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Gene: FGFR1OP2 |
Gene summary for FGFR1OP2 |
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Gene information | Species | Human | Gene symbol | FGFR1OP2 | Gene ID | 26127 |
Gene name | FGFR1 oncogene partner 2 | |
Gene Alias | HSPC123-like | |
Cytomap | 12p11.23 | |
Gene Type | protein-coding | GO ID | GO:0006950 | UniProtAcc | Q9NVK5 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
26127 | FGFR1OP2 | PTC06 | Human | Thyroid | PTC | 1.67e-27 | 5.39e-01 | 0.2057 |
26127 | FGFR1OP2 | PTC07 | Human | Thyroid | PTC | 4.58e-34 | 5.04e-01 | 0.2044 |
26127 | FGFR1OP2 | ATC09 | Human | Thyroid | ATC | 3.13e-08 | 2.40e-02 | 0.2871 |
26127 | FGFR1OP2 | ATC11 | Human | Thyroid | ATC | 3.12e-07 | 3.46e-01 | 0.3386 |
26127 | FGFR1OP2 | ATC12 | Human | Thyroid | ATC | 1.02e-18 | 2.71e-01 | 0.34 |
26127 | FGFR1OP2 | ATC13 | Human | Thyroid | ATC | 7.57e-45 | 6.92e-01 | 0.34 |
26127 | FGFR1OP2 | ATC1 | Human | Thyroid | ATC | 4.01e-04 | 9.39e-02 | 0.2878 |
26127 | FGFR1OP2 | ATC2 | Human | Thyroid | ATC | 1.43e-11 | 1.13e+00 | 0.34 |
26127 | FGFR1OP2 | ATC3 | Human | Thyroid | ATC | 1.17e-09 | 3.05e-01 | 0.338 |
26127 | FGFR1OP2 | ATC4 | Human | Thyroid | ATC | 1.41e-21 | 4.33e-01 | 0.34 |
26127 | FGFR1OP2 | ATC5 | Human | Thyroid | ATC | 9.68e-37 | 7.65e-01 | 0.34 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:004206027 | Esophagus | ESCC | wound healing | 243/8552 | 422/18723 | 4.62e-07 | 6.25e-06 | 243 |
GO:004206012 | Liver | Cirrhotic | wound healing | 155/4634 | 422/18723 | 2.12e-08 | 7.56e-07 | 155 |
GO:004206022 | Liver | HCC | wound healing | 219/7958 | 422/18723 | 5.34e-05 | 5.04e-04 | 219 |
GO:004206020 | Oral cavity | OSCC | wound healing | 237/7305 | 422/18723 | 4.51e-13 | 2.18e-11 | 237 |
GO:0042060110 | Oral cavity | LP | wound healing | 139/4623 | 422/18723 | 7.10e-05 | 9.48e-04 | 139 |
GO:004206030 | Thyroid | HT | wound healing | 60/1272 | 422/18723 | 4.06e-08 | 2.69e-06 | 60 |
GO:0042060112 | Thyroid | PTC | wound healing | 190/5968 | 422/18723 | 7.72e-09 | 1.92e-07 | 190 |
GO:004206034 | Thyroid | ATC | wound healing | 210/6293 | 422/18723 | 3.33e-12 | 1.37e-10 | 210 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
FGFR1OP2 | deletion | Frame_Shift_Del | novel | c.562delN | p.Ala189ProfsTer26 | p.A189Pfs*26 | Q9NVK5 | protein_coding | TCGA-EW-A2FV-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | docetaxel | SD | ||
FGFR1OP2 | SNV | Missense_Mutation | c.571N>A | p.Glu191Lys | p.E191K | Q9NVK5 | protein_coding | deleterious(0.02) | benign(0.062) | TCGA-FU-A23K-01 | Cervix | cervical & endocervical cancer | Female | <65 | III/IV | Unknown | Unknown | SD | |
FGFR1OP2 | SNV | Missense_Mutation | novel | c.535N>G | p.Ile179Val | p.I179V | Q9NVK5 | protein_coding | tolerated(0.08) | possibly_damaging(0.51) | TCGA-ZJ-AAXN-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD |
FGFR1OP2 | SNV | Missense_Mutation | rs761470386 | c.178N>T | p.Arg60Trp | p.R60W | Q9NVK5 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-A6-5661-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
FGFR1OP2 | SNV | Missense_Mutation | c.469N>A | p.Gln157Lys | p.Q157K | Q9NVK5 | protein_coding | tolerated_low_confidence(1) | possibly_damaging(0.893) | TCGA-DM-A28A-01 | Colorectum | colon adenocarcinoma | Male | >=65 | III/IV | Unknown | Unknown | SD | |
FGFR1OP2 | SNV | Missense_Mutation | rs144332739 | c.449N>A | p.Arg150Gln | p.R150Q | Q9NVK5 | protein_coding | tolerated_low_confidence(0.41) | benign(0.003) | TCGA-AG-A002-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
FGFR1OP2 | SNV | Missense_Mutation | novel | c.507G>T | p.Gln169His | p.Q169H | Q9NVK5 | protein_coding | tolerated(0.34) | benign(0.001) | TCGA-A5-A0G2-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
FGFR1OP2 | SNV | Missense_Mutation | novel | c.565G>T | p.Ala189Ser | p.A189S | Q9NVK5 | protein_coding | deleterious(0.01) | probably_damaging(0.985) | TCGA-A5-A0G2-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
FGFR1OP2 | SNV | Missense_Mutation | novel | c.638G>A | p.Gly213Asp | p.G213D | Q9NVK5 | protein_coding | tolerated(0.37) | benign(0.049) | TCGA-AX-A06F-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | carboplatin | SD |
FGFR1OP2 | SNV | Missense_Mutation | c.722C>T | p.Ala241Val | p.A241V | Q9NVK5 | protein_coding | tolerated_low_confidence(0.13) | benign(0.001) | TCGA-B5-A11N-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
26127 | FGFR1OP2 | NA | brivanib | BRIVANIB | 20124951 |
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