|
|||||
|
 | |
| |
| |
| |
| |
| |
|
Gene: FAM83B |
Gene summary for FAM83B |
 Gene summary. |
| Gene information | Species | Human | Gene symbol | FAM83B | Gene ID | 222584 |
| Gene name | family with sequence similarity 83 member B | |
| Gene Alias | C6orf143 | |
| Cytomap | 6p12.1 | |
| Gene Type | protein-coding | GO ID | GO:0007154 | UniProtAcc | Q5T0W9 |
Top |
Malignant transformation analysis |
| Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
| Malignant transformation involving gene list. |
| Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
| 222584 | FAM83B | P127T-E | Human | Esophagus | ESCC | 1.05e-17 | 3.69e-01 | 0.0826 |
| 222584 | FAM83B | P128T-E | Human | Esophagus | ESCC | 6.66e-11 | 4.54e-01 | 0.1241 |
| 222584 | FAM83B | P130T-E | Human | Esophagus | ESCC | 4.49e-49 | 9.68e-01 | 0.1676 |
| 222584 | FAM83B | C04 | Human | Oral cavity | OSCC | 6.12e-07 | 5.31e-01 | 0.2633 |
| 222584 | FAM83B | C21 | Human | Oral cavity | OSCC | 7.83e-23 | 7.87e-01 | 0.2678 |
| 222584 | FAM83B | C30 | Human | Oral cavity | OSCC | 1.44e-09 | 6.02e-01 | 0.3055 |
| 222584 | FAM83B | C43 | Human | Oral cavity | OSCC | 1.68e-02 | 9.05e-02 | 0.1704 |
| 222584 | FAM83B | C46 | Human | Oral cavity | OSCC | 1.54e-02 | 2.52e-01 | 0.1673 |
| 222584 | FAM83B | C51 | Human | Oral cavity | OSCC | 9.82e-04 | 4.11e-01 | 0.2674 |
| 222584 | FAM83B | C06 | Human | Oral cavity | OSCC | 1.06e-02 | 5.80e-01 | 0.2699 |
| 222584 | FAM83B | C07 | Human | Oral cavity | OSCC | 1.71e-02 | 6.89e-01 | 0.2491 |
| 222584 | FAM83B | C08 | Human | Oral cavity | OSCC | 2.66e-15 | 3.62e-01 | 0.1919 |
| 222584 | FAM83B | SYSMH1 | Human | Oral cavity | OSCC | 1.11e-12 | 2.90e-01 | 0.1127 |
| 222584 | FAM83B | SYSMH2 | Human | Oral cavity | OSCC | 6.50e-14 | 3.95e-01 | 0.2326 |
| 222584 | FAM83B | SYSMH3 | Human | Oral cavity | OSCC | 1.91e-24 | 5.89e-01 | 0.2442 |
| 222584 | FAM83B | SYSMH5 | Human | Oral cavity | OSCC | 7.28e-03 | 1.76e-01 | 0.0647 |
| 222584 | FAM83B | P1_S1_AK | Human | Skin | AK | 1.44e-29 | 6.07e-01 | -0.3399 |
| 222584 | FAM83B | P2_S3_AK | Human | Skin | AK | 3.79e-12 | 3.71e-01 | -0.3287 |
| 222584 | FAM83B | P2_S4_SCCIS | Human | Skin | SCCIS | 1.09e-20 | 5.35e-01 | -0.3043 |
| 222584 | FAM83B | P3_S6_AK | Human | Skin | AK | 3.39e-10 | 4.21e-01 | -0.3256 |
| Page: 1 2 3 4 5 6 7 |
| Transcriptomic changes along malignancy continuum. |
| Tissue | Expression Dynamics | Abbreviation |
| Cervix |  | CC: Cervix cancer |
| HSIL_HPV: HPV-infected high-grade squamous intraepithelial lesions | ||
| N_HPV: HPV-infected normal cervix | ||
| Colorectum (GSE201348) |  | FAP: Familial adenomatous polyposis |
| CRC: Colorectal cancer | ||
| Colorectum (HTA11) |  | AD: Adenomas |
| SER: Sessile serrated lesions | ||
| MSI-H: Microsatellite-high colorectal cancer | ||
| MSS: Microsatellite stable colorectal cancer | ||
| Esophagus |  | ESCC: Esophageal squamous cell carcinoma |
| HGIN: High-grade intraepithelial neoplasias | ||
| LGIN: Low-grade intraepithelial neoplasias | ||
| Oral Cavity |  | EOLP: Erosive Oral lichen planus |
| LP: leukoplakia | ||
| NEOLP: Non-erosive oral lichen planus | ||
| OSCC: Oral squamous cell carcinoma | ||
| Skin |  | AK: Actinic keratosis |
