-03 | 5.54e-03 | 20 |
hsa002801 | Colorectum | AD | Valine, leucine and isoleucine degradation | 25/2092 | 48/8465 | 3.97e-05 | 3.41e-04 | 2.18e-04 | 25 |
hsa003101 | Colorectum | AD | Lysine degradation | 27/2092 | 63/8465 | 1.17e-03 | 7.75e-03 | 4.94e-03 | 27 |
hsa000711 | Colorectum | AD | Fatty acid degradation | 20/2092 | 43/8465 | 1.50e-03 | 8.69e-03 | 5.54e-03 | 20 |
hsa00062 | Colorectum | SER | Fatty acid elongation | 11/1580 | 27/8465 | 6.38e-03 | 3.68e-02 | 2.67e-02 | 11 |
hsa000712 | Colorectum | SER | Fatty acid degradation | 15/1580 | 43/8465 | 8.60e-03 | 4.26e-02 | 3.09e-02 | 15 |
hsa000621 | Colorectum | SER | Fatty acid elongation | 11/1580 | 27/8465 | 6.38e-03 | 3.68e-02 | 2.67e-02 | 11 |
hsa000713 | Colorectum | SER | Fatty acid degradation | 15/1580 | 43/8465 | 8.60e-03 | 4.26e-02 | 3.09e-02 | 15 |
hsa003104 | Colorectum | FAP | Lysine degradation | 23/1404 | 63/8465 | 1.04e-04 | 9.46e-04 | 5.76e-04 | 23 |
hsa002804 | Colorectum | FAP | Valine, leucine and isoleucine degradation | 18/1404 | 48/8465 | 3.94e-04 | 3.06e-03 | 1.86e-03 | 18 |
hsa000716 | Colorectum | FAP | Fatty acid degradation | 15/1404 | 43/8465 | 2.73e-03 | 1.23e-02 | 7.50e-03 | 15 |
hsa00380 | Colorectum | FAP | Tryptophan metabolism | 13/1404 | 42/8465 | 1.54e-02 | 4.99e-02 | 3.03e-02 | 13 |
hsa003105 | Colorectum | FAP | Lysine degradation | 23/1404 | 63/8465 | 1.04e-04 | 9.46e-04 | 5.76e-04 | 23 |
hsa002805 | Colorectum | FAP | Valine, leucine and isoleucine degradation | 18/1404 | 48/8465 | 3.94e-04 | 3.06e-03 | 1.86e-03 | 18 |
hsa000717 | Colorectum | FAP | Fatty acid degradation | 15/1404 | 43/8465 | 2.73e-03 | 1.23e-02 | 7.50e-03 | 15 |
hsa003801 | Colorectum | FAP | Tryptophan metabolism | 13/1404 | 42/8465 | 1.54e-02 | 4.99e-02 | 3.03e-02 | 13 |
hsa003106 | Colorectum | CRC | Lysine degradation | 18/1091 | 63/8465 | 7.21e-04 | 6.34e-03 | 4.30e-03 | 18 |
hsa01212 | Colorectum | CRC | Fatty acid metabolism | 14/1091 | 57/8465 | 1.17e-02 | 4.99e-02 | 3.38e-02 | 14 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
HADH | SNV | Missense_Mutation | novel | c.856A>G | p.Thr286Ala | p.T286A | Q16836 | protein_coding | deleterious(0.01) | possibly_damaging(0.702) | TCGA-A2-A04Y-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | cytoxan | SD |
HADH | SNV | Missense_Mutation | rs150930917 | c.237N>T | p.Lys79Asn | p.K79N | Q16836 | protein_coding | deleterious(0.02) | possibly_damaging(0.59) | TCGA-A7-A0DB-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Hormone Therapy | arimidex | SD |
HADH | SNV | Missense_Mutation | c.775G>A | p.Glu259Lys | p.E259K | Q16836 | protein_coding | tolerated(0.22) | benign(0.103) | TCGA-D8-A1JC-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | adriamycin | SD | |
HADH | insertion | Nonsense_Mutation | novel | c.858_859insTCATAGCCACACCCCAAATATGCTGTGTTCCTTCCC | p.Thr286_Thr287insSerTerProHisProLysTyrAlaValPheLeuPro | p.T286_T287insS*PHPKYAVFLP | Q16836 | protein_coding | TCGA-A2-A04Y-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | cytoxan | SD | ||
HADH | insertion | In_Frame_Ins | novel | c.669_670insCTGCAGGAAAGCCTGGAA | p.Leu223_Val224insLeuGlnGluSerLeuGlu | p.L223_V224insLQESLE | Q16836 | protein_coding | TCGA-E9-A1NC-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | doxorubicin | CR | ||
HADH | insertion | Frame_Shift_Ins | novel | c.671_672insCAACCTGTTTAAAGCTTTTCCTC | p.Pro225AsnfsTer36 | p.P225Nfs*36 | Q16836 | protein_coding | TCGA-E9-A1NC-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | doxorubicin | CR | ||
HADH | SNV | Missense_Mutation | c.56N>T | p.Ser19Leu | p.S19L | Q16836 | protein_coding | tolerated(0.19) | benign(0.09) | TCGA-C5-A1BM-01 | Cervix | cervical & endocervical cancer | Female | >=65 | I/II | Unknown | Unknown | SD | |
HADH | SNV | Missense_Mutation | c.914N>G | p.Gln305Arg | p.Q305R | Q16836 | protein_coding | tolerated(0.33) | benign(0.025) | TCGA-A6-3809-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
HADH | SNV | Missense_Mutation | c.791N>T | p.Ala264Val | p.A264V | Q16836 | protein_coding | deleterious(0) | probably_damaging(0.987) | TCGA-AA-3977-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
HADH | SNV | Missense_Mutation | rs183387994 | c.737C>T | p.Ser246Leu | p.S246L | Q16836 | protein_coding | tolerated_low_confidence(1) | benign(0) | TCGA-AG-3592-01 | Colorectum | rectum adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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