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Gene: GUCD1 |
Gene summary for GUCD1 |
Gene summary. |
Gene information | Species | Human | Gene symbol | GUCD1 | Gene ID | 83606 |
Gene name | guanylyl cyclase domain containing 1 | |
Gene Alias | C22orf13 | |
Cytomap | 22q11.23 | |
Gene Type | protein-coding | GO ID | GO:0003674 | UniProtAcc | A0A087WVD9 |
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Malignant transformation analysis |
Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
Malignant transformation involving gene list. |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
83606 | GUCD1 | S027 | Human | Liver | HCC | 4.59e-07 | 8.88e-01 | 0.2446 |
83606 | GUCD1 | S028 | Human | Liver | HCC | 1.39e-15 | 8.27e-01 | 0.2503 |
83606 | GUCD1 | S029 | Human | Liver | HCC | 4.33e-21 | 1.03e+00 | 0.2581 |
83606 | GUCD1 | C04 | Human | Oral cavity | OSCC | 9.49e-08 | 3.94e-01 | 0.2633 |
83606 | GUCD1 | C21 | Human | Oral cavity | OSCC | 2.50e-26 | 6.94e-01 | 0.2678 |
83606 | GUCD1 | C30 | Human | Oral cavity | OSCC | 2.77e-27 | 1.01e+00 | 0.3055 |
83606 | GUCD1 | C38 | Human | Oral cavity | OSCC | 1.08e-05 | 7.00e-01 | 0.172 |
83606 | GUCD1 | C43 | Human | Oral cavity | OSCC | 3.63e-16 | 4.45e-01 | 0.1704 |
83606 | GUCD1 | C46 | Human | Oral cavity | OSCC | 1.86e-21 | 4.59e-01 | 0.1673 |
83606 | GUCD1 | C51 | Human | Oral cavity | OSCC | 1.67e-18 | 6.68e-01 | 0.2674 |
83606 | GUCD1 | C57 | Human | Oral cavity | OSCC | 5.09e-15 | 4.00e-01 | 0.1679 |
83606 | GUCD1 | C06 | Human | Oral cavity | OSCC | 1.31e-03 | 5.28e-01 | 0.2699 |
83606 | GUCD1 | C08 | Human | Oral cavity | OSCC | 3.21e-10 | 3.23e-01 | 0.1919 |
83606 | GUCD1 | LN22 | Human | Oral cavity | OSCC | 3.24e-02 | 4.02e-01 | 0.1733 |
83606 | GUCD1 | LN38 | Human | Oral cavity | OSCC | 9.48e-03 | 5.59e-01 | 0.168 |
83606 | GUCD1 | LN46 | Human | Oral cavity | OSCC | 1.59e-17 | 5.92e-01 | 0.1666 |
83606 | GUCD1 | LP15 | Human | Oral cavity | LP | 3.93e-12 | 1.04e+00 | 0.2174 |
83606 | GUCD1 | SYSMH1 | Human | Oral cavity | OSCC | 2.48e-02 | 1.61e-01 | 0.1127 |
83606 | GUCD1 | SYSMH2 | Human | Oral cavity | OSCC | 1.10e-04 | 2.40e-01 | 0.2326 |
83606 | GUCD1 | SYSMH3 | Human | Oral cavity | OSCC | 3.82e-11 | 3.43e-01 | 0.2442 |
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Transcriptomic changes along malignancy continuum. |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
Figure of enriched GO biological processes. |
Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | |
Colorectum | SER | |
Colorectum | MSS | |
Colorectum | MSI-H | |
Colorectum | FAP |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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Enriched GO biological processes. |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Enriched KEGG pathways. |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
Annotation of somatic variants for genes involved in malignant transformation |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
GUCD1 | SNV | Missense_Mutation | novel | c.515T>G | p.Phe172Cys | p.F172C | protein_coding | deleterious(0.02) | possibly_damaging(0.882) | TCGA-AN-A046-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
GUCD1 | SNV | Missense_Mutation | c.703N>T | p.Arg235Cys | p.R235C | protein_coding | deleterious(0.01) | benign(0.013) | TCGA-GM-A2D9-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Hormone Therapy | arimidex | SD | ||
GUCD1 | SNV | Missense_Mutation | rs747949402 | c.599N>G | p.His200Arg | p.H200R | protein_coding | tolerated(0.21) | possibly_damaging(0.457) | TCGA-A6-6780-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
GUCD1 | SNV | Missense_Mutation | novel | c.128N>T | p.Ala43Val | p.A43V | protein_coding | tolerated_low_confidence(0.3) | benign(0.003) | TCGA-CK-4951-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | PD | |
GUCD1 | SNV | Missense_Mutation | novel | c.416N>A | p.Arg139His | p.R139H | protein_coding | tolerated(0.35) | benign(0.067) | TCGA-A5-A1OF-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
GUCD1 | SNV | Missense_Mutation | novel | c.824N>C | p.Asn275Thr | p.N275T | protein_coding | tolerated(0.19) | possibly_damaging(0.889) | TCGA-A5-A2K5-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
GUCD1 | SNV | Missense_Mutation | c.863A>G | p.Asp288Gly | p.D288G | protein_coding | deleterious(0) | probably_damaging(0.987) | TCGA-AP-A0LM-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | cisplatin | SD | ||
GUCD1 | SNV | Missense_Mutation | c.496A>G | p.Thr166Ala | p.T166A | protein_coding | tolerated(0.65) | benign(0.039) | TCGA-AP-A0LM-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | cisplatin | SD | ||
GUCD1 | SNV | Missense_Mutation | rs141621665 | c.733N>A | p.Val245Met | p.V245M | protein_coding | deleterious(0) | probably_damaging(0.992) | TCGA-AP-A1DK-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
GUCD1 | SNV | Missense_Mutation | rs191716304 | c.499N>T | p.Arg167Trp | p.R167W | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-AX-A05U-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
Identification of chemicals and drugs interact with genes involved in malignant transfromation |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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