| cSCC: Cutaneous squamous cell carcinoma | ||
| SCCIS:squamous cell carcinoma in situ |
| ∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
Top |
Malignant transformation related pathway analysis |
| Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
| Figure of enriched GO biological processes. |
| Tissue | Disease Stage | Enriched GO biological Processes |
| Colorectum | AD |  |
| Colorectum | SER |  |
| Colorectum | MSS |  |
| Colorectum | MSI-H |  |
| Colorectum | FAP |  |
| ∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
| Page: 1 2 3 4 5 6 7 8 9 |
| Enriched GO biological processes. |
| GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
| GO:00071738 | Cervix | CC | epidermal growth factor receptor signaling pathway | 36/2311 | 108/18723 | 1.04e-08 | 8.44e-07 | 36 |
| GO:00381278 | Cervix | CC | ERBB signaling pathway | 37/2311 | 121/18723 | 8.57e-08 | 4.88e-06 | 37 |
| GO:0038127 | Colorectum | AD | ERBB signaling pathway | 55/3918 | 121/18723 | 1.19e-09 | 8.85e-08 | 55 |
| GO:0007173 | Colorectum | AD | epidermal growth factor receptor signaling pathway | 50/3918 | 108/18723 | 3.08e-09 | 2.07e-07 | 50 |
| GO:00071732 | Colorectum | MSS | epidermal growth factor receptor signaling pathway | 43/3467 | 108/18723 | 1.92e-07 | 8.31e-06 | 43 |
| GO:00381272 | Colorectum | MSS | ERBB signaling pathway | 46/3467 | 121/18723 | 3.63e-07 | 1.45e-05 | 46 |
| GO:00071734 | Colorectum | FAP | epidermal growth factor receptor signaling pathway | 42/2622 | 108/18723 | 1.29e-10 | 3.77e-08 | 42 |
| GO:00381274 | Colorectum | FAP | ERBB signaling pathway | 45/2622 | 121/18723 | 1.64e-10 | 4.38e-08 | 45 |
| GO:00071735 | Colorectum | CRC | epidermal growth factor receptor signaling pathway | 39/2078 | 108/18723 | 6.90e-12 | 5.90e-09 | 39 |
| GO:00381275 | Colorectum | CRC | ERBB signaling pathway | 41/2078 | 121/18723 | 2.12e-11 | 1.59e-08 | 41 |
| GO:003812717 | Esophagus | HGIN | ERBB signaling pathway | 29/2587 | 121/18723 | 1.83e-03 | 1.97e-02 | 29 |
| GO:000717317 | Esophagus | HGIN | epidermal growth factor receptor signaling pathway | 25/2587 | 108/18723 | 5.87e-03 | 4.77e-02 | 25 |
| GO:003812718 | Esophagus | ESCC | ERBB signaling pathway | 82/8552 | 121/18723 | 7.23e-07 | 9.40e-06 | 82 |
| GO:000717318 | Esophagus | ESCC | epidermal growth factor receptor signaling pathway | 73/8552 | 108/18723 | 3.36e-06 | 3.73e-05 | 73 |
| GO:003812715 | Oral cavity | OSCC | ERBB signaling pathway | 76/7305 | 121/18723 | 9.59e-08 | 1.66e-06 | 76 |
| GO:000717315 | Oral cavity | OSCC | epidermal growth factor receptor signaling pathway | 67/7305 | 108/18723 | 1.04e-06 | 1.40e-05 | 67 |
| GO:003812719 | Skin | AK | ERBB signaling pathway | 29/1910 | 121/18723 | 9.23e-06 | 1.98e-04 | 29 |
| GO:000717319 | Skin | AK | epidermal growth factor receptor signaling pathway | 25/1910 | 108/18723 | 6.89e-05 | 1.00e-03 | 25 |
| GO:0007173110 | Skin | SCCIS | epidermal growth factor receptor signaling pathway | 18/919 | 108/18723 | 4.95e-06 | 2.05e-04 | 18 |
| GO:0038127110 | Skin | SCCIS | ERBB signaling pathway | 19/919 | 121/18723 | 6.72e-06 | 2.64e-04 | 19 |
| Page: 1 2 |
| Enriched KEGG pathways. |
| Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
