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Gene: FAM63B |
Gene summary for FAM63B |
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Gene information | Species | Human | Gene symbol | FAM63B | Gene ID | 54629 |
Gene name | MINDY lysine 48 deubiquitinase 2 | |
Gene Alias | FAM63B | |
Cytomap | 15q21.3-q22.1 | |
Gene Type | protein-coding | GO ID | GO:0006464 | UniProtAcc | Q8NBR6 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
54629 | FAM63B | GSM5353223_PA_PB2B_Pool_2_S26_L001 | Human | Prostate | Tumor | 1.32e-06 | 3.41e-01 | 0.1604 |
54629 | FAM63B | GSM5353224_PA_PR5186_Pool_1_2_3_S27_L001 | Human | Prostate | Tumor | 1.92e-09 | 3.54e-01 | 0.1621 |
54629 | FAM63B | GSM5353225_PA_PR5196-1_Pool_1_2_3_S53_L002 | Human | Prostate | Tumor | 3.41e-03 | 3.39e-01 | 0.1619 |
54629 | FAM63B | GSM5353227_PA_PR5199-193K_Pool_1_2_3_S55_L002 | Human | Prostate | Tumor | 2.33e-03 | 2.47e-01 | 0.1602 |
54629 | FAM63B | P1_cSCC | Human | Skin | cSCC | 3.91e-15 | 5.91e-01 | 0.0292 |
54629 | FAM63B | P2_cSCC | Human | Skin | cSCC | 1.76e-05 | 3.13e-01 | -0.024 |
54629 | FAM63B | P4_cSCC | Human | Skin | cSCC | 7.48e-11 | 3.23e-01 | -0.00290000000000005 |
54629 | FAM63B | P10_cSCC | Human | Skin | cSCC | 6.87e-20 | 5.75e-01 | 0.1017 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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