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Gene: GADD45GIP1 |
Gene summary for GADD45GIP1 |
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Gene information | Species | Human | Gene symbol | GADD45GIP1 | Gene ID | 90480 |
Gene name | GADD45G interacting protein 1 | |
Gene Alias | CKBBP2 | |
Cytomap | 19p13.13 | |
Gene Type | protein-coding | GO ID | GO:0007049 | UniProtAcc | Q8TAE8 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
90480 | GADD45GIP1 | P48T-E | Human | Esophagus | ESCC | 5.39e-58 | 1.02e+00 | 0.0959 |
90480 | GADD45GIP1 | P49T-E | Human | Esophagus | ESCC | 7.71e-22 | 2.81e+00 | 0.1768 |
90480 | GADD45GIP1 | P52T-E | Human | Esophagus | ESCC | 6.07e-122 | 2.53e+00 | 0.1555 |
90480 | GADD45GIP1 | P54T-E | Human | Esophagus | ESCC | 3.41e-59 | 1.32e+00 | 0.0975 |
90480 | GADD45GIP1 | P56T-E | Human | Esophagus | ESCC | 3.33e-11 | 1.42e+00 | 0.1613 |
90480 | GADD45GIP1 | P57T-E | Human | Esophagus | ESCC | 1.23e-48 | 9.70e-01 | 0.0926 |
90480 | GADD45GIP1 | P61T-E | Human | Esophagus | ESCC | 4.38e-53 | 1.29e+00 | 0.099 |
90480 | GADD45GIP1 | P62T-E | Human | Esophagus | ESCC | 3.03e-89 | 1.84e+00 | 0.1302 |
90480 | GADD45GIP1 | P65T-E | Human | Esophagus | ESCC | 7.72e-49 | 1.17e+00 | 0.0978 |
90480 | GADD45GIP1 | P74T-E | Human | Esophagus | ESCC | 2.06e-61 | 1.94e+00 | 0.1479 |
90480 | GADD45GIP1 | P75T-E | Human | Esophagus | ESCC | 4.24e-95 | 2.06e+00 | 0.1125 |
90480 | GADD45GIP1 | P76T-E | Human | Esophagus | ESCC | 7.02e-65 | 1.42e+00 | 0.1207 |
90480 | GADD45GIP1 | P79T-E | Human | Esophagus | ESCC | 8.28e-50 | 1.09e+00 | 0.1154 |
90480 | GADD45GIP1 | P80T-E | Human | Esophagus | ESCC | 1.60e-64 | 2.04e+00 | 0.155 |
90480 | GADD45GIP1 | P82T-E | Human | Esophagus | ESCC | 4.00e-32 | 1.71e+00 | 0.1072 |
90480 | GADD45GIP1 | P83T-E | Human | Esophagus | ESCC | 1.22e-70 | 2.17e+00 | 0.1738 |
90480 | GADD45GIP1 | P84T-E | Human | Esophagus | ESCC | 3.63e-10 | 1.04e+00 | 0.0933 |
90480 | GADD45GIP1 | P89T-E | Human | Esophagus | ESCC | 2.58e-36 | 2.99e+00 | 0.1752 |
90480 | GADD45GIP1 | P91T-E | Human | Esophagus | ESCC | 4.21e-24 | 3.26e+00 | 0.1828 |
90480 | GADD45GIP1 | P94T-E | Human | Esophagus | ESCC | 1.38e-05 | 1.32e+00 | 0.0879 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
GADD45GIP1 | SNV | Missense_Mutation | novel | c.47N>T | p.Ala16Val | p.A16V | Q8TAE8 | protein_coding | tolerated(0.58) | benign(0.007) | TCGA-WS-AB45-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
GADD45GIP1 | deletion | Frame_Shift_Del | rs752340689 | c.585_586delNN | p.Lys196ThrfsTer43 | p.K196Tfs*43 | Q8TAE8 | protein_coding | TCGA-A6-6653-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | ||
GADD45GIP1 | SNV | Missense_Mutation | novel | c.301N>A | p.Glu101Lys | p.E101K | Q8TAE8 | protein_coding | tolerated(0.3) | benign(0.23) | TCGA-A5-A1OF-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
GADD45GIP1 | SNV | Missense_Mutation | novel | c.184N>A | p.Ala62Thr | p.A62T | Q8TAE8 | protein_coding | deleterious(0) | benign(0.023) | TCGA-A5-A1OF-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
GADD45GIP1 | SNV | Missense_Mutation | rs147251319 | c.566G>A | p.Arg189His | p.R189H | Q8TAE8 | protein_coding | tolerated(0.07) | probably_damaging(0.945) | TCGA-AX-A1CE-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unspecific | Paclitaxel | SD |
GADD45GIP1 | SNV | Missense_Mutation | rs779779033 | c.560G>A | p.Arg187His | p.R187H | Q8TAE8 | protein_coding | deleterious(0) | probably_damaging(0.984) | TCGA-B5-A3FA-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
GADD45GIP1 | SNV | Missense_Mutation | rs763367169 | c.521N>A | p.Arg174His | p.R174H | Q8TAE8 | protein_coding | deleterious(0) | probably_damaging(0.96) | TCGA-D1-A103-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
GADD45GIP1 | SNV | Missense_Mutation | novel | c.585N>T | p.Gln195His | p.Q195H | Q8TAE8 | protein_coding | deleterious(0.01) | possibly_damaging(0.855) | TCGA-EO-A22R-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
GADD45GIP1 | SNV | Missense_Mutation | rs753799047 | c.559C>T | p.Arg187Cys | p.R187C | Q8TAE8 | protein_coding | deleterious(0) | probably_damaging(0.993) | TCGA-EO-A22U-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
GADD45GIP1 | SNV | Missense_Mutation | rs755977311 | c.565N>T | p.Arg189Cys | p.R189C | Q8TAE8 | protein_coding | deleterious(0) | probably_damaging(0.981) | TCGA-EY-A1H0-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | taxol | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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