| Page: 1 |
Top |
Cell-cell communication analysis |
| Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
| Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
| Page: 1 |
Top |
Single-cell gene regulatory network inference analysis |
| Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
| TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
| ∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
| Page: 1 |
Top |
Somatic mutation of malignant transformation related genes |
| Annotation of somatic variants for genes involved in malignant transformation |
| Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
| FAM83B | SNV | Missense_Mutation | novel | c.61N>A | p.Glu21Lys | p.E21K | Q5T0W9 | protein_coding | deleterious(0.01) | possibly_damaging(0.9) | TCGA-5L-AAT1-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Hormone Therapy | letrozol | SD |
| FAM83B | SNV | Missense_Mutation | c.593N>T | p.Ser198Leu | p.S198L | Q5T0W9 | protein_coding | deleterious(0) | benign(0.038) | TCGA-A1-A0SH-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | tc | SD | |
| FAM83B | SNV | Missense_Mutation | c.821G>T | p.Arg274Ile | p.R274I | Q5T0W9 | protein_coding | deleterious(0) | possibly_damaging(0.858) | TCGA-AN-A046-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
| FAM83B | SNV | Missense_Mutation | novel | c.1956G>T | p.Lys652Asn | p.K652N | Q5T0W9 | protein_coding | deleterious(0.04) | benign(0.019) | TCGA-AN-A046-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
| FAM83B | SNV | Missense_Mutation | novel | c.2365C>A | p.Leu789Ile | p.L789I | Q5T0W9 | protein_coding | tolerated(0.21) | benign(0.045) | TCGA-AN-A046-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
| FAM83B | SNV | Missense_Mutation | c.2654C>T | p.Ser885Phe | p.S885F | Q5T0W9 | protein_coding | deleterious(0) | probably_damaging(0.998) | TCGA-BH-A0DZ-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | docetaxel | SD | |
| FAM83B | SNV | Missense_Mutation | c.1285N>C | p.Ser429Pro | p.S429P | Q5T0W9 | protein_coding | tolerated(0.19) | benign(0.276) | TCGA-D8-A1XQ-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
| FAM83B | insertion | Frame_Shift_Ins | novel | c.2979_2980insTCCT | p.Asn994SerfsTer2 | p.N994Sfs*2 | Q5T0W9 | protein_coding | TCGA-AN-A04C-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | ||
| FAM83B | insertion | Nonsense_Mutation | novel | c.2980_2981insCTTAAATGATCATTCAGAAGCT | p.Asn994ThrfsTer2 | p.N994Tfs*2 | Q5T0W9 | protein_coding | TCGA-AN-A04C-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | ||
| FAM83B | insertion | Frame_Shift_Ins | novel | c.2726_2727insCATGG | p.Glu909AspfsTer52 | p.E909Dfs*52 | Q5T0W9 | protein_coding | TCGA-AN-A0AS-01 | Breast | breast invasive carcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD |
| Page: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 |
Top |
Related drugs of malignant transformation related genes |
| Identification of chemicals and drugs interact with genes involved in malignant transfromation |
| (DGIdb 4.0) |
| Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
| Page: 1 |
Copyright 2023-Present -The University of Texas Health Science Center at Houston |